Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

Por: Ligthart, S, Vaez, A, Vosa, U, Stathopoulou, MG, de Vries, PS, Prins, BP, Van der Most, PJ, Tanaka, T, Naderi, E, Rose, LM, Wu, Y, Karlsson, R, Barbalic, M, Lin, HH, Pool, R, Zhu, G, Mace, A, Sidore, C, Trompet, S, Mangino, M, Sabater-Lleal, M, Kemp, JP, Abbasi, A, Kacprowski, T, Verweij, N, Smith, AV, Huang, T, Marzi, C, Feitosa, MF, Lohman, KK, Kleber, ME, Milaneschi, Y, Mueller, C, Huq, M, Vlachopoulou, E, Lyytikainen, LP, Oldmeadow, C, Deelen, J, Perola, M, Zhao, JH, Feenstra, B, Amini, M, Lahti, J, Schraut, KE, Fornage, M, Suktitipat, B, Chen, WM, Li, XH, Nutile, T, Malerba, G, Luan, JA, Bak, T, Schork, N, Del Greco, MF, Thiering, E, Mahajan, A, Marioni, RE, Mihailov, E, Eriksson, J, Ozel, AB, Zhang, WH, Nethander, M, Cheng, YC, Aslibekyan, S, Ang, W, Gandin, I, Yengo, L, Portas, L, Kooperberg, C, Hofer, E, Rajan, KB, Schurmann, C, den Hollander, W, Ahluwalia, TS, Zhao, J, Draisma, HHM, Ford, I, Timpson, N, Teumer, A, Huang, HY, Wahl, S, Liu, YM, Huang, J, Uh, HW, Geller, F, Joshi, PK, Yanek, LR, Trabetti, E, Lehne, B, Vozzi, D, Verbanck, M, Biino, G, Saba, Y, Meulenbelt, I, O'Connell, JR, Laakso, M, Giulianini, F, Magnusson, PKE, Ballantyne, CM, Hottenga, JJ, Montgomery, G, Rivadineira, F, Rueedi, R, Steri, M, Herzig, KH, Stott, DJ, Menni, C, Franberg, M, St Pourcain, B, Felix, SB, Pers, TH, Bakker, SJL, Kraft, P, Peters, A, Vaidya, D, Delgado, G, Smit, JH, Grossmann, V, Sinisalo, J, Seppala, I, Williams, SR, Holliday, EG, Moed, M, Langenberg, C, Raikkonen, K, Ding, JZ, Campbell, H, Sale, MM, Chen, YDI, James, AL, Ruggiero, D, Soranzo, N, Hartman, CA, Smith, EN, Berenson, GS, Fuchsberger, C, Hernandez, D, Tiesler, CMT, Giedraitis, V, Liewald, D, Fischer, K, Mellstrom, D, Larsson, A, Wang, YM, Scott, WR, Lorentzon, M, Beilby, J, Ryan, KA, Pennell, CE, Vuckovic, D, Balkau, B, Concas, MP, Schmidt, R, de Leon, CFM, Bottinger, EP, Kloppenburg, M, Paternoster, L, Boehnke, M, Musk, AW, Willemsen, G, Evans, DM, Madden, PAF, Kahonen, M, Kutalik, Z, Zoledziewska, M, Karhunen, V, Kritchevsky, SB, Sattar, N, Lachance, G, Clarke, R, Harris, TB, Raitakari, OT, Attia, JR, Van Heemst, D, Kajantie, E, Sorice, R, Gambaro, G, Scott, RA, Hicks, AA, Ferrucci, L, Standl, M, Lindgren, CM, Starr, JM, Karlsson, M, Lind, L, Li, JZ, Chambers, JC, Mori, TA, de Geus, EJCN, Heath, AC, Martin, NG, Auvinen, J, Buckley, BM, de Craen, AJM, Waldenberger, M, Strauch, K, Meitinger, T, Scott, RJ, McEvoy, M, Beekman, M, Bombieri, C, Ridker, PM, Mohlke, KL, Pedersen, NL, Morrison, AC, Boomsma, DI, Whitfield, JB, Strachan, DP, Hofman, A, Vollenweider, P, Cucca, F, Jarvelin, MR, Jukema, JW, Spector, TD, Hamsten, A, Zeller, T, Uitterlinden, AG, Nauck, M, Gudnason, V, Qi, L, Grallert, H, Borecki, IB, Rotter, JI, Marz, W, Wild, PS, Lokki, ML, Boyle, M, Salomaa, V, Melbye, M, Eriksson, JG, Wilson, JF, Penninx, BWJH, Becker, DM, Worrall, BB, Gibson, G, Krauss, RM, Ciullo, M, Zaza, G, Wareham, NJ, Oldehinkel, AJ, Palmer, LJ, Murray, SS, Pramstaller, PP, Bandinelli, S, Heinrich, J, Ingelsson, E, Deary, IJ, Magi, R, Vandenput, L, van der Harst, P, Desch, KC, Kooner, JS, Ohlsson, C, Hayward, C, Lehtimaki, T, Shuldiner, AR, Arnett, DK, Beilin, LJ, Robino, A, Froguel, P, Pirastu, M, Jess, T, Koenig, W, Loos, RJF, Evans, DA, Schmidt, H, Smith, GD, Slagboom, PE, Eiriksdottir, G, Morris, AP, Psaty, BM, Tracy, RP, Nolte, IM, Boerwinkle, E, Visvikis-Siest, S, Reiner, AP, Gross, M, Bis, JC, Franke, L, Franco, OH, Benjamin, EJ, Chasman, DI, Dupuis, J, Snieder, H, Dehghan, A, Alizadeh, BZ, LifeLines Cohort Study, CHARGE Inflammation Working Grp

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Publicada: 1 nov 2018

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Filiaciones:
Ligthart, S:
 Erasmus Univ, Med Ctr, Dept Epidemiol, NL-3000 CA Rotterdam, Netherlands

Vaez, A:
 Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, NL-9700 RB Groningen, Netherlands

 Isfahan Univ Med Sci, Dept Bioinformat, Esfahan 8174673461, Iran

Vosa, U:
 Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9700 RB Groningen, Netherlands

 Univ Tartu, Inst Genom, Estonian Genome Ctr, EE-51010 Tartu, Estonia

Stathopoulou, MG:
 Univ Lorraine, INSERM, IGE PCV, F-54000 Nancy, France

de Vries, PS:
 Erasmus Univ, Med Ctr, Dept Epidemiol, NL-3000 CA Rotterdam, Netherlands

 Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Ctr Human Genet, Houston, TX 77030 USA

Prins, BP:
 Wellcome Trust Sanger Inst, Dept Human Genet, Hinxton CB10 1SA, England

Van der Most, PJ:
 Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, NL-9700 RB Groningen, Netherlands

Tanaka, T:
 NIA, Translat Gerontol Branch, Baltimore, MD 21224 USA

Naderi, E:
 Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, NL-9700 RB Groningen, Netherlands

 Univ Groningen, Univ Med Ctr Groningen, Dept Radiat Oncol, NL-9713 GZ Groningen, Netherlands

Rose, LM:
 Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02215 USA

Wu, Y:
 Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA

Karlsson, R:
 Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden

Barbalic, M:
 Univ Split, Sch Med, Split 21000, Croatia

Lin, HH:
 Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA

Pool, R:
 Vrije Univ, Netherlands Twin Register, Dept Biol Psychol, NL-1081 BT Amsterdam, Netherlands

 Vrije Univ Amsterdam Med Ctr, Amsterdam Publ Hlth Res Inst, NL-1081 BT Amsterdam, Netherlands

Zhu, G:
 QIMR Berghofer Med Res Inst, Brisbane, Qld 4006, Australia

Mace, A:
 Univ Lausanne, Dept Computat Biol, CH-1010 Lausanne, Switzerland

 Swiss Inst Bioinformat, CH-1015 Lausanne, Switzerland

 Univ Hosp Lausanne, Inst Social & Prevent Med, CH-1010 Lausanne, Switzerland

Sidore, C:
 CNR, Ist Ric Genet & Biomed, I-08045 Sardinia, Italy

Trompet, S:
 Leiden Univ, Med Ctr, Dept Cardiol, NL-2300 RC Leiden, Netherlands

 Leiden Univ, Med Ctr, Dept Gerontol & Geriatr, NL-2333 ZA Leiden, Netherlands

Mangino, M:
 Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England

 Guys & St Thomas Fdn Trust, NIHR Biomed Res Ctr, London SE1 9RT, England

Sabater-Lleal, M:
 Inst Invest Biomed St Pau, Unit Genom Complex Dis, Barcelona 08025, Spain

 Karolinska Inst, Ctr Mol Med, Cardiovasc Med Unit, Dept Med, S-17176 Stockholm, Sweden

Kemp, JP:
 Univ Queensland, Diamantina Inst, Translat Res Inst, Brisbane, Qld 4102, Australia

 Univ Bristol, Bristol Med Sch, MRC, Integrat Epidemiol Unit, Bristol BS8 2BN, Avon, England

Abbasi, A:
 Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, NL-9700 RB Groningen, Netherlands

 Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, NL-9713 GZ Groningen, Netherlands

 Univ Cambridge, Sch Med, Inst Metab Sci, MRC,Epidemiol Unit,Addenbrookes Hosp, Cambridge Biomed Campus, Cambridge CB2 0QQ, England

Kacprowski, T:
 Univ Med, Interfac Inst Genet & Funct Genom, Dept Funct Genom, D-17475 Greifswald, Germany

 Ernst Moritz Arndt Univ Greifswald, D-17475 Greifswald, Germany

 German Ctr Cardiovasc Res, Partner Site Greifswald, D-17475 Greifswald, Germany

Verweij, N:
 Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-9713 AV Groningen, Netherlands

Smith, AV:
 Iceland Heart Assoc, IS-201 Kopavogur, Iceland

 Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland

Huang, T:
 Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China

 Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

Marzi, C:
 German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Inst Epidemiol 2, D-85764 Neuherberg, Germany

 German Ctr Diabet Res, Partner Site Munich, D-85764 Munich, Germany

Feitosa, MF:
 Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63108 USA

Lohman, KK:
 Wake Forest Univ Hlth Sci, Publ Hlth Sci, Dept Epidemiol & Prevent, Winston Salem, NC 27157 USA

Kleber, ME:
 Heidelberg Univ, Med Fac Mannheim, Dept Med 5, D-68167 Mannheim, Germany

Milaneschi, Y:
 Univ Amsterdam, Med Ctr, GGZ InGeest Res & Innovat, Dept Psychiat,Amsterdam Neurosci, NL-1081 HJ Amsterdam, Netherlands

 Univ Amsterdam, Med Ctr, GGZ InGeest Res & Innovat, Amsterdam Publ Hlth Res Inst, NL-1081 HJ Amsterdam, Netherlands

Mueller, C:
 Univ Heart Ctr Hamburg, Dept Gen & Intervent Cardiol, D-20246 Hamburg, Germany

 Univ Med Ctr Schleswig Holstein, Inst Med Biometry & Stat, Campus Luebeck, D-23562 Lubeck, Germany

 German Ctr Cardiovasc Res, Partner Site RhineMain, D-55131 Mainz, Germany

Huq, M:
 Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, NL-9700 RB Groningen, Netherlands

Vlachopoulou, E:
 Univ Helsinki, Transplantat Lab, Medicum, FIN-00014 Helsinki, Finland

Lyytikainen, LP:
 Fimlab Labs, Dept Clin Chem, Tampere 33014, Finland

 Univ Tampere, Fac Med & Life Sci, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Chem, Tampere 33520, Finland

Oldmeadow, C:
 Hunter Med Res Inst, New Lambon Hts, NSW 2305, Australia

 Univ Newcastle, Fac Hlth & Med, Ctr Clin Epidemiol & Biostat, Callaghan, NSW 2308, Australia

Deelen, J:
 Leiden Univ, Med Ctr, Mol Epidemiol, NL-2333 ZC Leiden, Netherlands

 Max Planck Inst Biol Ageing, D-50931 Cologne, Germany

Perola, M:
 Natl Inst Hlth & Welf, Helsinki 00271, Finland

Zhao, JH:
 Univ Cambridge, Sch Clin Med, Inst Metab Sci, MRC,Epidemiol Unit, Cambridge CB2 0QQ, England

Feenstra, B:
 Statens Serum Inst, Dept Epidemiol Res, DK-2300 Copenhagen, Denmark

Amini, M:
 Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, NL-9700 RB Groningen, Netherlands

Lahti, J:
 Univ Helsinki, Helsinki Coll Adv Studies, FIN-00014 Helsinki, Finland

 Univ Helsinki, Fac Med, Dept Psychol & Logoped, FIN-00014 Helsinki, Finland

 Folkhalsan Res Ctr, Helsinki 00250, Finland

Schraut, KE:
 Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Teviot Pl, Edinburgh EH16 4UX, Midlothian, Scotland

Fornage, M:
 Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Ctr Human Genet, Houston, TX 77030 USA

 Univ Texas Hlth Sci Ctr Houston, Brown Fdn Inst Mol Med, Houston, TX 77030 USA

Suktitipat, B:
 Mahidol Univ, Siriraj Hosp, Fac Med, Dept Biochem, Bangkok 10700, Thailand

Chen, WM:
 Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA

Li, XH:
 Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Dept Pediat, Inst Translat Genom & Populat Sci, Torrance, CA 90502 USA

Nutile, T:
 CNR, Inst Genet & Biophys A Buzzati Traverso, I-80131 Naples, Italy

Malerba, G:
 Univ Verona, Dept Neurosci Biomed & Movement Sci, I-37134 Verona, Italy

Luan, JA:
 Univ Cambridge, Sch Clin Med, Inst Metab Sci, MRC,Epidemiol Unit, Cambridge CB2 0QQ, England

Bak, T:
 Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, NL-9700 RB Groningen, Netherlands

Schork, N:
 J Craig Venter Inst, Human Biol, La Jolla, CA 92037 USA

 Translat Genom Res Inst, Quantitat Med, Phoenix, AZ 85004 USA

Del Greco, MF:
 Univ Lubeck, Affiliated Inst, Eurac Res, Inst Biomed, I-39100 Bolzano, Italy

Thiering, E:
 German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol, D-85764 Neuherberg, Germany

 Ludwig Maximilian Univ Munich, Dr von Hauner Childrens Hosp, D-80337 Munich, Germany

Mahajan, A:
 Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

Marioni, RE:
 Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland

 Univ Edinburgh, Inst Genet & Mol Med, Ctr Genom & Expt Med, Edinburgh EH4 2XU, Midlothian, Scotland

Mihailov, E:
 Univ Tartu, Inst Genom, Estonian Genome Ctr, EE-51010 Tartu, Estonia

Eriksson, J:
 Natl Inst Hlth & Welf, Helsinki 00271, Finland

 Folkhalsan Res Ctr, Helsinki 00250, Finland

 Univ Gothenburg, Dept Internal Med & Clin Nutr, S-41345 Gothenburg, Sweden

 Univ Helsinki, Dept Gen Practice & Primary Hlth Care, FIN-00014 Helsinki, Finland

 Helsinki Univ Hosp, Helsinki 00014, Finland

Ozel, AB:
 Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA

Zhang, WH:
 UCL, Dept Epidemiol & Biostat, London W2 1PG, England

 Ealing Gen Hosp, Dept Cardiol, Southall UB1 3HW, Middx, England

Nethander, M:
 Univ Gothenburg, Sahlgrenska Acad, Bioinformat Core Facil, S-41390 Gothenburg, Sweden

Cheng, YC:
 Univ Maryland, Sch Med, Dept Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA

Aslibekyan, S:
 Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL 35294 USA

Ang, W:
 Univ Western Australia, Sch Med, Perth, WA 6009, Australia

Gandin, I:
 AREA Sci Pk, I-34149 Trieste, Italy

Yengo, L:
 Univ Lille, Inst Pasteur Lille, European Genom Inst Diabet, CNRS,UMR 8199,FR 3508, F-59000 Lille, France

 Univ Queensland, Inst Mol Biosci, Program Complex Trait Genom, Brisbane, Qld 4072, Australia

Portas, L:
 CNR, Inst Genet & Biomed Res, Support OU, I-7100 Sassari, Italy

Kooperberg, C:
 Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Mail Stop M3-A410,1100 Fairview Ave N, Seattle, WA 98104 USA

Hofer, E:
 Med Univ Graz, Dept Neurol, Clin Div Neurogeriatr, A-8036 Graz, Austria

 Med Univ Graz, Inst Med Informat Stat & Documentat, A-8036 Graz, Austria

Rajan, KB:
 Rush Univ, Med Ctr, Dept Internal Med, Chicago, IL 60612 USA

Schurmann, C:
 Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA

 Icahn Sch Med Mt Sinai, Genet Obes & Related Metab Traits Program, New York, NY 10029 USA

den Hollander, W:
 Leiden Univ, Med Ctr, Sect Mol Epidemiol, Dept Med Stat & Bioinformat, NL-2333 ZC Leiden, Netherlands

Ahluwalia, TS:
 Steno Diabet Ctr Copenhagen, DK-2820 Gentofte, Denmark

 Univ Copenhagen, Novo Nordisk Fdn, Ctr Basic Metab Res, Sect Metab Genet,Fac Hlth & Med Sci, DK-2100 Copenhagen, Denmark

Zhao, J:
 Univ Cambridge, Sch Clin Med, Inst Metab Sci, MRC,Epidemiol Unit, Cambridge CB2 0QQ, England

 Georgia Inst Technol, Sch Biol, Ctr Integrat Genom, Atlanta, GA 30332 USA

Draisma, HHM:
 Vrije Univ, Netherlands Twin Register, Dept Biol Psychol, NL-1081 BT Amsterdam, Netherlands

 Vrije Univ Amsterdam Med Ctr, Amsterdam Publ Hlth Res Inst, NL-1081 BT Amsterdam, Netherlands

 Neurosci Campus Amsterdam, NL-1081 HV Amsterdam, Netherlands

Ford, I:
 Univ Glasgow, Robertson Ctr Biostat, Glasgow G12 8QQ, Lanark, Scotland

Timpson, N:
 Univ Bristol, Bristol Med Sch, MRC, Integrat Epidemiol Unit, Bristol BS8 2BN, Avon, England

Teumer, A:
 Univ Med Greifswald, Inst Community Med, Dept SHIP KEF, D-17475 Greifswald, Germany

Huang, HY:
 Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA 02115 USA

Wahl, S:
 German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Inst Epidemiol 2, D-85764 Neuherberg, Germany

 German Ctr Diabet Res, Partner Site Munich, D-85764 Munich, Germany

Liu, YM:
 Wake Forest Univ Hlth Sci, Publ Hlth Sci, Dept Epidemiol & Prevent, Winston Salem, NC 27157 USA

Huang, J:
 Boston VA Res Inst Inc, Boston, MA 02130 USA

Uh, HW:
 Leiden Univ, Med Ctr, Med Stat & Bioinformat, NL-2333 ZC Leiden, Netherlands

Geller, F:
 Statens Serum Inst, Dept Epidemiol Res, DK-2300 Copenhagen, Denmark

Joshi, PK:
 Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Teviot Pl, Edinburgh EH16 4UX, Midlothian, Scotland

Yanek, LR:
 Johns Hopkins Univ, Sch Med, Dept Med, GeneSTAR Res Ctr, Baltimore, MD 21287 USA

Trabetti, E:
 Univ Verona, Dept Neurosci Biomed & Movement Sci, I-37134 Verona, Italy

Lehne, B:
 UCL, Dept Epidemiol & Biostat, London W2 1PG, England

Vozzi, D:
 IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, I-34140 Trieste, Italy

Verbanck, M:
 Univ Lille, Inst Pasteur Lille, European Genom Inst Diabet, CNRS,UMR 8199,FR 3508, F-59000 Lille, France

Biino, G:
 CNR, Inst Mol Genet, I-27100 Pavia, Italy

Saba, Y:
 Gottfried Schatz Res Ctr, Inst Mol Biol & Biochem, A-8010 Graz, Austria

Meulenbelt, I:
 Leiden Univ, Med Ctr, Sect Mol Epidemiol, Dept Med Stat & Bioinformat, NL-2333 ZC Leiden, Netherlands

O'Connell, JR:
 Univ Maryland, Sch Med, Dept Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA

Laakso, M:
 Univ Eastern Finland, Inst Clin Med, Internal Med, Kuopio 70210, Finland

 Kuopio Univ Hosp, Kuopio 70210, Finland

Giulianini, F:
 Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02215 USA

Magnusson, PKE:
 Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden

Ballantyne, CM:
 Baylor Coll Med, Dept Med, Houston, TX 77030 USA

 Methodist DeBakey Heart & Vasc Ctr, Houston, TX 77030 USA

Hottenga, JJ:
 Vrije Univ, Netherlands Twin Register, Dept Biol Psychol, NL-1081 BT Amsterdam, Netherlands

Montgomery, G:
 QIMR Berghofer Med Res Inst, Brisbane, Qld 4006, Australia

Rivadineira, F:
 Erasmus Univ, Med Ctr, Dept Internal Med, NL-3015 CN Rotterdam, Netherlands

Rueedi, R:
 Univ Lausanne, Dept Computat Biol, CH-1010 Lausanne, Switzerland

 Swiss Inst Bioinformat, CH-1015 Lausanne, Switzerland

Steri, M:
 CNR, Ist Ric Genet & Biomed, I-08045 Sardinia, Italy

Herzig, KH:
 Univ Oulu, Med Res Ctr Oulu, Dept Physiol, Inst Biomed, Oulu 90014, Finland

 Oulu Univ Hosp, Oulu 90014, Finland

 Univ Oulu, Bioctr Oulu, SF-90220 Oulu, Finland

 Poznan Univ Med Sci, Dept Gastroenterol & Metab, PL-60512 Poznan, Poland

Stott, DJ:
 Univ Glasgow, Fac Med, Inst Cardiovasc & Med Sci, Glasgow G12 8QQ, Lanark, Scotland

Menni, C:
 Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England

Franberg, M:
 Karolinska Inst, Ctr Mol Med, Cardiovasc Med Unit, Dept Med, S-17176 Stockholm, Sweden

 Stockholm Univ, Dept Numer Anal & Comp Sci, S-10044 Stockholm, Sweden

St Pourcain, B:
 Univ Bristol, Bristol Med Sch, MRC, Integrat Epidemiol Unit, Bristol BS8 2BN, Avon, England

 Radboud Univ Nijmegen, Donders Inst, NL-6525 XD Nijmegen, Netherlands

Felix, SB:
 German Ctr Cardiovasc Res, Partner Site Greifswald, D-17475 Greifswald, Germany

 Univ Med Greifswald, Dept Internal Med B, D-17475 Greifswald, Germany

Pers, TH:
 Statens Serum Inst, Dept Epidemiol Res, DK-2300 Copenhagen, Denmark

 Univ Copenhagen, Novo Nordisk Fdn, Ctr Basic Metab Res, Sect Metab Genet,Fac Hlth & Med Sci, DK-2100 Copenhagen, Denmark

Bakker, SJL:
 Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, NL-9713 GZ Groningen, Netherlands

Kraft, P:
 Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA 02115 USA

Peters, A:
 German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, D-85764 Neuherber, Germany

Vaidya, D:
 Johns Hopkins Univ, Sch Med, Dept Med, GeneSTAR Res Ctr, Baltimore, MD 21287 USA

Delgado, G:
 Heidelberg Univ, Med Fac Mannheim, Dept Med 5, D-68167 Mannheim, Germany

Smit, JH:
 Univ Amsterdam, Med Ctr, GGZ InGeest Res & Innovat, Dept Psychiat,Amsterdam Neurosci, NL-1081 HJ Amsterdam, Netherlands

 Univ Amsterdam, Med Ctr, GGZ InGeest Res & Innovat, Amsterdam Publ Hlth Res Inst, NL-1081 HJ Amsterdam, Netherlands

Grossmann, V:
 Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Thrombosis & Hemostasis, D-55131 Mainz, Germany

Sinisalo, J:
 Helsinki Univ Hosp, Heart & Lung Ctr, Helsinki 00029, Finland

 Univ Helsinki, Helsinki 00029, Finland

Seppala, I:
 Fimlab Labs, Dept Clin Chem, Tampere 33014, Finland

 Univ Tampere, Fac Med & Life Sci, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Chem, Tampere 33520, Finland

Williams, SR:
 Univ Virginia, Dept Neurol, Charlottesville, VA 22908 USA

Holliday, EG:
 Hunter Med Res Inst, New Lambon Hts, NSW 2305, Australia

 Univ Newcastle, Fac Hlth & Med, Ctr Clin Epidemiol & Biostat, Callaghan, NSW 2308, Australia

Moed, M:
 Leiden Univ, Med Ctr, Mol Epidemiol, NL-2333 ZC Leiden, Netherlands

Langenberg, C:
 Univ Cambridge, Sch Clin Med, Inst Metab Sci, MRC,Epidemiol Unit, Cambridge CB2 0QQ, England

Raikkonen, K:
 Univ Helsinki, Fac Med, Dept Psychol & Logoped, FIN-00014 Helsinki, Finland

Ding, JZ:
 Wake Forest Univ Hlth Sci, Dept Internal Med Geriatr, Winston Salem, NC 27157 USA

Campbell, H:
 Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Teviot Pl, Edinburgh EH16 4UX, Midlothian, Scotland

Sale, MM:
 Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA

Chen, YDI:
 Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Dept Pediat, Inst Translat Genom & Populat Sci, Torrance, CA 90502 USA

James, AL:
 Sir Charles Gairdner Hosp, Busselton Populat Med Res Inst, Nedlands, WA 6009, Australia

 Sir Charles Gairdner Hosp, Dept Pulm Physiol & Sleep Med, Nedlands, WA 6009, Australia

Ruggiero, D:
 CNR, Inst Genet & Biophys A Buzzati Traverso, I-80131 Naples, Italy

 IRCCS Neuromed, I-86077 Pozzilli, IS, Italy

Soranzo, N:
 Sanger Inst, Wellcome Trust Genome Campus, Hinxton CB10 1SA, England

Hartman, CA:
 Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, NL-9700 RB Groningen, Netherlands

Smith, EN:
 Univ Calif San Diego, Dept Pediat, Sch Med, La Jolla, CA 92037 USA

 Univ Calif San Diego, Rady Childrens Hosp, Sch Med, La Jolla, CA 92037 USA

Berenson, GS:
 Tulane Univ, Ctr Cardiovasc Hlth, New Orleans, LA 70112 USA

Fuchsberger, C:
 Univ Lubeck, Affiliated Inst, Eurac Res, Inst Biomed, I-39100 Bolzano, Italy

Hernandez, D:
 NIA, Neurogenet Lab, Bethesda, MD 20892 USA

 Uppsala Univ, Dept Publ Hlth & Caring Sci, Mol Geriatr, S-75237 Uppsala, Sweden

Tiesler, CMT:
 German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol, D-85764 Neuherberg, Germany

 Ludwig Maximilian Univ Munich, Dr von Hauner Childrens Hosp, D-80337 Munich, Germany

Giedraitis, V:
 Uppsala Univ, Dept Publ Hlth & Caring Sci, Mol Geriatr, S-75237 Uppsala, Sweden

Liewald, D:
 Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland

Fischer, K:
 Univ Tartu, Inst Genom, Estonian Genome Ctr, EE-51010 Tartu, Estonia

Mellstrom, D:
 Univ Gothenburg, Dept Internal Med & Clin Nutr, S-41345 Gothenburg, Sweden

Larsson, A:
 Uppsala Univ, Dept Med Sci, S-75141 Uppsala, Sweden

Wang, YM:
 Case Western Reserve Univ, Case Cardiovasc Res Inst, Dept Med, Harrington Heart & Vasc Inst,Univ Hosp, Cleveland, OH 44106 USA

Scott, WR:
 UCL, Dept Epidemiol & Biostat, London W2 1PG, England

Lorentzon, M:
 Univ Gothenburg, Dept Internal Med & Clin Nutr, S-41345 Gothenburg, Sweden

 Sahlgrens Univ Hosp, Geriatr Med, S-43180 Molndal, Sweden

Beilby, J:
 PathWest Lab Med WA, Nedlands, WA 6009, Australia

 Univ Western Australia, Sch Biomed Sci, Perth, WA 6009, Australia

Ryan, KA:
 Univ Maryland, Sch Med, Dept Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA

Pennell, CE:
 Univ Western Australia, Sch Med, Perth, WA 6009, Australia

Vuckovic, D:
 Univ Trieste, Med Sci Surg & Hlth Dept, I-34137 Trieste, Italy

Balkau, B:
 Univ Paris Saclay, Univ Versailles St Quentin En Yvelines, Team EpReC Renal & Cardiovasc Epidemiol 5, INSERM,U1018,Ctr Rech Epidemiol & Sante Populat, F-94807 Villejuif, France

Concas, MP:
 IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, I-34140 Trieste, Italy

Schmidt, R:
 Med Univ Graz, Dept Neurol, Clin Div Neurogeriatr, A-8036 Graz, Austria

de Leon, CFM:
 Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA

Bottinger, EP:
 Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA

 Icahn Sch Med Mt Sinai, Dept Pharmacol & Syst Therapeut, New York, NY 10029 USA

Kloppenburg, M:
 Leiden Univ, Med Ctr, Dept Rheumatol, NL-2300 RC Leiden, Netherlands

 Leiden Univ, Med Ctr, Dept Clin Epidemiol, NL-2333 ZC Leiden, Netherlands

Paternoster, L:
 Univ Bristol, Bristol Med Sch, MRC, Integrat Epidemiol Unit, Bristol BS8 2BN, Avon, England

Boehnke, M:
 Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA

 Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA

Musk, AW:
 Sir Charles Gairdner Hosp, Busselton Populat Med Res Inst, Nedlands, WA 6009, Australia

 Sir Charles Gairdner Hosp, Dept Resp Med, Nedlands, WA 6009, Australia

Willemsen, G:
 Vrije Univ, Netherlands Twin Register, Dept Biol Psychol, NL-1081 BT Amsterdam, Netherlands

Evans, DM:
 Univ Queensland, Diamantina Inst, Translat Res Inst, Brisbane, Qld 4102, Australia

 Univ Bristol, Bristol Med Sch, MRC, Integrat Epidemiol Unit, Bristol BS8 2BN, Avon, England

Madden, PAF:
 Washington Univ, Sch Med, Dept Psychiat, 4560 Clayton Ave,Suite 1000, St Louis, MO 63110 USA

Kahonen, M:
 Tampere Univ Hosp, Dept Clin Physiol, Tampere 33520, Finland

 Univ Tampere, Fac Med & Life Sci, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Physiol, Tampere 33520, Finland

Kutalik, Z:
 Swiss Inst Bioinformat, CH-1015 Lausanne, Switzerland

 Univ Hosp Lausanne, Inst Social & Prevent Med, CH-1010 Lausanne, Switzerland

Zoledziewska, M:
 CNR, Ist Ric Genet & Biomed, I-08045 Sardinia, Italy

Karhunen, V:
 Univ Oulu, Ctr Life Course Hlth Res, Fac Med, Oulu 90014, Finland

Kritchevsky, SB:
 Wake Forest Univ Hlth Sci, Sticht Ctr Aging & Rehabil, Gerontol & Geriatr Med, Winston Salem, NC 27157 USA

Sattar, N:
 BHF Glasgow Cardiovasc Res Ctr, Fac Med, Glasgow G12 8TA, Lanark, Scotland

Lachance, G:
 Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England

Clarke, R:
 Univ Oxford, Clin Trial Serv Unit, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England

Harris, TB:
 NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, NIH, Bethesda, MD 20892 USA

Raitakari, OT:
 Turku Univ Hosp, Dept Clin Physiol & Nucl Med, FIN-20520 Turku, Finland

 Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, FIN-20520 Turku, Finland

Attia, JR:
 Hunter Med Res Inst, New Lambon Hts, NSW 2305, Australia

 Univ Newcastle, Fac Hlth & Med, Ctr Clin Epidemiol & Biostat, Callaghan, NSW 2308, Australia

 John Hunter Hosp, New Lambton Hts, NSW 2305, Australia

Van Heemst, D:
 Leiden Univ, Med Ctr, Dept Gerontol & Geriatr, NL-2333 ZA Leiden, Netherlands

Kajantie, E:
 Natl Inst Hlth & Welf, Chron Dis Prevent Unit, Helsinki 00014, Finland

 Univ Helsinki, Cent Hosp, Hosp Children & Adolescents, FIN-00290 Helsinki, Finland

 Univ Helsinki, FIN-00290 Helsinki, Finland

 Oulu Univ Hosp, MRC Oulu, Dept Obstet & Gynaecol, Oulu 90014, Finland

 Univ Oulu, Oulu 90014, Finland

Sorice, R:
 CNR, Inst Genet & Biophys A Buzzati Traverso, I-80131 Naples, Italy

Gambaro, G:
 Univ Cattolica Sacro Cuore, Columbus Gemelli Univ Hosp, Div Nephrol & Dialysis, I-168 Rome, Italy

Scott, RA:
 Univ Cambridge, Sch Clin Med, Inst Metab Sci, MRC,Epidemiol Unit, Cambridge CB2 0QQ, England

Hicks, AA:
 Univ Lubeck, Affiliated Inst, Eurac Res, Inst Biomed, I-39100 Bolzano, Italy

Ferrucci, L:
 NIA, Translat Gerontol Branch, Baltimore, MD 21224 USA

Standl, M:
 German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol, D-85764 Neuherberg, Germany

Lindgren, CM:
 Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

 Univ Oxford, Big Data Inst, Li Ka Shing Ctr Hlth Informat & Discovery, Oxford OX3 7FZ, England

 Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA

Starr, JM:
 Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland

 Univ Edinburgh, Alzheimers Scotland Dementia Res Ctr, Edinburgh EH8 9JZ, Midlothian, Scotland

Karlsson, M:
 Lund Univ, Dept Clin Sci & Orthopaed Surg, S-20502 Malmo, Sweden

Lind, L:
 Uppsala Univ, Dept Med Sci, S-75141 Uppsala, Sweden

Li, JZ:
 Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA

Chambers, JC:
 UCL, Dept Epidemiol & Biostat, London W2 1PG, England

 Ealing Gen Hosp, Dept Cardiol, Southall UB1 3HW, Middx, England

 Imperial Coll Healthcare NHS Trust, London W12 0HS, England

 Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore 308232, Singapore

 Imperial Coll London, MRC PHE Ctr Environm & Hlth, London W2 1PG, England

Mori, TA:
 Univ Western Australia, Sch Med, Perth, WA 6009, Australia

de Geus, EJCN:
 Vrije Univ, Netherlands Twin Register, Dept Biol Psychol, NL-1081 BT Amsterdam, Netherlands

 Vrije Univ Amsterdam Med Ctr, Amsterdam Publ Hlth Res Inst, NL-1081 BT Amsterdam, Netherlands

Heath, AC:
 Washington Univ, Sch Med, Dept Psychiat, 4560 Clayton Ave,Suite 1000, St Louis, MO 63110 USA

Martin, NG:
 QIMR Berghofer Med Res Inst, Brisbane, Qld 4006, Australia

Auvinen, J:
 Univ Oulu, Ctr Life Course Hlth Res, Fac Med, Oulu 90014, Finland

 Oulu Univ Hosp, Unit Primary Hlth Care, Oulu 90220, Finland

Buckley, BM:
 Univ Coll Cork, Dept Epidemiol & Publ Hlth, Cork T12 K8AF, Ireland

de Craen, AJM:
 Leiden Univ, Med Ctr, Dept Gerontol & Geriatr, NL-2333 ZA Leiden, Netherlands

Waldenberger, M:
 German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Inst Epidemiol 2, D-85764 Neuherberg, Germany

 German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, D-80636 Munich, Germany

Strauch, K:
 German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Genet Epidemiol, D-85764 Neuherberg, Germany

 Ludwig Maximilian Univ Munich, Fac Med, Inst Med Informat Biometry & Epidemiol, Genet Epidemiol, D-85764 Neuherberg, Germany

Meitinger, T:
 Tech Univ Munich, Inst Human Genet, D-85764 Munich, Germany

 Helmholtz Zentrum Munchen, Inst Human Genet, D-85764 Neuherberg, Germany

 Munich Cluster Syst Neurol SyNergy, D-81377 Munich, Germany

Scott, RJ:
 Hunter Med Res Inst, New Lambon Hts, NSW 2305, Australia

 Hunter Med Res Inst, Informat Based Med Stream, New Lambton Hts, NSW 2305, Australia

McEvoy, M:
 Hunter Med Res Inst, New Lambon Hts, NSW 2305, Australia

 Univ Newcastle, Fac Hlth & Med, Ctr Clin Epidemiol & Biostat, Callaghan, NSW 2308, Australia

Beekman, M:
 Leiden Univ, Med Ctr, Mol Epidemiol, NL-2333 ZC Leiden, Netherlands

Bombieri, C:
 Univ Verona, Dept Neurosci Biomed & Movement Sci, I-37134 Verona, Italy

Ridker, PM:
 Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02215 USA

 Harvard Med Sch, Boston, MA 02115 USA

Mohlke, KL:
 Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA

Pedersen, NL:
 Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden

Morrison, AC:
 Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Ctr Human Genet, Houston, TX 77030 USA

Boomsma, DI:
 Vrije Univ, Netherlands Twin Register, Dept Biol Psychol, NL-1081 BT Amsterdam, Netherlands

Whitfield, JB:
 QIMR Berghofer Med Res Inst, Brisbane, Qld 4006, Australia

Strachan, DP:
 St Georges Univ London, Populat Hlth Res Inst, London SW17 0RE, England

Hofman, A:
 Erasmus Univ, Med Ctr, Dept Epidemiol, NL-3000 CA Rotterdam, Netherlands

Vollenweider, P:
 CHU Vaudois, Dept Internal Med, CH-1011 Lausanne, Switzerland

Cucca, F:
 CNR, Ist Ric Genet & Biomed, I-08045 Sardinia, Italy

Jarvelin, MR:
 Univ Oulu, Bioctr Oulu, SF-90220 Oulu, Finland

 Univ Oulu, Ctr Life Course Hlth Res, Fac Med, Oulu 90014, Finland

 Oulu Univ Hosp, Unit Primary Hlth Care, Oulu 90220, Finland

 Imperial Coll London, Dept Epidemiol & Biostat, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, London W2 1PG, England

 Brunel Univ London, Coll Hlth & Life Sci, Dept Life Sci, Kingston Lane, Uxbridge UB8 3PH, Middx, England

Jukema, JW:
 Leiden Univ, Med Ctr, Dept Cardiol, NL-2300 RC Leiden, Netherlands

 Durrer Ctr Cardiogenet Res, NL-3501 DG Amsterdam, Netherlands

 Interuniv Cardiol Inst Netherlands, NL-3511 EP Utrecht, Netherlands

Spector, TD:
 Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England

Hamsten, A:
 Karolinska Inst, Ctr Mol Med, Cardiovasc Med Unit, Dept Med, S-17176 Stockholm, Sweden

Zeller, T:
 Univ Heart Ctr Hamburg, Dept Gen & Intervent Cardiol, D-20246 Hamburg, Germany

 German Ctr Cardiovasc Res, Partner Site RhineMain, D-55131 Mainz, Germany

Uitterlinden, AG:
 Erasmus Univ, Med Ctr, Dept Internal Med, NL-3015 CN Rotterdam, Netherlands

Nauck, M:
 German Ctr Cardiovasc Res, Partner Site Greifswald, D-17475 Greifswald, Germany

 Univ Med Greifswald, Inst Clin Chem & Lab Med, D-17475 Greifswald, Germany

Gudnason, V:
 Iceland Heart Assoc, IS-201 Kopavogur, Iceland

 Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland

Qi, L:
 Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

 Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA 70112 USA

Grallert, H:
 German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Inst Epidemiol 2, D-85764 Neuherberg, Germany

 German Ctr Diabet Res, Partner Site Munich, D-85764 Munich, Germany

Borecki, IB:
 Regeneron Pharmaceut Inc, Regeneron Genet Ctr, Analyt Genet Grp, Tarrytown, NY 10591 USA

Rotter, JI:
 Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Inst Translat Genom & Populat Sci, Dept Pediat, Torrance, CA 90502 USA

 Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Inst Translat Genom & Populat Sci, Dept Med, Torrance, CA 90502 USA

Marz, W:
 Heidelberg Univ, Med Fac Mannheim, Dept Med 5, D-68167 Mannheim, Germany

 Synlab Holding Deutschland GmbH, Synlab Acad, D-68161 Mannheim, Germany

 Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, A-8036 Graz, Austria

Wild, PS:
 German Ctr Cardiovasc Res, Partner Site RhineMain, D-55131 Mainz, Germany

 Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Thrombosis & Hemostasis, D-55131 Mainz, Germany

 Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Cardiol, Prevent Cardiol & Prevent Med, D-55131 Mainz, Germany

Lokki, ML:
 Univ Helsinki, Transplantat Lab, Medicum, FIN-00014 Helsinki, Finland

Boyle, M:
 John Hunter Hosp, New Lambton Hts, NSW 2305, Australia

Salomaa, V:
 Natl Inst Hlth & Welf, Helsinki 00271, Finland

Melbye, M:
 Statens Serum Inst, Dept Epidemiol Res, DK-2300 Copenhagen, Denmark

 Univ Copenhagen, Dept Clin Med, DK-2300 Copenhagen, Denmark

 Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA

Eriksson, JG:
 Natl Inst Hlth & Welf, Helsinki 00271, Finland

 Folkhalsan Res Ctr, Helsinki 00250, Finland

 Univ Helsinki, Dept Gen Practice & Primary Hlth Care, FIN-00014 Helsinki, Finland

 Helsinki Univ Hosp, Helsinki 00014, Finland

Wilson, JF:
 Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Teviot Pl, Edinburgh EH16 4UX, Midlothian, Scotland

 Univ Edinburgh, Western Gen Hosp, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland

Penninx, BWJH:
 Univ Amsterdam, Med Ctr, GGZ InGeest Res & Innovat, Dept Psychiat,Amsterdam Neurosci, NL-1081 HJ Amsterdam, Netherlands

 Univ Amsterdam, Med Ctr, GGZ InGeest Res & Innovat, Amsterdam Publ Hlth Res Inst, NL-1081 HJ Amsterdam, Netherlands

Becker, DM:
 Johns Hopkins Univ, Sch Med, Dept Med, GeneSTAR Res Ctr, Baltimore, MD 21287 USA

Worrall, BB:
 Univ Virginia Charlottesville, Dept Neurol, Charlottesville, VA 22908 USA

 Univ Virginia Charlottesville, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA

Gibson, G:
 Georgia Inst Technol, Sch Biol, Ctr Integrat Genom, Atlanta, GA 30332 USA

Krauss, RM:
 Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USA

Ciullo, M:
 CNR, Inst Genet & Biophys A Buzzati Traverso, I-80131 Naples, Italy

 IRCCS Neuromed, I-86077 Pozzilli, IS, Italy

Zaza, G:
 Verona Univ Hosp, Dept Med, Renal Unit, I-37126 Verona, Italy

Wareham, NJ:
 Univ Cambridge, Sch Clin Med, Inst Metab Sci, MRC,Epidemiol Unit, Cambridge CB2 0QQ, England

Oldehinkel, AJ:
 Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, NL-9700 RB Groningen, Netherlands

Palmer, LJ:
 Univ Adelaide, Sch Publ Hlth, Adelaide, SA 5000, Australia

Murray, SS:
 Univ Calif San Diego, Dept Pathol, San Diego, CA 92121 USA

Pramstaller, PP:
 Univ Lubeck, Affiliated Inst, Eurac Res, Inst Biomed, I-39100 Bolzano, Italy

 Gen Cent Hosp, Dept Neurol, I-39100 Bolzano, Italy

 Univ Lubeck, Dept Neurol, D-23538 Lubeck, Germany

Bandinelli, S:
 Azienda Sanit Firenze, Geriatr Unit, I-50122 Florence, Italy

Heinrich, J:
 German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol, D-85764 Neuherberg, Germany

 Ludwig Maximilians Univ Munchen, Univ Hosp, Inst & Clin Occupat Social & Environm Med, Comprehens Pneumol Ctr Munich,DZL,German Ctr Lung, D-81377 Munich, Germany

Ingelsson, E:
 Uppsala Univ, Dept Med Sci, Mol Epidemiol & Sci Life Lab, S-75141 Uppsala, Sweden

 Stanford Univ, Sch Med, Div Cardiovasc Med, Dept Med, Stanford, CA 94305 USA

 Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA

Deary, IJ:
 Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland

 Univ Edinburgh, Dept Psychol, Edinburgh EH8 9JZ, Midlothian, Scotland

Magi, R:
 Univ Tartu, Inst Genom, Estonian Genome Ctr, EE-51010 Tartu, Estonia

Vandenput, L:
 Univ Gothenburg, Dept Internal Med & Clin Nutr, S-41345 Gothenburg, Sweden

van der Harst, P:
 Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-9713 AV Groningen, Netherlands

Desch, KC:
 Univ Michigan, Dept Pediat & Communicable Dis, Ann Arbor, MI 48109 USA

Kooner, JS:
 Ealing Gen Hosp, Dept Cardiol, Southall UB1 3HW, Middx, England

 Imperial Coll Healthcare NHS Trust, London W12 0HS, England

 Imperial Coll London, MRC PHE Ctr Environm & Hlth, London W2 1PG, England

 Imperial Coll London, Natl Heart & Lung Inst, London W12 0NN, England

Ohlsson, C:
 Univ Gothenburg, Dept Internal Med & Clin Nutr, S-41345 Gothenburg, Sweden

Hayward, C:
 Univ Edinburgh, Western Gen Hosp, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland

Lehtimaki, T:
 Fimlab Labs, Dept Clin Chem, Tampere 33014, Finland

 Univ Tampere, Fac Med & Life Sci, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Chem, Tampere 33520, Finland

Shuldiner, AR:
 Univ Maryland, Sch Med, Dept Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA

Arnett, DK:
 Univ Kentucky, Coll Publ Hlth, Lexington, KY 40508 USA

Beilin, LJ:
 Univ Western Australia, Sch Med, Perth, WA 6009, Australia

Robino, A:
 IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, I-34140 Trieste, Italy

Froguel, P:
 Univ Lille, Inst Pasteur Lille, European Genom Inst Diabet, CNRS,UMR 8199,FR 3508, F-59000 Lille, France

 Imperial Coll London, Sch Publ Hlth, Dept Genom Common Dis, London SW7 2AZ, England

Pirastu, M:
 CNR, Inst Genet & Biomed Res, Support OU, I-7100 Sassari, Italy

Jess, T:
 Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, DK-2200 Frederiksberg, Denmark

Koenig, W:
 German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, D-80636 Munich, Germany

 Univ Ulm, Med Ctr, Dept Internal Med Cardiol 2, D-80801 Ulm, Germany

 Tech Univ Munich, Deutsch Herzzentrum Muchen, D-80636 Munich, Germany

Loos, RJF:
 Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA

 Icahn Sch Med Mt Sinai, Genet Obes & Related Metab Traits Program, New York, NY 10029 USA

 Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA

Evans, DA:
 Rush Univ, Med Ctr, Dept Internal Med, Chicago, IL 60612 USA

Schmidt, H:
 Med Univ Graz, Dept Neurol, A-8010 Graz, Austria

 Med Univ Graz, Ctr Mol Med, Inst Mol Biol & Biochem, A-8010 Graz, Austria

Smith, GD:
 Univ Bristol, Bristol Med Sch, MRC, Integrat Epidemiol Unit, Bristol BS8 2BN, Avon, England

Slagboom, PE:
 Leiden Univ, Med Ctr, Mol Epidemiol, NL-2333 ZC Leiden, Netherlands

Eiriksdottir, G:
 Iceland Heart Assoc, IS-201 Kopavogur, Iceland

Morris, AP:
 Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

 Univ Liverpool, Dept Biostat, Liverpool L69 3GL, Merseyside, England

Psaty, BM:
 Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA

 Univ Washington, Dept Epidemiol, Seattle, WA 98101 USA

 Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA

 Kaiser Permanente Washington Hlth Res Inst, Seattle, WA 98101 USA

Tracy, RP:
 Univ Vermont, Dept Pathol, Burlington, VT 05405 USA

Nolte, IM:
 Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, NL-9700 RB Groningen, Netherlands

Boerwinkle, E:
 Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Ctr Human Genet, Houston, TX 77030 USA

 Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA

Visvikis-Siest, S:
 Univ Lorraine, INSERM, IGE PCV, F-54000 Nancy, France

Reiner, AP:
 Univ Washington, Dept Epidemiol, Seattle, WA 98101 USA

Gross, M:
 Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA

Bis, JC:
 Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA

Franke, L:
 Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9700 RB Groningen, Netherlands

Franco, OH:
 Erasmus Univ, Med Ctr, Dept Epidemiol, NL-3000 CA Rotterdam, Netherlands

 Univ Bern, Inst Social & Prevent Med, CH-3012 Bern, Switzerland

Benjamin, EJ:
 Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA

 Natl Heart Lung & Blood Inst, Framingham Heart Study, Framingham, MA 01702 USA

Chasman, DI:
 Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02215 USA

 Harvard Med Sch, Boston, MA 02115 USA

Dupuis, J:
 Natl Heart Lung & Blood Inst, Framingham Heart Study, Framingham, MA 01702 USA

 Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA

Snieder, H:
 Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, NL-9700 RB Groningen, Netherlands

Dehghan, A:
 Erasmus Univ, Med Ctr, Dept Epidemiol, NL-3000 CA Rotterdam, Netherlands

 Imperial Coll London, Dept Epidemiol & Biostat, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, London W2 1PG, England

Alizadeh, BZ:
 Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, NL-9700 RB Groningen, Netherlands