An analysis of the impact of CD56 expression in de novo acute promyelocytic leukemia patients treated with upfront all-trans retinoic acid and anthracycline-based regimens


Por: Sobas, M, Montesinos, P, Boluda, B, Bernal, T, Vellenga, E, Nomdedeu, J, Gonzalez-Campos, J, Chillon, M, Holowiecka, A, Esteve, J, Bergua, J, Gonzalez-Sanmiguel, JD, Gil-Cortes, C, Tormo, M, Salamero, O, Manso, F, Fernandez, I, de la Serna, J, Moreno, MJ, Perez-Encinas, M, Krsnik, I, Ribera, JM, Escoda, L, Lowenberg, B, Sanz, MA, de Heredia, JMB, Hernandez, JM, Arias, J, Ramos, F, Roman, A, Negri, S, Rayon, C, Fernandez-Calvo, FJ, Diaz-Mediavilla, J, Gil, C, Olave, M, Amutio, E, Pedro, C, Gorosquieta, A, Viguria, M, Zudaire, M, Molero, T, Sayas, MJ, Guardia, R, Esquembre, C, Garcia, R, Alcala, A, Lopez, JA, Rubio, V, Amigo, ML, Linares, M, San Miguel, JDG, Coruna, A, Deben, G, de la Camara, R, Molines, A, Loureiro, C, Allegue, MJ, Amador, L, Marti, JM, Madero, L, Lassaletta, A, Cabezudo, M, Garcia-Larana, J, Rojas, R, Ortega, F, Penarrubia, MJ, Puente, F, Lopez-Ibor, B, Brunet, S, Ibanez, J, Sanchez, P, Novo, A, Guinea, JM, Montero, A, Gonzalez, M, Martin, G, Martinez, J, Verdeguer, A, Garcia, P, Conde, E, Garcia, J, Capote, FJ, Bueno, J, Bastida, P, Rubio, A, Fuster, JL, Gonzalez, J, Perez, I, Molina, J, Mateos, MC, Ardaiz, MA, Rodriguez-calvillo, M, Poderos, C, Arnan, M, Duarte, R, Diaz-Morfa, M, Martin-Chacon, E, Calvo-Villas, JM, Garcia-Belmonte, D, Hernandez-Maraver, D, Ossenkoppele, GJ, van der Lelie, J, Sonneveld, P, Zijlmans, M, Maertens, J, de Valk, B, Wijermans, PW, de Groot, MR, Schouten, HC, Biesma, DH, van Marwijk, M, de Lisa, E, Golos, A, Ejduk, A, Armatys, A, Zarzycka, E, Knopinska, W, Miskiewicz, W, Jastrzab, B, Pluta, A, Paluszewska, M, Podhorecka, M, Gromek, T, Jakubas, B, Majcherek, M, Skret, A, Watek, M, Charlinski, G, Calbecka, M, Becht, R, Gadomska, A, Rzenno, E, Piszcz, J, Grosicki, S, Palmer, L, Ciarlo, S, Bezares, F, Rojas, F, Longoni, H, Gelemur, M, Fazio, P, Canepa, C, Saba, S, Balladares, G, Negri, P, Giunta, M, Milone, J, Lafalse, D, Sossa, C, Jaramillo, F, Mayer, J, Protivankova, M, Scwarz, J

Publicada: 21 mar 2019
Resumen:
Out of 956, there were 95 (10%) CD56+ APL patients treated with PETHEMA ATRA and chemotherapy. CD56+ expression was associated with high WBC, BCR3 isoform, and co-expression of CD2, CD34, CD7, HLA-DR, CD15, and CD117 antigens. CD56+ vs CD56- APL presented higher induction death rate (16% vs 8%, p = .02) and 5-years cumulative incidence of relapse (33% versus 10%, p = .006), irrespectively of the Sanz score (low-risk 47% versus 5%, p < .001; intermediate 23% versus 7%, p < .001; and high-risk 42% versus 21%, p = .007). In the multivariate analysis, CD56 + (p < .0001), higher relapse-risk score (p = .001), and male gender (p = .05) retained the independent predictive value. CD56+ APL also showed a greater risk of CNS relapse (6% versus 1%, p < .001) and lower 5-year OS (75% versus 83%, p = .003). The AIDA-based LPA2012 trial, with an intensified consolidation schedule for CD56+ APL, will elucidate whether an intensified consolidation schedule could mitigate the relapse rate in this setting.

Filiaciones:
Sobas, M:
 Wroclaw Med Univ, Dept Haematol Blood Neoplasms & Bone Marrow Trans, Pasteura 4, PL-50367 Wroclaw, Poland

Montesinos, P:
 Univ Hosp La Fe, Dept Med, Valencia, Spain

 Carlos III Inst, CIBERONC, Madrid, Spain

 Hosp Univ La Fe, Valencia, Spain

Boluda, B:
 Univ Hosp La Fe, Dept Med, Valencia, Spain

Bernal, T:
 Cent Univ Hosp Asturias, Oviedo, Spain

Vellenga, E:
 Univ Hosp, Groningen, Netherlands

 Univ Med Ctr Groningen, Groningen, Netherlands

Nomdedeu, J:
 Univ Autonoma Barcelona, Univ Hosp Santa Creu & St Paul, Hosp Holy Cross & St Paul, Barcelona, Spain

Gonzalez-Campos, J:
 Univ Hosp Virgen Rocio, Seville, Spain

Chillon, M:
 Carlos III Inst, CIBERONC, Madrid, Spain

 Univ Hosp Salamanca, Salamanca, Spain

Holowiecka, A:
 Silesian Med Univ, Katowice, Poland

Esteve, J:
 Hosp Clin Barcelona, Barcelona, Spain

Bergua, J:
 Hosp San Pedro Alcantara, Caceres, Spain

Gonzalez-Sanmiguel, JD:
 Insular Univ Hosp Gran Canaria, Las Palmas Gran Canaria, Spain

Gil-Cortes, C:
 Gen Hosp, Alicante, Spain

Tormo, M:
 Univ Hosp, Valencia, Spain

 Hosp Clin Univ, Valencia, Spain

Salamero, O:
 Univ Hosp Vall dHebron, Barcelona, Spain

Manso, F:
 Gen Hosp, Albacete, Spain

 Hosp Gen Albacete, Albacete, Spain

Fernandez, I:
 Fundaleu, Buenos Aires, DF, Argentina

de la Serna, J:
 Hosp 12 Octube, Madrid, Spain

 Hosp 12 Octubre, Madrid, Spain

Moreno, MJ:
 Univ Hosp Virgen Victoria, Malaga, Spain

Perez-Encinas, M:
 Univ Hosp Santiago De Compostela, Santiago De Compostela, Spain

 Hosp Clin Univ, Santiago De Compostela, Spain

Krsnik, I:
 Hosp Puerta Hierro, Madrid, Spain

 Hosp Univ Puerta Hierro, Madrid, Spain

Ribera, JM:
 Univ Hosp Germans Trias & Pujol, ICO, Badalona, Spain

 Jose Carreras Res Inst, Badalona, Spain

 Hosp Badalona Germans Trias & Pujol, Badalona, Spain

Escoda, L:
 Hosp Joan 23, Tarragona, Spain

Lowenberg, B:
 Erasmus Univ, Med Ctr, Rotterdam, Netherlands

Sanz, MA:
 Univ Hosp La Fe, Dept Med, Valencia, Spain

 Carlos III Inst, CIBERONC, Madrid, Spain

 Hosp Univ La Fe, Valencia, Spain

de Heredia, JMB:
 Basurtuko Ospitalea, Programa Espanol Tratamiento Hemopatias Malignas, PETHEMA, Bilbao, Spain

Hernandez, JM:
 Complejo Hosp Segovia, Lugo, Spain

 Hosp Fuenlabrada, Fuenlabrada, Spain

Arias, J:
 Complexo Hosp Xeral Calde, Lugo, Spain

Ramos, F:
 Hosp Univ, Leon, Spain

Roman, A:
 Fdn Jimenez Diaz, Madrid, Spain

Negri, S:
 Hosp Carlos Haya, Malaga, Spain

Rayon, C:
 Hosp Cent Asturias, Oviedo, Spain

Fernandez-Calvo, FJ:
 Hosp Clin Valladolid, Madrid, Spain

Diaz-Mediavilla, J:
 Hosp Clin San Carlos, Madrid, Spain

Gil, C:
 Hosp Clin San Carlos H Infantil, Madrid, Spain

Olave, M:
 Hosp Clin Univ Lozano Blesa, Zaragoza, Spain

Amutio, E:
 Hosp Cruces, Baracaldo, Spain

Pedro, C:
 Hosp del Mar, Barcelona, Spain

Gorosquieta, A:
 Hosp Navarra, Pamplona, Spain

Viguria, M:
 Hosp Navarra, Pamplona, Spain

Zudaire, M:
 Hosp Navarra, Pamplona, Spain

Molero, T:
 Hosp Dr Negrin, Las Palmas Gran Canaria, Spain

Sayas, MJ:
 Hosp Dr Peset, Valencia, Spain

Guardia, R:
 Hosp Dr Trueta, Girona, Spain

Esquembre, C:
 Hosp Gen Albacete Oncol Pediat, Albacete, Spain

Garcia, R:
 Hosp Gen Castellon, Castellon De La Plana, Spain

Alcala, A:
 Hosp Gen Especialidades Ciudad Jaen, Jaen, Spain

Lopez, JA:
 Hosp Gen Especialidades Ciudad Jaen, Jaen, Spain

Rubio, V:
 Hosp Gen Jerez Frontera, Andalucia, Spain

Amigo, ML:
 Hosp Gen Murcia, Murcia, Spain

Linares, M:
 Hosp Gen Valencia, Valencia, Spain

San Miguel, JDG:
 Hosp Insular Las Palmas, La Coruna, Spain

Deben, G:
 Hosp Juan Canalejo, La Coruna, Spain

de la Camara, R:
 Hosp La Princesa, Madrid, Spain

Molines, A:
 Hosp Maternoinfantil Las Palmas, Vigo, Spain

Loureiro, C:
 Hosp Meixoeiro, Vigo, Spain

Allegue, MJ:
 Hosp Montecelo, Pontevedra, Spain

Amador, L:
 Hosp Montecelo, Pontevedra, Spain

Marti, JM:
 Hosp Mutua Terrasa, Madrid, Spain

Madero, L:
 Hosp Nino Jesus, Madrid, Spain

Lassaletta, A:
 Hosp Nino Jesus, Madrid, Spain

Cabezudo, M:
 Hosp Ntra Sra Sonsoles, Avila, Spain

Garcia-Larana, J:
 Hosp Ramon & Cajal, Madrid, Spain

Rojas, R:
 Hosp Reina Sofia, Cordoba, Spain

Ortega, F:
 Hosp Rio Carrion, Palencia, Spain

Penarrubia, MJ:
 Hosp Rio Hortega, Valladolid, Spain

Puente, F:
 Hosp San Jorge, Huesca, Spain

Lopez-Ibor, B:
 Hosp San Rafael, Madrid, Spain

Brunet, S:
 Hosp Santa Creu & Sant Pau, Barcelona, Spain

Ibanez, J:
 Hosp Santa Maria Rosell, Cartagena, Spain

Sanchez, P:
 Hosp Severo Ochoa, Leganes, Spain

Novo, A:
 Hosp Son Dureta, Palma de Mallorca, Spain

Guinea, JM:
 Hosp Txagorritxu, Vitoria, Spain

Montero, A:
 Hosp Univ Aire, Madrid, Spain

Gonzalez, M:
 Hosp Univ Salamanca, Salamanca, Spain

Martin, G:
 Hosp Univ La Fe, Valencia, Spain

Martinez, J:
 Hosp Univ La Fe, Valencia, Spain

Verdeguer, A:
 Hosp Univ La Fe, Hosp Infantil, Valencia, Spain

Garcia, P:
 Hosp Univ La Fe, Hosp Infantil, Madrid, Spain

Conde, E:
 Hosp Univ Marques Valdecilla, Santander, Spain

Garcia, J:
 Hosp Univ Principe Asturias, Alcala De Henares, Spain

Capote, FJ:
 Hosp Univ Puerta Mar, Cadiz, Spain

Bueno, J:
 Hosp Univ Vall dHebron, Barcelona, Spain

Bastida, P:
 Hosp Univ Materno Infantil Vall DHebron, Barcelona, Spain

Rubio, A:
 Hosp Univ Virgen Arrixaca, Murcia, Spain

Fuster, JL:
 Hosp Univ Virgen Arrixaca Pediat, Murcia, Spain

Gonzalez, J:
 Hosp Univ Virgen Rocio, Seville, Spain

Perez, I:
 Hosp Univ Virgen Victoria, Malaga, Spain

Molina, J:
 Hosp Virgen Camino Infantil, Pamplona, Spain

Mateos, MC:
 Hosp Virgen Camino Adultos, Pamplona, Spain

Ardaiz, MA:
 Hosp Virgen Camino Adultos, Pamplona, Spain

Rodriguez-calvillo, M:
 Clin San Miguel, Pamplona, Spain

Poderos, C:
 Hosp Xeral Cies, Vigo, Spain

Arnan, M:
 Inst Catala Oncol, Lhospitalet De Llobregat, Spain

Duarte, R:
 Inst Catala Oncol, Lhospitalet De Llobregat, Spain

Diaz-Morfa, M:
 Hosp Gen Guadalajara, Guadalajara, Spain

Martin-Chacon, E:
 Hosp Juan Ramon Jimenez, Huelva, Spain

Calvo-Villas, JM:
 Hosp Doctor Jose Molina Orosa, Lanzarote, Spain

Garcia-Belmonte, D:
 Hosp Madrid Norte Sanchinarro, Madrid, Spain

Hernandez-Maraver, D:
 Hosp U La Paz, Madrid, Spain

Ossenkoppele, GJ:
 VU Med Ctr Amsterdam, Dutch Belgian Hematooncol Cooperat Grp, HOVON, Amsterdam, Netherlands

van der Lelie, J:
 Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands

Sonneveld, P:
 Erasmus Univ, Med Ctr, Rotterdam, Netherlands

Zijlmans, M:
 Erasmus Univ, Med Ctr, Rotterdam, Netherlands

Maertens, J:
 Gasthuisberg Hosp, Leuven, Belgium

de Valk, B:
 OLVG Hosp, Amsterdam, Netherlands

Wijermans, PW:
 Den Haag Hosp, Leyenburg, Netherlands

de Groot, MR:
 Med Spectrum Twente Hosp, Enschede, Netherlands

Schouten, HC:
 Acad Hosp Maastricht, Maastricht, Netherlands

Biesma, DH:
 St Antonius Hosp, Nieuwegein, Netherlands

van Marwijk, M:
 Sophia Hosp, Zwolle, Netherlands

de Lisa, E:
 Hosp Maciel, Montevideo, Uruguay

Golos, A:
 PALG, Inst Hematol, Warsaw, Poland

Ejduk, A:
 PALG, Inst Hematol, Warsaw, Poland

Armatys, A:
 Silesian Med Univ, Katowice, Poland

Zarzycka, E:
 Med Univ Sch, Gdansk, Poland

Knopinska, W:
 Med Univ Sch, Gdansk, Poland

Miskiewicz, W:
 Wroclaw Med Univ, Wroclaw, Poland

Jastrzab, B:
 Wroclaw Med Univ, Wroclaw, Poland

Pluta, A:
 Med Univ, Lodz, Poland

Paluszewska, M:
 Med Univ, Warsaw, Poland

Podhorecka, M:
 Med Univ, Lublin, Poland

Gromek, T:
 Med Univ, Lublin, Poland

Jakubas, B:
 Jagiellonian Univ, Coll Med, Krakow, Poland

Majcherek, M:
 Poznan Med Univ, Poznan, Poland

Skret, A:
 City Hosp, Rzeszow, Poland

Watek, M:
 Ctr Oncol, Kielce, Poland

Charlinski, G:
 City Hosp, Torun, Poland

Calbecka, M:
 City Hosp, Torun, Poland

Becht, R:
 Univ Hosp, Szczecin, Poland

Gadomska, A:
 City Hosp, Bydgoszcz, Poland

Rzenno, E:
 City Hosp, Krakow, Poland

Piszcz, J:
 Med Univ, Bialystok, Poland

Grosicki, S:
 City Hosp, Chorzow, Poland

Palmer, L:
 Complejo Med Policia Fed, GATLA, La Plata, Buenos Aires, Argentina

 Hosp Tortosa, Vitoria, Spain

Ciarlo, S:
 Hosp Clemente Alvarez, Rosario, Santa Fe, Argentina

Bezares, F:
 Hosp Clemente Alvarez, Rosario, Santa Fe, Argentina

Rojas, F:
 Hosp Clin Buenos Aires, Buenos Aires, DF, Argentina

Longoni, H:
 Hosp Clin Buenos Aires, Buenos Aires, DF, Argentina

Gelemur, M:
 Hosp Gen San Martin, La Plata, Buenos Aires, Argentina

Fazio, P:
 Hosp Gen San Martin, La Plata, Buenos Aires, Argentina

Canepa, C:
 Hosp Rossi, La Plata, Buenos Aires, Argentina

Saba, S:
 Hosp Rossi, La Plata, Buenos Aires, Argentina

Balladares, G:
 Hosp Rossi, La Plata, Buenos Aires, Argentina

Negri, P:
 Hosp San Martin Parana, Entre Rios, Argentina

Giunta, M:
 Inst Privado Hematol, Parana, Argentina

Milone, J:
 Inst Trasplante Medula Osea, La Plata, Buenos Aires, Argentina

Lafalse, D:
 Hosp Tornu, Buenos Aires, DF, Argentina

Sossa, C:
 Inst FOSCAL, Bucaramanga, Colombia

Jaramillo, F:
 Fdn Valle Lili, Cali, Colombia

Mayer, J:
 Fac Hosp, Brno, Czech Republic

Protivankova, M:
 Fac Hosp, Brno, Czech Republic

Scwarz, J:
 IHBT, Prague, Czech Republic
ISSN: 10428194
Editorial
TAYLOR & FRANCIS LTD, 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND, Reino Unido
Tipo de documento: Article
Volumen: 60 Número: 4
Páginas: 1030-1035
WOS Id: 000463807800022
ID de PubMed: 30322324
imagen Open Access

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