Cerebral changes and disrupted gray matter cortical networks in asymptomatic older adults at risk for Alzheimer's disease
Por:
Cantero, JL, Atienza, M, Sanchez-Juan, P, Rodriguez-Rodriguez, E, Vazquez-Higuera, JL, Pozueta, A, Gonzalez-Suarez, A, Vilaplana, E, Pegueroles, J, Montal, V, Blesa, R, Alcolea, D, Lleo, A, Fortea, J
Publicada:
1 abr 2018
Resumen:
The diagnostic value of cerebrospinal fluid (CSF) biomarkers is well established in Alzheimer's disease, but our current knowledge about how abnormal CSF levels affect cerebral integrity, at local and network levels, is incomplete in asymptomatic older adults. Here, we have collected CSF samples and performed structural magnetic resonance imaging scans in cognitively normal elderly as part of a cross-sectional multicenter study (SIGNAL project). To identify group differences in cortical thickness, white matter volume, and properties of structural networks, participants were split into controls (N = 20), positive amyloid-beta (A beta(1-42) (+)) (N = 19), and positive phosphorylated tau (N = 18). The A beta(1-42) + group exhibited thickening of middle temporal regions, while positive phosphorylated tau individuals showed thinning in the superior parietal and orbitofrontal cortices. Subjects with abnormal CSF biomarkers further showed regional white matter atrophy and more segregated cortical networks, the A beta(1-42) + group showing heightened isolation of cingulate and temporal cortices. Collectively, these findings highlight the relevance of combining structural brain imaging and connectomics for in vivo tracking of Alzheimer's disease lesions in asymptomatic stages. (C) 2017 Elsevier Inc. All rights reserved.
Filiaciones:
Cantero, JL:
Pablo de Olavide Univ, Lab Funct Neurosci, Ctra Utrera Km 1, ES-41013 Seville, Spain
CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Seville, Spain
Atienza, M:
Pablo de Olavide Univ, Lab Funct Neurosci, Ctra Utrera Km 1, ES-41013 Seville, Spain
CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Seville, Spain
Sanchez-Juan, P:
CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Seville, Spain
Univ Cantabria, IDIVAL, Univ Hosp Marques de Valdecilla, Serv Neurol, Santander, Spain
Rodriguez-Rodriguez, E:
CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Seville, Spain
Univ Cantabria, IDIVAL, Univ Hosp Marques de Valdecilla, Serv Neurol, Santander, Spain
Vazquez-Higuera, JL:
CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Seville, Spain
Univ Cantabria, IDIVAL, Univ Hosp Marques de Valdecilla, Serv Neurol, Santander, Spain
Pozueta, A:
CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Seville, Spain
Univ Cantabria, IDIVAL, Univ Hosp Marques de Valdecilla, Serv Neurol, Santander, Spain
Gonzalez-Suarez, A:
CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Seville, Spain
Univ Cantabria, IDIVAL, Univ Hosp Marques de Valdecilla, Serv Neurol, Santander, Spain
Vilaplana, E:
CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Seville, Spain
Univ Autonoma Barcelona, Inst Invest Biomed St Pau, Dept Neurol, Hosp Santa Creu & St Pau, Barcelona, Spain
Pegueroles, J:
CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Seville, Spain
Univ Autonoma Barcelona, Inst Invest Biomed St Pau, Dept Neurol, Hosp Santa Creu & St Pau, Barcelona, Spain
Montal, V:
CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Seville, Spain
Univ Autonoma Barcelona, Inst Invest Biomed St Pau, Dept Neurol, Hosp Santa Creu & St Pau, Barcelona, Spain
Blesa, R:
CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Seville, Spain
Univ Autonoma Barcelona, Inst Invest Biomed St Pau, Dept Neurol, Hosp Santa Creu & St Pau, Barcelona, Spain
Alcolea, D:
CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Seville, Spain
Univ Autonoma Barcelona, Inst Invest Biomed St Pau, Dept Neurol, Hosp Santa Creu & St Pau, Barcelona, Spain
Lleo, A:
CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Seville, Spain
Univ Autonoma Barcelona, Inst Invest Biomed St Pau, Dept Neurol, Hosp Santa Creu & St Pau, Barcelona, Spain
Fortea, J:
CIBERNED, Network Ctr Biomed Res Neurodegenerat Dis, Seville, Spain
Univ Autonoma Barcelona, Inst Invest Biomed St Pau, Dept Neurol, Hosp Santa Creu & St Pau, Barcelona, Spain
Green Accepted
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