Multivariate analysis for coronary heart disease in heterozygote familial hypercholesterolemia patients
Por:
Munoz-Torrero, JFS, Rivas, MD, Zamorano, J, Joya-Vazquez, PP, de Isla, LP, Padro, T, Mata, P
Publicada:
1 mar 2018
Resumen:
Aim: rs599839 polymorphism has been related with low levels of cholesterol and reduced coronary heart disease (CHD). Methods: We investigated the frequency of this polymorphism in patients with heterozygous familial hypercholesterolemia (HeFH) in the Spanish familial hypercholesterolemia cohort, 230 with and 202 without CHD. Results & discussion: A lower G-allele prevalence was observed in HeFH patients with CHD with respect to controls, 35 versus 45%, respectively (p = 0.029), suggesting a protective effect. However, it was found that there was no association between rs599839 alleles and CHD in the multivariate analysis. Conclusion: The frequency of the protective G-allele of the rs599839 polymorphism was lower in HeFH patients with CHD compared with those HeFH patients without CHD. However, its role in HeFH may be masked by very high levels of cholesterol.
Filiaciones:
Munoz-Torrero, JFS:
Hosp San Pedro de Alcantara, Dept Internal Med, Caceres, Spain
Rivas, MD:
Hosp San Pedro de Alcantara, Res Unit, Caceres, Spain
Zamorano, J:
Hosp San Pedro de Alcantara, Res Unit, Caceres, Spain
Joya-Vazquez, PP:
Hosp Gen Llerena, Digest Unit, Llerena, Spain
de Isla, LP:
Hosp Clin San Carlos, Dept Cardiol, Madrid, Spain
Padro, T:
Hosp Santa Creu & Sant Pau, Ctr Invest Cardiovasc CSIC ICCC, Barcelona, Spain
IIB St Pau, Barcelona, Spain
ISC III, CIBEROBN, Barcelona, Spain
Mata, P:
Fdn Hipercolesterolemia Familial, Madrid, Spain
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