Prevalence of Medication Nonadherence to Co-medication Compared to Immunosuppressants in Heart Transplant Recipients: Findings From the International Cross-sectional BRIGHT Study


Por: Helmy, R, Denhaerynck, K, Berben, L, Dobbels, F, Russell, CL, Roza, BD, De Geest, S, Crespo-Leiro, MG, Guppies, S, De Simone, P, Groenewoud, A, Kugler, C, Ohler, L, Van Cleemput, J, Poncelet, AJ, Sebbag, L, Michel, M, Bernard, A, Doesch, A, Livi, U, Potena, L, Brossa-Loidi, V, Segovia-Cubero, J, Almenar-Bonet, L, Saint-Gerons, CS, Mohacsi, P, Horvath, E, Riotto, C, Parry, G, Firouzi, A, Kozuszko, S, Haddad, H, Kaan, A, Fisher, G, Miller, T, Flattery, M, Ludrosky, K, Albert, N, Coleman, B, Trammell, J, Epstein, F, St Clair, K, Kao, A, Molina, M, Canales, KR, de Almeida, SS, Ayoub, AC, Barone, F, Harkess, M, Maddicks-Law, J, BRIGHT Study Team

Publicada: 1 ene 2019
Resumen:
Purpose: To assess and compare the prevalence of medication nonadherence (MNA) (implementation and persistence) to immunosuppressants and co-medications in heart transplant recipients. Methods: MNA prevalence was assessed using the Basel Assessment of Adherence to Immunosuppressive Medications Scale (self-report) and compared using logistic regression in a 4-continent sample of 1397 heart transplant recipients from 36 heart transplant centers in 11 countries. Findings: MNA was significantly (alpha = 0.05) higher to co-medications than to immunosuppressants (taking nonadherence: 23.9% vs 17.3%; odds ratio [OR] = 1.5; 95% CI, 1.30-1.73; drug holiday: 5.7% vs 1.9%; OR = 3.17; 95% CI, 2.13-4.73; dose alteration: 3.8% vs 1.6%; OR = 2.46; 95% CI, 1.49-4.06; and discontinuation: 2.6% vs 0.5%; OR = 5.15; 95% CI, 2.36-11.20). (C) 2018 Elsevier Inc. All rights reserved.

Filiaciones:
Helmy, R:
 Univ Basel, Fac Med, Dept Publ Hlth, Inst Nursing Sci, Basel, Switzerland

Denhaerynck, K:
 Univ Basel, Fac Med, Dept Publ Hlth, Inst Nursing Sci, Basel, Switzerland

Berben, L:
 Univ Basel, Fac Med, Dept Publ Hlth, Inst Nursing Sci, Basel, Switzerland

 Univ Hosp Basel, Basel, Switzerland

Dobbels, F:
 Katholieke Univ Leuven, Dept Publ Hlth & Primary Care, Acad Ctr Nursing & Midwifery, Leuven, Belgium

Russell, CL:
 Univ Missouri, Sch Nursing & Hlth Studies, Kansas City, MO 64110 USA

Roza, BD:
 Univ Fed Sao Paulo, Sch Nursing, Sao Paulo, Brazil

De Geest, S:
 Univ Basel, Fac Med, Dept Publ Hlth, Inst Nursing Sci, Basel, Switzerland

 Katholieke Univ Leuven, Dept Publ Hlth & Primary Care, Acad Ctr Nursing & Midwifery, Leuven, Belgium

Crespo-Leiro, MG:
 Univ A Coruna, INIBIC, CIBERCV, Complexo Hosp Univ A Coruna, La Coruna, Spain

Guppies, S:
 US Dept Vet Affairs, Vet Hlth Adm, Washington, DC USA

De Simone, P:
 Azienda Osped Univ Pisana, Osped Cisanello, Pisa, Italy

Groenewoud, A:
 Astellas Pharma Europe Ltd, Chertsey, England

Kugler, C:
 Hannover Med Sch, Hannover, Germany

Ohler, L:
 George Washington Univ, Washington, DC USA

Van Cleemput, J:
 Univ Hosp Leuven, Leuven, Belgium

Poncelet, AJ:
 Clin Univ St Luc, Brussels, Belgium

Sebbag, L:
 Hop Louis Pradel, Lyon, France

Michel, M:
 Hop Nord Laennec, Nantes, France

Bernard, A:
 Hop Univ Pitie Salpetriere, Paris, France

Doesch, A:
 Univ Hosp Heidelberg, Heidelberg, Germany

Livi, U:
 Univ Hosp Udine, Udine, Italy

Potena, L:
 Univ Bologna, Bologna, Italy

Brossa-Loidi, V:
 Hosp Santa Creu & Sant Pau, Barcelona, Spain

Segovia-Cubero, J:
 Hosp Puerta Hierro, Madrid, Spain

Almenar-Bonet, L:
 Hosp Univ & Politecn La Fe Valencia, Valencia, Spain

Saint-Gerons, CS:
 Hosp Univ Reina Sofia, Cordoba, Spain

Mohacsi, P:
 Univ Hosp Bern, Bern, Switzerland

Horvath, E:
 Univ Zurich Hosp, Zurich, Switzerland

Riotto, C:
 Papworth Hosp, Cambridge, England

Parry, G:
 Freeman Rd Hosp, Newcastle, England

Firouzi, A:
 Royal Brompton & Harefield NHS Fdn Trust, London, England

Kozuszko, S:
 Toronto Gen Hosp, Toronto, ON, Canada

Haddad, H:
 Univ Ottawa, Inst Heart, Ottawa, ON, Canada

Kaan, A:
 St Pauls Hosp, Vancouver, BC, Canada

Fisher, G:
 London Hlth Sci Ctr, London, ON, Canada

Miller, T:
 Duke Univ Hosp, Durham, NC USA

Flattery, M:
 Virginia Commonwealth Univ Hlth Syst, Richmond, VA USA

Ludrosky, K:
 Cleveland Clin, Cleveland, OH 44106 USA

Albert, N:
 Cleveland Clin, Cleveland, OH 44106 USA

Coleman, B:
 Cedars Sinai Med Ctr, Los Angeles, CA USA

Trammell, J:
 Kaiser Permanente Santa Clara Med Ctr, Santa Clara, CA USA

Epstein, F:
 Kaiser Permanente Santa Clara Med Ctr, Santa Clara, CA USA

St Clair, K:
 St Lukes Hosp, Kansas City, MO USA

Kao, A:
 St Lukes Hosp, Kansas City, MO USA

Molina, M:
 Hosp Univ Penn, 3400 Spruce St, Philadelphia, PA 19104 USA

Canales, KR:
 Ochsner Med Ctr, New Orleans, LA USA

de Almeida, SS:
 Hosp Municipal Vila Santa Catarina, Minist Saude PROADI SUS, Sao Paulo, Brazil

 Univ Fed Sao Paulo, Sch Nursing, Sao Paulo, Brazil

 Univ Fed Sao Paulo, Hosp Israelita Albert Einstein, Sao Paulo & Paulista Nursing Sch, Sao Paulo, Brazil

Ayoub, AC:
 Inst Dante Pazzanese Cardiol, Sao Paulo, Brazil

Barone, F:
 Univ Sao Paulo, Inst Coracao, Sao Paulo, Brazil

Harkess, M:
 St Vincents Hosp, Sydney, NSW, Australia

Maddicks-Law, J:
 Prince Charles Hosp, Brisbane, Qld, Australia
ISSN: 01492918
Editorial
ELSEVIER, 685 ROUTE 202-206, BRIDGEWATER, NJ 08807 USA, Estados Unidos America
Tipo de documento: Article
Volumen: 41 Número: 1
Páginas: 130-136
WOS Id: 000457649700015
ID de PubMed: 30591285
imagen Green Published

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