Individual trajectories of cognitive performance in first episode psychosis: a 2-year follow-up study
Por:
Sanchez-Torres, AM, Moreno-Izco, L, Lorente-Omenaca, R, Cabrera, B, Lobo, A, Gonzalez-Pinto, AM, Merchan-Naranjo, J, Corripio, I, Vieta, E, de la Serna, E, Butjosa, A, Contreras, F, Sarro, S, Mezquida, G, Ribeiro, M, Bernardo, M, Cuesta, MJ
Publicada:
1 oct 2018
Resumen:
Individual changes over time in cognition in patients with psychotic disorders have been studied very little, especially in the case of first episode psychosis (FEP). We aimed to establish whether change in individual trajectories in cognition over 2years of a sample of 159 FEP patients was reliable and clinically significant, using the reliable change index (RCI) and clinically significant change (CSC) methods. We also studied a sample of 151 matched healthy controls. Patients and controls were assessed with a set of neuropsychological tests, as well as premorbid, clinical and functionality measures. We analysed the course of cognitive measures over time, using analysis of variance, and the individual trajectories in the cognitive measures with the regression-based RCI (RCISRB) and the CSC. The RCISRB showed that between 5.4 and 31.2% of the patients showed deterioration patterns, and between 0.6 and 8.8% showed improvement patterns in these tests over time. Patients showing better cognitive profiles according to RCISRB (worsening in zero to two cognitive measures) showed better premorbid, clinical and functional profiles than patients showing deterioration patterns in more than three tests. When combining RCISRB and CSC values, we found that less than 10% of patients showed improvement or deterioration patterns in executive function and attention measures. These results support the view that cognitive impairments are stable over the first 2years of illness, but also that the analysis of individual trajectories could help to identify a subgroup of patients with particular phenotypes, who may require specific interventions.
Filiaciones:
Sanchez-Torres, AM:
Complejo Hosp Navarra, Dept Psychiat, C Irunlarrea 3, Pamplona 31008, Spain
Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain
Moreno-Izco, L:
Complejo Hosp Navarra, Dept Psychiat, C Irunlarrea 3, Pamplona 31008, Spain
Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain
Lorente-Omenaca, R:
Complejo Hosp Navarra, Dept Psychiat, C Irunlarrea 3, Pamplona 31008, Spain
Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain
Cabrera, B:
Hosp Clin Barcelona, Barcelona Clin, Schizophrenia Unit, Barcelona, Spain
Network Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain
Lobo, A:
Univ Zaragoza, Aragon Inst Hlth Res IIS Aragon, Dept Med & Psychiat, Zaragoza, Spain
Gonzalez-Pinto, AM:
Network Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain
OSI Araba Univ Hosp, BIOARABA Hlth Res Inst, Vitoria, Spain
Univ Basque Country, Vitoria, Spain
Merchan-Naranjo, J:
Network Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain
Univ Complutense, Hosp Gen Univ Gregorio Maranon, Child & Adolescent Psychiat Dept, Sch Med,IISGM, Madrid, Spain
Corripio, I:
Network Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain
UAB, Hosp Santa Creu St & Pau, Dept Psychiat, Barcelona, Spain
Vieta, E:
Network Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain
Hosp Clin Barcelona, Clin Inst Neurosci, Dept Psychiat & Psychol, Catalonia, Spain
August Pi i Sunyer Inst Biomed Res IDIBAPS, Barcelona, Spain
Univ Barcelona, Dept Psychiat & Clin Psychol, Catalonia, Spain
de la Serna, E:
Network Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain
Hosp Clin Barcelona, Dept Child & Adolescent Psychiat & Psychol, Barcelona, Spain
Butjosa, A:
Network Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain
Parc Sanitari St Joan de Deu, Teaching Res & Innovat Unit, Barcelona, Spain
St Joan de Deu Res Fdn, Barcelona, Spain
Univ Barcelona, Fac Psychol, Dept Personal Evaluat & Psychol Treatment, Barcelona, Spain
Contreras, F:
Network Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain
Bellvitge Univ Hosp, IDIBELL, Psychiat Dept, Lhospitalet De Llobregat, Spain
Univ Barcelona, Sch Med, Dept Clin Sci, Barcelona, Spain
Sarro, S:
Network Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain
FIDMAG Hermanas Hosp Res Fdn, Barcelona, Spain
Mezquida, G:
Hosp Clin Barcelona, Barcelona Clin, Schizophrenia Unit, Barcelona, Spain
Ribeiro, M:
Complejo Hosp Navarra, Dept Psychiat, C Irunlarrea 3, Pamplona 31008, Spain
Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain
Bernardo, M:
Hosp Clin Barcelona, Barcelona Clin, Schizophrenia Unit, Barcelona, Spain
Network Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain
Univ Barcelona, IDIBAPS, Dept Psychiat & Clin Psychobiol, Barcelona, Spain
Cuesta, MJ:
Complejo Hosp Navarra, Dept Psychiat, C Irunlarrea 3, Pamplona 31008, Spain
Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain
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