Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition
Por:
Mikropoulos, C, Selkirk, CGH, Saya, S, Bancroft, E, Vertosick, E, Dadaev, T, Brendler, C, Page, E, Dias, A, Evans, DG, Rothwell, J, Maehle, L, Axcrona, K, Richardson, K, Eccles, D, Jensen, T, Osther, PJ, van Asperen, CJ, Vasen, H, Kiemeney, LA, Ringelberg, J, Cybulski, C, Wokolorczyk, D, Hart, R, Glover, W, Lam, J, Taylor, L, Salinas, M, Feliubadalo, L, Oldenburg, R, Cremers, R, Verhaegh, G, van Zelst-Stams, WA, Oosterwijk, JC, Cook, J, Rosario, DJ, Buys, SS, Conner, T, Domchek, S, Powers, J, Ausems, MGEM, Teixeira, MR, Maia, S, Izatt, L, Schmutzler, R, Rhiem, K, Foulkes, WD, Boshari, T, Davidson, R, Ruijs, M, Helderman-van den Enden, ATJM, Andrews, L, Walker, L, Snape, K, Henderson, A, Jobson, I, Lindeman, GJ, Liljegren, A, Harris, M, Adank, MA, Kirk, J, Taylor, A, Susman, R, Chen-Shtoyerman, R, Pachter, N, Spigelman, A, Side, L, Zgajnar, J, Mora, J, Brewer, C, Gadea, N, Brady, AF, Gallagher, D, van Os, T, Donaldson, A, Stefansdottir, V, Barwell, J, James, PA, Murphy, D, Friedman, E, Nicolai, N, Greenhalgh, L, Obeid, E, Murthy, V, Copakova, L, McGrath, J, Teo, SH, Strom, S, Kast, K, Leongamornlert, DA, Chamberlain, A, Pope, J, Newlin, AC, Aaronson, N, Ardern-Jones, A, Bangma, C, Castro, E, Dearnaley, D, Eyfjord, J, Falconer, A, Foster, CS, Gronberg, H, Hamdy, FC, Johannsson, O, Khoo, V, Lubinski, J, Grindedal, EM, McKinley, J, Shackleton, K, Mitra, AV, Moynihan, C, Rennert, G, Suri, M, Tricker, K, Moss, S, Kote-Jarai, Z, Vickers, A, Lilja, H, Helfand, BT, Eeles, RA, IMPACT Study Collaborators
Publicada:
23 ene 2018
Resumen:
Background: Prostate-specific antigen (PSA) and PSA-velocity (PSAV) have been used to identify men at risk of prostate cancer (PrCa). The IMPACT study is evaluating PSA screening in men with a known genetic predisposition to PrCa due to BRCA1/2 mutations. This analysis evaluates the utility of PSA and PSAV for identifying PrCa and high-grade disease in this cohort.
Methods: PSAV was calculated using logistic regression to determine if PSA or PSAV predicted the result of prostate biopsy (PB) in men with elevated PSA values. Cox regression was used to determine whether PSA or PSAV predicted PSA elevation in men with low PSAs. Interaction terms were included in the models to determine whether BRCA status influenced the predictiveness of PSA or PSAV.
Results: 1634 participants had >= 3 PSA readings of whom 174 underwent PB and 45 PrCas diagnosed. In men with PSA >3.0 ng ml(-1), PSAV was not significantly associated with presence of cancer or high-grade disease. PSAV did not add to PSA for predicting time to an elevated PSA. When comparing BRCA1/2 carriers to non-carriers, we found a significant interaction between BRCA status and last PSA before biopsy (P = 0.031) and BRCA2 status and PSAV (P = 0.024). However, PSAV was not predictive of biopsy outcome in BRCA2 carriers.
Conclusions: PSA is more strongly predictive of PrCa in BRCA carriers than non-carriers. We did not find evidence that PSAV aids decision-making for BRCA carriers over absolute PSA value alone.
Filiaciones:
Mikropoulos, C:
Inst Canc Res, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England
Selkirk, CGH:
North Shore Univ Hlth Syst, Dept Surg, John & Carol Walter Ctr Urol Hlth, Evanston, IL 60201 USA
North Shore Univ Hlth Syst, Dept Med, Ctr Med Genet, Evanston, IL 60201 USA
Saya, S:
Inst Canc Res, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England
Bancroft, E:
Inst Canc Res, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England
Royal Marsden NHS Fdn Trust, Fulham Rd, London SW3 6JJ, England
Vertosick, E:
Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10065 USA
Dadaev, T:
Inst Canc Res, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England
Brendler, C:
North Shore Univ Hlth Syst, Dept Surg, John & Carol Walter Ctr Urol Hlth, Evanston, IL 60201 USA
Page, E:
Inst Canc Res, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England
Dias, A:
Inst Canc Res, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England
Royal Marsden NHS Fdn Trust, Fulham Rd, London SW3 6JJ, England
Evans, DG:
Univ Manchester, Cent Manchester Univ Hosp NHS Fdn Trust, Div Evolut & Genom Sci, Gen Med Manchester Acad Hlth Sci Ctr, Manchester M13 9WL, Lancs, England
Rothwell, J:
Univ Manchester, Cent Manchester Univ Hosp NHS Fdn Trust, Div Evolut & Genom Sci, Gen Med Manchester Acad Hlth Sci Ctr, Manchester M13 9WL, Lancs, England
Maehle, L:
Oslo Univ Hosp, Dept Med Genet, N-0372 Oslo, Norway
Axcrona, K:
Akershus Univ Hosp, N-1478 Lorenskog, Norway
Richardson, K:
Parkville Familial Canc Ctr, Peter MacCallum Canc Ctr, East Melbourne, Vic 3000, Australia
Sir Peter MacCallum Dept Oncol, Melbourne, Vic 3010, Australia
Eccles, D:
Princess Anne Hosp, Wessex Clin Genet Serv, Southampton SO16 5YA, Hants, England
Univ Southampton, Univ Hosp Southampton NHS Fdn Trust, Cancer Sci Fac Med, Southampton SO16 6YD, Hants, England
Jensen, T:
Vejle Hosp, Dept Clin Genet, DK-7100 Vejle, Denmark
Osther, PJ:
Vejle Hosp, Dept Clin Genet, DK-7100 Vejle, Denmark
van Asperen, CJ:
Leiden Univ, Med Ctr, Dept Clin Genet, NL-2333 ZA Leiden, Netherlands
Vasen, H:
Netherlands Fdn Detect Hereditary Tumors, NL-2333 Nijmegen, GA, Netherlands
Kiemeney, LA:
Radboud Univ Nijmegen, Med Ctr, NL-6525 Nijmegen, GA, Netherlands
Ringelberg, J:
Netherlands Fdn Detect Hereditary Tumors, NL-2333 Nijmegen, GA, Netherlands
Cybulski, C:
Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, PL-70204 Szczecin, Poland
Wokolorczyk, D:
Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, PL-70204 Szczecin, Poland
Hart, R:
Birmingham Womens Hosp, Clin Genet Unit, Birmingham B15 2TG, W Midlands, England
Glover, W:
Birmingham Womens Hosp, Clin Genet Unit, Birmingham B15 2TG, W Midlands, England
Lam, J:
Repatriat Gen Hosp, Dept Urol, Daw Pk, SA 5041, Australia
Taylor, L:
Repatriat Gen Hosp, Dept Urol, Daw Pk, SA 5041, Australia
Salinas, M:
Hosp Llobregat, Catalan Inst Oncol, ICO IDIBELL, CIBERONC,Hereditary Canc Program, Barcelona 08908, Spain
Feliubadalo, L:
Hosp Llobregat, Catalan Inst Oncol, ICO IDIBELL, CIBERONC,Hereditary Canc Program, Barcelona 08908, Spain
Oldenburg, R:
Erasmus MC, Dept Clin Genet, NL-3015 Rotterdam, Netherlands
Cremers, R:
Radboud Univ Nijmegen, Med Ctr, NL-6525 Nijmegen, GA, Netherlands
Verhaegh, G:
Radboud Univ Nijmegen, Med Ctr, NL-6525 Nijmegen, GA, Netherlands
van Zelst-Stams, WA:
Netherlands Fdn Detect Hereditary Tumors, NL-2333 Nijmegen, GA, Netherlands
Oosterwijk, JC:
Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9713 Groningen, Netherlands
Cook, J:
Sheffield Childrens Hosp, Sheffield Clin Genet Serv, Sheffield S10 2TH, S Yorkshire, England
Rosario, DJ:
Royal Hallamshire Hosp, Sheffield S10 2JF, S Yorkshire, England
Buys, SS:
Univ Utah, Huntsman Canc Inst, Salt Lake City, UT 84103 USA
Conner, T:
Univ Utah, Huntsman Canc Inst, Salt Lake City, UT 84103 USA
Domchek, S:
Univ Penn, Basser Res Ctr, Philadelphia, PA 19104 USA
Powers, J:
Univ Penn, Basser Res Ctr, Philadelphia, PA 19104 USA
Ausems, MGEM:
Univ Med Ctr Utrecht, Dept Genet, Utrecht, CX, Netherlands
Teixeira, MR:
Portuguese Oncol Inst, Genet Dept, P-4200072 Oporto, Portugal
Portuguese Oncol Inst, Res Ctr, P-4200072 Oporto, Portugal
Univ Porto, Biomed Sci Inst ICBAS, P-4200072 Oporto, Portugal
Maia, S:
Portuguese Oncol Inst, Genet Dept, P-4200072 Oporto, Portugal
Portuguese Oncol Inst, Res Ctr, P-4200072 Oporto, Portugal
Izatt, L:
Guys Hosp, South East Thames Genet Serv, London SE1 9RT, England
Schmutzler, R:
Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, D-50829 Cologne, Germany
Rhiem, K:
Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, D-50829 Cologne, Germany
Foulkes, WD:
McGill Univ, Dept Oncol, McGill Program Canc Genet, Montreal, PQ, Canada
McGill Univ, Dept Human Genet, Montreal, PQ, Canada
Boshari, T:
McGill Univ, Dept Oncol, McGill Program Canc Genet, Montreal, PQ, Canada
McGill Univ, Dept Human Genet, Montreal, PQ, Canada
Davidson, R:
Duncan Guthrie Inst Med Genet, Yorkhill NHS Trust, Glasgow G38SJ, Lanark, Scotland
Ruijs, M:
Netherlands Canc Inst, NL-1066 CX Amsterdam, Netherlands
Helderman-van den Enden, ATJM:
Maastricht Univ, Med Ctr, Dept Clin Genet, NL-6229 HX Maastricht, Netherlands
Andrews, L:
Prince Wales Hosp, Hereditary Canc Clin, Randwick, NSW 2031, Australia
Walker, L:
Churchill Hosp, Oxford OX3 7LE, England
Snape, K:
St George Hosp, London SW17 0QT, England
Henderson, A:
Newcastle Upon Tyne Hosp, Northern Genet Serv, Newcastle NE1 3BZ, England
Jobson, I:
Newcastle Upon Tyne Hosp, Northern Genet Serv, Newcastle NE1 3BZ, England
Lindeman, GJ:
Royal Melbourne Hosp, Parkville Familial Canc Ctr, Grattan St, Parkville, Vic 3050, Australia
Walter & Eliza Hall Inst Med Res, Stem Cells & Canc Div, Parkville, Vic 3050, Australia
Univ Melbourne, Dept Med, Parkville, Vic 3050, Australia
Liljegren, A:
Karolinska Univ Hosp, S-17184 Solna, Sweden
Karolinska Inst, S-17184 Solna, Sweden
Harris, M:
Monash Hlth, Familial Canc Ctr, Clayton, Vic 3168, Australia
Adank, MA:
Vrije Univ Amsterdam Med Ctr, NL-1081 HV Amsterdam, Netherlands
Kirk, J:
Westmead Hosp, Familial Canc Serv, Sydney, NSW 2145, Australia
Westmead Inst Med Res, Ctr Canc Res, Sydney, NSW 2155, Australia
Taylor, A:
Cambridge Univ Hosp NHS Fdn Trust, Cambridge CB2 0QQ, England
Susman, R:
Royal Brisbane & Womens Hosp, Genet Hlth Queensland, Herston, Qld 4029, Australia
Chen-Shtoyerman, R:
Kaplan Med Ctr, Genet Inst, IL-76100 Rehovot, Israel
Pachter, N:
King Edward Mem Hosp, Genet Serv WA, Subiaco, WA 6008, Australia
Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6009, Australia
Spigelman, A:
Hunter Family Canc Serv, Waratah, NSW 2298, Australia
Univ New South Wales, St Vincents Clin Sch, Sydney, NSW 2052, Australia
St Vincents Hosp, Kinghorn Canc Ctr, Sydney, NSW 2010, Australia
Side, L:
Great Ormond St Hosp Sick Children, NE Thames Reg Genet Serv, London WC1N 3JH, England
UCL Inst Womens Hlth, London WC1N 3JH, England
Zgajnar, J:
Inst Oncol, Ljubljana 1000, Slovenia
Mora, J:
Hosp Santa Creu & Sant Pau, Barcelona 08041, Spain
Brewer, C:
Derriford Hosp, Peninsular Genet, Plymouth PL6 8DH, Devon, England
Royal Devon & Exeter Hosp, Exeter EX2 5DW, Devon, England
Gadea, N:
Vall dHebron Univ Hosp, High Risk & Canc Prevent Clin, Barcelona 08035, Spain
Brady, AF:
London North West Healthcare NHS Trust, North West Thames Reg Genet Serv, Harrow HA1 3UJ, Middx, England
Gallagher, D:
St James Hosp, Dublin 8, Ireland
van Os, T:
Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands
Donaldson, A:
St Michaels Hosp, Bristol BS2 8EG, Avon, England
Stefansdottir, V:
Landspitali Natl Univ Hosp Iceland, IS-101 Reykjavik, Iceland
Barwell, J:
Univ Leicester, Leicester LE1 7RH, Leics, England
Univ Hosp Leicester, Leicester LE1 5WW, Leics, England
James, PA:
Parkville Familial Canc Ctr, Peter MacCallum Canc Ctr, East Melbourne, Vic 3000, Australia
Sir Peter MacCallum Dept Oncol, Melbourne, Vic 3010, Australia
Royal Melbourne Hosp, Genet Med, Melbourne, Vic 3050, Australia
Murphy, D:
Sir Peter MacCallum Dept Oncol, Melbourne, Vic 3010, Australia
Friedman, E:
Chaim Sheba Med Ctr, IL-52621 Tel Hashomer, Israel
Tel Aviv Univ, Sackler Sch Med, IL-6997801 Tel Aviv, Israel
Nicolai, N:
Ist Nazl Tumori, I-20133 Milan, Italy
Greenhalgh, L:
Liverpool Womens Hosp, Cheshire & Mersey Clin Genet Serv, Liverpool L8 7SS, Merseyside, England
Obeid, E:
Fox Chase Canc Ctr, Philadelphia, PA 19111 USA
Murthy, V:
Tata Mem Hosp, Mumbai 400012, Maharashtra, India
Copakova, L:
Natl Canc Inst, Bratislava 83310, Slovakia
McGrath, J:
Royal Devon & Exeter Hosp, Exeter EX2 5DW, Devon, England
Teo, SH:
Subang Jaya Med Ctr, Canc Res Initiat Fdn, Subang Jaya, Selangor 47500, Malaysia
Strom, S:
Univ Texas Houston, MD Anderson Canc Ctr, Houston, TX 77030 USA
Kast, K:
Tech Univ Dresden, Dept Gynecol & Obstet, Fac Med, D-01069 Dresden, Germany
Tech Univ Dresden, Univ Hosp Carl Gustav Carus, D-01069 Dresden, Germany
Natl Ctr Tumor Dis NCT, Partner Site Dresden, D-01307 Dresden, Germany
Leongamornlert, DA:
Inst Canc Res, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England
Chamberlain, A:
Inst Canc Res, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England
Pope, J:
Inst Canc Res, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England
Newlin, AC:
North Shore Univ Hlth Syst, Dept Med, Ctr Med Genet, Evanston, IL 60201 USA
Aaronson, N:
Netherlands Canc Inst, NL-1066 CX Amsterdam, Netherlands
Ardern-Jones, A:
Royal Marsden NHS Fdn Trust, Fulham Rd, London SW3 6JJ, England
Bangma, C:
Erasmus MC, Dept Clin Genet, NL-3015 Rotterdam, Netherlands
Castro, E:
Spanish Natl Canc Res Ctr, Prostate Canc Unit, Madrid 28029, Spain
Dearnaley, D:
Inst Canc Res, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England
Royal Marsden NHS Fdn Trust, Fulham Rd, London SW3 6JJ, England
Eyfjord, J:
Univ Iceland, Sch Hlth Sci, Fac Med, IS-101 Reykjavik, Iceland
Falconer, A:
Imperial Coll Healthcare NHS Trust, London W2 1NY, England
Foster, CS:
HCA Healthcare Labs, London WC1E 6JA, England
Gronberg, H:
Univ Hosp, S-90737 Umea, Sweden
Hamdy, FC:
Churchill Hosp, Oxford OX3 7LE, England
Univ Oxford, Nuffield Dept Surg Sci, Oxford OX1 2JD, England
Johannsson, O:
Landspitali Natl Univ Hosp Iceland, IS-101 Reykjavik, Iceland
Khoo, V:
Royal Marsden NHS Fdn Trust, Fulham Rd, London SW3 6JJ, England
Lubinski, J:
Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, PL-70204 Szczecin, Poland
Grindedal, EM:
Oslo Univ Hosp, Dept Med Genet, N-0372 Oslo, Norway
McKinley, J:
Parkville Familial Canc Ctr, Peter MacCallum Canc Ctr, East Melbourne, Vic 3000, Australia
Shackleton, K:
Royal Melbourne Hosp, Parkville Familial Canc Ctr, Grattan St, Parkville, Vic 3050, Australia
Mitra, AV:
Univ Coll London Hosp NHS Fdn Trust, London NW1 2BU, England
Moynihan, C:
Inst Canc Res, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England
Rennert, G:
CHS Natl Canc Control Ctr, Carmel Med Ctr, IL-31999 Haifa, Israel
Suri, M:
City Hosp Nottingham, Nottingham NG5 1PB, England
Tricker, K:
Univ Manchester, Cent Manchester Univ Hosp NHS Fdn Trust, Div Evolut & Genom Sci, Gen Med Manchester Acad Hlth Sci Ctr, Manchester M13 9WL, Lancs, England
Moss, S:
Queen Mary Univ London, Ctr Canc Prevent, London EC1M 6BQ, England
Kote-Jarai, Z:
Inst Canc Res, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England
Vickers, A:
City Hosp Nottingham, Nottingham NG5 1PB, England
Lilja, H:
Univ Oxford, Nuffield Dept Surg Sci, Oxford OX1 2JD, England
Mem Sloan Kettering Canc Ctr, Dept Lab Med, New York, NY 10065 USA
Mem Sloan Kettering Canc Ctr, Dept Surg & Med, New York, NY 10065 USA
Helfand, BT:
North Shore Univ Hlth Syst, Dept Surg, John & Carol Walter Ctr Urol Hlth, Evanston, IL 60201 USA
Eeles, RA:
Inst Canc Res, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England
Royal Marsden NHS Fdn Trust, Fulham Rd, London SW3 6JJ, England
Dresden & German Canc Res Ctr DKFZ, German Canc Consortium DKTK, D-69120 Heidelberg, Germany.
Lund Univ, Dept Translat Med, S-20502 Malmo, Sweden.
Hybrid Gold, Green Published, Green Accepted
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