Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain
Por:
Roman, M, Caicoya, M, Espinas, JA, Sala, M, Tora-Rocamora, I, Quinta, MJ, Vernet-Tomas, M, Saladie, F, Romero, A, Sanchez, M, Bare, M, Vidal, C, Servitja, S, Natal, C, Corominas, JM, Ferrer, J, Rodriguez-Arana, A, Castells, X
Publicada:
1 jul 2018
Resumen:
Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population-based mammography screening. Retrospective cohort study of all women aged 50-69years who were screened at least once in a population-based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow-up was 6.1years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma insitu (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2cm (OR=1.46; 95%CI=1.03-2.08), metastatic positive (OR=2.66; 95%CI=1.21-5.86), and with a high Ki-67 proliferation rate (OR=1.93; 95%CI=1.24-2.99). No differences were found across histologic subtypes of BBD. Screening participants with a previous pathologic diagnosis of BBD had a higher proportion of DCIS. However, invasive carcinomas detected in women with a BBD were associated with clinical and histologic characteristics conferring a worst prognosis.
Filiaciones:
Roman, M:
Hosp del Mar Med Res Inst, IMIM, Dept Epidemiol & Evaluat, Barcelona, Spain
Res Network Hlth Serv Chron Dis REDISSEC, Barcelona, Spain
Caicoya, M:
Hosp del Mar Med Res Inst, IMIM, Dept Epidemiol & Evaluat, Barcelona, Spain
Res Network Hlth Serv Chron Dis REDISSEC, Barcelona, Spain
Espinas, JA:
Catalan Canc Plan, Dept Hlth, Barcelona, Spain
Sala, M:
Hosp del Mar Med Res Inst, IMIM, Dept Epidemiol & Evaluat, Barcelona, Spain
Res Network Hlth Serv Chron Dis REDISSEC, Barcelona, Spain
Tora-Rocamora, I:
Hosp Clin Barcelona, Prevent Med & Epidemiol Dept, Barcelona, Spain
Quinta, MJ:
Hosp Santa Creu & Sant Pau, Epidemiol Dept, Barcelona, Spain
Vernet-Tomas, M:
Hosp del Mar Med Res Inst IMIM, Dept Obstet & Gynecol, Barcelona, Spain
Saladie, F:
Fdn League Res & Prevent Canc, Breast Canc Screening Program Tarragona, Tarragona, Spain
Romero, A:
Hosp del Mar Med Res Inst, IMIM, Dept Epidemiol & Evaluat, Barcelona, Spain
Res Network Hlth Serv Chron Dis REDISSEC, Barcelona, Spain
Sanchez, M:
Govt Cantabria, Gen Directorate Publ Hlth, Santander, Spain
Bare, M:
Parc Tauli Univ Hosp, Clin Epidemiol & Canc Screening, Sabadell, Spain
Vidal, C:
Catalan Inst Oncol, Canc Prevent & Monitoring Program, Barcelona, Spain
Servitja, S:
Hosp del Mar Med Res Inst IMIM, Dept Oncol, Barcelona, Spain
Natal, C:
Breast Canc Screening Program, Principal Asturias, Oviedo, Spain
Corominas, JM:
Hosp del Mar Med Res Inst IMIM, Dept Pathol Anat, Barcelona, Spain
Ferrer, J:
Hosp Santa Caterina, Radiol Dept, Girona, Spain
Rodriguez-Arana, A:
Hosp del Mar Med Res Inst IMIM, Dept Image Diagnost, Barcelona, Spain
Castells, X:
Hosp del Mar Med Res Inst, IMIM, Dept Epidemiol & Evaluat, Barcelona, Spain
Res Network Hlth Serv Chron Dis REDISSEC, Barcelona, Spain
Green Accepted
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