Variation in antiretroviral treatment coverage and virological suppression among three HIV key populations
Por:
Laut, KG, Shepherd, L, Gottfredsson, M, Sedlacek, D, Knysz, B, Begovac, J, Radoi, R, Schmied, B, Chkhartishvili, N, Florence, E, Ristola, M, Fatkenheuer, G, Mulcahy, F, Schmid, P, Kuzovatova, E, Paduta, D, Smidt, J, Domingo, P, Szlavik, J, Lundgren, J, Mocroft, A, Kirk, O, EuroSIDA Study Grp
Publicada:
28 nov 2018
Resumen:
Objectives: We assessed differences in antiretroviral treatment (ART) coverage and virological suppression across three HIV key populations, as defined by self-reported HIV transmission category: sex between men, injection drug use (IDU) and heterosexual transmission.
Design: A multinational cohort study.
Methods: Within the EuroSIDA study, we assessed region-specific percentages of ART coverage among those in care and virological suppression (<500 copies/ml) among those on ART, and analysed differences between transmission categories using logistic regression.
Results: Among 12 872 participants followed from 1 July 2014 to 30 June 2016, the percentages of ART-coverage and virological suppression varied between transmission categories, depending on geographical region (global P for interaction: P = 0.0148 for ART-coverage, P = 0.0006 for virological suppression). In Western [adjusted odds ratio (aOR) 1.41 (95% confidence interval 1.14-1.75)] and Northern Europe [aOR 1.68 (95% confidence interval 1.25-2.26)], heterosexuals were more likely to receive ART than MSM, while in Eastern Europe, there was some evidence that infection through IDU [aOR 0.60 (95% confidence interval 0.31-1.14)] or heterosexual contact [aOR 0.58 (95% confidence interval 0.30-1.10)] was associated with lower odds of receiving ART. In terms of virological suppression, people infected through IDU or heterosexual contact in East Central and Eastern Europe were around half as likely as MSM to have a suppressed viral load on ART, while we observed no differences in virological suppression across transmission categories in Western and Northern Europe.
Conclusion: In our cohort, patterns of ART-coverage and virological suppression among key populations varied by geographical region, emphasizing the importance of tailoring HIV programmes to the local epidemic. Copyright (C) 2018 Wolters Kluwer Health, Inc. All rights reserved.
Filiaciones:
Laut, KG:
Univ Copenhagen, Rigshosp, Dept Infect Dis, CHIP,Ctr Excellence Hlth Immun & Infect, Copenhagen, Denmark
Shepherd, L:
UCL, Ctr Clin Res Epidemiol Modelling & Evaluat CREME, Inst Global Hlth, London, England
Gottfredsson, M:
Univ Iceland, Sch Hlth Sci, Fac Med, Reykjavik, Iceland
Landspitali Univ Hosp, Dept Infect Dis, Reykjavik, Iceland
Sedlacek, D:
Charles Univ Hosp Plzen, AIDS Ctr, Plzen, Czech Republic
Knysz, B:
Med Univ, Wroclaw, Poland
Begovac, J:
Univ Hosp Infect Dis, Zagreb, Croatia
Radoi, R:
Clin Hosp Infect Dis Dr Victor Babes, Bucharest, Romania
Schmied, B:
Pulmol Zentrum Stadt Wien, Vienna, Austria
Chkhartishvili, N:
Infect Dis AIDS & Clin Immunol Res Ctr, Tbilisi, Georgia
Florence, E:
Inst Trop Med, Antwerp, Belgium
Ristola, M:
Helsinki Univ Hosp, Helsinki, Finland
Fatkenheuer, G:
Univ Hosp Cologne, Cologne, Germany
Mulcahy, F:
St James Hosp, Dublin, Ireland
Schmid, P:
Kantonsspital St Gallen, St Gallen, Switzerland
Kuzovatova, E:
Nizhny Novgorod Sci & Res Inst Epidemiol & Microb, Nizhnii Novgorod, Russia
Paduta, D:
Reg AIDS Ctr, Svetlogorsk, BELARUS
Smidt, J:
Nakkusosakond Siseklin, Kohtla Jarve, Estonia
Domingo, P:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Szlavik, J:
United Szent Istvan & Szent Laszlo Hosp, Budapest, Hungary
Lundgren, J:
Univ Copenhagen, Rigshosp, Dept Infect Dis, CHIP,Ctr Excellence Hlth Immun & Infect, Copenhagen, Denmark
Mocroft, A:
UCL, Ctr Clin Res Epidemiol Modelling & Evaluat CREME, Inst Global Hlth, London, England
Kirk, O:
Univ Copenhagen, Rigshosp, Dept Infect Dis, CHIP,Ctr Excellence Hlth Immun & Infect, Copenhagen, Denmark
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