Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry
Por:
Lewczuk, P, Riederer, P, O'Bryant, SE, Verbeek, MM, Dubois, B, Visser, PJ, Jellinger, KA, Engelborghs, S, Ramirez, A, Parnetti, L, Jack, CR, Teunissen, CE, Hampel, H, Lleo, A, Jessen, F, Glodzik, L, de Leon, MJ, Fagan, AM, Molinuevo, JL, Jansen, WJ, Winblad, B, Shaw, LM, Andreasson, U, Otto, M, Mollenhauer, B, Wiltfang, J, Turner, MR, Zerr, I, Handels, R, Thompson, AG, Johansson, G, Ermann, N, Trojanowski, JQ, Karaca, I, Wagner, H, Oeckl, P, van Doorn, LV, Bjerke, M, Kapogiannis, D, Kuiperij, HB, Farotti, L, Li, Y, Gordon, BA, Epelbaum, S, Vos, SJB, Klijn, CJM, Van Nostrand, WE, Minguillon, C, Schmitz, M, Gallo, C, Mato, AL, Thibaut, F, Lista, S, Alcolea, D, Zetterberg, H, Blennow, K, Kornhuber, J, WFSBP Task Force
Publicada:
1 ene 2018
Resumen:
In the 12 years since the publication of the first Consensus Paper of the WFSBP on biomarkers of neurodegenerative dementias, enormous advancement has taken place in the field, and the Task Force takes now the opportunity to extend and update the original paper. New concepts of Alzheimer's disease (AD) and the conceptual interactions between AD and dementia due to AD were developed, resulting in two sets for diagnostic/research criteria. Procedures for pre-analytical sample handling, biobanking, analyses and post-analytical interpretation of the results were intensively studied and optimised. A global quality control project was introduced to evaluate and monitor the inter-centre variability in measurements with the goal of harmonisation of results. Contexts of use and how to approach candidate biomarkers in biological specimens other than cerebrospinal fluid (CSF), e.g. blood, were precisely defined. Important development was achieved in neuroimaging techniques, including studies comparing amyloid- positron emission tomography results to fluid-based modalities. Similarly, development in research laboratory technologies, such as ultra-sensitive methods, raises our hopes to further improve analytical and diagnostic accuracy of classic and novel candidate biomarkers. Synergistically, advancement in clinical trials of anti-dementia therapies energises and motivates the efforts to find and optimise the most reliable early diagnostic modalities. Finally, the first studies were published addressing the potential of cost-effectiveness of the biomarkers-based diagnosis of neurodegenerative disorders.
Filiaciones:
Lewczuk, P:
Univ Klinikum Erlangen, Dept Psychiat & Psychotherapy, Erlangen, Germany
Friedrich Alexander Univ Erlangen Nurnberg, Erlangen, Germany
Med Univ Biaystok, Dept Neurodegenerat Diagnost, Biaystok, Poland
Univ Hosp Bialystok, Dept Biochem Diagnost, Biaystok, Poland
Riederer, P:
Univ Hosp Wurzburg, Ctr Mental Hlth, Clin & Policlin Psychiat Psychosomat & Psychother, Wurzburg, Germany
O'Bryant, SE:
Univ North Texas, Inst Hlth Aging, Hlth Sci Ctr, Ft Worth, TX USA
Verbeek, MM:
Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Neurol,Radboud Alzheimer Ctr, Nijmegen, Netherlands
Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Lab Med,Radboud Alzheimer Ctr, Nijmegen, Netherlands
Dubois, B:
Paris 6 Univ, Inst Memoire & Malad Alzheimer IM2A, Salpetrierie Hosp, INSERM UMR S 975 ICM, Paris, France
Visser, PJ:
Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Alzheimer Ctr Limburg, Maastricht, Netherlands
Amsterdam Neurosci VU Univ Med Ctr, Dept Neurol, Alzheimer Ctr, Amsterdam, Netherlands
Jellinger, KA:
Inst Clin Neurobiol, Vienna, Austria
Engelborghs, S:
Univ Antwerp, Reference Ctr Biol Markers Dementia BIODEM, Antwerp, Belgium
Hosp Network Antwerp ZNA Middelheim & Hoge Beuken, Dept Neurol, Antwerp, Belgium
Hosp Network Antwerp ZNA Middelheim & Hoge Beuken, Memory Clin, Antwerp, Belgium
Ramirez, A:
Univ Bonn, Dept Psychiat & Psychotherapy, Bonn, Germany
Univ Bonn, Inst Human Genet, Bonn, Germany
Univ Cologne, Dept Psychiat & Psychotherapy, Cologne, Germany
Parnetti, L:
Univ Perugia, Neurol Sect, Lab Clin Neurochem, Ctr Memory Disturbances, Perugia, Italy
Jack, CR:
Mayo Clin, Dept Radiol, Rochester, MN USA
Teunissen, CE:
VU Univ Med Ctr Amsterdam, Neurochem Lab, Dept Clin Chem, Amsterdam Neurosci, Amsterdam, Netherlands
VU Univ Med Ctr Amsterdam, Biobank, Dept Clin Chem, Amsterdam Neurosci, Amsterdam, Netherlands
Hampel, H:
Univ Pierre & Marie Curie UPMC Paris 06, Inst Cerveau & Moelle Epiniere ICM, Sorbonne Univ, AXA Res Fund,Inserm,CNRS,Dept Neurol,IM2A,Hop Pit, Blvd Hop, Paris, France
Univ Pierre & Marie Curie UPMC Paris 06, Inst Cerveau & Moelle Epiniere ICM, Sorbonne Univ, UPMC Chair,Inserm,CNRS,Dept Neurol,IM2A,Hop Pitie, Blvd Hop, Paris, France
Lleo, A:
Univ Autnoma Barcelona, Inst Invest Biomed St Pau, Dept Neurol, Hosp St Pau, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Barcelona, Spain
Jessen, F:
Univ Cologne, Dept Psychiat & Psychotherapy, Cologne, Germany
German Ctr Neurodegenerat Disorders DZNE, Bonn, Germany
Glodzik, L:
NYU Langone Med Ctr, Dept Psychiat, Ctr Brain Hlth, New York, NY USA
de Leon, MJ:
NYU Langone Med Ctr, Dept Psychiat, Ctr Brain Hlth, New York, NY USA
Fagan, AM:
Washington Univ, Sch Med, Knight Alzheimers Dis Res Ctr, St Louis, MO USA
Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA
Molinuevo, JL:
Pasqual Maragall Fdn, BarcelonaBeta Brain Res Ctr, Barcelona, Spain
Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Alzheimers Dis & Other Cognit Disorders Unit, Barcelona, Spain
Jansen, WJ:
Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Alzheimer Ctr Limburg, Maastricht, Netherlands
Winblad, B:
Karolinska Inst, Div Neurogeriatr, Dept NVS, Ctr Alzheimer Res, Huddinge, Sweden
Shaw, LM:
Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA USA
Andreasson, U:
Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden
Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Molndal, Sweden
Otto, M:
Univ Ulm, Dept Neurol, Ulm, Germany
Mollenhauer, B:
Paracelsus Elena Klin, Kassel, Germany
Univ Med Ctr Gottingen, Dept Neurol, Gottingen, Germany
Wiltfang, J:
Univ Gottingen, Dept Psychiat & Psychotherapy, Gottingen, Germany
German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany
Univ Aveiro, Dept Med Sci, iBiMED, Aveiro, Portugal
Turner, MR:
Univ Oxford, Nuffield Dept Clin Neurosci, Oxford, England
Zerr, I:
German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany
Univ Med Sch, Dept Neurol, Clin Dementia Ctr, Gottingen, Germany
Handels, R:
Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Alzheimer Ctr Limburg, Maastricht, Netherlands
Karolinska Inst, Div Neurogeriatr, Dept NVS, Ctr Alzheimer Res, Huddinge, Sweden
Thompson, AG:
Univ Oxford, Nuffield Dept Clin Neurosci, Oxford, England
Johansson, G:
Karolinska Inst, Div Neurogeriatr, Dept NVS, Ctr Alzheimer Res, Huddinge, Sweden
Ermann, N:
Univ Klinikum Erlangen, Dept Psychiat & Psychotherapy, Erlangen, Germany
Friedrich Alexander Univ Erlangen Nurnberg, Erlangen, Germany
Trojanowski, JQ:
Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA USA
Karaca, I:
Univ Bonn, Dept Psychiat & Psychotherapy, Bonn, Germany
Wagner, H:
Univ Bonn, Dept Psychiat & Psychotherapy, Bonn, Germany
Oeckl, P:
Univ Ulm, Dept Neurol, Ulm, Germany
van Doorn, LV:
Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Neurol,Radboud Alzheimer Ctr, Nijmegen, Netherlands
Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Lab Med,Radboud Alzheimer Ctr, Nijmegen, Netherlands
Bjerke, M:
Univ Antwerp, Reference Ctr Biol Markers Dementia BIODEM, Antwerp, Belgium
Kapogiannis, D:
NIA, Lab Neurosci, NIH, Baltimore, MD 21224 USA
Kuiperij, HB:
Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Neurol,Radboud Alzheimer Ctr, Nijmegen, Netherlands
Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Lab Med,Radboud Alzheimer Ctr, Nijmegen, Netherlands
Farotti, L:
Univ Perugia, Neurol Sect, Lab Clin Neurochem, Ctr Memory Disturbances, Perugia, Italy
Li, Y:
NYU Langone Med Ctr, Dept Psychiat, Ctr Brain Hlth, New York, NY USA
Gordon, BA:
Washington Univ, Sch Med, Knight Alzheimers Dis Res Ctr, St Louis, MO USA
Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63110 USA
Epelbaum, S:
Paris 6 Univ, Inst Memoire & Malad Alzheimer IM2A, Salpetrierie Hosp, INSERM UMR S 975 ICM, Paris, France
Vos, SJB:
Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Alzheimer Ctr Limburg, Maastricht, Netherlands
Klijn, CJM:
Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Neurol,Radboud Alzheimer Ctr, Nijmegen, Netherlands
Van Nostrand, WE:
SUNY Stony Brook, Dept Neurosurg, HSC T-12-086, New York, NY USA
Minguillon, C:
Pasqual Maragall Fdn, BarcelonaBeta Brain Res Ctr, Barcelona, Spain
Schmitz, M:
German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany
Univ Med Sch, Dept Neurol, Clin Dementia Ctr, Gottingen, Germany
Gallo, C:
Univ Peruana Cayetano Heredia, Fac Ciencias & Filosofia, Dept Ciencias Celulares & Mol, Labs Invest & Desarrollo, Lima, Peru
Mato, AL:
Maimonides Univ, Chair Psychoneuroimmunoendocrinol, Buenos Aires, Argentina
Thibaut, F:
Univ Hosp Cochin, Fac Med Paris Descartes, INSERM 894, Dept Psychiat, Site Tarnier 89 Rue Assas, Paris, France
Lista, S:
Univ Pierre & Marie Curie UPMC Paris 06, Inst Cerveau & Moelle Epiniere ICM, Sorbonne Univ, AXA Res Fund,Inserm,CNRS,Dept Neurol,IM2A,Hop Pit, Blvd Hop, Paris, France
Univ Pierre & Marie Curie UPMC Paris 06, Inst Cerveau & Moelle Epiniere ICM, Sorbonne Univ, UPMC Chair,Inserm,CNRS,Dept Neurol,IM2A,Hop Pitie, Blvd Hop, Paris, France
Alcolea, D:
Univ Autnoma Barcelona, Inst Invest Biomed St Pau, Dept Neurol, Hosp St Pau, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Barcelona, Spain
Zetterberg, H:
Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden
Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Molndal, Sweden
UCL Inst Neurol, Dept Mol Neurosci, London, England
Blennow, K:
Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden
Kornhuber, J:
Univ Klinikum Erlangen, Dept Psychiat & Psychotherapy, Erlangen, Germany
Friedrich Alexander Univ Erlangen Nurnberg, Erlangen, Germany
Green Accepted, Hybrid Gold, Green Published
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