Altered topology of the functional speech production network in non-fluent/agrammatic variant of PPA
Por:
Mandelli, ML, Welch, AE, Vilaplana, E, Watson, C, Battistella, G, Brown, JA, Possin, KL, Hubbard, HI, Miller, ZA, Henry, ML, Marx, GA, Santos-Santos, MA, Bajorek, LP, Fortea, J, Boxer, A, Rabinovici, G, Lee, S, Deleon, J, Rosen, HJ, Miller, BL, Seeley, WW, Gorno-Tempini, ML
Publicada:
1 nov 2018
Resumen:
Non-fluent/agrammatic primary progressive aphasia (nfvPPA) is caused by neuro-degeneration within the left fronto-insular speech and language production network (SPN). Graph theory is a branch of mathematics that studies network architecture (topology) by quantifying features based on its elements (nodes and connections). This approach has been recently applied to neuroimaging data to explore the complex architecture of the brain connectome, though few studies have exploited this technique in PPA. Here, we used graph theory on functional MRI resting state data from a group of 20 nfvPPA patients and 20 matched controls to investigate topological changes in response to focal neuro-degeneration. We hypothesized that changes in the network architecture would be specific to the affected SPN in nfvPPA, while preserved in the spared default mode network (DMN). Topological configuration was quantified by hub location and global network metrics. Our findings showed a less efficiently wired and less optimally clustered SPN, while no changes were detected in the DMN. The SPN in the nfvPPA group showed a loss of hubs in the left fronto-parietal-temporal area and new critical nodes in the anterior left inferior-frontal and right frontal regions. Behaviorally, speech production score and rule violation errors correlated with the strength of functional connectivity of the left (lost) and right (new) regions respectively. This study shows that focal neurodegeneration within the SPN in nfvPPA is associated with network-specific topological alterations, with the loss and gain of crucial hubs and decreased global efficiency that were better accounted for through functional rather than structural changes. These findings support the hypothesis of selective network vulnerability in nfvPPA and may offer biomarkers for future behavioral intervention. (C) 2018 Elsevier Ltd. All rights reserved.
Filiaciones:
Mandelli, ML:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Welch, AE:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Vilaplana, E:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Watson, C:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Battistella, G:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Brown, JA:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Possin, KL:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Hubbard, HI:
Univ Alberta, Fac Rehabil Med, Dept Commun Sci & Disorders, Edmonton, AB, Canada
Miller, ZA:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Henry, ML:
Univ Texas Austin, Dept Commun Sci & Disorders, Austin, TX 78712 USA
Marx, GA:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Santos-Santos, MA:
Bellvitge Biomed Res Inst IDIBELL, Cognit & Brain Plast Grp, Barcelona, Spain
Fdn ACE, Memory Clin, Barcelona, Spain
Inst Catala Neurociencies Aplicades, Res Ctr, Barcelona, Spain
Bajorek, LP:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Fortea, J:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, Memory Unit,Dept Neurol, Barcelona, Spain
Boxer, A:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Rabinovici, G:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Lee, S:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Deleon, J:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Rosen, HJ:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Miller, BL:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Seeley, WW:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA
Gorno-Tempini, ML:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Green Accepted
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