Cortical microstructural changes along the Alzheimer's disease continuum
Por:
Montal, V, Vilaplana, E, Alcolea, D, Pegueroles, J, Pasternak, O, Gonzalez-Ortiz, S, Clarimon, J, Carmona-Iragui, M, Illan-Gala, I, Morenas-Rodriguez, E, Ribosa-Nogue, R, Sala, I, Sanchez-Saudinos, MB, Garcia-Sebastian, M, Villanua, J, Izagirre, A, Estanga, A, Ecay-Torres, M, Iriondo, A, Clerigue, M, Tainta, M, Pozueta, A, Gonzalez, A, Martinez-Heras, E, Llufriu, S, Blesa, R, Sanchez-Juan, P, Martinez-Lage, P, Lleo, A, Fortea, J
Publicada:
1 mar 2018
Resumen:
Introduction: Cortical mean diffusivity (MD) and free water fraction (FW) changes are proposed biomarkers for Alzheimer's disease (AD).
Methods: We included healthy control subjects (N = 254), mild cognitive impairment (N = 41), and AD dementia (N = 31) patients. Participants underwent a lumbar puncture and a 3 T magnetic resonance imaging. Healthy control subjects were classified following National Institute on Aging-Alzheimer's Association stages (stage 0, N = 220; stage 1, N = 25; and stage 2/3, N = 9). We assessed the cortical MD, cortical FW, and cortical thickness (CTh) changes along the AD continuum.
Results: Microstructural and macrostructural changes show a biphasic trajectory. Stage 1 subjects showed increased CTh and decreased MD and FW with respect the stage 0 subjects. Stage 2/3 subjects showed decreased CTh and increased cortical MD and FW, changes that were more widespread in symptomatic stages.
Discussion: These results support a biphasic model of changes in AD, which could affect the selection of patients for clinical trials and the use of magnetic resonance imaging as a surrogate marker of disease modification. (C) 2017 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
Filiaciones:
Montal, V:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Vilaplana, E:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Alcolea, D:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Pegueroles, J:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Pasternak, O:
Harvard Med Sch, Brigham & Womens Hosp, Dept Psychiat, Boston, MA USA
Harvard Med Sch, Brigham & Womens Hosp, Dept Radiol, Boston, MA USA
Gonzalez-Ortiz, S:
Hosp del Mar, Dept Radiol, Barcelona, Spain
Clarimon, J:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Carmona-Iragui, M:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Illan-Gala, I:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Morenas-Rodriguez, E:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Ribosa-Nogue, R:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Sala, I:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Sanchez-Saudinos, MB:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Garcia-Sebastian, M:
Fdn CITA Alzheimer Fundazioa, Ctr Res & Adv Therapies, Donostia San Sebastian, Spain
Fdn CITA Alzheimer Fundazioa, Memory Clin, Donostia San Sebastian, Spain
Villanua, J:
Fdn CITA Alzheimer Fundazioa, Ctr Res & Adv Therapies, Donostia San Sebastian, Spain
Fdn CITA Alzheimer Fundazioa, Memory Clin, Donostia San Sebastian, Spain
Donostia Univ Hosp, Osatek SA, Donostia Unit, San Sebastian, Spain
Izagirre, A:
Fdn CITA Alzheimer Fundazioa, Ctr Res & Adv Therapies, Donostia San Sebastian, Spain
Fdn CITA Alzheimer Fundazioa, Memory Clin, Donostia San Sebastian, Spain
Estanga, A:
Fdn CITA Alzheimer Fundazioa, Ctr Res & Adv Therapies, Donostia San Sebastian, Spain
Fdn CITA Alzheimer Fundazioa, Memory Clin, Donostia San Sebastian, Spain
Ecay-Torres, M:
Fdn CITA Alzheimer Fundazioa, Ctr Res & Adv Therapies, Donostia San Sebastian, Spain
Fdn CITA Alzheimer Fundazioa, Memory Clin, Donostia San Sebastian, Spain
Iriondo, A:
Fdn CITA Alzheimer Fundazioa, Ctr Res & Adv Therapies, Donostia San Sebastian, Spain
Fdn CITA Alzheimer Fundazioa, Memory Clin, Donostia San Sebastian, Spain
Clerigue, M:
Fdn CITA Alzheimer Fundazioa, Ctr Res & Adv Therapies, Donostia San Sebastian, Spain
Fdn CITA Alzheimer Fundazioa, Memory Clin, Donostia San Sebastian, Spain
Tainta, M:
Fdn CITA Alzheimer Fundazioa, Ctr Res & Adv Therapies, Donostia San Sebastian, Spain
Fdn CITA Alzheimer Fundazioa, Memory Clin, Donostia San Sebastian, Spain
Pozueta, A:
Hosp Univ Marques de Valdecilla, Serv Neurol, Santander, Spain
Gonzalez, A:
Hosp Univ Marques de Valdecilla, Serv Neurol, Santander, Spain
Martinez-Heras, E:
Hosp Clin Barcelona, IDIBAPS, Ctr Neuroimmunol, Barcelona, Spain
Llufriu, S:
Hosp Clin Barcelona, IDIBAPS, Ctr Neuroimmunol, Barcelona, Spain
Blesa, R:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Sanchez-Juan, P:
Hosp Univ Marques de Valdecilla, Serv Neurol, Santander, Spain
Martinez-Lage, P:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Fdn CITA Alzheimer Fundazioa, Ctr Res & Adv Therapies, Donostia San Sebastian, Spain
Fdn CITA Alzheimer Fundazioa, Memory Clin, Donostia San Sebastian, Spain
Lleo, A:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Fortea, J:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
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