Correlates of non-target vessel-related adverse events in patients with ST-segment elevation myocardial infarction: insights from five-year follow-up of the EXAMINATION trial
Por:
Spitaleri, G, Moscarella, E, Brugaletta, S, Pernigotti, A, Ortega-Paz, L, Gomez-Lara, J, Cequier, A, Iniguez, A, Serra, A, Jimenez-Quevedo, P, Mainar, V, Campo, G, Tespili, M, den Heijer, P, Bethencourt, A, Vazquez, N, Valgimigli, M, Serruys, PW, Sabate, M
Publicada:
1 mar 2018
Resumen:
Aims: The aim of this substudy was to determine the five-year correlates of non-TV-related adverse events (AE) in STEMI patients included in the EXAMINATION trial.
Methods and results: The EXAMINATION trial randomised 1,498 STEMI patients to bare metal or everolimus-eluting stent implantation. In this substudy, patients were analysed according to non-TV-related AE, defined as the composite of either non-TV revascularisation (non-TVR) or non-TV-related myocardial infarction (MI). At five-year follow-up, 125 patients (8.3%) exhibited 136 non-TV-related AE (124 [8.3%] non-TVR, 12 [0.8%] non-TV-related MI), accounting for 47.1% of 289 non-fatal cardiac events overall. These patients had a higher incidence of diabetes mellitus (p<0.001), arterial hypertension (p=0.032), previous MI (p=0.073), multivessel disease (p<0.001), and incomplete revascularisation (p=0.049), and a lower rate of ST-segment resolution >70% (p=0.042) as compared to the rest. At Cox analysis, previous MI (HR 1.872, 95% CI: 1.004-3.489; p=0.048), incomplete revascularisation (HR 1.746, 95% CI: 1.029-2.963; p=0.039) and diabetes (HR 1.942, 95% CI: 1.292-2.919; p=0.001) were independent correlates of non-TV-related AE.
Conclusions: In STEMI patients undergoing primary percutaneous coronary intervention, previous MI, incomplete revascularisation and diabetes resulted in being independent correlates of five-year non-TV-related AE.
Filiaciones:
Spitaleri, G:
Univ Hosp Clin, IDIBAPS, Cardiovasc Clin Inst, Barcelona, Spain
Moscarella, E:
Univ Hosp Clin, IDIBAPS, Cardiovasc Clin Inst, Barcelona, Spain
Brugaletta, S:
Univ Hosp Clin, IDIBAPS, Cardiovasc Clin Inst, Barcelona, Spain
Pernigotti, A:
Univ Hosp Clin, IDIBAPS, Cardiovasc Clin Inst, Barcelona, Spain
Ortega-Paz, L:
Univ Hosp Clin, IDIBAPS, Cardiovasc Clin Inst, Barcelona, Spain
Gomez-Lara, J:
Univ Hosp Bellvitge, Dept Cardiol, Barcelona, Spain
Cequier, A:
Univ Hosp Bellvitge, Dept Cardiol, Barcelona, Spain
Iniguez, A:
Hosp do Meixoeiro, Dept Cardiol, Vigo, Spain
Serra, A:
Univ Hosp St Pau, Dept Cardiol, Barcelona, Spain
Jimenez-Quevedo, P:
Univ Hosp San Carlos, Dept Cardiol, Madrid, Spain
Mainar, V:
Hosp Gen Alicante, Dept Cardiol, Alicante, Spain
Campo, G:
Azienda Osped Univ Ferrara, Cardiovasc Inst, Cona, FE, Italy
Maria Cecilia Hosp, ES Hlth Sci Fdn, GVM Care & Res, Cotignola, Italy
Tespili, M:
Univ Hosp Bolognini Seriate, Dept Cardiol, Bergamo, Italy
den Heijer, P:
Amphia Ziekenhuis, Dept Cardiol, Breda, Netherlands
Bethencourt, A:
Hosp Son Espases, Dept Cardiol, Palma De Mallorca, Spain
Vazquez, N:
Hosp Juan Canalejo, Dept Cardiol, La Coruna, Spain
Valgimigli, M:
Univ Hosp Bern, Inselspital, Bern, Switzerland
Serruys, PW:
Imperial Coll London, Int Ctr Circulatory Hlth, London, England
Sabate, M:
Univ Hosp Clin, IDIBAPS, Cardiovasc Clin Inst, Barcelona, Spain
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