Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events
Por:
Ramos-Vicente, D, Ji, J, Gratacos-Batlle, E, Gou, G, Reig-Viader, R, Luis, J, Burguera, D, Navas-Perez, E, Garcia-Fernandez, J, Fuentes-Prior, P, Escriva, H, Roher, N, Soto, D, Bayes, A
Publicada:
22 nov 2018
Resumen:
Glutamate receptors are divided in two unrelated families: ionotropic (iGluR), driving synaptic transmission, and metabotropic (mGluR), which modulate synaptic strength. The present classification of GluRs is based on vertebrate proteins and has remained unchanged for over two decades. Here we report an exhaustive phylogenetic study of GluRs in metazoans. Importantly, we demonstrate that GluRs have followed different evolutionary histories in separated animal lineages. Our analysis reveals that the present organization of iGluRs into six classes does not capture the full complexity of their evolution. Instead, we propose an organization into four subfamilies and ten classes, four of which have never been previously described. Furthermore, we report a sister class to mGluR classes I-III, class IV. We show that many unreported proteins are expressed in the nervous system, and that new Epsilon receptors form functional ligand-gated ion channels. We propose an updated classification of glutamate receptors that includes our findings.
Filiaciones:
Ramos-Vicente, D:
Biomed Res Inst St Pau, Mol Physiol Synapse Lab, Barcelona, Spain
Univ Autonoma Barcelona, Barcelona, Spain
Ji, J:
Univ Autonoma Barcelona, Dept Cell Biol Anim Physiol & Immunol, Inst Biotechnol & Biomed, Barcelona, Spain
Gratacos-Batlle, E:
Univ Barcelona, Inst Neurosci, August Pi & Sunyer Biomed Res Inst, Neurophysiol Lab,Dept Biomed,Med Sch, Barcelona, Spain
Gou, G:
Biomed Res Inst St Pau, Mol Physiol Synapse Lab, Barcelona, Spain
Univ Autonoma Barcelona, Barcelona, Spain
Reig-Viader, R:
Biomed Res Inst St Pau, Mol Physiol Synapse Lab, Barcelona, Spain
Univ Autonoma Barcelona, Barcelona, Spain
Luis, J:
Biomed Res Inst St Pau, Mol Physiol Synapse Lab, Barcelona, Spain
Univ Autonoma Barcelona, Barcelona, Spain
Burguera, D:
Univ Barcelona, Sch Biol, Inst Biomed, Dept Genet, Barcelona, Spain
Navas-Perez, E:
Univ Barcelona, Sch Biol, Inst Biomed, Dept Genet, Barcelona, Spain
Garcia-Fernandez, J:
Univ Barcelona, Sch Biol, Inst Biomed, Dept Genet, Barcelona, Spain
Fuentes-Prior, P:
Hosp Santa Creu & Sant Pau, Mol Bases Dis, Biomed Res Inst St Pau, Barcelona, Spain
Escriva, H:
Sorbonne Univ, CNRS, Biol Integrat Organismes Marins, Banyuls Sur Mer, France
Roher, N:
Univ Autonoma Barcelona, Dept Cell Biol Anim Physiol & Immunol, Inst Biotechnol & Biomed, Barcelona, Spain
Soto, D:
Univ Barcelona, Inst Neurosci, August Pi & Sunyer Biomed Res Inst, Neurophysiol Lab,Dept Biomed,Med Sch, Barcelona, Spain
Bayes, A:
Biomed Res Inst St Pau, Mol Physiol Synapse Lab, Barcelona, Spain
Univ Autonoma Barcelona, Barcelona, Spain
Gold, Green Published
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