A novel KRAS mutation in metastasic conjunctival melanoma: a case report and literature review
Por:
Huerta, LPD, Castells, MM, Palacios, GA, Sullivan, I, Vidal, AG, Tarruella, MM
Publicada:
1 abr 2018
Resumen:
Conjunctival melanoma is a rare disease, and little is known about its molecular background. Here, we present the case of a 48-year-old patient with conjunctival melanoma and metachronic lymph node and skin metastasis with KRAS p.K117Y mutation in exon 4 in all the lesions. The cancer genome interpreter predicted this mutation to have driver function. To our knowledge, this is the first time this mutation is found in conjunctival melanoma. An important role in the disease development is suggested.
Filiaciones:
Huerta, LPD:
Hosp Santa Creu & Sant Pau, Dept Med Oncol, Mas Casanovas 90, Barcelona 08025, Spain
Castells, MM:
Hosp Santa Creu & Sant Pau, Dept Med Oncol, Mas Casanovas 90, Barcelona 08025, Spain
Palacios, GA:
Hosp Santa Creu & Sant Pau, Dept Med Oncol, Mas Casanovas 90, Barcelona 08025, Spain
Sullivan, I:
Hosp Santa Creu & Sant Pau, Dept Med Oncol, Mas Casanovas 90, Barcelona 08025, Spain
Vidal, AG:
Hosp Santa Creu & Sant Pau, Dept Med Oncol, Mas Casanovas 90, Barcelona 08025, Spain
Tarruella, MM:
Hosp Santa Creu & Sant Pau, Dept Med Oncol, Mas Casanovas 90, Barcelona 08025, Spain
|