Cognitive reserve as an outcome predictor: first-episode affective versus non-affective psychosis
Por:
Amoretti, S, Cabrera, B, Torrent, C, Mezquida, G, Lobo, A, Gonzalez-Pinto, A, Parellada, M, Corripio, I, Vieta, E, de la Serna, E, Butjosa, A, Contreras, F, Sarro, S, Penades, R, Sanchez-Torres, AM, Cuesta, M, Bernardo, M
Publicada:
1 nov 2018
Resumen:
ObjectiveMethodCognitive reserve (CR) refers to the brain's capacity to cope with pathology in order to minimize the symptoms. CR is associated with different outcomes in severe mental illness. This study aimed to analyze the impact of CR according to the diagnosis of first-episode affective or non-affective psychosis (FEP).
A total of 247 FEP patients (211 non-affective and 36 affective) and 205 healthy controls were enrolled. To assess CR, common proxies have been integrated (premorbid IQ; education-occupation; leisure activities). The groups were divided into high and low CR.
ResultsConclusionIn non-affective patients, those with high CR were older, had higher socioeconomic status (SES), shorter duration of untreated psychosis, and a later age of onset. They also showed greater performance in most cognitive domains. In affective patients, those with a greater CR showed a higher SES, better functioning, and greater verbal memory performance.
CR plays a differential role in the outcome of psychoses according to the diagnosis. Specifically, in order to address the needs of non-affective patients with low CR, cognitive rehabilitation treatments will need to be enriched' by adding pro-cognitive pharmacological agents or using more sophisticated approaches. However, a functional remediation therapy may be of choice for those with an affective psychosis and low CR.
Filiaciones:
Amoretti, S:
Univ Barcelona, Neurosci Inst, Hosp Clin Barcelona, Barcelona Clin Schizophrenia Unit, Barcelona, Spain
Biomed Res Networking Ctr Mental Hlth Network CIB, Madrid, Spain
Cabrera, B:
Univ Barcelona, Neurosci Inst, Hosp Clin Barcelona, Barcelona Clin Schizophrenia Unit, Barcelona, Spain
Biomed Res Networking Ctr Mental Hlth Network CIB, Madrid, Spain
Torrent, C:
Biomed Res Networking Ctr Mental Hlth Network CIB, Madrid, Spain
August Pi i Sunyer Biomed Res Inst IDIBAPS, Barcelona, Spain
Univ Barcelona, Inst Neurosci, Barcelona Bipolar Disorders Program, Barcelona, Spain
Mezquida, G:
Univ Barcelona, Neurosci Inst, Hosp Clin Barcelona, Barcelona Clin Schizophrenia Unit, Barcelona, Spain
Biomed Res Networking Ctr Mental Hlth Network CIB, Madrid, Spain
Lobo, A:
Biomed Res Networking Ctr Mental Hlth Network CIB, Madrid, Spain
Zaragoza Univ, Inst Invest Sanitaria Aragon IIS Aragon, Dept Med & Psychiat, Zaragoza, Spain
Gonzalez-Pinto, A:
Biomed Res Networking Ctr Mental Hlth Network CIB, Madrid, Spain
Araba Univ Hosp, Bioaraba Res Inst, Vitoria, Spain
Univ Basque Country, UPV EHU, Vitoria, Spain
Parellada, M:
Biomed Res Networking Ctr Mental Hlth Network CIB, Madrid, Spain
Univ Complutense, Sch Med, Hosp Gen Univ Gregorio Maraon, Child & Adolescent Psychiat Dept, Madrid, Spain
Corripio, I:
Biomed Res Networking Ctr Mental Hlth Network CIB, Madrid, Spain
UAB, Hosp Santa Creu & St Pau, Inst Invest Biomed St Pau IIB SANT PAU, Dept Psychiat, Barcelona, Spain
Vieta, E:
Biomed Res Networking Ctr Mental Hlth Network CIB, Madrid, Spain
August Pi i Sunyer Biomed Res Inst IDIBAPS, Barcelona, Spain
Univ Barcelona, Inst Neurosci, Barcelona Bipolar Disorders Program, Barcelona, Spain
de la Serna, E:
Biomed Res Networking Ctr Mental Hlth Network CIB, Madrid, Spain
Hosp Clin Barcelona, Dept Child & Adolescent Psychiat & Psychol, Barcelona, Spain
Butjosa, A:
Biomed Res Networking Ctr Mental Hlth Network CIB, Madrid, Spain
Parc Sanitari St Joan Deu, Inst Recerca St Joan Deu, Barcelona, Spain
Fundacio St Joan Deu, Inst Recerca St Joan Deu, Esplugas de Llobregat, Spain
Contreras, F:
Biomed Res Networking Ctr Mental Hlth Network CIB, Madrid, Spain
Bellvitge Univ Hosp IDIBELL, Psychiat Dept, Lhospitalet De Llobregat, Spain
Sarro, S:
Biomed Res Networking Ctr Mental Hlth Network CIB, Madrid, Spain
FIDMAG Germanes Hosp Res Fdn, Barcelona, Spain
Neurosci Res Australia, Sydney, NSW, Australia
Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia
ARC Ctr Excellence Cognit & Its Disorders, Sydney, NSW, Australia
Penades, R:
Univ Barcelona, Neurosci Inst, Hosp Clin Barcelona, Barcelona Clin Schizophrenia Unit, Barcelona, Spain
Biomed Res Networking Ctr Mental Hlth Network CIB, Madrid, Spain
August Pi i Sunyer Biomed Res Inst IDIBAPS, Barcelona, Spain
Sanchez-Torres, AM:
Complejo Hosp Navarra, Dept Psychiat, Pamplona, Spain
Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain
Cuesta, M:
Complejo Hosp Navarra, Dept Psychiat, Pamplona, Spain
Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain
Bernardo, M:
Univ Barcelona, Neurosci Inst, Hosp Clin Barcelona, Barcelona Clin Schizophrenia Unit, Barcelona, Spain
Biomed Res Networking Ctr Mental Hlth Network CIB, Madrid, Spain
August Pi i Sunyer Biomed Res Inst IDIBAPS, Barcelona, Spain
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