Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia
Por:
Swarup, V, Hinz, FI, Rexach, JE, Noguchi, K, Toyoshiba, H, Oda, A, Hirai, K, Sarkar, A, Seyfried, NT, Cheng, CL, Haggarty, SJ, Ferrari, R, Rohrer, JD, Ramasamy, A, Hardy, J, Hernandez, DG, Nalls, MA, Singleton, AB, Kwok, JBJ, Dobson-Stone, C, Brooks, WS, Schofield, PR, Halliday, GM, Hodges, JR, Piguet, O, Bartley, L, Thompson, E, Haan, E, Hernandez, I, Ruiz, A, Boada, M, Borroni, B, Padovani, A, Cairns, NJ, Cruchaga, C, Binetti, G, Ghidoni, R, Benussi, L, Forloni, G, Albani, D, Galimberti, D, Fenoglio, C, Serpente, M, Scarpini, E, Clarimon, J, Lleo, A, Blesa, R, Waldo, ML, Nilsson, K, Nilsson, C, Mackenzie, IRA, Hsiung, GYR, Mann, DMA, Grafman, J, Morris, CM, Attems, J, Griffiths, TD, McKeith, IG, Thomas, AJ, Jaros, E, Pietrini, P, Huey, ED, Wassermann, EM, Tierney, MC, Baborie, A, Pastor, P, Ortega-Cubero, S, Razquin, C, Alonso, E, Perneczky, R, Diehl-Schmid, J, Alexopoulos, P, Kurz, A, Rainero, I, Rubino, E, Pinessi, L, Rogaeva, E, St George-Hyslop, P, Rossi, G, Tagliavini, F, Giaccone, G, Rowe, JB, Schlachetzki, JCM, Uphill, J, Collinge, J, Mead, S, Danek, A, Pickering-Brown, S, Momeni, P, van der Zee, J, Cruts, M, Van Broeckhoven, C, Cappa, SF, Leber, I, Brice, A, Hannequin, D, Golfier, V, Vercelletto, M, Nacmias, B, Sorbi, S, Bagnoli, S, Piaceri, I, Nielsen, JE, Hjermind, LE, Riemenschneider, M, Mayhaus, M, Gasparoni, G, Pichler, S, Ibach, B, Rossor, MN, Fox, NC, Warren, JD, Spillantini, MG, Morris, HR, Rizzu, P, Heutink, P, Snowden, JS, Rollinson, S, Gerhard, A, Richardson, A, Bruni, AC, Maletta, R, Frangipane, F, Cupidi, C, Bernardi, L, Anfossi, M, Gallo, M, Conidi, ME, Smirne, N, Rademakers, R, Baker, M, Dickson, DW, Graff-Radford, NR, Petersen, RC, Knopman, D, Josephs, KA, Boeve, BF, Parisi, JE, Miller, BL, Karydas, AM, Rosen, H, Seeley, WW, van Swieten, JC, Dopper, EGP, Seelaar, H, Pijnenburg, YAL, Scheltens, P, Logroscino, G, Capozzo, R, Novelli, V, Puca, AA, Franceschi, M, Postiglione, A, Milan, G, Sorrentino, P, Kristiansen, M, Chiang, HH, Graff, C, Pasquier, F, Rollin, A, Deramecourt, V, Lebouvier, T, Ferrucci, L, Kapogiannis, D, Grossman, M, Van Deerlin, VM, Trojanowski, JQ, Lah, JJ, Levey, AI, Kondou, S, Geschwind, DH
Publicada:
1 ene 2019
Resumen:
Identifying the mechanisms through which genetic risk causes dementia is an imperative for new therapeutic development. Here, we apply a multistage, systems biology approach to elucidate the disease mechanisms in frontotemporal dementia. We identify two gene coexpression modules that are preserved in mice harboring mutations in MAPT, GRN and other dementia mutations on diverse genetic backgrounds. We bridge the species divide via integration with proteomic and transcriptomic data from the human brain to identify evolutionarily conserved, disease-relevant networks. We find that overexpression of miR-203, a hub of a putative regulatory microRNA (miRNA) module, recapitulates mRNA coexpression patterns associated with disease state and induces neuronal cell death, establishing this miRNA as a regulator of neurodegeneration. Using a database of drug-mediated gene expression changes, we identify small molecules that can normalize the disease-associated modules and validate this experimentally. Our results highlight the utility of an integrative, cross-species network approach to drug discovery.
Filiaciones:
Swarup, V:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Program Neurogenet, Los Angeles, CA 90095 USA
Hinz, FI:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Program Neurogenet, Los Angeles, CA 90095 USA
Rexach, JE:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Program Neurogenet, Los Angeles, CA 90095 USA
Noguchi, K:
Takeda Pharmaceut Co Ltd, Pharmaceut Res Div, CNS, Drug Discovery Unit, Fujisawa, Kanagawa, Japan
Toyoshiba, H:
Takeda Pharmaceut Co Ltd, Pharmaceut Res Div, CNS, Drug Discovery Unit, Fujisawa, Kanagawa, Japan
Oda, A:
Takeda Pharmaceut Co Ltd, Pharmaceut Res Div, CNS, Drug Discovery Unit, Fujisawa, Kanagawa, Japan
Hirai, K:
Takeda Pharmaceut Co Ltd, Pharmaceut Res Div, CNS, Drug Discovery Unit, Fujisawa, Kanagawa, Japan
Sarkar, A:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Program Neurogenet, Los Angeles, CA 90095 USA
Seyfried, NT:
Emory Univ, Sch Med, Dept Biochem, Atlanta, GA 30322 USA
Emory Univ, Sch Med, Alzheimers Dis Res Ctr, Atlanta, GA USA
Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA
Cheng, CL:
MIT, Ctr Genom Med, Chem Neurobiol Lab, Boston, MA USA
Harvard Med Sch, Boston, MA USA
Haggarty, SJ:
MIT, Ctr Genom Med, Chem Neurobiol Lab, Boston, MA USA
Harvard Med Sch, Boston, MA USA
Ferrari, R:
UCL, Dept Mol Neurosci, London, England
Rohrer, JD:
UCL, Dept Mol Neurosci, London, England
Ramasamy, A:
UCL, Dept Mol Neurosci, London, England
Hardy, J:
UCL, Dept Mol Neurosci, London, England
Hernandez, DG:
NIA, Lab Neurogenet, NIH, Bethesda, MD 20892 USA
Nalls, MA:
NIA, Lab Neurogenet, NIH, Bethesda, MD 20892 USA
Singleton, AB:
NIA, Lab Neurogenet, NIH, Bethesda, MD 20892 USA
Kwok, JBJ:
Neurosci Res Australia, Sydney, NSW, Australia
Dobson-Stone, C:
Neurosci Res Australia, Sydney, NSW, Australia
Brooks, WS:
Neurosci Res Australia, Sydney, NSW, Australia
Schofield, PR:
Neurosci Res Australia, Sydney, NSW, Australia
Halliday, GM:
Neurosci Res Australia, Sydney, NSW, Australia
Hodges, JR:
Neurosci Res Australia, Sydney, NSW, Australia
Piguet, O:
Neurosci Res Australia, Sydney, NSW, Australia
Bartley, L:
Neurosci Res Australia, Sydney, NSW, Australia
Thompson, E:
Womens & Childrens Hosp, South Australian Clin Genet Serv, Adelaide, SA, Australia
Haan, E:
Womens & Childrens Hosp, South Australian Clin Genet Serv, Adelaide, SA, Australia
Hernandez, I:
Inst Catala Neurociencies Aplicades, Res Ctr & Memory Clin Fundacio ACE, Barcelona, Spain
Ruiz, A:
Inst Catala Neurociencies Aplicades, Res Ctr & Memory Clin Fundacio ACE, Barcelona, Spain
Boada, M:
Inst Catala Neurociencies Aplicades, Res Ctr & Memory Clin Fundacio ACE, Barcelona, Spain
Borroni, B:
Univ Brescia, Neurol Clin, Brescia, Italy
Padovani, A:
Univ Brescia, Neurol Clin, Brescia, Italy
Cairns, NJ:
Washington Univ, Sch Med, Hope Ctr, St Louis, MO USA
Cruchaga, C:
Washington Univ, Sch Med, Hope Ctr, St Louis, MO USA
Binetti, G:
Ist Ctr San Giovanni Dio Fatebenefratelli, IRCCS, Brescia, Italy
Ghidoni, R:
Ist Ctr San Giovanni Dio Fatebenefratelli, IRCCS, Brescia, Italy
Benussi, L:
Ist Ctr San Giovanni Dio Fatebenefratelli, IRCCS, Brescia, Italy
Forloni, G:
Ist Ric Farmacol, IRCCS, Biol Neurodegenerat Disorders, Milan, Italy
Albani, D:
Ist Ric Farmacol, IRCCS, Biol Neurodegenerat Disorders, Milan, Italy
Galimberti, D:
Univ Milan, Milan, Italy
Osped Maggiore Policlin, Fdn IRCCS Ca Granda, Milan, Italy
Fenoglio, C:
Univ Milan, Milan, Italy
Osped Maggiore Policlin, Fdn IRCCS Ca Granda, Milan, Italy
Serpente, M:
Univ Milan, Milan, Italy
Osped Maggiore Policlin, Fdn IRCCS Ca Granda, Milan, Italy
Scarpini, E:
Univ Milan, Milan, Italy
Osped Maggiore Policlin, Fdn IRCCS Ca Granda, Milan, Italy
Clarimon, J:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Neurol Dept, Memory Unit, Barcelona, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, St Pau Biomed Res Inst, Barcelona, Spain
Lleo, A:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Neurol Dept, Memory Unit, Barcelona, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, St Pau Biomed Res Inst, Barcelona, Spain
Blesa, R:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Neurol Dept, Memory Unit, Barcelona, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, St Pau Biomed Res Inst, Barcelona, Spain
Waldo, ML:
Lund Univ, Dept Clin Sci, Unit Geriatr Psychiat, Lund, Sweden
Nilsson, K:
Lund Univ, Dept Clin Sci, Unit Geriatr Psychiat, Lund, Sweden
Nilsson, C:
Lund Univ, Dept Clin Sci, Unit Geriatr Psychiat, Lund, Sweden
Mackenzie, IRA:
Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada
Hsiung, GYR:
Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada
Mann, DMA:
Univ Manchester, Salford Royal Hosp, Inst Brain Behav & Mental Hlth, Salford, Lancs, England
Grafman, J:
Northwestern Univ, Dept Phys Med & Rehabil, Feinberg Sch Med, Chicago, IL 60611 USA
Northwestern Univ, Dept Psychiat, Feinberg Sch Med, Chicago, IL 60611 USA
Northwestern Univ, Dept Cognit Neurol, Feinberg Sch Med, Chicago, IL 60611 USA
Northwestern Univ, Alzheimers Dis Ctr, Feinberg Sch Med, Chicago, IL 60611 USA
Morris, CM:
Newcastle Univ, Inst Ageing, Newcastle Upon Tyne, Tyne & Wear, England
Attems, J:
Newcastle Univ, Inst Ageing, Newcastle Upon Tyne, Tyne & Wear, England
Griffiths, TD:
Newcastle Univ, Inst Ageing, Newcastle Upon Tyne, Tyne & Wear, England
McKeith, IG:
Newcastle Univ, Inst Ageing, Newcastle Upon Tyne, Tyne & Wear, England
Thomas, AJ:
Newcastle Univ, Inst Ageing, Newcastle Upon Tyne, Tyne & Wear, England
Jaros, E:
Newcastle Univ, Inst Ageing, Newcastle Upon Tyne, Tyne & Wear, England
Pietrini, P:
IMT Sch Adv Studies, Lucca, Italy
Huey, ED:
Columbia Univ, Dept Psychiat, Taub Inst, New York, NY USA
Columbia Univ, Dept Neurol, Taub Inst, New York, NY USA
Wassermann, EM:
NINDS, Behav Neurol Unit, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA
Tierney, MC:
NINDS, Behav Neurol Unit, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA
Baborie, A:
Univ Alberta, Dept Lab Med & Pathol, Edmonton, AB, Canada
Pastor, P:
Ctr Networker Biomed Res Neurodegenerat Dis CIBER, Madrid, Spain
Ortega-Cubero, S:
Ctr Networker Biomed Res Neurodegenerat Dis CIBER, Madrid, Spain
Razquin, C:
Univ Navarra, Ctr Appl Med Res, Div Neurosci, Neurogenet Lab, Pamplona, Spain
Alonso, E:
Univ Navarra, Ctr Appl Med Res, Div Neurosci, Neurogenet Lab, Pamplona, Spain
Perneczky, R:
Imperial Coll Sci Technol & Med, Sch Publ Hlth, Neuroepidemiol & Ageing Res Unit, London, England
Diehl-Schmid, J:
Tech Univ Munich, Dept Psychiat & Psychotherapy, Munich, Germany
Alexopoulos, P:
Tech Univ Munich, Dept Psychiat & Psychotherapy, Munich, Germany
Kurz, A:
Tech Univ Munich, Dept Psychiat & Psychotherapy, Munich, Germany
Rainero, I:
Univ Torino, Dept Neurosci, Turin, Italy
Rubino, E:
Univ Torino, Dept Neurosci, Turin, Italy
Pinessi, L:
Univ Torino, Dept Neurosci, Turin, Italy
Rogaeva, E:
Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada
St George-Hyslop, P:
Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada
Rossi, G:
Fdn IRCCS Ist Neurol Carlo Besta, Div Neurol & Neuropathol 5, Milan, Italy
Tagliavini, F:
Fdn IRCCS Ist Neurol Carlo Besta, Div Neurol & Neuropathol 5, Milan, Italy
Giaccone, G:
Fdn IRCCS Ist Neurol Carlo Besta, Div Neurol & Neuropathol 5, Milan, Italy
Rowe, JB:
Univ Cambridge, Dept Clin Neurosci, Cambridge, England
Schlachetzki, JCM:
Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA
Uphill, J:
UCL Inst Neurol, Dept Neurodegenerat Dis, MRC Prion Unit, London, England
Collinge, J:
UCL Inst Neurol, Dept Neurodegenerat Dis, MRC Prion Unit, London, England
Mead, S:
UCL Inst Neurol, Dept Neurodegenerat Dis, MRC Prion Unit, London, England
Danek, A:
Ludwig Maximilians Univ Munchen, Neurol Klin & Poliklin, Munich, Germany
Pickering-Brown, S:
Univ Manchester, Fac Med & Human Sci, Inst Brain Behav & Mental Hlth, Manchester, Lancs, England
Momeni, P:
Texas Tech Univ, Hlth Sci Ctr, Dept Internal Med, Lab Neurogenet, Lubbock, TX 79430 USA
van der Zee, J:
VIB, Dept Mol Genet, Neurodegenerat Brain Dis Grp, Antwerp, Belgium
Cruts, M:
VIB, Dept Mol Genet, Neurodegenerat Brain Dis Grp, Antwerp, Belgium
Van Broeckhoven, C:
VIB, Dept Mol Genet, Neurodegenerat Brain Dis Grp, Antwerp, Belgium
Cappa, SF:
Univ Vita Salute San Raffaele, Dept Clin Neurosci, Neurorehabilitat Unit, Milan, Italy
Ist Sci San Raffaele, Milan, Italy
Leber, I:
CRICM, INSERM, Paris, France
Brice, A:
CRICM, INSERM, Paris, France
Hannequin, D:
Rouen Univ Hosp, Serv Neurol, Rouen, France
Golfier, V:
Serv Neurol, St Brieuc, France
Vercelletto, M:
CHU Nantes, Serv Neurol, Nantes, France
Nacmias, B:
Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth NEURO, Florence, Italy
Sorbi, S:
Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth NEURO, Florence, Italy
Bagnoli, S:
Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth NEURO, Florence, Italy
Piaceri, I:
Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth NEURO, Florence, Italy
Nielsen, JE:
Copenhagen Univ Hosp, Rigshosp, Dept Neurol, Danish Dementia Res Ctr,Neurogenet Clin, Copenhagen, Denmark
Hjermind, LE:
Copenhagen Univ Hosp, Rigshosp, Dept Neurol, Danish Dementia Res Ctr,Neurogenet Clin, Copenhagen, Denmark
Riemenschneider, M:
Saarland Univ Hosp, Lab Neurogenet, Homburg, Saar, Germany
Mayhaus, M:
Saarland Univ Hosp, Lab Neurogenet, Homburg, Saar, Germany
Gasparoni, G:
Saarland Univ Hosp, Lab Neurogenet, Homburg, Saar, Germany
Pichler, S:
Saarland Univ Hosp, Lab Neurogenet, Homburg, Saar, Germany
Ibach, B:
Univ Regensburg, Dept Psychiat Psychotherapy & Psychosomat, Regensburg, Germany
Rossor, MN:
UCL Inst Neurol, Dept Neurodegenerat Dis, Dementia Res Ctr, London, England
Fox, NC:
UCL Inst Neurol, Dept Neurodegenerat Dis, Dementia Res Ctr, London, England
Warren, JD:
UCL Inst Neurol, Dept Neurodegenerat Dis, Dementia Res Ctr, London, England
Spillantini, MG:
Univ Cambridge, John Van Geest Brain Repair Ctr, Dept Clin Neurosci, Cambridge, England
Morris, HR:
UCL, Dept Mol Neurosci, London, England
Rizzu, P:
German Ctr Neurodegenerat Diseases Tubingen, Tubingen, Germany
Heutink, P:
German Ctr Neurodegenerat Diseases Tubingen, Tubingen, Germany
Snowden, JS:
Univ Manchester, Fac Med & Human Sci, Inst Brain Behav & Mental Hlth, Manchester, Lancs, England
Rollinson, S:
Univ Manchester, Fac Med & Human Sci, Inst Brain Behav & Mental Hlth, Manchester, Lancs, England
Gerhard, A:
Univ Manchester, Fac Med & Human Sci, Inst Brain Behav & Mental Hlth, Manchester, Lancs, England
Richardson, A:
Univ Manchester, Fac Med & Human Sci, Salford Royal Fdn Trust, Manchester, Lancs, England
Bruni, AC:
Univ Manchester, Fac Med & Human Sci, Salford Royal Fdn Trust, Manchester, Lancs, England
Maletta, R:
Univ Manchester, Fac Med & Human Sci, Salford Royal Fdn Trust, Manchester, Lancs, England
Frangipane, F:
Univ Manchester, Fac Med & Human Sci, Salford Royal Fdn Trust, Manchester, Lancs, England
Cupidi, C:
Univ Manchester, Fac Med & Human Sci, Salford Royal Fdn Trust, Manchester, Lancs, England
Bernardi, L:
Univ Manchester, Fac Med & Human Sci, Salford Royal Fdn Trust, Manchester, Lancs, England
Anfossi, M:
Univ Manchester, Fac Med & Human Sci, Salford Royal Fdn Trust, Manchester, Lancs, England
Gallo, M:
ASPCZ, Reg Neurogenet Ctr, Lamezia Terme, Italy
Conidi, ME:
ASPCZ, Reg Neurogenet Ctr, Lamezia Terme, Italy
Smirne, N:
ASPCZ, Reg Neurogenet Ctr, Lamezia Terme, Italy
Rademakers, R:
Mayo Clin Jacksonville, Dept Neurosci, 4500 San Pablo Rd, Jacksonville, FL 32224 USA
Baker, M:
Mayo Clin Jacksonville, Dept Neurosci, 4500 San Pablo Rd, Jacksonville, FL 32224 USA
Dickson, DW:
Mayo Clin Jacksonville, Dept Neurosci, 4500 San Pablo Rd, Jacksonville, FL 32224 USA
Graff-Radford, NR:
Mayo Clin Jacksonville, Dept Neurosci, 4500 San Pablo Rd, Jacksonville, FL 32224 USA
Petersen, RC:
Mayo Clin Rochester, Dept Neurol, Rochester, MN USA
Knopman, D:
Mayo Clin Rochester, Dept Neurol, Rochester, MN USA
Josephs, KA:
Mayo Clin Rochester, Dept Neurol, Rochester, MN USA
Boeve, BF:
Mayo Clin Rochester, Dept Neurol, Rochester, MN USA
Parisi, JE:
Mayo Clin Rochester, Dept Pathol, Rochester, MN USA
Miller, BL:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA USA
Karydas, AM:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA USA
Rosen, H:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA USA
Seeley, WW:
Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA
van Swieten, JC:
Erasmus MC, Dept Neurol, Rotterdam, Netherlands
Dopper, EGP:
Erasmus MC, Dept Neurol, Rotterdam, Netherlands
Seelaar, H:
Erasmus MC, Dept Neurol, Rotterdam, Netherlands
Pijnenburg, YAL:
Vrije Univ Amsterdam, Med Ctr, Alzheimer Ctr, Amsterdam, Netherlands
Vrije Univ Amsterdam, Med Ctr, Dept Neurol, Amsterdam, Netherlands
Scheltens, P:
Vrije Univ Amsterdam, Med Ctr, Alzheimer Ctr, Amsterdam, Netherlands
Vrije Univ Amsterdam, Med Ctr, Dept Neurol, Amsterdam, Netherlands
Logroscino, G:
Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy
Capozzo, R:
Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy
Novelli, V:
Fdn Policlin Univ Agostino Gemelli, Med Genet Unit, Rome, Italy
Puca, AA:
IRCCS Multimed, Cardiovasc Res Unit, Milan, Italy
Univ Salerno, Dept Med & Surg, Baronissi, Italy
Franceschi, M:
IRCCS Multimed, Neurol Dept, Milan, Italy
Postiglione, A:
Univ Naples Federico II, Dept Clin Med & Surg, Naples, Italy
Milan, G:
ASL Napoli 1 Ctr, Geriatr Ctr Frullone, Naples, Italy
Sorrentino, P:
ASL Napoli 1 Ctr, Geriatr Ctr Frullone, Naples, Italy
Kristiansen, M:
UCL, ICH, UCL Genom, London, England
Chiang, HH:
Karolinska Inst, Alzheimer Res Ctr, Dept NVS, Stockholm, Sweden
Graff, C:
Karolinska Inst, Alzheimer Res Ctr, Dept NVS, Stockholm, Sweden
Pasquier, F:
Univ Lille, Lille, France
Rollin, A:
Univ Lille, Lille, France
Deramecourt, V:
Univ Lille, Lille, France
Lebouvier, T:
Univ Lille, Lille, France
Ferrucci, L:
NIA, Clin Res Branch, Baltimore, MD 21224 USA
Kapogiannis, D:
NIA, Cellular & Mol Neurosci Sect, Baltimore, MD 21224 USA
Grossman, M:
Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Ctr Neurodegenerat Dis Res, Philadelphia, PA USA
Van Deerlin, VM:
Univ Penn, Dept Neurol, Perelman Sch Med, Penn FTD Ctr, Philadelphia, PA 19104 USA
Trojanowski, JQ:
Univ Penn, Dept Neurol, Perelman Sch Med, Penn FTD Ctr, Philadelphia, PA 19104 USA
Lah, JJ:
Emory Univ, Sch Med, Alzheimers Dis Res Ctr, Atlanta, GA USA
Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA
Levey, AI:
Emory Univ, Sch Med, Alzheimers Dis Res Ctr, Atlanta, GA USA
Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA
Kondou, S:
Takeda Pharmaceut Co Ltd, Pharmaceut Res Div, CNS, Drug Discovery Unit, Fujisawa, Kanagawa, Japan
Geschwind, DH:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Program Neurogenet, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Inst Precis Hlth, Los Angeles, CA 90095 USA
Green Accepted
|