Two Year Outcomes, Cognitive and Behavioral Markers of Decline in Healthy, Cognitively Normal Older Persons with Global Deterioration Scale Stage 2 (Subjective Cognitive Decline with Impairment)
Por:
Reisberg, B, Torossian, C, Shulman, MB, Monteiro, I, Boksay, I, Golomb, J, Benarous, FG, Ulysse, A, Oo, T, Vedvyas, A, Rao, JA, Marsh, K, Kluger, A, Sangha, J, Hassan, M, Alshalabi, M, Arain, F, Shaikhh, N, Buj, M, Kenowsky, S, Masurkar, AV, Rabin, L, Noroozian, M, Sanchez-Saudinos, MB, Blesa, R, Auer, S, Zhang, Y, de Leon, M, Sadowski, M, Wisniewski, T, Gauthier, S, Shao, YZ
Publicada:
1 ene 2019
Resumen:
Background: Little is known with respect to behavioral markers of subjective cognitive decline (SCD), a condition initially described in association with Global Deterioration Scale (GDS) stage 2.
Objective: Two-year interval behavioral markers were investigated herein.
Methods: Subjects from a published 7-year outcome study of GDS stage 2 subjects were selected. This study had demonstrated a hazard ratio of 4.5 for progression of GDS stage 2, in comparison with GDS stage 1 (no subjective or objective cognitive decline) subjects, after controlling for demographic and temporal variables. Because GDS 2 subjects have previously demonstrated impairment in comparison with healthy persons free of complaints, we herein suggest the terminology "SCD(I)" for these persons. 98 SCD(I) persons, 63 women and 35 men, mean baseline age, 67.12 +/- 8.75 years, with a mean educational background of 15.55 +/- 2.60 years, and mean baseline MMSE scores of 28.9 +/- 1.24 were followed for 2.13 +/- 0.30 years.
Results: Observed annual decline on the GDS was 6.701% per annum, very close to a 1986 published estimate. At follow up, the MMSE, and 7 of 8 psychometric tests did not decline significantly. Of 21 Hamilton Depression Scale items, 2 improved and the remainder were unchanged. Anxieties declined from multiple perspectives. The Brief Cognitive Rating Scale (BCRS) declined significantly (p < 0.001), with component declines in Remote memory (p < 0.01), and Functioning/self-care (p = 0 .01).
Conclusion: SCD(I) persons decline at an annual rate of approximately 6.7%/year from several recent studies. The BCRS assessments and the Digit Symbol Substitution Test can be sensitive measures for future studies of progression mitigation.
Filiaciones:
Reisberg, B:
NYU, Langone Hlth, Dept Psychiat, New York, NY 10016 USA
McGill Univ, Res Ctr Studies Aging, Dept Neurol & Neurosurg, Montreal, PQ, Canada
McGill Univ, Res Ctr Studies Aging, Dept Psychiat, Montreal, PQ, Canada
McGill Univ, Res Ctr Studies Aging, Dept Med, Montreal, PQ, Canada
ADI, Subject Cognit Impairment Working Grp, Chicago, IL USA
Alzheimers Assoc, PIA, SCD I, Chicago, IL USA
Torossian, C:
NYU, Langone Hlth, Dept Psychiat, New York, NY 10016 USA
Shulman, MB:
NYU, Langone Hlth, Dept Psychiat, New York, NY 10016 USA
NYU, Langone Hlth, Dept Neurol, New York, NY 10016 USA
Monteiro, I:
NYU, Langone Hlth, Dept Psychiat, New York, NY 10016 USA
Boksay, I:
NYU, Langone Hlth, Dept Psychiat, New York, NY 10016 USA
Golomb, J:
NYU, Langone Hlth, Dept Psychiat, New York, NY 10016 USA
NYU, Langone Hlth, Dept Neurol, New York, NY 10016 USA
Benarous, FG:
NYU, Langone Hlth, Dept Psychiat, New York, NY 10016 USA
NYU, Langone Hlth, Dept Neurol, New York, NY 10016 USA
Ulysse, A:
NYU, Langone Hlth, Dept Neurol, New York, NY 10016 USA
Oo, T:
NYU, Langone Hlth, Dept Neurol, New York, NY 10016 USA
Vedvyas, A:
NYU, Langone Hlth, Dept Neurol, New York, NY 10016 USA
Rao, JA:
NYU, Langone Hlth, Dept Neurol, New York, NY 10016 USA
Marsh, K:
NYU, Langone Hlth, Dept Neurol, New York, NY 10016 USA
Kluger, A:
NYU, Langone Hlth, Dept Psychiat, New York, NY 10016 USA
CUNY, Lehman Coll, Dept Psychol, New York, NY 10021 USA
Sangha, J:
NYU, Langone Hlth, Dept Psychiat, New York, NY 10016 USA
Hassan, M:
NYU, Langone Hlth, Dept Psychiat, New York, NY 10016 USA
Alshalabi, M:
NYU, Langone Hlth, Dept Psychiat, New York, NY 10016 USA
Arain, F:
NYU, Langone Hlth, Dept Psychiat, New York, NY 10016 USA
Shaikhh, N:
Kings Cty Hosp Ctr, New York, NY USA
Buj, M:
NYU, Langone Hlth, Dept Psychiat, New York, NY 10016 USA
Kenowsky, S:
NYU, Langone Hlth, Dept Psychiat, New York, NY 10016 USA
Masurkar, AV:
NYU, Langone Hlth, Dept Neurol, New York, NY 10016 USA
Rabin, L:
CUNY, Brooklyn Coll, Dept Psychol, New York, NY 10021 USA
CUNY, Grad Ctr, New York, NY USA
Alzheimers Assoc, PIA, SCD I, Chicago, IL USA
Noroozian, M:
Univ Tehran Med Sci, Dept Psychiat, Roozbeh Hosp, Memory & Behav Neurol Div, Tehran, Iran
ADI, Subject Cognit Impairment Working Grp, Chicago, IL USA
Sanchez-Saudinos, MB:
Hosp Santa Creu & Sant Pau, Dept Neurol, Barcelona, Spain
Autonomous Univ Barcelona, Dept Neurol, Barcelona, Spain
Blesa, R:
Hosp Santa Creu & Sant Pau, Dept Neurol, Barcelona, Spain
Autonomous Univ Barcelona, Dept Neurol, Barcelona, Spain
ADI, Subject Cognit Impairment Working Grp, Chicago, IL USA
Auer, S:
Danube Univ, Fac Hlth & Med, Dept Clin Neurosci & Prevent Med, Krems, Austria
Zhang, Y:
NYU, Langone Hlth, Dept Populat Hlth, Div Biostat, New York, NY 10016 USA
NYU, Langone Hlth, Dept Environm Med, New York, NY 10016 USA
de Leon, M:
NYU, Langone Hlth, Dept Psychiat, New York, NY 10016 USA
Sadowski, M:
NYU, Langone Hlth, Dept Psychiat, New York, NY 10016 USA
NYU, Langone Hlth, Dept Neurol, New York, NY 10016 USA
NYU, Langone Hlth, Dept Biochem, New York, NY 10016 USA
NYU, Langone Hlth, Dept Mol Pharmacol, New York, NY 10016 USA
Wisniewski, T:
NYU, Langone Hlth, Dept Psychiat, New York, NY 10016 USA
NYU, Langone Hlth, Dept Neurol, New York, NY 10016 USA
NYU, Langone Hlth, Dept Pathol, New York, NY 10016 USA
Gauthier, S:
McGill Univ, Res Ctr Studies Aging, Dept Neurol & Neurosurg, Montreal, PQ, Canada
McGill Univ, Res Ctr Studies Aging, Dept Psychiat, Montreal, PQ, Canada
McGill Univ, Res Ctr Studies Aging, Dept Med, Montreal, PQ, Canada
ADI, Subject Cognit Impairment Working Grp, Chicago, IL USA
Shao, YZ:
NYU, Langone Hlth, Dept Populat Hlth, Div Biostat, New York, NY 10016 USA
NYU, Langone Hlth, Dept Environm Med, New York, NY 10016 USA
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