Association between night-time surgery and occurrence of intraoperative adverse events and postoperative pulmonary complications


Por: Cortegiani, A, Gregoretti, C, Neto, AS, Hemmes, SNT, Ball, L, Canet, J, Hiesmayr, M, Hollmann, MW, Mills, GH, Melo, MFV, Putensen, C, Schmid, W, Severgnini, P, Wrigge, H, de Abreu, MG, Schultz, MJ, Pelosi, P, Kroell, W, Metzler, H, Struber, G, Wegscheider, T, Gombotz, H, Hiesmayr, M, Schmid, W, Urbanek, B, Kahn, D, Momeni, M, Pospiech, A, Lois, F, Forget, P, Grosu, I, Poelaert, J, van Mossevelde, V, van Malderen, MC, Dylst, D, van Melkebeek, J, Beran, M, de Hert, S, De Baerdemaeker, L, Heyse, B, Van Limmen, J, Wyffels, P, Jacobs, T, Roels, N, De Bruyne, A, van de Velde, S, Leva, B, Damster, S, Plichon, B, Juros-Zovko, M, Djonovic-Omanovic, D, Pernar, S, Zunic, J, Miskovic, P, Zilic, A, Kvolik, S, Ivic, D, Azenic-Venzera, D, Skiljic, S, Vinkovic, H, Oputric, I, Juricic, K, Frkovic, V, Kopic, J, Mirkovic, I, Karanovic, N, Carev, M, Dropulic, N, Saric, JP, Erceg, G, Dvorscak, MB, Mazul-Sunko, B, Pavicic, AM, Goranovic, T, Maldini, B, Radocaj, T, Gavranovic, Z, Mladic-Batinica, I, Sehovic, M, Stourac, P, Harazim, H, Smekalova, O, Kosinova, M, Kolacek, T, Hudacek, K, Drab, M, Brujevic, J, Vitkova, K, Jirmanova, K, Volfova, I, Dzurnakova, P, Liskova, K, Dudas, R, Filipsky, R, el Kafrawy, S, Abdelwahab, HH, Metwally, T, Abdel-Razek, A, El-Shaarawy, AM, Hasan, WF, Ahmed, AG, Yassin, H, Magdy, M, Abdelhady, M, Mahran, M, Herodes, E, Kivik, P, Oganjan, J, Aun, A, Sormus, A, Sarapuu, K, Mall, M, Karjagin, J, Futier, E, Petit, A, Gerard, A, Marret, E, Solier, M, Jaber, S, Prades, A, Krassler, J, Merzky, S, Uhlig, C, Kiss, T, Bundy, A, Bluth, T, Gueldner, A, Spieth, P, Scharffenberg, M, Thiem, DT, Koch, T, Treschan, T, Schaefer, M, Bastin, B, Geib, J, Weiss, M, Kienbaum, P, Pannen, B, Gottschalk, A, Konrad, M, Westerheide, D, Schwerdtfeger, B, Wrigge, H, Simon, P, Reske, A, Nestler, C, Valsamidis, D, Stroumpoulis, K, Antholopoulos, G, Andreou, A, Karapanos, D, Theodorak, K, Gkiokas, G, Tasoulis, MK, Sidiropoulou, T, Zafeiropoulou, F, Florou, P, Pandazi, A, Tsaousi, G, Nouris, C, Pourzitaki, C, Bystritski, D, Pizov, R, Eden, A, Pesce, CV, Campanile, A, Marrella, A, Grasso, S, De Michele, M, Bona, F, Giacoletto, G, Sardo, E, Sottosanti, LGV, Solca, M, Volta, CA, Spadaro, S, Verri, M, Ragazzi, R, Zoppellari, R, Cinnella, G, Raimondo, P, La Bella, D, Mirabella, L, D'antini, D, Molin, A, Brunetti, I, Gratarola, A, Pellerano, G, Sileo, R, Pezzatto, S, Montagnani, L, Pasin, L, Landoni, G, Zangrillo, A, Beretta, L, Di Parma, AL, Tarzia, V, Dossi, R, Sassone, ME, Sances, D, Tredici, S, Spano, G, Castellani, G, Delunas, L, Peradze, S, Venturino, M, Arpino, I, Sher, S, Tommasino, C, Rapido, F, Morelli, P, Vargas, M, Servillo, G, Raineri, SM, Montalto, F, Russotto, V, Giarratano, A, Baciarello, M, Generali, M, Cerati, G, Leykin, Y, Bressan, F, Bartolini, V, Zamidei, L, Brazzi, L, Liperi, C, Sales, G, Pistidda, L, Severgnini, P, Brugnoni, E, Musella, G, Bacuzzi, A, Muhardri, D, Gecaj-Gashi, A, Sada, F, Bytyqi, A, Karbonskiene, A, Aukstakalniene, R, Teberaite, Z, Salciute, E, Tikuisis, R, Miliauskas, P, Jurate, S, Kontrimaviciute, E, Tomkute, G, Xuereb, J, Bezzina, M, Borg, FJ, Hemmes, S, Schultz, M, Hollmann, M, Wiersma, I, Binnekade, J, Bos, L, Boer, C, Duvekot, A, in 't Veld, B, Werger, A, Dennesen, P, Severijns, C, De Jong, J, Hering, J, van Beek, R, Ivars, S, Jammer, I, Breidablik, A, Hodt, KS, Fjellanger, F, Avalos, MV, Mellin-Olsen, J, Andersson, E, Shafi-Kabiri, A, Molina, R, Wutai, S, Morais, E, Tareco, G, Ferreira, D, Amaral, J, Castro, MDG, Cadilha, S, Appleton, S, Parente, S, Correia, M, Martins, D, Monteirosa, A, Ricardo, A, Rodrigues, S, Horhota, L, Grintescu, IM, Mirea, L, Grintescu, IC, Corneci, D, Negoita, S, Dutu, M, Garotescu, IP, Filipescu, D, Prodan, AB, Droc, G, Fota, R, Popescu, M, Tomescu, D, Petcu, AM, Tudoroiu, MI, Moise, A, Guran, CT, Gherghina, I, Costea, D, Cindea, I, Copotoiu, SM, Copotoiu, R, Barsan, V, Tolcser, Z, Riciu, M, Moldovan, SG, Veres, M, Gritsan, A, Kapkan, T, Gritsan, G, Korolkov, O, Kulikov, A, Lubnin, A, Ovezov, A, Prokoshev, P, Lugovoy, A, Anipchenko, N, Babayants, A, Komissarova, I, Zalina, K, Likhvantsev, V, Fedorov, S, Lazukic, A, Pejakovic, J, Mihajlovic, D, Kusnierikova, Z, Zelinkova, M, Bruncakova, K, Polakovicova, L, Sobona, V, Novak-Supe, B, Pekle-Golez, A, Jovanov, M, Strazisar, B, Markovic-Bozic, J, Novak-Jankovic, V, Voje, M, Grynyuk, A, Kostadinov, I, Spindler-Vesel, A, Moral, V, Unzueta, MC, Puigbo, C, Fava, J, Moret, E, Nunez, MR, Sendra, M, Brunelli, A, Rodenas, F, Monedero, P, Martinez, FH, Temino, MJY, Simon, AM, Larriba, AD, Lisi, A, Perez, G, Martinez, R, Granell, M, Vivo, JT, Ruiz, CS, Ibanez, JAD, Pastor, E, Soro, M, Ferrando, C, Defez, M, Alvares-Santullano, CA, Perez, R, Rico, J, Jawad, M, Saeed, Y, Gillberg, L, Bengisun, ZK, Kazbek, BK, Coskunfirat, N, Boztug, N, Sanli, S, Yilmaz, M, Hadimioglu, N, Senturk, NM, Camci, E, Kucukgoncu, S, Sungur, Z, Sivrikoz, N, Ozgen, SU, Toraman, F, Selvi, O, Senturk, O, Yildiz, M, Kuvaki, B, Gunenc, F, Kucukguclu, S, Ozbilgin, S, Maral, J, Canli, S, Arun, O, Saltali, A, Aydogan, E, Akgun, FN, Sanlikarip, C, Karaman, FM, Mazur, A, Vorotyntsev, S, Rousseau, G, Barrett, C, Stancombe, L, Shelley, B, Scholes, H, Limb, J, Rafi, A, Wayman, L, Deane, J, Rogerson, D, Williams, J, Yates, S, Rogers, E, Pulletz, M, Moreton, S, Jones, S, Venkatesh, S, Burton, M, Brown, L, Goodall, C, Rucklidge, M, Fuller, D, Nadolski, M, Kusre, S, Lundberg, M, Everett, L, Nutt, H, Zuleika, M, Carvalho, P, Clements, D, Creagh-Brown, B, Watt, P, Raymode, P, Pearse, R, Mohr, O, Raj, A, Creary, T, Chishti, A, Bell, A, Higham, C, Cain, A, Gibb, S, Mowat, S, Franklin, D, West, C, Minto, G, Boyd, N, Mills, G, Calton, E, Walker, R, Mackenzie, F, Ellison, B, Roberts, H, Chikungwa, M, Jackson, C, Donovan, A, Foot, J, Homan, E, Montgomery, J, Portch, D, Mercer, P, Palmer, J, Paddle, J, Fouracres, A, Datson, A, Andrew, A, Welch, L, Rose, A, Varma, S, Simeson, K, Rambhatla, M, Susarla, J, Marri, S, Kodaganallur, K, Das, A, Algarsamy, S, Colley, J, Davies, S, Szewczyk, M, Smith, T, Fernandez-Bustamante, A, Luzier, E, Almagro, A, Melo, MV, Fernando, L, Sulemanji, D, Sprung, J, Weingarten, T, Kor, D, Scavonetto, F, Tze, Y

Publicada: 1 mar 2019
Resumen:
Background: The aim of this post hoc analysis of a large cohort study was to evaluate the association between night-time surgery and the occurrence of intraoperative adverse events (AEs) and postoperative pulmonary complications (PPCs). Methods: LAS VEGAS (Local Assessment of Ventilatory Management During General Anesthesia for Surgery) was a prospective international 1-week study that enrolled adult patients undergoing surgical procedures with general anaesthesia and mechanical ventilation in 146 hospitals across 29 countries. Surgeries were defined as occurring during 'daytime' when induction of anaesthesia was between 8: 00 AM and 7: 59 PM, and as 'night-time' when induction was between 8: 00 PM and 7: 59 AM. Results: Of 9861 included patients, 555 (5.6%) underwent surgery during night-time. The proportion of patients who developed intraoperative AEs was higher during night-time surgery in unmatched (43.6% vs 34.1%; P<0.001) and propensity-matched analyses (43.7% vs 36.8%; P = 0.029). PPCs also occurred more often in patients who underwent night-time surgery (14% vs 10%; P = 0.004) in an unmatched cohort analysis, although not in a propensity-matched analysis (13.8% vs 11.8%; P = 0.39). In a multivariable regression model, including patient characteristics and types of surgery and anaesthesia, night-time surgery was independently associated with a higher incidence of intraoperative AEs (odds ratio: 1.44; 95% confidence interval: 1.09-1.90; P = 0.01), but not with a higher incidence of PPCs (odds ratio: 1.32; 95% confidence interval: 0.89-1.90; P = 0.15). Conclusions: Intraoperative adverse events and postoperative pulmonary complications occurred more often in patients undergoing night-time surgery. Imbalances in patients' clinical characteristics, types of surgery, and intraoperative management at night-time partially explained the higher incidence of postoperative pulmonary complications, but not the higher incidence of adverse events.

Filiaciones:
Cortegiani, A:
 Univ Palermo, Policlin Paolo Giaccone, Sect Anesthesia Analgesia Intens Care & Emergency, Dept Surg Oncol & Oral Sci, Palermo, Italy

 Policlin P Giaccone, Palermo, Italy

Gregoretti, C:
 Univ Palermo, Policlin Paolo Giaccone, Sect Anesthesia Analgesia Intens Care & Emergency, Dept Surg Oncol & Oral Sci, Palermo, Italy

Neto, AS:
 Univ Amsterdam, Dept Intens Care, Amsterdam, Netherlands

 Univ Amsterdam, Amsterdam UMC, Lab Expt Intens Care & Anesthesia, Amsterdam, Netherlands

 Hosp Israelita Albert Einstein, Dept Crit Care Med, Sao Paulo, Brazil

Hemmes, SNT:
 Univ Amsterdam, Dept Intens Care, Amsterdam, Netherlands

 Univ Amsterdam, Amsterdam UMC, Lab Expt Intens Care & Anesthesia, Amsterdam, Netherlands

 Univ Amsterdam, Amsterdam UMC, Dept Anaesthesiol, Amsterdam, Netherlands

Ball, L:
 Univ Genoa, Dipartimento Sci Chirurg & Diagnost Integrate, Genoa, Italy

 IRCCS Osped Policlin San Martino, Genoa, Italy

Canet, J:
 Hosp Badalona Germans Trias & Pujol, Dept Anesthesiol & Postoperat Care, Barcelona, Spain

 Hosp Badalona Germans Trias & Pujol, Barcelona, Spain

Hiesmayr, M:
 Med Univ Vienna, Div Cardiac Thorac Vasc Anesthesia & Intens Care, Vienna, Austria

 Med Univ Vienna, Vienna, Austria

Hollmann, MW:
 Univ Amsterdam, Amsterdam UMC, Dept Anaesthesiol, Amsterdam, Netherlands

Mills, GH:
 Sheffield Teaching Hosp, Operating Serv Crit Care & Anesthesia, Sheffield, S Yorkshire, England

 Univ Sheffield, Sheffield, S Yorkshire, England

Melo, MFV:
 Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02114 USA

Putensen, C:
 Univ Hosp Bonn, Dept Anesthesiol & Intens Care Med, Bonn, Germany

Schmid, W:
 Med Univ Vienna, Div Cardiac Thorac Vasc Anesthesia & Intens Care, Vienna, Austria

 Med Univ Vienna, Vienna, Austria

Severgnini, P:
 Univ Insubria, ASST Sette Laghi Osped Circolo, Dept Biotechnol & Sci Life, Varese, Italy

 Univ Insubria, Fdn Macchi, Varese, Italy

 Insubria Univ, Varese, Italy

Wrigge, H:
 Univ Leipzig, Dept Anesthesiol & Intens Care Med, Leipzig, Germany

 Univ Leipzig, Leipzig, Germany

de Abreu, MG:
 Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Pulm Engn Grp, Dept Anaesthesiol & Intens Care Med, Dresden, Germany

 Univ Hosp Carl Gustav Carus, Dresden, Germany

Schultz, MJ:
 Univ Amsterdam, Dept Intens Care, Amsterdam, Netherlands

 Univ Amsterdam, Amsterdam UMC, Lab Expt Intens Care & Anesthesia, Amsterdam, Netherlands

 Mahidol Univ, Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand

Pelosi, P:
 Univ Genoa, Dipartimento Sci Chirurg & Diagnost Integrate, Genoa, Italy

 IRCCS Osped Policlin San Martino, Genoa, Italy

 Univ Genoa, IRCCS AOU San Martino IST Hosp, Genoa, Italy

Kroell, W:
 LKH Graz, Graz, Austria

Metzler, H:
 LKH Graz, Graz, Austria

Struber, G:
 LKH Graz, Graz, Austria

Wegscheider, T:
 LKH Graz, Graz, Austria

Gombotz, H:
 AKH Linz, Linz, Austria

Hiesmayr, M:
 Med Univ Vienna, Div Cardiac Thorac Vasc Anesthesia & Intens Care, Vienna, Austria

 Med Univ Vienna, Vienna, Austria

Schmid, W:
 Med Univ Vienna, Div Cardiac Thorac Vasc Anesthesia & Intens Care, Vienna, Austria

 Med Univ Vienna, Vienna, Austria

Urbanek, B:
 Med Univ Vienna, Vienna, Austria

Kahn, D:
 UCL Clin Univ St Luc Brussels, Brussels, Belgium

Momeni, M:
 UCL Clin Univ St Luc Brussels, Brussels, Belgium

Pospiech, A:
 UCL Clin Univ St Luc Brussels, Brussels, Belgium

Lois, F:
 UCL Clin Univ St Luc Brussels, Brussels, Belgium

Forget, P:
 UCL Clin Univ St Luc Brussels, Brussels, Belgium

Grosu, I:
 UCL Clin Univ St Luc Brussels, Brussels, Belgium

Poelaert, J:
 Univ Hosp Brussels UZ Brussel, Brussels, Belgium

van Mossevelde, V:
 Univ Hosp Brussels UZ Brussel, Brussels, Belgium

van Malderen, MC:
 Univ Hosp Brussels UZ Brussel, Brussels, Belgium

Dylst, D:
 Ziekenhuis Oost Limburg ZOL, Genk, Belgium

van Melkebeek, J:
 Ziekenhuis Oost Limburg ZOL, Genk, Belgium

Beran, M:
 Ziekenhuis Oost Limburg ZOL, Genk, Belgium

de Hert, S:
 Ghent Univ Hosp, Ghent, Belgium

De Baerdemaeker, L:
 Ghent Univ Hosp, Ghent, Belgium

Heyse, B:
 Ghent Univ Hosp, Ghent, Belgium

Van Limmen, J:
 Ghent Univ Hosp, Ghent, Belgium

Wyffels, P:
 Ghent Univ Hosp, Ghent, Belgium

Jacobs, T:
 Ghent Univ Hosp, Ghent, Belgium

Roels, N:
 Ghent Univ Hosp, Ghent, Belgium

De Bruyne, A:
 Ghent Univ Hosp, Ghent, Belgium

van de Velde, S:
 Maria Middelares, Ghent, Belgium

Leva, B:
 European Soc Anaesthesiol, Brussels, Belgium

Damster, S:
 European Soc Anaesthesiol, Brussels, Belgium

Plichon, B:
 European Soc Anaesthesiol, Brussels, Belgium

Juros-Zovko, M:
 Gen Hosp Prim Dr Abdulah Nakas Sarajevo, Sarajevo, Bosnia & Herceg

Djonovic-Omanovic, D:
 Gen Hosp Prim Dr Abdulah Nakas Sarajevo, Sarajevo, Bosnia & Herceg

Pernar, S:
 Gen Hosp Cakovec, Cakovec, Croatia

Zunic, J:
 Gen Hosp Karlovac, Karlovac, Croatia

Miskovic, P:
 Gen Hosp Karlovac, Karlovac, Croatia

Zilic, A:
 Gen Hosp Karlovac, Karlovac, Croatia

Kvolik, S:
 Univ Clin Hosp Osijek, Osijek, Croatia

Ivic, D:
 Univ Clin Hosp Osijek, Osijek, Croatia

Azenic-Venzera, D:
 Univ Clin Hosp Osijek, Osijek, Croatia

Skiljic, S:
 Univ Clin Hosp Osijek, Osijek, Croatia

Vinkovic, H:
 Univ Clin Hosp Osijek, Osijek, Croatia

Oputric, I:
 Univ Clin Hosp Osijek, Osijek, Croatia

Juricic, K:
 Univ Hosp Rijeka, Rijeka, Croatia

Frkovic, V:
 Univ Hosp Rijeka, Rijeka, Croatia

Kopic, J:
 Gen Hosp Dr J Bencevic, Slavonski Brod, Croatia

Mirkovic, I:
 Gen Hosp Dr J Bencevic, Slavonski Brod, Croatia

Karanovic, N:
 Univ Hosp Ctr Split, Split, Croatia

Carev, M:
 Univ Hosp Ctr Split, Split, Croatia

Dropulic, N:
 Univ Hosp Ctr Split, Split, Croatia

Saric, JP:
 Univ Hosp Merkur, Zagreb, Croatia

Erceg, G:
 Univ Hosp Merkur, Zagreb, Croatia

Dvorscak, MB:
 Univ Hosp Merkur, Zagreb, Croatia

Mazul-Sunko, B:
 Univ Hosp Sveti Duh, Zagreb, Croatia

Pavicic, AM:
 Univ Hosp Sveti Duh, Zagreb, Croatia

Goranovic, T:
 Univ Hosp Sveti Duh, Zagreb, Croatia

Maldini, B:
 Univ Hosp, Sch Med, Sestre Milosrdnice Sister Char, Zagreb, Croatia

Radocaj, T:
 Univ Hosp, Sch Med, Sestre Milosrdnice Sister Char, Zagreb, Croatia

Gavranovic, Z:
 Univ Hosp, Sch Med, Sestre Milosrdnice Sister Char, Zagreb, Croatia

Mladic-Batinica, I:
 Univ Hosp, Sch Med, Sestre Milosrdnice Sister Char, Zagreb, Croatia

Sehovic, M:
 Univ Hosp, Sch Med, Sestre Milosrdnice Sister Char, Zagreb, Croatia

Stourac, P:
 Univ Hosp Brno, Brno, Czech Republic

Harazim, H:
 Univ Hosp Brno, Brno, Czech Republic

Smekalova, O:
 Univ Hosp Brno, Brno, Czech Republic

Kosinova, M:
 Univ Hosp Brno, Brno, Czech Republic

Kolacek, T:
 Univ Hosp Brno, Brno, Czech Republic

Hudacek, K:
 Univ Hosp Brno, Brno, Czech Republic

Drab, M:
 Univ Hosp Brno, Brno, Czech Republic

Brujevic, J:
 Univ Hosp Hradec Kralove, Hradec Kralove, Czech Republic

Vitkova, K:
 Univ Hosp Hradec Kralove, Hradec Kralove, Czech Republic

Jirmanova, K:
 Univ Hosp Hradec Kralove, Hradec Kralove, Czech Republic

Volfova, I:
 Univ Hosp Ostrava, Ostrava, Czech Republic

Dzurnakova, P:
 Univ Hosp Ostrava, Ostrava, Czech Republic

Liskova, K:
 Univ Hosp Ostrava, Ostrava, Czech Republic

Dudas, R:
 Nemocnice Znojmo, Znojmo, Czech Republic

Filipsky, R:
 Nemocnice Znojmo, Znojmo, Czech Republic

el Kafrawy, S:
 El Sahel Teaching Hosp, Cairo, Egypt

Abdelwahab, HH:
 Cairo Univ, Kasr Al Ainy Med Sch, Giza, Egypt

Metwally, T:
 Cairo Univ, Kasr Al Ainy Med Sch, Giza, Egypt

Abdel-Razek, A:
 Cairo Univ, Kasr Al Ainy Med Sch, Giza, Egypt

El-Shaarawy, AM:
 Beni Sueif Univ Hosp, Giza, Egypt

Hasan, WF:
 Beni Sueif Univ Hosp, Giza, Egypt

Ahmed, AG:
 Beni Sueif Univ Hosp, Giza, Egypt

Yassin, H:
 Fayoum Univ Hosp, Giza, Egypt

Magdy, M:
 Fayoum Univ Hosp, Giza, Egypt

Abdelhady, M:
 Fayoum Univ Hosp, Giza, Egypt

Mahran, M:
 Suis Med Insurance Hosp, Suis, Egypt

Herodes, E:
 North Estonia Med Ctr, Tallinn, Estonia

Kivik, P:
 North Estonia Med Ctr, Tallinn, Estonia

Oganjan, J:
 North Estonia Med Ctr, Tallinn, Estonia

Aun, A:
 North Estonia Med Ctr, Tallinn, Estonia

Sormus, A:
 Tartu Univ Hosp, Tartu, Estonia

Sarapuu, K:
 Tartu Univ Hosp, Tartu, Estonia

Mall, M:
 Tartu Univ Hosp, Tartu, Estonia

Karjagin, J:
 Tartu Univ Hosp, Tartu, Estonia

Futier, E:
 Univ Hosp Clermont Ferrand, Clermont Ferrand, France

Petit, A:
 Univ Hosp Clermont Ferrand, Clermont Ferrand, France

Gerard, A:
 Univ Hosp Clermont Ferrand, Clermont Ferrand, France

Marret, E:
 Inst Hosp Franco Britann, Levallois Perret, France

Solier, M:
 Inst Hosp Franco Britann, Levallois Perret, France

Jaber, S:
 St Eloi Univ Hosp, Montpellier, France

Prades, A:
 St Eloi Univ Hosp, Montpellier, France

Krassler, J:
 Fachkrankenhaus Coswig, Coswig, Germany

Merzky, S:
 Fachkrankenhaus Coswig, Coswig, Germany

Uhlig, C:
 Univ Hosp Carl Gustav Carus, Dresden, Germany

Kiss, T:
 Univ Hosp Carl Gustav Carus, Dresden, Germany

Bundy, A:
 Univ Hosp Carl Gustav Carus, Dresden, Germany

Bluth, T:
 Univ Hosp Carl Gustav Carus, Dresden, Germany

Gueldner, A:
 Univ Hosp Carl Gustav Carus, Dresden, Germany

Spieth, P:
 Univ Hosp Carl Gustav Carus, Dresden, Germany

Scharffenberg, M:
 Univ Hosp Carl Gustav Carus, Dresden, Germany

Thiem, DT:
 Univ Hosp Carl Gustav Carus, Dresden, Germany

Koch, T:
 Univ Hosp Carl Gustav Carus, Dresden, Germany

Treschan, T:
 Heinrich Heine Univ, Duesseldorf Univ Hosp, Dusseldorf, Germany

Schaefer, M:
 Heinrich Heine Univ, Duesseldorf Univ Hosp, Dusseldorf, Germany

Bastin, B:
 Heinrich Heine Univ, Duesseldorf Univ Hosp, Dusseldorf, Germany

Geib, J:
 Heinrich Heine Univ, Duesseldorf Univ Hosp, Dusseldorf, Germany

Weiss, M:
 Heinrich Heine Univ, Duesseldorf Univ Hosp, Dusseldorf, Germany

Kienbaum, P:
 Heinrich Heine Univ, Duesseldorf Univ Hosp, Dusseldorf, Germany

Pannen, B:
 Heinrich Heine Univ, Duesseldorf Univ Hosp, Dusseldorf, Germany

Gottschalk, A:
 Diakoniekrankenhaus Friederikenstift, Hannover, Germany

Konrad, M:
 Diakoniekrankenhaus Friederikenstift, Hannover, Germany

Westerheide, D:
 Diakoniekrankenhaus Friederikenstift, Hannover, Germany

Schwerdtfeger, B:
 Diakoniekrankenhaus Friederikenstift, Hannover, Germany

Wrigge, H:
 Univ Leipzig, Dept Anesthesiol & Intens Care Med, Leipzig, Germany

 Univ Leipzig, Leipzig, Germany

Simon, P:
 Univ Leipzig, Leipzig, Germany

Reske, A:
 Univ Leipzig, Leipzig, Germany

Nestler, C:
 Univ Leipzig, Leipzig, Germany

Valsamidis, D:
 Alexandra Gen Hosp Athens, Athens, Greece

Stroumpoulis, K:
 Alexandra Gen Hosp Athens, Athens, Greece

Antholopoulos, G:
 Gen Air Force Hosp, Athens, Greece

Andreou, A:
 Gen Air Force Hosp, Athens, Greece

Karapanos, D:
 Gen Air Force Hosp, Athens, Greece

Theodorak, K:
 Aretaie Univ Hosp, Athens, Greece

Gkiokas, G:
 Aretaie Univ Hosp, Athens, Greece

Tasoulis, MK:
 Aretaie Univ Hosp, Athens, Greece

Sidiropoulou, T:
 Attikon Univ Hosp, Athens, Greece

Zafeiropoulou, F:
 Attikon Univ Hosp, Athens, Greece

Florou, P:
 Attikon Univ Hosp, Athens, Greece

Pandazi, A:
 Attikon Univ Hosp, Athens, Greece

Tsaousi, G:
 Ahepa Univ Hosp Thessaloniki, Thessaloniki, Greece

Nouris, C:
 Ahepa Univ Hosp Thessaloniki, Thessaloniki, Greece

Pourzitaki, C:
 Ahepa Univ Hosp Thessaloniki, Thessaloniki, Greece

Bystritski, D:
 Lady Davis Carmel Med Ctr, Haifa, Israel

Pizov, R:
 Lady Davis Carmel Med Ctr, Haifa, Israel

Eden, A:
 Lady Davis Carmel Med Ctr, Haifa, Israel

Pesce, CV:
 Osped San Paolo Bari, Bari, Italy

Campanile, A:
 Osped San Paolo Bari, Bari, Italy

Marrella, A:
 Osped San Paolo Bari, Bari, Italy

Grasso, S:
 Univ Bari Aldo Moro, Bari, Italy

De Michele, M:
 Univ Bari Aldo Moro, Bari, Italy

Bona, F:
 Inst Canc Res & Treatment, Turin, Italy

Giacoletto, G:
 Inst Canc Res & Treatment, Turin, Italy

Sardo, E:
 Inst Canc Res & Treatment, Turin, Italy

Sottosanti, LGV:
 Azienda Osped Iemergenza Cannizzaro, Catania, Italy

Solca, M:
 Osped Melegnano, Milan, Italy

Volta, CA:
 Azienda Osped Univ St Anna, Ferrara, Italy

Spadaro, S:
 Azienda Osped Univ St Anna, Ferrara, Italy

Verri, M:
 Azienda Osped Univ St Anna, Ferrara, Italy

Ragazzi, R:
 Azienda Osped Univ St Anna, Ferrara, Italy

Zoppellari, R:
 Azienda Osped Univ St Anna, Ferrara, Italy

Cinnella, G:
 Univ Foggia, Osped Riuniti Foggia, Foggia, Italy

Raimondo, P:
 Univ Foggia, Osped Riuniti Foggia, Foggia, Italy

La Bella, D:
 Univ Foggia, Osped Riuniti Foggia, Foggia, Italy

Mirabella, L:
 Univ Foggia, Osped Riuniti Foggia, Foggia, Italy

D'antini, D:
 Univ Foggia, Osped Riuniti Foggia, Foggia, Italy

Molin, A:
 Univ Genoa, IRCCS AOU San Martino IST Hosp, Genoa, Italy

Brunetti, I:
 Univ Genoa, IRCCS AOU San Martino IST Hosp, Genoa, Italy

Gratarola, A:
 Univ Genoa, IRCCS AOU San Martino IST Hosp, Genoa, Italy

Pellerano, G:
 Univ Genoa, IRCCS AOU San Martino IST Hosp, Genoa, Italy

Sileo, R:
 Univ Genoa, IRCCS AOU San Martino IST Hosp, Genoa, Italy

Pezzatto, S:
 Univ Genoa, IRCCS AOU San Martino IST Hosp, Genoa, Italy

Montagnani, L:
 Univ Genoa, IRCCS AOU San Martino IST Hosp, Genoa, Italy

Pasin, L:
 IRCCS San Raffaele Sci Inst, Milan, Italy

Landoni, G:
 IRCCS San Raffaele Sci Inst, Milan, Italy

Zangrillo, A:
 IRCCS San Raffaele Sci Inst, Milan, Italy

Beretta, L:
 IRCCS San Raffaele Sci Inst, Milan, Italy

Di Parma, AL:
 IRCCS San Raffaele Sci Inst, Milan, Italy

Tarzia, V:
 IRCCS San Raffaele Sci Inst, Milan, Italy

Dossi, R:
 IRCCS San Raffaele Sci Inst, Milan, Italy

Sassone, ME:
 IRCCS San Raffaele Sci Inst, Milan, Italy

Sances, D:
 Ist Europeo Oncol Ieo, Milan, Italy

Tredici, S:
 Ist Europeo Oncol Ieo, Milan, Italy

Spano, G:
 Ist Europeo Oncol Ieo, Milan, Italy

Castellani, G:
 Ist Europeo Oncol Ieo, Milan, Italy

Delunas, L:
 Ist Europeo Oncol Ieo, Milan, Italy

Peradze, S:
 Ist Europeo Oncol Ieo, Milan, Italy

Venturino, M:
 Ist Europeo Oncol Ieo, Milan, Italy

Arpino, I:
 Osped Niguarda Ca Granda Milano, Milan, Italy

Sher, S:
 Osped Niguarda Ca Granda Milano, Milan, Italy

Tommasino, C:
 Univ Milan, Osped San Paolo, Milan, Italy

Rapido, F:
 Univ Milan, Osped San Paolo, Milan, Italy

Morelli, P:
 Univ Milan, Osped San Paolo, Milan, Italy

Vargas, M:
 Univ Naples Federico II Naples, Naples, Italy

Servillo, G:
 Univ Naples Federico II Naples, Naples, Italy

Raineri, SM:
 Policlin P Giaccone, Palermo, Italy

Montalto, F:
 Policlin P Giaccone, Palermo, Italy

Russotto, V:
 Policlin P Giaccone, Palermo, Italy

Giarratano, A:
 Policlin P Giaccone, Palermo, Italy

Baciarello, M:
 Azienda Osped Univ, Parma, Italy

Generali, M:
 Azienda Osped Univ, Parma, Italy

Cerati, G:
 Azienda Osped Univ, Parma, Italy

Leykin, Y:
 Santa Maria Angeli, Pordenone, Italy

Bressan, F:
 Osped Misericordia & Dolce Usl4 Prato, Prato, Italy

Bartolini, V:
 Osped Misericordia & Dolce Usl4 Prato, Prato, Italy

Zamidei, L:
 Osped Misericordia & Dolce Usl4 Prato, Prato, Italy

Brazzi, L:
 Univ Hosp Sassari, Sassari, Italy

Liperi, C:
 Univ Hosp Sassari, Sassari, Italy

Sales, G:
 Univ Hosp Sassari, Sassari, Italy

Pistidda, L:
 Univ Hosp Sassari, Sassari, Italy

Severgnini, P:
 Univ Insubria, ASST Sette Laghi Osped Circolo, Dept Biotechnol & Sci Life, Varese, Italy

 Univ Insubria, Fdn Macchi, Varese, Italy

 Insubria Univ, Varese, Italy

Brugnoni, E:
 Insubria Univ, Varese, Italy

Musella, G:
 Insubria Univ, Varese, Italy

Bacuzzi, A:
 Insubria Univ, Varese, Italy

Muhardri, D:
 Distr Hosp Gjakova, Gjakove, Kosovo

Gecaj-Gashi, A:
 Univ Clin Ctr Kosova, Prishtina, Kosovo

Sada, F:
 Univ Clin Ctr Kosova, Prishtina, Kosovo

Bytyqi, A:
 Reg Hosp Prim Dr Daut Mustafa, Prizren, Kosovo

Karbonskiene, A:
 Hosp Lithuanian Univ Hlth Sci, Med Univ Hosp, Kaunas, Lithuania

Aukstakalniene, R:
 Hosp Lithuanian Univ Hlth Sci, Med Univ Hosp, Kaunas, Lithuania

Teberaite, Z:
 Hosp Lithuanian Univ Hlth Sci, Med Univ Hosp, Kaunas, Lithuania

Salciute, E:
 Hosp Lithuanian Univ Hlth Sci, Med Univ Hosp, Kaunas, Lithuania

Tikuisis, R:
 Vilnius Univ Hosp, Inst Oncol, Vilnius, Lithuania

Miliauskas, P:
 Vilnius Univ Hosp, Inst Oncol, Vilnius, Lithuania

Jurate, S:
 Vilnius Univ Hosp, Santariskiu Clin, Vilnius, Lithuania

Kontrimaviciute, E:
 Vilnius Univ Hosp, Santariskiu Clin, Vilnius, Lithuania

Tomkute, G:
 Vilnius Univ Hosp, Santariskiu Clin, Vilnius, Lithuania

Xuereb, J:
 Mater Dei Hosp, Msida, Malta

Bezzina, M:
 Mater Dei Hosp, Msida, Malta

Borg, FJ:
 Mater Dei Hosp, Msida, Malta

Hemmes, S:
 Univ Amsterdam, Dept Intens Care, Amsterdam, Netherlands

 Univ Amsterdam, Amsterdam UMC, Lab Expt Intens Care & Anesthesia, Amsterdam, Netherlands

 Univ Amsterdam, Amsterdam UMC, Dept Anaesthesiol, Amsterdam, Netherlands

 Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands

Schultz, M:
 Univ Amsterdam, Dept Intens Care, Amsterdam, Netherlands

 Univ Amsterdam, Amsterdam UMC, Lab Expt Intens Care & Anesthesia, Amsterdam, Netherlands

 Mahidol Univ, Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand

 Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands

Hollmann, M:
 Univ Amsterdam, Amsterdam UMC, Dept Anaesthesiol, Amsterdam, Netherlands

 Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands

Wiersma, I:
 Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands

Binnekade, J:
 Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands

Bos, L:
 Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands

Boer, C:
 Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands

Duvekot, A:
 Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands

in 't Veld, B:
 MC Haaglanden, The Hague, Netherlands

Werger, A:
 MC Haaglanden, The Hague, Netherlands

Dennesen, P:
 MC Haaglanden, The Hague, Netherlands

Severijns, C:
 MC Haaglanden, The Hague, Netherlands

De Jong, J:
 Westfriesgasthuis, Hoorn, Netherlands

Hering, J:
 Westfriesgasthuis, Hoorn, Netherlands

van Beek, R:
 Westfriesgasthuis, Hoorn, Netherlands

Ivars, S:
 Haukeland Hosp, Bergen, Norway

Jammer, I:
 Haukeland Hosp, Bergen, Norway

Breidablik, A:
 Forde Cent Hosp, Forde, Norway

Hodt, KS:
 Martina Hansens Hosp, Gjettum, Norway

Fjellanger, F:
 Martina Hansens Hosp, Gjettum, Norway

Avalos, MV:
 Martina Hansens Hosp, Gjettum, Norway

Mellin-Olsen, J:
 Vestre Viken, Baerum Hosp, Rud, Norway

Andersson, E:
 Vestre Viken, Baerum Hosp, Rud, Norway

Shafi-Kabiri, A:
 Stavanger Univ Hosp, Stavanger, Norway

Molina, R:
 Hosp Santo Tomas, Panama City, Panama

Wutai, S:
 Hosp Santo Tomas, Panama City, Panama

Morais, E:
 Hosp Santo Tomas, Panama City, Panama

Tareco, G:
 Hosp Espirito Santo Evora, EPE, Evora, Portugal

Ferreira, D:
 Hosp Espirito Santo Evora, EPE, Evora, Portugal

Amaral, J:
 Hosp Espirito Santo Evora, EPE, Evora, Portugal

Castro, MDG:
 Ctr Hosp Lisboa Cent, EPE, Lisbon, Portugal

Cadilha, S:
 Ctr Hosp Lisboa Cent, EPE, Lisbon, Portugal

Appleton, S:
 Ctr Hosp Lisboa Cent, EPE, Lisbon, Portugal

Parente, S:
 EPE Hosp S Francisco Xavier, Ctr Hosp Lisboa Ocidental, Lisbon, Portugal

Correia, M:
 EPE Hosp S Francisco Xavier, Ctr Hosp Lisboa Ocidental, Lisbon, Portugal

Martins, D:
 EPE Hosp S Francisco Xavier, Ctr Hosp Lisboa Ocidental, Lisbon, Portugal

Monteirosa, A:
 Santarem Hosp, Santarem, Portugal

Ricardo, A:
 Santarem Hosp, Santarem, Portugal

Rodrigues, S:
 Santarem Hosp, Santarem, Portugal

Horhota, L:
 Spital Orasenesc, Bolintin, Vale, Romania

Grintescu, IM:
 Clin Emergency Hosp Bucharest, Bucharest, Romania

Mirea, L:
 Clin Emergency Hosp Bucharest, Bucharest, Romania

Grintescu, IC:
 Clin Emergency Hosp Bucharest, Bucharest, Romania

Corneci, D:
 Elias Univ Emergency Hosp, Bucharest, Romania

Negoita, S:
 Elias Univ Emergency Hosp, Bucharest, Romania

Dutu, M:
 Elias Univ Emergency Hosp, Bucharest, Romania

Garotescu, IP:
 Elias Univ Emergency Hosp, Bucharest, Romania

Filipescu, D:
 Emergency Inst Cardiovasc Dis Inst Prof CC Iliesc, Bucharest, Romania

Prodan, AB:
 Emergency Inst Cardiovasc Dis Inst Prof CC Iliesc, Bucharest, Romania

Droc, G:
 Fundeni Clin Inst Anaesthesia & Intens Care, Bucharest, Romania

Fota, R:
 Fundeni Clin Inst Anaesthesia & Intens Care, Bucharest, Romania

Popescu, M:
 Fundeni Clin Inst Anaesthesia & Intens Care, Bucharest, Romania

Tomescu, D:
 Fundeni Clin Inst, Intens Care Unit, Bucharest, Romania

Petcu, AM:
 Fundeni Clin Inst, Intens Care Unit, Bucharest, Romania

Tudoroiu, MI:
 Fundeni Clin Inst, Intens Care Unit, Bucharest, Romania

Moise, A:
 Hosp Prof D Gerota, Bucharest, Romania

Guran, CT:
 Hosp Prof D Gerota, Bucharest, Romania

Gherghina, I:
 Constanta Cty Emergency Hosp, Constanta, Romania

Costea, D:
 Constanta Cty Emergency Hosp, Constanta, Romania

Cindea, I:
 Constanta Cty Emergency Hosp, Constanta, Romania

Copotoiu, SM:
 Univ Emergency Cty Hosp Targu Mures, Targu Mures, Romania

Copotoiu, R:
 Univ Emergency Cty Hosp Targu Mures, Targu Mures, Romania

Barsan, V:
 Univ Emergency Cty Hosp Targu Mures, Targu Mures, Romania

Tolcser, Z:
 Univ Emergency Cty Hosp Targu Mures, Targu Mures, Romania

Riciu, M:
 Univ Emergency Cty Hosp Targu Mures, Targu Mures, Romania

Moldovan, SG:
 Univ Emergency Cty Hosp Targu Mures, Targu Mures, Romania

Veres, M:
 Univ Emergency Cty Hosp Targu Mures, Targu Mures, Romania

Gritsan, A:
 Krasnoyarsk State Med Univ, Krasnoyarsk, Russia

Kapkan, T:
 Krasnoyarsk State Med Univ, Krasnoyarsk, Russia

Gritsan, G:
 Krasnoyarsk State Med Univ, Krasnoyarsk, Russia

Korolkov, O:
 Krasnoyarsk State Med Univ, Krasnoyarsk, Russia

Kulikov, A:
 Burdenko Neurosurg Inst, Moscow, Russia

Lubnin, A:
 Burdenko Neurosurg Inst, Moscow, Russia

Ovezov, A:
 Moscow Reg Res Clin Inst, Moscow, Russia

Prokoshev, P:
 Moscow Reg Res Clin Inst, Moscow, Russia

Lugovoy, A:
 Moscow Reg Res Clin Inst, Moscow, Russia

Anipchenko, N:
 Moscow Reg Res Clin Inst, Moscow, Russia

Babayants, A:
 Municipal Clin Hosp 7, Moscow, Russia

Komissarova, I:
 Municipal Clin Hosp 7, Moscow, Russia

Zalina, K:
 Municipal Clin Hosp 7, Moscow, Russia

Likhvantsev, V:
 Reanimatol Res Inst, Moscow, Russia

Fedorov, S:
 Reanimatol Res Inst, Moscow, Russia

Lazukic, A:
 Clin Ctr Vojvodina, Emergency Ctr, Novisad, Serbia

Pejakovic, J:
 Clin Ctr Vojvodina, Emergency Ctr, Novisad, Serbia

Mihajlovic, D:
 Clin Ctr Vojvodina, Emergency Ctr, Novisad, Serbia

Kusnierikova, Z:
 Natl Canc Inst, Bratislava, Slovakia

Zelinkova, M:
 Natl Canc Inst, Bratislava, Slovakia

Bruncakova, K:
 FD Roosevelt Teaching Hosp, Banska Bystrica, Slovakia

Polakovicova, L:
 FD Roosevelt Teaching Hosp, Banska Bystrica, Slovakia

Sobona, V:
 Fac Hosp Nove Zamky, Nove Zamky, Slovakia

Novak-Supe, B:
 Inst Oncol Ljubljana, Ljubljana, Slovenia

Pekle-Golez, A:
 Inst Oncol Ljubljana, Ljubljana, Slovenia

Jovanov, M:
 Inst Oncol Ljubljana, Ljubljana, Slovenia

Strazisar, B:
 Inst Oncol Ljubljana, Ljubljana, Slovenia

Markovic-Bozic, J:
 Univ Med Ctr Ljubljana, Ljubljana, Slovenia

Novak-Jankovic, V:
 Univ Med Ctr Ljubljana, Ljubljana, Slovenia

Voje, M:
 Univ Med Ctr Ljubljana, Ljubljana, Slovenia

Grynyuk, A:
 Univ Med Ctr Ljubljana, Ljubljana, Slovenia

Kostadinov, I:
 Univ Med Ctr Ljubljana, Ljubljana, Slovenia

Spindler-Vesel, A:
 Univ Med Ctr Ljubljana, Ljubljana, Slovenia

Moral, V:
 Hosp Santa Creu & Sant Pau, Barcelona, Spain

Unzueta, MC:
 Hosp Santa Creu & Sant Pau, Barcelona, Spain

Puigbo, C:
 Hosp Santa Creu & Sant Pau, Barcelona, Spain

Fava, J:
 Hosp Santa Creu & Sant Pau, Barcelona, Spain

Moret, E:
 Hosp Badalona Germans Trias & Pujol, Barcelona, Spain

Nunez, MR:
 Hosp Badalona Germans Trias & Pujol, Barcelona, Spain

Sendra, M:
 Hosp Badalona Germans Trias & Pujol, Barcelona, Spain

Brunelli, A:
 Hosp Badalona Germans Trias & Pujol, Barcelona, Spain

Rodenas, F:
 Hosp Badalona Germans Trias & Pujol, Barcelona, Spain

Monedero, P:
 Univ Navarra, Pamplona, Spain

Martinez, FH:
 Univ Navarra, Pamplona, Spain

Temino, MJY:
 Univ Navarra, Pamplona, Spain

Simon, AM:
 Univ Navarra, Pamplona, Spain

Larriba, AD:
 Univ Navarra, Pamplona, Spain

Lisi, A:
 Corp Sanitaria Parc Tauli, Sabadell, Spain

Perez, G:
 Corp Sanitaria Parc Tauli, Sabadell, Spain

Martinez, R:
 Corp Sanitaria Parc Tauli, Sabadell, Spain

Granell, M:
 Consorcio Hosp Gen Univ Valencia, Valencia, Spain

Vivo, JT:
 Consorcio Hosp Gen Univ Valencia, Valencia, Spain

Ruiz, CS:
 Consorcio Hosp Gen Univ Valencia, Valencia, Spain

Ibanez, JAD:
 Consorcio Hosp Gen Univ Valencia, Valencia, Spain

Pastor, E:
 Hosp Clin Valencia, Valencia, Spain

Soro, M:
 Hosp Clin Valencia, Valencia, Spain

Ferrando, C:
 Hosp Clin Valencia, Valencia, Spain

Defez, M:
 Hosp Clin Valencia, Valencia, Spain

Alvares-Santullano, CA:
 Hosp Univ Rio Hortega, Valladolid, Spain

Perez, R:
 Hosp Univ Rio Hortega, Valladolid, Spain

Jawad, M:
 Cent Hosp Kristianstad, Kristianstad, Sweden

Saeed, Y:
 Cent Hosp Kristianstad, Kristianstad, Sweden

Gillberg, L:
 Cent Hosp Kristianstad, Kristianstad, Sweden

Bengisun, ZK:
 Ufuk Univ Hosp Ankara, Ankara, Turkey

Kazbek, BK:
 Ufuk Univ Hosp Ankara, Ankara, Turkey

Coskunfirat, N:
 Akdeniz Univ Hosp, Antalya, Turkey

Boztug, N:
 Akdeniz Univ Hosp, Antalya, Turkey

Sanli, S:
 Akdeniz Univ Hosp, Antalya, Turkey

Yilmaz, M:
 Akdeniz Univ Hosp, Antalya, Turkey

Hadimioglu, N:
 Akdeniz Univ Hosp, Antalya, Turkey

Senturk, NM:
 Istanbul Univ, Istanbul Med Fac, Istanbul, Turkey

Camci, E:
 Istanbul Univ, Istanbul Med Fac, Istanbul, Turkey

Kucukgoncu, S:
 Istanbul Univ, Istanbul Med Fac, Istanbul, Turkey

Sungur, Z:
 Istanbul Univ, Istanbul Med Fac, Istanbul, Turkey

Sivrikoz, N:
 Istanbul Univ, Istanbul Med Fac, Istanbul, Turkey

Ozgen, SU:
 Acibadem Univ, Istanbul, Turkey

Toraman, F:
 Acibadem Univ, Istanbul, Turkey

Selvi, O:
 Maltepe Univ, Istanbul, Turkey

Senturk, O:
 Maltepe Univ, Istanbul, Turkey

Yildiz, M:
 Maltepe Univ, Istanbul, Turkey

Kuvaki, B:
 Dokuz Eylul Univ, Tip Fak, Izmir, Turkey

Gunenc, F:
 Dokuz Eylul Univ, Tip Fak, Izmir, Turkey

Kucukguclu, S:
 Dokuz Eylul Univ, Tip Fak, Izmir, Turkey

Ozbilgin, S:
 Dokuz Eylul Univ, Tip Fak, Izmir, Turkey

Maral, J:
 Ifa Univ Hosp, Izmir, Turkey

Canli, S:
 Ifa Univ Hosp, Izmir, Turkey

Arun, O:
 Selcuk Univ, Fac Med, Konya, Turkey

Saltali, A:
 Selcuk Univ, Fac Med, Konya, Turkey

Aydogan, E:
 Selcuk Univ, Fac Med, Konya, Turkey

Akgun, FN:
 Fatih Sultan Mehmet Egitim & Aratirma Hastanesi, Istanbul, Turkey

Sanlikarip, C:
 Fatih Sultan Mehmet Egitim & Aratirma Hastanesi, Istanbul, Turkey

Karaman, FM:
 Fatih Sultan Mehmet Egitim & Aratirma Hastanesi, Istanbul, Turkey

Mazur, A:
 Inst Surg & Transplantol, Kiev, Ukraine

Vorotyntsev, S:
 Zaporizhzhia State Med Univ, Zaporizhzhia, Ukraine

Rousseau, G:
 Northern Devon Healthcare NHS Trust, Barnstaple, England

Barrett, C:
 Northern Devon Healthcare NHS Trust, Barnstaple, England

Stancombe, L:
 Northern Devon Healthcare NHS Trust, Barnstaple, England

Shelley, B:
 Golden Jubilee Natl Hosp, Clydebank, Scotland

Scholes, H:
 Golden Jubilee Natl Hosp, Clydebank, Scotland

Limb, J:
 Cty Durham & Darlington Fdn NHS Trust, Darlington Mem Hosp, Darlington, Durham, England

Rafi, A:
 Cty Durham & Darlington Fdn NHS Trust, Darlington Mem Hosp, Darlington, Durham, England

Wayman, L:
 Cty Durham & Darlington Fdn NHS Trust, Darlington Mem Hosp, Darlington, Durham, England

Deane, J:
 Cty Durham & Darlington Fdn NHS Trust, Darlington Mem Hosp, Darlington, Durham, England

Rogerson, D:
 Royal Derby Hosp, Derby, England

Williams, J:
 Royal Derby Hosp, Derby, England

Yates, S:
 Royal Derby Hosp, Derby, England

Rogers, E:
 Royal Derby Hosp, Derby, England

Pulletz, M:
 Dorset Cty Hosp, Dorchester, England

Moreton, S:
 Dorset Cty Hosp, Dorchester, England

Jones, S:
 Dorset Cty Hosp, Dorchester, England

Venkatesh, S:
 Princess Alexandra NHS Hosp Trust, Harlow, Essex, England

Burton, M:
 Princess Alexandra NHS Hosp Trust, Harlow, Essex, England

Brown, L:
 Princess Alexandra NHS Hosp Trust, Harlow, Essex, England

Goodall, C:
 Princess Alexandra NHS Hosp Trust, Harlow, Essex, England

Rucklidge, M:
 Royal Devon & Exeter NHS Fdn Trust, Exeter, Devon, England

Fuller, D:
 Royal Devon & Exeter NHS Fdn Trust, Exeter, Devon, England

Nadolski, M:
 Royal Devon & Exeter NHS Fdn Trust, Exeter, Devon, England

Kusre, S:
 Royal Devon & Exeter NHS Fdn Trust, Exeter, Devon, England

Lundberg, M:
 Hosp James Paget Univ Hosp NHS Fdn Trust, Great Yarmouth, England

Everett, L:
 Hosp James Paget Univ Hosp NHS Fdn Trust, Great Yarmouth, England

Nutt, H:
 Hosp James Paget Univ Hosp NHS Fdn Trust, Great Yarmouth, England

Zuleika, M:
 Royal Surrey Cty Hosp NHS Fdn Trust, Guildford, Surrey, England

Carvalho, P:
 Royal Surrey Cty Hosp NHS Fdn Trust, Guildford, Surrey, England

Clements, D:
 Royal Surrey Cty Hosp NHS Fdn Trust, Guildford, Surrey, England

Creagh-Brown, B:
 Royal Surrey Cty Hosp NHS Fdn Trust, Guildford, Surrey, England

Watt, P:
 Kettering Gen Hosp NHS Fdn Trust, Kettering, England

Raymode, P:
 Kettering Gen Hosp NHS Fdn Trust, Kettering, England

Pearse, R:
 Royal London Hosp, Barts Hlth NHS Trust, London, England

Mohr, O:
 Royal London Hosp, Barts Hlth NHS Trust, London, England

Raj, A:
 Royal London Hosp, Barts Hlth NHS Trust, London, England

Creary, T:
 Royal London Hosp, Barts Hlth NHS Trust, London, England

Chishti, A:
 Freeman Hosp High Heaton, Newcastle Upon Tyne Hosp NHS Trust, Newcastle Upon Tyne, Tyne & Wear, England

Bell, A:
 Freeman Hosp High Heaton, Newcastle Upon Tyne Hosp NHS Trust, Newcastle Upon Tyne, Tyne & Wear, England

Higham, C:
 Freeman Hosp High Heaton, Newcastle Upon Tyne Hosp NHS Trust, Newcastle Upon Tyne, Tyne & Wear, England

Cain, A:
 Freeman Hosp High Heaton, Newcastle Upon Tyne Hosp NHS Trust, Newcastle Upon Tyne, Tyne & Wear, England

Gibb, S:
 Freeman Hosp High Heaton, Newcastle Upon Tyne Hosp NHS Trust, Newcastle Upon Tyne, Tyne & Wear, England

Mowat, S:
 Freeman Hosp High Heaton, Newcastle Upon Tyne Hosp NHS Trust, Newcastle Upon Tyne, Tyne & Wear, England

Franklin, D:
 Derriford Hosp Plymouth Hosp NHS Trust, Plymouth, Devon, England

West, C:
 Derriford Hosp Plymouth Hosp NHS Trust, Plymouth, Devon, England

Minto, G:
 Derriford Hosp Plymouth Hosp NHS Trust, Plymouth, Devon, England

Boyd, N:
 Derriford Hosp Plymouth Hosp NHS Trust, Plymouth, Devon, England

Mills, G:
 Sheffield Teaching Hosp, Operating Serv Crit Care & Anesthesia, Sheffield, S Yorkshire, England

 Univ Sheffield, Sheffield, S Yorkshire, England

 Royal Hallamshire Hosp, Sheffield, S Yorkshire, England

Calton, E:
 Royal Hallamshire Hosp, Sheffield, S Yorkshire, England

Walker, R:
 Royal Hallamshire Hosp, Sheffield, S Yorkshire, England

Mackenzie, F:
 Royal Hallamshire Hosp, Sheffield, S Yorkshire, England

Ellison, B:
 Royal Hallamshire Hosp, Sheffield, S Yorkshire, England

Roberts, H:
 Royal Hallamshire Hosp, Sheffield, S Yorkshire, England

Chikungwa, M:
 Mid Staffordshire NHS, Stafford, England

Jackson, C:
 Mid Staffordshire NHS, Stafford, England

Donovan, A:
 Musgrove Pk Hosp, Taunton, Somerset, England

Foot, J:
 Musgrove Pk Hosp, Taunton, Somerset, England

Homan, E:
 Musgrove Pk Hosp, Taunton, Somerset, England

Montgomery, J:
 Torbay Hosp, South Devon Healthcare NHS Fdn Trust, Torquay, Torbay, England

Portch, D:
 Torbay Hosp, South Devon Healthcare NHS Fdn Trust, Torquay, Torbay, England

Mercer, P:
 Torbay Hosp, South Devon Healthcare NHS Fdn Trust, Torquay, Torbay, England

Palmer, J:
 Torbay Hosp, South Devon Healthcare NHS Fdn Trust, Torquay, Torbay, England

Paddle, J:
 Royal Cornwall Hosp, Truro, England

Fouracres, A:
 Royal Cornwall Hosp, Truro, England

Datson, A:
 Royal Cornwall Hosp, Truro, England

Andrew, A:
 Royal Cornwall Hosp, Truro, England

Welch, L:
 Royal Cornwall Hosp, Truro, England

Rose, A:
 Mid Yorkshire Hosp NHS Trust, Wakefield, England

 Pinderfields Gen Hosp, Wakefield, England

Varma, S:
 Mid Yorkshire Hosp NHS Trust, Wakefield, England

 Pinderfields Gen Hosp, Wakefield, England

Simeson, K:
 Mid Yorkshire Hosp NHS Trust, Wakefield, England

 Pinderfields Gen Hosp, Wakefield, England

Rambhatla, M:
 Sandwell & West Birmingham NHS Trust, West Bromich, England

Susarla, J:
 Sandwell & West Birmingham NHS Trust, West Bromich, England

Marri, S:
 Sandwell & West Birmingham NHS Trust, West Bromich, England

Kodaganallur, K:
 Sandwell & West Birmingham NHS Trust, West Bromich, England

Das, A:
 Sandwell & West Birmingham NHS Trust, West Bromich, England

Algarsamy, S:
 Sandwell & West Birmingham NHS Trust, West Bromich, England

Colley, J:
 Sandwell & West Birmingham NHS Trust, West Bromich, England

Davies, S:
 York Teaching Hosp NHS Fdn Trust, York, N Yorkshire, England

Szewczyk, M:
 York Teaching Hosp NHS Fdn Trust, York, N Yorkshire, England

Smith, T:
 York Teaching Hosp NHS Fdn Trust, York, N Yorkshire, England

Fernandez-Bustamante, A:
 Univ Colorado, Sch Med, Univ Colorado Hosp, Aurora, CO USA

Luzier, E:
 Univ Colorado, Sch Med, Univ Colorado Hosp, Aurora, CO USA

Almagro, A:
 Univ Colorado, Sch Med, Univ Colorado Hosp, Aurora, CO USA

Melo, MV:
 Massachusetts Gen Hosp, Boston, MA 02114 USA

Fernando, L:
 Massachusetts Gen Hosp, Boston, MA 02114 USA

Sulemanji, D:
 Massachusetts Gen Hosp, Boston, MA 02114 USA

Sprung, J:
 Mayo Clin, Rochester, MN USA

Weingarten, T:
 Mayo Clin, Rochester, MN USA

Kor, D:
 Mayo Clin, Rochester, MN USA

Scavonetto, F:
 Mayo Clin, Rochester, MN USA

Tze, Y:
 Mayo Clin, Rochester, MN USA
ISSN: 00070912





BRITISH JOURNAL OF ANAESTHESIA
Editorial
ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND, Reino Unido
Tipo de documento: Article
Volumen: 122 Número: 3
Páginas: 361-369
WOS Id: 000458513600019
ID de PubMed: 30770054
imagen Green Published, Bronze

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