C-Reactive Protein in Atherothrombosis and Angiogenesis
Por:
Badimon, L, Pena, E, Arderiu, G, Padro, T, Slevin, M, Vilahur, G, Chiva-Blanch, G
Publicada:
2 mar 2018
Resumen:
C-reactive protein (CRP) is a short pentraxin mainly found as a pentamer in the circulation, or as non-soluble monomers CRP (mCRP) in tissues, exerting different functions. This review is focused on discussing the role of CRP in cardiovascular disease, including recent advances on the implication of CRP and its forms specifically on the pathogenesis of atherothrombosis and angiogenesis. Besides its role in the humoral innate immune response, CRP contributes to cardiovascular disease progression by recognizing and binding multiple intrinsic ligands. mCRP is not present in the healthy vessel wall but it becomes detectable in the early stages of atherogenesis and accumulates during the progression of atherosclerosis. CRP inhibits endothelial nitric oxide production and contributes to plaque instability by increasing endothelial cell adhesion molecules expression, by promoting monocyte recruitment into the atheromatous plaque and by enzymatically binding to modified low-density lipoprotein. CRP also contributes to thrombosis, but depending on its form it elicits different actions. Pentameric CRP has no involvement in thrombogenesis, whereas mCRP induces platelet activation and thrombus growth. In addition, mCRP has apparently contradictory pro-angiogenic and anti-angiogenic effects determining tissue remodeling in the atherosclerotic plaque and in infarcted tissues. Overall, CRP contributes to cardiovascular disease by several mechanisms that deserve an in-depth analysis.
Filiaciones:
Badimon, L:
Hosp Santa Creu & Sant Pau, Cardiovasc Sci Inst ICCC, IIB St Pau, Barcelona, Spain
Inst Carlos III, CiberCV, Madrid, Spain
Pena, E:
Hosp Santa Creu & Sant Pau, Cardiovasc Sci Inst ICCC, IIB St Pau, Barcelona, Spain
Inst Carlos III, CiberCV, Madrid, Spain
Arderiu, G:
Hosp Santa Creu & Sant Pau, Cardiovasc Sci Inst ICCC, IIB St Pau, Barcelona, Spain
Padro, T:
Hosp Santa Creu & Sant Pau, Cardiovasc Sci Inst ICCC, IIB St Pau, Barcelona, Spain
Inst Carlos III, CiberCV, Madrid, Spain
Slevin, M:
Manchester Metropolitan Univ, Sch Healthcare Sci, Manchester, Lancs, England
Vilahur, G:
Hosp Santa Creu & Sant Pau, Cardiovasc Sci Inst ICCC, IIB St Pau, Barcelona, Spain
Inst Carlos III, CiberCV, Madrid, Spain
Chiva-Blanch, G:
Hosp Santa Creu & Sant Pau, Cardiovasc Sci Inst ICCC, IIB St Pau, Barcelona, Spain
Gold, Green Published, Green Accepted
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