Dopamine modulates the reward experiences elicited by music
Por:
Ferreri, L, Mas-Herrero, E, Zatorre, RJ, Ripolles, P, Gomez-Andres, A, Alicart, H, Olive, G, Marco-Pallares, J, Antonijoan, RM, Valle, M, Riba, J, Rodriguez-Fornells, A
Publicada:
26 feb 2019
Resumen:
Understanding how the brain translates a structured sequence of sounds, such as music, into a pleasant and rewarding experience is a fascinating question which may be crucial to better understand the processing of abstract rewards in humans. Previous neuroimaging findings point to a challenging role of the dopaminergic system in music-evoked pleasure. However, there is a lack of direct evidence showing that dopamine function is causally related to the pleasure we experience from music. We addressed this problem through a double blind within-subject pharmacological design in which we directly manipulated dopaminergic synaptic availability while healthy participants (n = 27) were engaged in music listening. We orally administrated to each participant a dopamine precursor (levodopa), a dopamine antagonist (risperidone), and a placebo (lactose) in three different sessions. We demonstrate that levodopa and risperidone led to opposite effects in measures ofmusical pleasure and motivation: while the dopamine precursor levodopa, compared with placebo, increased the hedonic experience and music-related motivational responses, risperidone led to a reduction of both. This study shows a causal role of dopamine in musical pleasure and indicates that dopaminergic transmission might play different or additive roles than the ones postulated in affective processing so far, particularly in abstract cognitive activities.
Filiaciones:
Ferreri, L:
Bellvitge Biomed Res Inst, Cognit & Brain Plast Unit, Barcelona 08907, Spain
Univ Barcelona, Dept Cognit Dev & Educ Psychol, Barcelona 08035, Spain
Univ Lumiere Lyon 2, Lab Etud Mecanismes Cognitifs, F-69676 Lyon, France
Mas-Herrero, E:
McGill Univ, Montreal Neurol Inst, Montreal, PQ H3A 2B4, Canada
Int Lab Brain Mus & Sound Res, Montreal, PQ H2V 4P3, Canada
Zatorre, RJ:
McGill Univ, Montreal Neurol Inst, Montreal, PQ H3A 2B4, Canada
Int Lab Brain Mus & Sound Res, Montreal, PQ H2V 4P3, Canada
Ripolles, P:
NYU, Dept Psychol, 6 Washington Pl, New York, NY 10003 USA
Gomez-Andres, A:
Bellvitge Biomed Res Inst, Cognit & Brain Plast Unit, Barcelona 08907, Spain
Univ Barcelona, Dept Cognit Dev & Educ Psychol, Barcelona 08035, Spain
Alicart, H:
Bellvitge Biomed Res Inst, Cognit & Brain Plast Unit, Barcelona 08907, Spain
Olive, G:
Bellvitge Biomed Res Inst, Cognit & Brain Plast Unit, Barcelona 08907, Spain
Univ Barcelona, Dept Cognit Dev & Educ Psychol, Barcelona 08035, Spain
Marco-Pallares, J:
Bellvitge Biomed Res Inst, Cognit & Brain Plast Unit, Barcelona 08907, Spain
Univ Barcelona, Dept Cognit Dev & Educ Psychol, Barcelona 08035, Spain
Univ Barcelona, Inst Neurosci, Barcelona 08035, Spain
Antonijoan, RM:
Hosp Santa Creu & Sant Pau, Serv Farmacol Clin, Ctr Invest Medicaments, Barcelona 08041, Spain
Univ Autonoma Barcelona, Dept Farmacol & Terapeut, E-08193 Barcelona, Spain
Valle, M:
Univ Autonoma Barcelona, Dept Farmacol & Terapeut, E-08193 Barcelona, Spain
St Pau Inst Biomed Res, Pharmacokinet Pharmacodynam Modeling & Simulat, Barcelona 08041, Spain
Riba, J:
Maastricht Univ, Dept Neuropsychol & Psychopharmacol, NL-6229 Maastricht, Netherlands
Rodriguez-Fornells, A:
Bellvitge Biomed Res Inst, Cognit & Brain Plast Unit, Barcelona 08907, Spain
Univ Barcelona, Dept Cognit Dev & Educ Psychol, Barcelona 08035, Spain
Inst Catalana Recerca & Estudis Avancats, Barcelona 08010, Spain
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