Potential drug-drug interactions of OMBITASVIR, PARITAPREVIR/ritonavir +/- DASABUVIR +/- ribavirin in clinical practice
Por:
Gonzalez-Colominas, E, Londono, MC, Morillas, RM, Torras, X, Mojal, S, Lens, S, Lopez, D, Gallego, A, Marino, Z, Ardevol, M, Pages, N, Sola, R, Carrion, JA
Publicada:
1 may 2018
Resumen:
Background & AimsDrug-drug interactions (DDIs) with ombitasvir/paritaprevir/ritonavir with or without dasabuvir and with or without ribavirin (OBV/PTV/rDSVRBV) are common in clinical trials. Our aim was to analyze the prevalence and management of potential DDIs and adverse events (AEs) related to DDIs in patients with chronic hepatitis C (CHC) receiving OBV/PTV/rDSV +/- RBV in clinical practice.
Methods177 CHC patients started OBV/PTV/r +/- DSV +/- RBV in 4 Spanish hospitals and were screened for potential DDIs using the University of Liverpool database. Patients were classified according to the most serious potential DDIs at baseline and AEs during therapy.
ResultsAt least one potential DDI was found in 110 (62.1%) patients: 100 (56.5%) had at least one manageable potential DDI and 10 (5.6%) at least one contraindicated. Patients with potential DDIs were receiving a higher number of concomitant drugs (4 vs. 2, P<0.001). Routine medication was modified at baseline due to potential DDIs in 49 (27.7%) patients. During antiviral treatment, 67 (37.9%) patients presented at least one AE. In 9 (4.5%) patients, a DDI was suspected between OBV/PTV/r +/- DSV +/- RBV and the concomitant drug, requiring antiviral discontinuation in 4 patients.
ConclusionsPotential DDIs are frequent with OBV/PTV/r +/- DSV +/- RBV, although a change in baseline medication is made in only one-quarter of patients. More than half of potential DDIs were only followed, and only 5% of patients developed AEs in which the implication of DDIs could not be excluded.
Filiaciones:
Gonzalez-Colominas, E:
Hosp del Mar, Dept Pharm, Parc Salut Mar, Barcelona, Spain
Londono, MC:
Hosp Clin Barcelona, Liver Unit, IDIBAPS, CIBERehd, Barcelona, Spain
Morillas, RM:
Hosp Badalona Germans Trias & Pujol, Dept Hepatol, CIBERehd, Badalona, Spain
Torras, X:
Hosp Santa Creu & Sant Pau, Dept Gastroenterol, CIBERehd, Barcelona, Spain
Mojal, S:
Hosp del Mar Med Res Inst IMIM, Barcelona, Spain
Lens, S:
Hosp Clin Barcelona, Liver Unit, IDIBAPS, CIBERehd, Barcelona, Spain
Lopez, D:
Hosp Badalona Germans Trias & Pujol, Dept Hepatol, CIBERehd, Badalona, Spain
Gallego, A:
Hosp Santa Creu & Sant Pau, Dept Gastroenterol, CIBERehd, Barcelona, Spain
Marino, Z:
Hosp Clin Barcelona, Liver Unit, IDIBAPS, CIBERehd, Barcelona, Spain
Ardevol, M:
Hosp Badalona Germans Trias & Pujol, Dept Pharm, Badalona, Spain
Pages, N:
Hosp Santa Creu & Sant Pau, Dept Pharm, Barcelona, Spain
Sola, R:
Univ Autonoma Barcelona, Hosp del Mar, Liver Sect, IMIM,Gastroenterol Dept, Barcelona, Spain
Carrion, JA:
Univ Autonoma Barcelona, Hosp del Mar, Liver Sect, IMIM,Gastroenterol Dept, Barcelona, Spain
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