Smoking does not impact social and non-social cognition in patients with first episode psychosis
Por:
Sanchez-Gutierrez, T, Garcia-Portilla, MP, Parellada, M, Bobes, J, Calvo, A, Moreno-Izco, L, Gonzalez-Pinto, A, Lobo, A, de la Serna, E, Cabrera, B, Torrent, C, Roldan, L, Sanjuan, J, Ibanez, A, Sanchez-Torres, AM, Corripio, I, Bernardo, M, Cuesta, MJ, Vieta, E, Martinez-Aran, A, Castro-Fornieles, J, Baeza, I, Bioque, M, Mezquida, G, Lopez-Ilundain, JM, Alonso, A, Rabela, M, Lopez, P, Zorrilla, I, Arbej, J, Rivero, G, Aguilar, EJ, Mane, A, Berge, D, Contreras, F, Albacete, A, Garcia-Alvarez, L, Al-Halabi, S, Gutierrez, M, Segarra, R, Morales-Munoz, I, Rodriguez-Jimenez, R, Butjosa, A, Usall, J, Sarro, S, Landin-Romero, R, Ruiz, JS, Balanza, V
Publicada:
1 sep 2018
Resumen:
Background: Many studies having shown significant improvements in non-social and social cognitive performance in smoking FEP patients compared to non-smoking FEP patients. The findings are controversial. This study analyzed the effects of tobacco use on non-social and social cognitive function in a large group of FEP patients and a matched healthy control group.
Methods: A sample of 335 patients with FEP and 253 healthy controls was divided into four subgroups: control tobacco users (CTU), control non-tobacco users (CNTU), patient tobacco users (PTU) and patient non-tobacco users (PNTU). Demographic variables, tobacco use variables (presence or absence, frequency and duration of tobacco use), neurocognitive (non-social) performance and social cognition were assessed.
Results: Comparison of 4 subgroups in non-social cognitive function revealed significant differences after controlling for covariables in executive functions (F = 13.45; p <= 0.001) and working memory domains (F = 4.30; p = 0.005). CTU and CNTU subgroups scored higher in all the domains compared to the PTU and the PNTU subgroups respectively. Social cognitive function was also significantly different within the four subgroups, with control subgroups showing better social cognition than patient subgroups. Significant differences in the executive functions domain were observed when comparing PTU and CTU groups (F = 19.60; p = 0.001). No significant differences were revealed in the comparison between the patient groups.
Conclusions: This large study suggests that tobacco use in FEP patients is not related to better non-social or social cognitive performance. (c) 2018 Elsevier B.V. All rights reserved.
Filiaciones:
Sanchez-Gutierrez, T:
Univ Complutense, IiSGM, CIBERSAM,Sch Med, Child & Adolescent Psychiat Dept,Hosp Gen Univ Gr, Madrid, Spain
Univ Int La Rioja UNIR, Fac Hlth Sci, Logrono, Spain
Garcia-Portilla, MP:
Univ Oviedo, CIBERSAM, Sch Med, Dept Psychiat, Oviedo, Spain
Parellada, M:
Univ Complutense, IiSGM, CIBERSAM,Sch Med, Child & Adolescent Psychiat Dept,Hosp Gen Univ Gr, Madrid, Spain
Bobes, J:
Univ Oviedo, CIBERSAM, Sch Med, Dept Psychiat, Oviedo, Spain
Calvo, A:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Complutense, IiSGM, CIBERSAM,Sch Med, Child & Adolescent Psychiat Dept,Hosp Gen Univ Gr, Madrid, Spain
Univ Int La Rioja UNIR, Fac Hlth Sci, Logrono, Spain
Moreno-Izco, L:
Inst Hlth Res, Pamplona, Spain
Complejo Hosp Navarra, IdiSNA, Dept Psychiat, Navarra, Spain
Gonzalez-Pinto, A:
Univ Basque Country, Cibersam, BIOARABA, Hosp Univ Alava,Serv Psiquiatria, Bilbao, Spain
Lobo, A:
Univ Zaragoza, Dept Med & Psiquiatria, Zaragoza, Spain
CIBERSAM, Inst Invest Sanitaria Aragon IIS Aragon, Zaragoza, Spain
de la Serna, E:
Hosp Clin Barcelona, Inst Neurosci, Dept Child & Adolescent Psychiat & Psychol, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Cabrera, B:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Hosp Clin Barcelona, Neurosci Inst, Dept Psychiat & Clin Psychobiol, Barcelona Clin,Schizophrenia Unit, Barcelona, Spain
Torrent, C:
Univ Barcelona, Hosp Clin, IDIBAPS, CIBERSAM, Barcelona, Spain
Roldan, L:
Univ Complutense, IiSGM, CIBERSAM,Sch Med, Child & Adolescent Psychiat Dept,Hosp Gen Univ Gr, Madrid, Spain
Sanjuan, J:
Clin Hosp INCLIVA, Valencia, Spain
Ibanez, A:
Univ Alcala De Henares, Hosp Ramon y Cajal, Serv Psiquiatria, CIBERSAM,IRYCIS, Madrid, Spain
Sanchez-Torres, AM:
Inst Hlth Res, Pamplona, Spain
Complejo Hosp Navarra, IdiSNA, Dept Psychiat, Navarra, Spain
Corripio, I:
Hosp Santa Reu & St Pau, CIBERSAM, Serv Psiquiatria, Barcelona, Spain
Bernardo, M:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Barcelona, Hosp Clin Barcelona, Dept Psychiat & Clin Psychobiol,IDIBAPS, Barcelona Clin,Schizophrenia Unit,Neurosci Inst, Barcelona, Spain
Cuesta, MJ:
Inst Hlth Res, Pamplona, Spain
Complejo Hosp Navarra, IdiSNA, Dept Psychiat, Navarra, Spain
Vieta, E:
Univ Barcelona, Hosp Clin, IDIBAPS, CIBERSAM, Barcelona, Spain
Martinez-Aran, A:
Univ Barcelona, Hosp Clin, IDIBAPS, CIBERSAM, Barcelona, Spain
Castro-Fornieles, J:
Hosp Clin Barcelona, Inst Neurosci, Dept Child & Adolescent Psychiat & Psychol, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Baeza, I:
Hosp Clin Barcelona, Inst Neurosci, Dept Child & Adolescent Psychiat & Psychol, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Bioque, M:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Hosp Clin Barcelona, Neurosci Inst, Dept Psychiat & Clin Psychobiol, Barcelona Clin,Schizophrenia Unit, Barcelona, Spain
Mezquida, G:
Hosp Clin Barcelona, Neurosci Inst, Dept Psychiat & Clin Psychobiol, Barcelona Clin,Schizophrenia Unit, Barcelona, Spain
Lopez-Ilundain, JM:
Complejo Hosp Navarra, Dept Psychiat, Pamplona, Spain
IdiSNA, Navarra, Spain
Inst Hlth Res, Pamplona, Spain
Alonso, A:
Hosp Santa Creu & Sant Pau, CIBERSAM, Inst Recerca, Barcelona, Spain
Rabela, M:
Hosp Santa Creu & Sant Pau, CIBERSAM, Inst Recerca, Barcelona, Spain
Lopez, P:
Univ Basque Country, Cibersam, BIOARABA, Hosp Univ Alava,Serv Psiquiatria, Bilbao, Spain
Zorrilla, I:
Univ Basque Country, Cibersam, BIOARABA, Hosp Univ Alava,Serv Psiquiatria, Bilbao, Spain
Arbej, J:
Hosp Clin Univ, Serv Psiquiatria, Zaragoza, Spain
Inst Invest Sanitaria Aragon IIS Aragon, Zaragoza, Spain
Rivero, G:
Hosp Clin Univ, Serv Psiquiatria, Zaragoza, Spain
Inst Invest Sanitaria Aragon IIS Aragon, Zaragoza, Spain
Aguilar, EJ:
Clin Hosp INCLIVA, Valencia, Spain
Mane, A:
Hosp del Mar Med Res Inst IMIM, Dept Neurosci & Psychiat, Barcelona, Spain
Ctr Invest Red Salud Mental CIBERSAM, Madrid, Spain
Berge, D:
Hosp del Mar Med Res Inst IMIM, Dept Neurosci & Psychiat, Barcelona, Spain
Ctr Invest Red Salud Mental CIBERSAM, Madrid, Spain
Contreras, F:
Bellvitge Univ Hosp IDIBELL, Dept Psychiat, Barcelona, Spain
Univ Barcelona, Sch Med, Dept Clin Sci, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Carlos Hlth Inst 3, Barcelona, Spain
Albacete, A:
Bellvitge Univ Hosp IDIBELL, Dept Psychiat, Barcelona, Spain
Univ Barcelona, Sch Med, Dept Clin Sci, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Carlos Hlth Inst 3, Barcelona, Spain
Garcia-Alvarez, L:
Univ Oviedo, Ctr Invest Biomed Red Salud Mental, CIBERSAM, Oviedo, Spain
Al-Halabi, S:
Univ Oviedo, Ctr Invest Biomed Red Salud Mental, CIBERSAM, Oviedo, Spain
Gutierrez, M:
Univ Basque Country, UPV EHU, Dept Neurosci, Greater Bilbao, Spain
CIBERSAM, Ctr Invest Biomed Red Salud Mental, Madrid, Spain
Araba Univ Hosp, Dept Psychiat, Bioaraba Hlth Res Inst, Vitoria, Spain
Segarra, R:
Univ Basque Country, UPV EHU, Dept Neurosci, Greater Bilbao, Spain
CIBERSAM, Ctr Invest Biomed Red Salud Mental, Madrid, Spain
Araba Univ Hosp, Dept Psychiat, Vitoria, Spain
Cruces Univ Hosp, BioCruces Hlth Res Inst, Dept Psychiat, Baracaldo, Spain
Morales-Munoz, I:
Hosp 12 Octubre i 12, Inst Invest, Madrid, Spain
CIBERSAM, Madrid, Spain
Rodriguez-Jimenez, R:
Hosp 12 Octubre i 12, Inst Invest, Madrid, Spain
CIBERSAM, Madrid, Spain
Butjosa, A:
Teaching Res & Innovat Unit, Parc Sanitari St Joan de Deu, Barcelona, Spain
St Joan de Deu Res Fdn, CIBERSAM, Barcelona, Spain
Univ Barcelona, Fac Psychol, Dept Personal Evaluat & Psychol Treatment, Barcelona, Spain
Usall, J:
CIBERSAM, Teaching Res & Innovat Unit, Parc Sanitari St Joan de Deu, Barcelona, Spain
Sarro, S:
Network Ctr Biomed Res Mental Hlth CIBERSAM, FIDMAG Hermanas Hosp Res Fdn, Madrid, Spain
Landin-Romero, R:
Network Ctr Biomed Res Mental Hlth CIBERSAM, FIDMAG Hermanas Hosp Res Fdn, Madrid, Spain
Ruiz, JS:
Univ Alcala De Henares, Hosp Ramon y Cajal, Serv Psiquiatria, CIBERSAM,IRYCIS, Madrid, Spain
Balanza, V:
Univ Valencia, CIBERSAM, Hosp Univ Doctor Peset, Serv Psiquiatria, Valencia, Spain
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