Clinical Presentation of Individuals With Human T-Cell Leukemia Virus Type-1 Infection in Spain
Por:
de Mendoza, C, Piron, M, Gonzalez, R, Jimenez, A, Caballero, E, Roc, L, Benito, R, Ramos, JM, Soriano, V, Rodriguez, C, Vera, M, del Romero, J, Marcaida, G, Ocete, MD, Caballero, E, Molina, I, Aguilera, A, Rodriguez-Calvino, JJ, Navarro, D, Rivero, C, Vilarino, MD, Benito, R, Algarate, S, Gil, J, de Lejarazu, RO, Rojo, S, Eiros, JM, San Miguel, A, Manzardo, C, Miro, JM, Garcia, J, Paz, I, Poveda, E, Calderon, E, Escudero, D, Trigo, M, Diz, J, Garcia-Campello, M, Rodriguez-Iglesias, M, Hernandez-Betancor, A, Martin, AM, Ramos, JM, Gimeno, A, Gutierrez, F, Rodriguez, JC, Sanchez, V, Gomez-Hernando, C, Cilla, G, Perez-Trallero, E, Lopez-Aldeguer, J, Fernandez-Pereira, L, Niubo, J, Hernandez, M, Lopez-Lirola, AM, Gomez-Sirvent, JL, Force, L, Cifuentes, C, Perez, S, Morano, L, Raya, C, Gonzalez-Praetorius, A, Perez, JL, Penaranda, M, Hernaez-Crespo, S, Montejo, JM, Roc, L, Martinez-Sapina, A, Viciana, I, Cabezas, T, Lozano, A, Fernandez, JM, Garcia-Bermejo, I, Gaspar, G, Garcia, R, Gorgolas, M, Vegas, C, Blas, J, Miralles, P, Valeiro, M, Aldamiz, T, Margall, N, Guardia, C, do Pico, E, Polo, I, Aguinaga, A, Ezpeleta, C, Sauleda, S, Piron, M, Torres, P, Gonzalez, R, Jimenez, A, Blanco, L, Suarez, A, Rodriguez-Avial, I, Perez-Rivilla, A, Parra, P, Fernandez, M, Fernandez-Alonso, M, Trevino, A, Requena, S, Benitez-Gutierrez, L, Cuervas-Mons, V, de Mendoza, C, Barreiro, P, Soriano, V, Corral, O, Gomez-Gallego, F
Publicada:
1 feb 2019
Resumen:
Background. Although only 8%-10% of persons infected with human T-cell leukemia virus type 1 (HTLV-1) may develop virus-associated diseases lifelong, misdiagnosis of asymptomatic infected carriers frequently leads to late diagnoses.
Methods. A nationwide HTLV-1 register was created in Spain in 1989. A total of 351 infected persons had been reported by the end of 2017. We examined all new HTLV-1 diagnoses during the last decade and compared their clinical presentation.
Results. A total of 247 individuals with HTLV-1 infection had been reported in Spain since year 2008. The incidence has remained stable with 20-25 new diagnoses yearly. Women represented 62%. Only 12% were native Spaniards, most of whom were foreigners from Latin America (72.5%). Up to 57 (23%) individuals presented clinically with HTLV-1-associated conditions, including subacute myelopathy (n = 24; 42.1%), T-cell lymphoma (n = 19; 33.3%), or Strongyloides stercoralis infestation (n = 8; 14%). Human T-cell leukemia virus type 1 diagnosis had been made either at blood banks (n = 109; 44%) or at clinics (n = 138; 56%). It is interesting to note that Spaniards and especially Africans were overrepresented among patients presenting with HTLV-1-associated illnesses, suggesting that misdiagnosis and late presentation are more frequent in these populations compared to Latin Americans.
Conclusions. Given that 23% of new HTLV-1 diagnoses in Spain are symptomatic, underdiagnosis must be common. Although screening in blood banks mostly identifies asymptomatic Latin American carriers, a disproportionately high number of Spaniards and Africans are unveiled too late, that is, they already suffer from classic HTLV-1 illnesses.
Filiaciones:
de Mendoza, C:
Puerta de Hierro Res Inst, Madrid, Spain
Univ Hosp, Madrid, Spain
IIS Hosp Univ Puerta de Hierro, Majadahonda, Spain
Piron, M:
Blood & Tissue Bank, Barcelona, Spain
Banco Sangre & Tejidos, Barcelona, Spain
Gonzalez, R:
Reg Transfus Ctr, Madrid, Spain
Ctr Transfus, Madrid, Spain
Jimenez, A:
Ctr Hemoterapia Castilla Leon, Valladolid, Spain
Ctr Hemoterapia & Hemodonac Castilla & Leon, Valladolid, Spain
Caballero, E:
Hosp Valle De Hebron, Barcelona, Spain
Roc, L:
Hosp Miguel Servet, Zaragoza, Spain
Hosp Virgen de la Victoria, Malaga, Spain
Benito, R:
Hosp Clin Univ Lozano Blesa, Zaragoza, Spain
Ramos, JM:
Gen Hosp, Alicante, Spain
Soriano, V:
UNIR Hlth Sci Sch, Calle Almansa 101, Madrid 28040, Spain
La Paz Univ Hosp, Madrid, Spain
UNIR Hlth Sci Sch, Madrid, Spain
Rodriguez, C:
Ctr Sanitario Sandoval, Madrid, Spain
Vera, M:
Ctr Sanitario Sandoval, Madrid, Spain
del Romero, J:
Ctr Sanitario Sandoval, Madrid, Spain
Marcaida, G:
Hosp Gen Univ, Valencia, Spain
Ocete, MD:
Hosp Gen Univ, Valencia, Spain
Caballero, E:
Hosp Valle De Hebron, Barcelona, Spain
Molina, I:
Hosp Valle De Hebron, Barcelona, Spain
Aguilera, A:
Hosp Conxo CHUS, Santiago, Chile
Rodriguez-Calvino, JJ:
Hosp Conxo CHUS, Santiago, Chile
Navarro, D:
Hosp Conxo CHUS, Santiago, Chile
Rivero, C:
Hosp Conxo CHUS, Santiago, Chile
Vilarino, MD:
Hosp Conxo CHUS, Santiago, Chile
Benito, R:
Hosp Clin Univ Lozano Blesa, Zaragoza, Spain
Algarate, S:
Hosp Clin Univ Lozano Blesa, Zaragoza, Spain
Gil, J:
Hosp Clin Univ Lozano Blesa, Zaragoza, Spain
de Lejarazu, RO:
Hosp Clin Univ, Valladolid, Spain
Rojo, S:
Hosp Clin Univ, Valladolid, Spain
Eiros, JM:
Hosp Rio Hortega, Valladolid, Spain
San Miguel, A:
Hosp Rio Hortega, Valladolid, Spain
Manzardo, C:
Hosp Clin Barcelona, IDIBAPS, Barcelona, Spain
Miro, JM:
Hosp Clin Barcelona, IDIBAPS, Barcelona, Spain
Garcia, J:
Hosp Cristal Pinor, Orense, Spain
Paz, I:
Hosp Cristal Pinor, Orense, Spain
Poveda, E:
INIBIC Complejo Hosp Univ, La Coruna, Spain
Calderon, E:
Hosp Virgen del Rocio, Seville, Spain
CIBERESP, Seville, Spain
Escudero, D:
Hosp Badalona Germans Trias & Pujol, Barcelona, Spain
Trigo, M:
Complejo Hosp, Pontevedra, Spain
Diz, J:
Complejo Hosp, Pontevedra, Spain
Garcia-Campello, M:
Complejo Hosp, Pontevedra, Spain
Rodriguez-Iglesias, M:
Hosp Univ, Puerto Real, Spain
Hernandez-Betancor, A:
Hosp Insular Hosp Univ, Las Palmas Gran Canaria, Canaria, Spain
Martin, AM:
Hosp Insular Hosp Univ, Las Palmas Gran Canaria, Canaria, Spain
Ramos, JM:
Hosp Univ, Alicante, Spain
Gimeno, A:
Hosp Univ, Alicante, Spain
Gutierrez, F:
Hosp Gen, Elche, Spain
Rodriguez, JC:
Hosp Gen, Elche, Spain
Sanchez, V:
Hosp Gen, Elche, Spain
Gomez-Hernando, C:
Complejo Hosp Virgen Salud, Toledo, Spain
Cilla, G:
Hosp Donostia, San Sebastian, Spain
Perez-Trallero, E:
Hosp Donostia, San Sebastian, Spain
Lopez-Aldeguer, J:
Hosp La Fe, Valencia, Spain
Fernandez-Pereira, L:
Hosp San Pedro Alcantara, Caceres, Spain
Niubo, J:
Ciudad Sanitaria Bellvitge, Barcelona, Spain
Hernandez, M:
Hosp Univ La Laguna, Tenerife, Spain
Lopez-Lirola, AM:
Hosp Univ La Laguna, Tenerife, Spain
Gomez-Sirvent, JL:
Hosp Univ La Laguna, Tenerife, Spain
Force, L:
Hosp Gen, Mataro, Spain
Cifuentes, C:
Hosp Son Llatzer, Palma De Mallorca, Spain
Perez, S:
Hosp Meixoeiro, Vigo, Spain
Morano, L:
Hosp Meixoeiro, Vigo, Spain
Raya, C:
Hosp Bierzo, Ponferrada, Spain
Gonzalez-Praetorius, A:
Hosp Univ, Guadalajara, Spain
Perez, JL:
Hosp Son Espases, Mallorca, Spain
Penaranda, M:
Hosp Son Espases, Mallorca, Spain
Hernaez-Crespo, S:
Hosp Basurto, Bilbao, Spain
Montejo, JM:
Hosp Cruces, Bilbao, Spain
Roc, L:
Hosp Miguel Servet, Zaragoza, Spain
Hosp Virgen de la Victoria, Malaga, Spain
Martinez-Sapina, A:
Hosp Virgen de la Victoria, Malaga, Spain
Cabezas, T:
Hosp Poniente, Almeria, Spain
Lozano, A:
Hosp Poniente, Almeria, Spain
Fernandez, JM:
Hosp Poniente, Almeria, Spain
Garcia-Bermejo, I:
Hosp Univ, Getafe, Spain
Gaspar, G:
Hosp Univ, Getafe, Spain
Garcia, R:
Fdn Jimenez Diaz, Madrid, Spain
Gorgolas, M:
Fdn Jimenez Diaz, Madrid, Spain
Vegas, C:
Fdn Jimenez Diaz, Madrid, Spain
Blas, J:
Fdn Jimenez Diaz, Madrid, Spain
Miralles, P:
Hosp Gregorio Maranon, Madrid, Spain
Valeiro, M:
Hosp Gregorio Maranon, Madrid, Spain
Aldamiz, T:
Hosp Gregorio Maranon, Madrid, Spain
Margall, N:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Guardia, C:
ICS, Barcelona, Spain
do Pico, E:
ICS, Barcelona, Spain
Polo, I:
Complejo Hosp Navarra, Pamplona, Spain
Aguinaga, A:
Complejo Hosp Navarra, Pamplona, Spain
Ezpeleta, C:
Complejo Hosp Navarra, Pamplona, Spain
Sauleda, S:
Banco Sangre & Tejidos, Barcelona, Spain
Piron, M:
Blood & Tissue Bank, Barcelona, Spain
Banco Sangre & Tejidos, Barcelona, Spain
Torres, P:
Ctr Transfus, Madrid, Spain
Gonzalez, R:
Reg Transfus Ctr, Madrid, Spain
Ctr Transfus, Madrid, Spain
Jimenez, A:
Ctr Hemoterapia Castilla Leon, Valladolid, Spain
Ctr Hemoterapia & Hemodonac Castilla & Leon, Valladolid, Spain
Blanco, L:
Ctr Hemoterapia & Hemodonac Castilla & Leon, Valladolid, Spain
Suarez, A:
Hosp Clin San Carlos, Madrid, Spain
Rodriguez-Avial, I:
Hosp Clin San Carlos, Madrid, Spain
Perez-Rivilla, A:
Hosp Univ 12 Octubre, Madrid, Spain
Parra, P:
Hosp Univ 12 Octubre, Madrid, Spain
Fernandez, M:
Hosp Univ 12 Octubre, Madrid, Spain
Fernandez-Alonso, M:
Clin Univ, Pamplona, Spain
Trevino, A:
IIS Hosp Univ Puerta de Hierro, Majadahonda, Spain
Requena, S:
IIS Hosp Univ Puerta de Hierro, Majadahonda, Spain
Benitez-Gutierrez, L:
IIS Hosp Univ Puerta de Hierro, Majadahonda, Spain
Cuervas-Mons, V:
IIS Hosp Univ Puerta de Hierro, Majadahonda, Spain
de Mendoza, C:
Puerta de Hierro Res Inst, Madrid, Spain
Univ Hosp, Madrid, Spain
IIS Hosp Univ Puerta de Hierro, Majadahonda, Spain
Barreiro, P:
Hosp Univ La Paz, Madrid, Spain
Soriano, V:
UNIR Hlth Sci Sch, Calle Almansa 101, Madrid 28040, Spain
La Paz Univ Hosp, Madrid, Spain
UNIR Hlth Sci Sch, Madrid, Spain
Corral, O:
UNIR Hlth Sci Sch, Madrid, Spain
Gomez-Gallego, F:
UNIR Hlth Sci Sch, Madrid, Spain
Gold, Green Published
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