Hyperlipidaemia and cardioprotection: Animal models for translational studies
Por:
Andreadou, I, Schulz, R, Badimon, L, Adameova, A, Kleinbongard, P, Lecour, S, Nikolaou, PE, Falcao-Pires, I, Vilahur, G, Woudberg, N, Heusch, G, Ferdinandy, P
Publicada:
1 dic 2020
Ahead of Print:
1 ene 2020
Resumen:
Hyperlipidaemia is a well-established risk factor for cardiovascular diseases and therefore, many animal model have been developed to mimic the human abnormal elevation of blood lipid levels. In parallel, extensive research for the alleviation of ischaemia/reperfusion injury has revealed that hyperlipidaemia is a major co-morbidity that attenuates the cardioprotective effect of conditioning strategies (preconditioning, postconditioning and remote conditioning) and that of pharmacological interventions by interfering with cardioprotective signalling pathways. In the present review article, we summarize the existing data on animal models of hypercholesterolaemia (total, low density and HDL abnormalities) and hypertriglyceridaemia used in ischaemia/reperfusion injury and protection from it. We also provide recommendations on preclinical animal models to be used for translations of the cardioprotective strategies into clinical practice.
Filiaciones:
Andreadou, I:
Natl & Kapodistrian Univ Athens, Fac Pharm, Lab Pharmacol, Athens 15771, Greece
Schulz, R:
Justus Liebig Univ Giessen, Inst Physiol, Giessen, Germany
Badimon, L:
Res Inst Hosp Santa Creu & St Pau, IIB St Pau, Cardiovasc Program ICCC, Barcelona, Spain
Inst Salud Carlos III, CIBERCV, Madrid, Spain
Autonomous Univ Barcelona, Cardiovasc Res Chair, Barcelona, Spain
Adameova, A:
Comenius Univ, Fac Pharm, Dept Pharmacol & Toxicol, Bratislava, Slovakia
Slovak Acad Sci, Ctr Expt Med, Inst Heart Res, Bratislava, Slovakia
Kleinbongard, P:
Univ Klinikum Essen, Westdeutsch Herz & Gefasszentrum, Inst Pathophysiol, Essen, Germany
Lecour, S:
Univ Cape Town, Fac Hlth Sci, Hatter Inst Cardiovasc Res Africa, Dept Med, Cape Town, South Africa
Nikolaou, PE:
Natl & Kapodistrian Univ Athens, Fac Pharm, Lab Pharmacol, Athens 15771, Greece
Falcao-Pires, I:
Univ Porto, Fac Med, Dept Cirurgia & Fisiol, Unidade Invest Cardiovasc, Porto, Portugal
Vilahur, G:
Res Inst Hosp Santa Creu & St Pau, IIB St Pau, Cardiovasc Program ICCC, Barcelona, Spain
Inst Salud Carlos III, CIBERCV, Madrid, Spain
Woudberg, N:
Univ Cape Town, Fac Hlth Sci, Hatter Inst Cardiovasc Res Africa, Dept Med, Cape Town, South Africa
Heusch, G:
Univ Klinikum Essen, Westdeutsch Herz & Gefasszentrum, Inst Pathophysiol, Essen, Germany
Ferdinandy, P:
Semmelweis Univ, Dept Pharmacol & Pharmacotherapy, Nagyvarad Ter 4, Budapest, Hungary
Pharmahungary Grp, Szeged, Hungary
Green Published, Bronze
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