Effectiveness and impact of the hepatitis B vaccination program in preadolescents in Catalonia 21 years after its introduction
Por:
Borras, E, Urbiztondo, L, Carmona, G, Jane, M, Barrabeig, I, Sala, MR, Balana, JPJ, Company, M, Parron, I, Godoy, P, Rius, C, Soldevila, N, Cabezas, C, Dominguez, A, Alseda, M, Alvarez, J, Arias, C, Balana, PJ, Camps, N, Carol, M, Farras, J, Ferrus, G, Follia, N, Martinez, A, Minguell, S, Planas, C, Rovira, A, Sala, MR, Torres, J, Manzanares, S
Publicada:
21 feb 2019
Resumen:
Hepatitis B is a viral disease of global importance. In Catalonia in the 1980s, the seroepidemiological pattern of HBV infection was low-intermediate. In 1990, the Expert Committee on Vaccinations of the Department of Health of the Generalitat of Catalonia evaluated the systematic introduction of hepatitis B vaccination in preadolescents, maintaining the vaccination of risk groups. The objective of this study was to estimate the effectiveness and impact of the systematic hepatitis B vaccination programme in preadolescents in Catalonia 21 years after its introduction. A retrospective cohort study was conducted, comparing the disease incidence in vaccinated and unvaccinated cohorts. Cases of hepatitis B were defined as those reported by the General Subdirectorate of Surveillance and Response to Public Health Emergencies between 2000 and 2014. The incidence rate was 2.5 per 100,000 persons in 1991 and 1.2 per 100,000 persons in 2014, a reduction of 52%. During the study period, 388 cases of hepatitis B infection were notified, of which three were classified as vaccine failures. Vaccine effectiveness was 99.30% (95% CI: 97.83-99.78) and the population prevented fraction in the cohorts of preadolescents studied was 64.56% (95% CI: 60.45-68.66). The effectiveness and impact of the hepatitis B vaccination program in preadolescents in Catalonia is high, with the consequent benefits for the population. (C) 2019 Published by Elsevier Ltd.
Filiaciones:
Borras, E:
Generalitat Catalunya, Agencia Salut Publ Catalunya, Barcelona, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
Univ Barcelona, Dept Med, Barcelona, Spain
Agencia Salut Publ Catalunya, Barcelona, Spain
Urbiztondo, L:
Generalitat Catalunya, Agencia Salut Publ Catalunya, Barcelona, Spain
Agencia Salut Publ Catalunya, Barcelona, Spain
Carmona, G:
Generalitat Catalunya, Agencia Salut Publ Catalunya, Barcelona, Spain
Agencia Salut Publ Catalunya, Barcelona, Spain
Jane, M:
Generalitat Catalunya, Agencia Salut Publ Catalunya, Barcelona, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
Agencia Salut Publ Catalunya, Barcelona, Spain
Barrabeig, I:
Generalitat Catalunya, Agencia Salut Publ Catalunya, Barcelona, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
Agencia Salut Publ Catalunya, Barcelona, Spain
Sala, MR:
Generalitat Catalunya, Agencia Salut Publ Catalunya, Barcelona, Spain
Balana, JPJ:
Generalitat Catalunya, Agencia Salut Publ Catalunya, Barcelona, Spain
Company, M:
Generalitat Catalunya, Agencia Salut Publ Catalunya, Barcelona, Spain
Agencia Salut Publ Catalunya, Barcelona, Spain
Parron, I:
Generalitat Catalunya, Agencia Salut Publ Catalunya, Barcelona, Spain
Agencia Salut Publ Catalunya, Barcelona, Spain
Godoy, P:
Generalitat Catalunya, Agencia Salut Publ Catalunya, Barcelona, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
Agencia Salut Publ Catalunya, Barcelona, Spain
Rius, C:
CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
Agencia Salut Publ Barcelona, Barcelona, Spain
Soldevila, N:
CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
Univ Barcelona, Dept Med, Barcelona, Spain
Univ Barcelona, Barcelona, Spain
Cabezas, C:
Generalitat Catalunya, Agencia Salut Publ Catalunya, Barcelona, Spain
Agencia Salut Publ Catalunya, Barcelona, Spain
Dominguez, A:
CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
Univ Barcelona, Dept Med, Barcelona, Spain
Univ Barcelona, Barcelona, Spain
Alseda, M:
Agencia Salut Publ Catalunya, Barcelona, Spain
Alvarez, J:
Agencia Salut Publ Catalunya, Barcelona, Spain
Arias, C:
Agencia Salut Publ Catalunya, Barcelona, Spain
Balana, PJ:
Agencia Salut Publ Catalunya, Barcelona, Spain
Camps, N:
Agencia Salut Publ Catalunya, Barcelona, Spain
Carol, M:
Agencia Salut Publ Catalunya, Barcelona, Spain
Farras, J:
Agencia Salut Publ Catalunya, Barcelona, Spain
Ferrus, G:
Agencia Salut Publ Catalunya, Barcelona, Spain
Follia, N:
Agencia Salut Publ Catalunya, Barcelona, Spain
Martinez, A:
Agencia Salut Publ Catalunya, Barcelona, Spain
Minguell, S:
Agencia Salut Publ Catalunya, Barcelona, Spain
Planas, C:
Agencia Salut Publ Catalunya, Barcelona, Spain
Rovira, A:
Agencia Salut Publ Catalunya, Barcelona, Spain
Sala, MR:
Agencia Salut Publ Catalunya, Barcelona, Spain
Torres, J:
Agencia Salut Publ Catalunya, Barcelona, Spain
Manzanares, S:
Agencia Salut Publ Barcelona, Barcelona, Spain
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