Gray and white matter changes and their relation to illness trajectory in first episode psychosis
Por:
Keymer-Gausset, A, Alonso-Solis, A, Corripio, I, Sauras-Quetcuti, RB, Pomarol-Clotet, E, Canales-Rodriguez, EJ, Grasa-Bello, E, Alvarez, E, Portella, MJ
Publicada:
1 mar 2018
Resumen:
Previous works have studied structural brain characteristics in first-episode psychosis (FEP), but few have focused on the relation between brain differences and illness trajectories. The aim of this study is to analyze gray and white matter changes in FEP patients and their relation with one-year clinical outcomes. A sample of 41 FEP patients and 41 healthy controls (HC), matched by age and educational level was scanned with a 3 T MRI during the first month of illness onset. One year later, patients were assigned to two illness trajectories (schizophrenia and non schizophrenia). Voxel-based morphometry (VBM) was used for gray matter and Tract-based spatial statistics (TBSS) was used for white matter data analysis. VBM revealed significant and widespread bilateral gray matter density differences between FEP and HC groups in areas that included the right insular Cortex, the inferior frontal gyrus and orbito-frontal cortices, and segments of the occipital cortex. TBSS showed a significant lower fractional anisotropy (FA) in 8 clusters that included segments of the anterior thalamic radiation, the left body and forceps minor of corpus callosum, the right anterior segment of the inferior fronto-occipital fasciculus and the anterior segments of the cingulum. The sub-groups comparison revealed significant lower FA in the schizophrenia sub-group in two clusters: the anterior thalamic radiation and the anterior segment of left cingulum. These findings are coherent with previous morphology studies. The results suggest that gray and white matter abnormalities are present at early stages of the disease, and white matter differences may distinguish different illness prognosis. (C) 2018 Elsevier B.V. and ECNP. All rights reserved.
Filiaciones:
Keymer-Gausset, A:
Hosp Santa Creu & Sant Pau, Dept Psychiat, Barcelona, Spain
IIB St Pau, Barcelona, Spain
Alonso-Solis, A:
IIB St Pau, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Catalonia, Spain
Corripio, I:
Hosp Santa Creu & Sant Pau, Dept Psychiat, Barcelona, Spain
IIB St Pau, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Catalonia, Spain
Sauras-Quetcuti, RB:
IIB St Pau, Barcelona, Spain
Pomarol-Clotet, E:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Catalonia, Spain
Benito Menni Complex Assistencial Salut Mental, Barcelona 08830, Spain
Canales-Rodriguez, EJ:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Catalonia, Spain
Benito Menni Complex Assistencial Salut Mental, Barcelona 08830, Spain
Grasa-Bello, E:
Hosp Santa Creu & Sant Pau, Dept Psychiat, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Catalonia, Spain
Alvarez, E:
Hosp Santa Creu & Sant Pau, Dept Psychiat, Barcelona, Spain
IIB St Pau, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Catalonia, Spain
UAB, Barcelona, Spain
Portella, MJ:
Hosp Santa Creu & Sant Pau, Dept Psychiat, Barcelona, Spain
IIB St Pau, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Catalonia, Spain
UAB, Barcelona, Spain
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