pCRP-mCRP Dissociation Mechanisms as Potential Targets for the Development of Small-Molecule Anti-Inflammatory Chemotherapeutics
Por:
Caprio, V, Badimon, L, Di Napoli, M, Fang, WH, Ferris, GR, Guo, BQ, Iemma, RS, Liu, DH, Zeinolabediny, Y, Slevin, M
Publicada:
28 may 2018
Resumen:
Circulating C-reactive protein (CRP) is a key acute-phase protein and one of the main clinical biomarkers for inflammation and infection. CRP is an important upstream mediator of inflammation and is associated with the onset of a number of important disease states including cardiovascular disease and neurodegenerative disorders such as Alzheimer's disease. This pentraxin exerts pro-inflammatory properties via dissociation of the pentamer (pCRP) to a monomeric form (mCRP). This dissociation is induced by binding of pCRP to cell surface phosphocholine residues exposed by the action of phospholipase A(2) (PLA(2)). Given the association of CRP with the onset of a range of serious disease states this CRP dissociation process is a tempting drug target for the development of novel small-molecule therapeutics. This review will discuss potential targets for chemotherapeutic intervention elucidated during studies of CRP-mediated inflammation and provide an up-to-date summary of the development of small molecules, not only targeted directly at inhibiting conversion of pCRP to mCRP, but also those developed for activity against PLA2, given the key role of this enzyme in the activation of CRP.
Filiaciones:
Caprio, V:
Manchester Metropolitan Univ, Sch Healthcare Sci, Fac Sci & Engn, Manchester, Lancs, England
Badimon, L:
Hosp Santa Creu & Sant Pau, IIB St Pau, Barcelona, Spain
Di Napoli, M:
Osped San Camillo Lellis, Neurol Serv, Rieti, Italy
Fang, WH:
Manchester Metropolitan Univ, Sch Healthcare Sci, Fac Sci & Engn, Manchester, Lancs, England
Ferris, GR:
Manchester Metropolitan Univ, Sch Healthcare Sci, Fac Sci & Engn, Manchester, Lancs, England
Guo, BQ:
Manchester Metropolitan Univ, Sch Healthcare Sci, Fac Sci & Engn, Manchester, Lancs, England
Weifang Med Univ, Inst Dementia & Neurol Aging, Weifang, Peoples R China
Iemma, RS:
Manchester Metropolitan Univ, Sch Healthcare Sci, Fac Sci & Engn, Manchester, Lancs, England
Liu, DH:
Manchester Metropolitan Univ, Sch Healthcare Sci, Fac Sci & Engn, Manchester, Lancs, England
Univ Med & Pharm, Targu Mures, Romania
Zeinolabediny, Y:
Manchester Metropolitan Univ, Sch Healthcare Sci, Fac Sci & Engn, Manchester, Lancs, England
Univ Med & Pharm, Targu Mures, Romania
Slevin, M:
Manchester Metropolitan Univ, Sch Healthcare Sci, Fac Sci & Engn, Manchester, Lancs, England
Hosp Santa Creu & Sant Pau, IIB St Pau, Barcelona, Spain
Weifang Med Univ, Inst Dementia & Neurol Aging, Weifang, Peoples R China
Univ Med & Pharm, Targu Mures, Romania
Gold, Green Published, Green Accepted
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