White matter cortico-striatal tracts predict apathy subtypes in Huntington's disease
Por:
De Paepe, AE, Sierpowska, J, Garcia-Gorro, C, Martinez-Horta, S, Perez-Perez, J, Kulisevsky, J, Rodriguez-Dechicha, N, Vaquer, I, Subira, S, Calopa, M, Munoz, E, Santacruz, P, Ruiz-Idiago, J, Mareca, C, de Diego-Balaguer, R, Camara, E
Publicada:
1 ene 2019
Resumen:
Background: Apathy is the neuropsychiatric syndrome that correlates most highly with Huntington's disease progression, and, like early patterns of neurodegeneration, is associated with lesions to cortico-striatal connections. However, due to its multidimensional nature and elusive etiology, treatment options are limited.
Objectives: To disentangle underlying white matter microstructural correlates across the apathy spectrum in Huntington's disease.
Methods: Forty-six Huntington's disease individuals (premanifest (N = 22) and manifest (N = 24)) and 35 healthy controls were scanned at 3-tesla and underwent apathy evaluation using the short-Problem Behavior Assessment and short-Lille Apathy Rating Scale, with the latter being characterized into three apathy domains, namely emotional, cognitive, and auto-activation deficit. Diffusion tensor imaging was used to study whether individual differences in specific cortico-striatal tracts predicted global apathy and its subdomains.
Results: We elucidate that apathy profiles may develop along differential timelines, with the auto-activation deficit domain manifesting prior to motor onset. Furthermore, diffusion tensor imaging revealed that inter-individual variability in the disruption of discrete cortico-striatal tracts might explain the heterogeneous severity of apathy profiles. Specifically, higher levels of auto-activation deficit symptoms significantly correlated with increased mean diffusivity in the right uncinate fasciculus. Conversely, those with severe cognitive apathy demonstrated increased mean diffusivity in the right frontostriatal tract and left dorsolateral prefrontal cortex to caudate nucleus tract.
Conclusions: The current study provides evidence that white matter correlates associated with emotional, cognitive, and auto-activation subtypes may elucidate the heterogeneous nature of apathy in Huntington's disease, as such opening a door for individualized pharmacological management of apathy as a multidimensional syndrome in other neurodegenerative disorders.
Filiaciones:
De Paepe, AE:
Pomona Coll, Dept Neurosci, Claremont, CA 91711 USA
Bellvitge Biomed Res Inst IDIBELL, Cognit & Brain Plast Unit, Feixa Larga S-N, Barcelona 08097, Spain
Sierpowska, J:
Bellvitge Biomed Res Inst IDIBELL, Cognit & Brain Plast Unit, Feixa Larga S-N, Barcelona 08097, Spain
Univ Barcelona, Dept Cognit Dev & Educ Psychol, Barcelona, Spain
Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands
Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Med Psychol, Nijmegen, Netherlands
Garcia-Gorro, C:
Bellvitge Biomed Res Inst IDIBELL, Cognit & Brain Plast Unit, Feixa Larga S-N, Barcelona 08097, Spain
Univ Barcelona, Dept Cognit Dev & Educ Psychol, Barcelona, Spain
Martinez-Horta, S:
European Huntingtons Dis Network, Ulm, Germany
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau IIB St Pau, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Perez-Perez, J:
European Huntingtons Dis Network, Ulm, Germany
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau IIB St Pau, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Kulisevsky, J:
European Huntingtons Dis Network, Ulm, Germany
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau IIB St Pau, Dept Neurol, Movement Disorders Unit, Barcelona, Spain
Carlos III Inst, CIBERNED Ctr Networked Biomed Res Neurodegenerat, Madrid, Spain
Rodriguez-Dechicha, N:
Hosp Duran & Reynals, Hestia Duran & Reynals, Barcelona, Spain
Vaquer, I:
Hosp Duran & Reynals, Hestia Duran & Reynals, Barcelona, Spain
Subira, S:
Hosp Duran & Reynals, Hestia Duran & Reynals, Barcelona, Spain
Univ Autonoma Barcelona, Dept Clin & Hlth Psychol, Barcelona, Spain
Calopa, M:
Hosp Univ Bellvitge, Neurol Serv, Movement Disorders Unit, Barcelona, Spain
Munoz, E:
Hosp Clin Barcelona, Neurol Serv, Movement Disorders Unit, Barcelona, Spain
IDIBAPS Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain
Univ Barcelona, Fac Med, Barcelona, Spain
Santacruz, P:
Hosp Clin Barcelona, Neurol Serv, Movement Disorders Unit, Barcelona, Spain
Ruiz-Idiago, J:
Univ Autonoma Barcelona, Dept Psychiat & Forens Med, Barcelona, Spain
Hosp Mare Deu Merce, Barcelona, Spain
Mareca, C:
Hosp Mare Deu Merce, Barcelona, Spain
de Diego-Balaguer, R:
Bellvitge Biomed Res Inst IDIBELL, Cognit & Brain Plast Unit, Feixa Larga S-N, Barcelona 08097, Spain
Univ Barcelona, Dept Cognit Dev & Educ Psychol, Barcelona, Spain
Univ Barcelona, Inst Neurosci, Barcelona, Spain
ICREA Catalan Inst Res & Adv Studies, Barcelona, Spain
Camara, E:
Bellvitge Biomed Res Inst IDIBELL, Cognit & Brain Plast Unit, Feixa Larga S-N, Barcelona 08097, Spain
Gold, Green Published
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