Is cognitive impairment associated with antipsychotic dose and anticholinergic equivalent loads in first-episode psychosis?
Por:
Ballesteros, A, Sanchez-Torres, AM, Lopez-Ilundain, JM, Cabrera, B, Lobo, A, Gonzalez-Pinto, AM, Diaz-Caneja, C, Corripio, I, Vieta, E, la Serna, E, Bobes, J, Usall, J, Contreras, F, Lorente-Omenaca, R, Mezquida, G, Bernardo, M, Cuesta, MJ
Publicada:
1 oct 2018
Resumen:
Background. Cognitive deficits are a core feature of early stages in schizophrenia. However, the extent to which antipsychotic (AP) have a deleterious effect on cognitive performance remains under debate. We aim to investigate whether anticholinergic loadings and dose of AP drugs in first episode of psychosis (FEP) in advanced phase of remission are associated with cognitive impairment and the differences between premorbid intellectual quotient (IQ) subgroups.
Methods. Two hundred and sixty-six patients participated. The primary outcomes were cognitive dimensions, dopaminergic/anticholinergic load of AP [in chlorpromazine equivalents (Eq-CPZ) and the Anticholinergic Risk Scale (ARS), respectively].
Results. Impairments in processing speed, verbal memory and global cognition were significantly associated with high Eq-CPZ and verbal impairment with high ARS score. Moreover, this effect was higher in the low IQ subgroup.
Conclusions. Clinicians should be aware of the potential cognitive impairment associated with AP in advanced remission FEP, particularly in lower premorbid IQ patients.
Filiaciones:
Ballesteros, A:
Estella Mental Hlth Ctr, Direcc Salud Mental, Pamplona, Navarra, Spain
Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain
Sanchez-Torres, AM:
Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain
Complejo Hosp Navarra, Dept Psychiat, Pamplona, Spain
Lopez-Ilundain, JM:
Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain
Complejo Hosp Navarra, Dept Psychiat, Pamplona, Spain
Cabrera, B:
Hosp Clin Barcelona, Neurosci Inst, Schizophrenia Unit, Barcelona Clin, Barcelona, Spain
Network Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain
Lobo, A:
Univ Zaragoza, Aragon Inst Hlth Res IIS Aragon, Dept Med & Psychiat, Zaragoza, Spain
Gonzalez-Pinto, AM:
Network Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain
Univ Hosp, OSI Araba, BIOARABA Hlth Res Inst, Vitoria, Spain
Univ Basque Country, Vitoria, Spain
Diaz-Caneja, C:
Network Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain
Univ Complutense, Univ Gregorio Maranon, Sch Med, Hosp Gen,IiSGM,Dept Child & Adolescent Psychiat, Madrid, Spain
Corripio, I:
Network Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain
UAB, Hosp Santa Creu & Sant Pau, Dept Psychiat, Barcelona, Spain
Vieta, E:
Network Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain
Hosp Clin Barcelona, Clin Inst Neurosci, Dept Psychiat & Psychol, Catalonia, Spain
August Pi i Sunyer Inst Biomed Res IDIBAPS, Barcelona, Catalonia, Spain
Univ Barcelona, Dept Psychiat & Clin Psychol, Barcelona, Catalonia, Spain
Univ Barcelona, IDIBAPS, Dept Psychiat & Clin Psychobiol, Barcelona, Spain
la Serna, E:
Network Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain
Univ Barcelona, Hosp Clin Barcelona, Inst Clin Neurosci,Dept Med,2014SGR489, IDIBAPS,Child & Adolescent Psychiat & Psychol Dep, Barcelona, Spain
Bobes, J:
Network Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain
Univ Oviedo, Psychiat Dept, Oviedo, Spain
INEUROPA, Inst Neurosci Principal Asturias, Oviedo, Spain
Usall, J:
Network Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain
Parc Sanitari St Joan Deu, Barcelona, Spain
Contreras, F:
Network Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain
Bellvitge Univ Hospital, IDIBELL, Psychiat Dept, Lhospitalet De Llobregat, Spain
Univ Barcelona, Sch Med, Dept Clin Sci, Barcelona, Spain
Lorente-Omenaca, R:
Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain
Complejo Hosp Navarra, Dept Psychiat, Pamplona, Spain
Mezquida, G:
Hosp Clin Barcelona, Neurosci Inst, Schizophrenia Unit, Barcelona Clin, Barcelona, Spain
Network Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain
Bernardo, M:
Hosp Clin Barcelona, Neurosci Inst, Schizophrenia Unit, Barcelona Clin, Barcelona, Spain
Network Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain
Univ Barcelona, IDIBAPS, Dept Psychiat & Clin Psychobiol, Barcelona, Spain
Cuesta, MJ:
Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain
Complejo Hosp Navarra, Dept Psychiat, Pamplona, Spain
Univ Gregorio Maranon, Hosp Gen, Dept Child & Adolescent Psychiat, IiSGM, Madrid, Spain.
Inst Invest Sanitaria Aragon IIS Aragon, Hosp Clin Univ, Dept Psychiat, Zaragoza, Spain.
Inst Invest Sanitaria Aragon IIS Aragon, Quiron Hosp, Zaragoza, Spain.
Valencia Clin Hosp, INCLIVA, Episode Psychiat Unit 1, Valencia, Spain.
UAB, Hosp Mar Med Res Inst IMIM, Barcelona, Spain.
Univ Basque Country, UPV EHU, Biocruces Hlth Res Inst, Dept Neurosci, Baracaldo, Spain.
Hosp 12 Octubre i 12, Inst Invest, Madrid, Spain.
St Joan Deu Res Fdn, Barcelona, Spain.
Univ Barcelona, Fac Psychol, Barcelona, Spain.
Hosp St Joan Deu, Barcelona, Spain.
FIDMAG Hermanas Hosp Res Fdn, Barcelona, Spain.
Neurosci Res Australia, Sydney, NSW, Australia.
Univ New South Wales, Australia Sch Med Sci, Sydney, NSW, Australia.
Australia ARC Ctr Excellence Cognit & Disorders, Sydney, NSW, Australia.
Univ Alcala De Henares, Hosp Univ Ramon & Cajal, IRYCIS, Dept Psychiat, Madrid, Spain.
La Fe Univ & Polytech Hosp, Serv Psychiat, Valencia, Spain.
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