Evolution of metabolic risk factors over a two-year period in a cohort of first episodes of psychosis
Por:
Bioque, M, Garcia-Portilla, MP, Garcia-Rizo, C, Cabrera, B, Lobo, A, Gonzalez-Pinto, A, Diaz-Caneja, CM, Corripio, I, Vieta, E, Castro-Fornieles, J, Bobes, J, Gutierrez-Fraile, M, Rodriguez-Jimenez, R, Mezquida, G, Llerena, A, Saiz-Ruiz, J, Bernardo, M
Publicada:
1 mar 2018
Resumen:
Patients with a first episode of psychosis (FEP) display a broad range of metabolic risk factors related to the development of diverse medical comorbidities. Initial stages of these disorders are essential in understanding the increased vulnerability of developing cardiometabolic disturbances, associated with a reduced life expectancy. This study aimed to evaluate the metabolic profile of a cohort of patients with a FEP and its evolution during a two year follow-up, as well as the factors that influence the changes in their metabolic status.
16 participating centers from the PEPs Project recruited 335 subjects with a FEP and 253 matched healthy controls, aged 9-35 years. We investigated a set of anthropometric measures, vital signs and laboratory data obtained from each participant over two years in a prospective, naturalistic study.
From the beginning of the study the FEP group showed differences in the metabolic profile compared to the control group, together with a progressive worsening in the major part of the analyzed variables during the followup period, with higher rates of obesity and metabolic syndrome. Certain risk factors were related to determinate clinical variables such as male gender, the presence of affective symptoms or an early onset or to treatment variables such as the use of antipsychotic polypharmacy, antidepressants or mood stabilizers.
Our results highlight the extremely high risk of patients at early phases of schizophrenia and other psychotic disorders of developing cardiovascular comorbidity and the fast worsening of the metabolic profile during the first two years. (c) 2017 Elsevier B.V. All rights reserved.
Filiaciones:
Bioque, M:
Hosp Clin Barcelona, Barcelona Clin, Schizophrenia Unit, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Garcia-Portilla, MP:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Oviedo, Dept Psychiat, Oviedo, Spain
Garcia-Rizo, C:
Hosp Clin Barcelona, Barcelona Clin, Schizophrenia Unit, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
IDIBAPS, Barcelona, Spain
Cabrera, B:
Hosp Clin Barcelona, Barcelona Clin, Schizophrenia Unit, Barcelona, Spain
Lobo, A:
Univ Zaragoza, IIS Aragon, Dept Med & Psychiat, Zaragoza, Spain
Gonzalez-Pinto, A:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Basque Country, Univ Hosp, BIOARABA Hlth Res Inst, OSI Araba, Vitoria, Spain
Diaz-Caneja, CM:
Univ Complutense, Hosp Gen Univ Gregorio Maranon, Dept Child & Adolescent Psychiat, IiSGM,Sch Med, Madrid, Spain
Corripio, I:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Hosp Santa Creu & Sant Pau, Dept Psychiat, Barcelona, Spain
Vieta, E:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
IDIBAPS, Barcelona, Spain
Univ Barcelona, Hosp Clin Barcelona, Psychiat & Dept, Barcelona, Spain
Castro-Fornieles, J:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Barcelona, Child & Adolescent Psychiat & Psychol Dept, Hosp Clin Barcelona, SGR489,Inst Neurosci, Barcelona, Spain
Bobes, J:
Univ Oviedo, Dept Psychiat, Oviedo, Spain
Gutierrez-Fraile, M:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Basque Country, Hosp Santiago Apostol, Dept Psychiat, Vitoria, Spain
Rodriguez-Jimenez, R:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Inst Invest Hosp 12 Octubre Imas12, Madrid, Spain
Mezquida, G:
Hosp Clin Barcelona, Barcelona Clin, Schizophrenia Unit, Barcelona, Spain
Llerena, A:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Extremadura, CICAB CAIBER Ctr Invest Clin, Hosp Univ, SES,Fac Med, Badajoz, Spain
Saiz-Ruiz, J:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Hosp Univ Ramon y Cajal, IRYCIS, Dept Psychiat, Madrid, Spain
Bernardo, M:
IDIBAPS, Barcelona, Spain
Hosp Clin Barcelona, Barcelona Clin Schizophrenia Unit, Neurosci Inst, Barcelona, Spain
Univ Barcelona, Dept Psychiat & Clin Psychobiol, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, G04, Barcelona, Spain
Green Accepted
|