Transcranial diffuse optical assessment of the microvascular reperfusion after thrombolysis for acute ischemic stroke
Por:
Delgado-Mederos, R, Gregori-Pla, C, Zirak, P, Blanco, I, Dinia, L, Marin, R, Durduran, T, Marti-Fabregas, J
Publicada:
1 mar 2018
Resumen:
In this pilot study, we have evaluated bedside diffuse optical monitoring combining diffuse correlation spectroscopy and near-infrared diffuse optical spectroscopy to assess the effect of thrombolysis with an intravenous recombinant tissue plasminogen activator (rtPA) on cerebral hemodynamics in an acute ischemic stroke. Frontal lobes of five patients with an acute middle cerebral artery occlusion were measured bilaterally during rtPA treatment. Both ipsilesional and contralesional hemispheres showed significant increases in cerebral blood flow, total hemoglobin concentration and oxy-hemoglobin concentration during the first 2.5 hours after rtPA bolus. The increases were faster and higher in the ipsilesional hemisphere. The results show that bedside optical monitoring can detect the effect of reperfusion therapy for ischemic stroke in real-time. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
Filiaciones:
Delgado-Mederos, R:
Hosp Santa Creu & Sant Pau, Dept Neurol, C St Antoni M Claret 167, Barcelona 08025, Spain
Gregori-Pla, C:
Barcelona Inst Sci & Technol, ICFO Inst Ciencies Foton, Ave Carl Friedrich Gauss 3, Castelldefels 08860, Barcelona, Spain
Zirak, P:
Barcelona Inst Sci & Technol, ICFO Inst Ciencies Foton, Ave Carl Friedrich Gauss 3, Castelldefels 08860, Barcelona, Spain
Blanco, I:
Barcelona Inst Sci & Technol, ICFO Inst Ciencies Foton, Ave Carl Friedrich Gauss 3, Castelldefels 08860, Barcelona, Spain
Dinia, L:
Hosp Santa Creu & Sant Pau, Dept Neurol, C St Antoni M Claret 167, Barcelona 08025, Spain
Marin, R:
Hosp Santa Creu & Sant Pau, Dept Neurol, C St Antoni M Claret 167, Barcelona 08025, Spain
Durduran, T:
Barcelona Inst Sci & Technol, ICFO Inst Ciencies Foton, Ave Carl Friedrich Gauss 3, Castelldefels 08860, Barcelona, Spain
ICREA, Passeig Lluis Companys 23, Barcelona 08010, Spain
Marti-Fabregas, J:
Hosp Santa Creu & Sant Pau, Dept Neurol, C St Antoni M Claret 167, Barcelona 08025, Spain
Gold, Green Published
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