Circular RNAs in Blood
Por:
Vea, A, Llorente-Cortes, V, de Gonzalo-Calvo, D
Publicada:
1 ene 2018
Resumen:
Recent advances in RNA sequencing and bioinformatic analysis have allowed the development of a new research field: circular RNAs (circRNAs). These members of the non-coding transcriptome are generated by backsplicing, which results in a covalently closed, single-stranded RNA molecule. To date, thousands of circRNAs have been identified in different human cell types. CircRNAs are evolutionarily conserved, highly stable, cell-/developmental stage-specific and have longer half-lives compared with linear RNAs. Interestingly, different studies have demonstrated that circRNAs are abundantly expressed in the bloodstream. In this chapter, we review the current knowledge of circRNA biology in blood cells and the cell-free compartment, including extracellular vesicles. The potential clinical application of blood circRNAs in the biomarker and therapy fields is also discussed. Finally, perspectives for future studies are proposed.
Filiaciones:
Vea, A:
Biomed Res Inst St Pau IIB St Pau, Barcelona, Spain
Llorente-Cortes, V:
Biomed Res Inst St Pau IIB St Pau, Barcelona, Spain
CSIC, Inst Biomed Res Barcelona IIBB, Barcelona, Spain
Inst Hlth Carlos III, CIBERCV, Madrid, Spain
de Gonzalo-Calvo, D:
Biomed Res Inst St Pau IIB St Pau, Barcelona, Spain
CSIC, Inst Biomed Res Barcelona IIBB, Barcelona, Spain
Inst Hlth Carlos III, CIBERCV, Madrid, Spain
|