Late growth of infantile hemangiomas in children > 3 years of age: A retrospective study
Por:
O'Brien, KF, Shah, SD, Pope, E, Phillips, RJ, Blei, F, Baselga, E, Garzon, MC, McCuaig, C, Haggstrom, AN, Hoeger, PH, Treat, JR, Perman, MJ, Bellet, JS, Cubiro, X, Poole, J, Frieden, IJ
Publicada:
1 feb 2019
Resumen:
Background: The proliferative phase of infantile hemangiomas (IHs) is usually complete by 9 months of life. Late growth beyond age 3 years is rarely reported.
Objective: To describe the demographic and clinic characteristics of a cohort of patients with late growth of IH, defined as growth in a patient >3 years of age.
Methods: A multicenter, retrospective cohort study.
Results: In total, 59 patients, 85% of which were female, met the inclusion criteria. The mean first episode of late growth was 4.3 (range 3-8.5) years. Head and neck location (55/59; 93%) and presence of deep hemangioma (52/59; 88%) were common characteristics. Posterior fossa malformations, hemangiomas, arterial anomalies, cardiac defects, eye abnormalities (PHACE) syndrome was noted in 20 of 38 (53%) children with segmental facial IH. Systemic therapy (corticosteroid or beta-blocker) was given during infancy in 58 of 59 (98%) and 24 of 59 (41%) received systemic therapy (beta-blockers) for late IH growth.
Limitations: The retrospective nature and ascertainment by investigator recall are limitations of the study.
Conclusion: Late IH growth can occur in children after 3 years of age. Risk factors include head and neck location, segmental morphology, and involvement of deep dermal/subcutaneous tissues.
Filiaciones:
O'Brien, KF:
Georgetown Univ, Sch Med, Washington, DC USA
Shah, SD:
Univ Calif San Francisco, San Francisco, CA 94143 USA
Pope, E:
Hosp Sick Children, Toronto, ON, Canada
Univ Toronto, Toronto, ON, Canada
Phillips, RJ:
Royal Childrens Hosp, Melbourne, Vic, Australia
Blei, F:
Northwell Hlth, Lenox Hill Hosp, New York, NY USA
Baselga, E:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Garzon, MC:
Columbia Univ, Dept Dermatol, New York, NY 10027 USA
Columbia Univ, Dept Pediat, New York, NY 10027 USA
McCuaig, C:
St Justine Univ Hosp Ctr, Montreal, PQ, Canada
Haggstrom, AN:
Indiana Univ, Dept Dermatol, Indianapolis, IN 46204 USA
Indiana Univ, Dept Pediat, Indianapolis, IN 46204 USA
Hoeger, PH:
Catholic Childrens Hosp Wilhelmstift, Dept Pediat Dermatol, Hamburg, Germany
Treat, JR:
Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA
Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA
Perman, MJ:
Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA
Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA
Bellet, JS:
Duke Univ, Dept Dermatol & Pediat, Durham, NC USA
Cubiro, X:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Poole, J:
Childrens Hosp New Orleans, New Orleans, LA USA
Frieden, IJ:
Univ Calif San Francisco, San Francisco, CA 94143 USA
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