Multivariate analysis for coronary heart disease in heterozygote familial hypercholesterolemia patients


Por: Munoz-Torrero, JFS, Rivas, MD, Zamorano, J, Joya-Vazquez, PP, de Isla, LP, Padro, T, Mata, P

Publicada: 1 mar 2018
Resumen:
Aim: rs599839 polymorphism has been related with low levels of cholesterol and reduced coronary heart disease (CHD). Methods: We investigated the frequency of this polymorphism in patients with heterozygous familial hypercholesterolemia (HeFH) in the Spanish familial hypercholesterolemia cohort, 230 with and 202 without CHD. Results & discussion: A lower G-allele prevalence was observed in HeFH patients with CHD with respect to controls, 35 versus 45%, respectively (p = 0.029), suggesting a protective effect. However, it was found that there was no association between rs599839 alleles and CHD in the multivariate analysis. Conclusion: The frequency of the protective G-allele of the rs599839 polymorphism was lower in HeFH patients with CHD compared with those HeFH patients without CHD. However, its role in HeFH may be masked by very high levels of cholesterol.

Filiaciones:
Munoz-Torrero, JFS:
 Hosp San Pedro de Alcantara, Dept Internal Med, Caceres, Spain

Rivas, MD:
 Hosp San Pedro de Alcantara, Res Unit, Caceres, Spain

Zamorano, J:
 Hosp San Pedro de Alcantara, Res Unit, Caceres, Spain

Joya-Vazquez, PP:
 Hosp Gen Llerena, Digest Unit, Llerena, Spain

de Isla, LP:
 Hosp Clin San Carlos, Dept Cardiol, Madrid, Spain

Padro, T:
 Hosp Santa Creu & Sant Pau, Ctr Invest Cardiovasc CSIC ICCC, Barcelona, Spain

 IIB St Pau, Barcelona, Spain

 ISC III, CIBEROBN, Barcelona, Spain

Mata, P:
 Fdn Hipercolesterolemia Familial, Madrid, Spain
ISSN: 17410541





Personalized Medicine
Editorial
FUTURE MEDICINE LTD, UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3 1QB, ENGLAND, Reino Unido
Tipo de documento: Article
Volumen: 15 Número: 2
Páginas: 87-92
WOS Id: 000425857900005
ID de PubMed: 29714125

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