Microvascular cerebral blood flow fluctuations in association with apneas and hypopneas in acute ischemic stroke
Por:
Gregori-Pla, C, Delgado-Mederos, R, Cotta, G, Giacalone, G, Maruccia, F, Avtzi, S, Prats-Sanchez, L, Martinez-Domeno, A, Camps-Renom, P, Marti-Fabregas, J, Durduran, T, Mayos, M
Publicada:
1 abr 2019
Resumen:
In a pilot study on acute ischemic stroke (AIS) patients, unexpected periodic fluctuations in microvascular cerebral blood flow (CBF) had been observed. Motivated by the relative lack of information about the impact of the emergence of breathing disorders in association with stroke on cerebral hemodynamics, we hypothesized that these fluctuations are due to apneic and hypopneic events. A total of 28 patients were screened within the first week after stroke with a pulse oximeter. Five (18%) showed fluctuations of arterial blood oxygen saturation (>= 3 % ) and were included in the study. Near-infrared diffuse correlation spectroscopy (DCS) was utilized bilaterally to measure the frontal lobe CBF alongside respiratory polygraphy. Biphasic CBF fluctuations were observed with a bilateral increase of 27.1 % +/- 17.7 % and 29.0 % +/- 17.4 % for the ipsilesional and contralesional hemispheres, respectively, and a decrease of -19.3 % +/- 9.1 % and -21.0 % +/- 8.9 % for the ipsilesional and contralesional hemispheres, respectively. The polygraph revealed that, in general, the fluctuations were associated with apneic and hypopneic events. This study motivates us to investigate whether the impact of altered respiratory patterns on cerebral hemodynamics can be detrimental in AIS patients. patients. (C) The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License.
Filiaciones:
Gregori-Pla, C:
Barcelona Inst Sci & Technol, ICFO Inst Ciencies Fotan, Castelldefels, Barcelona, Spain
Delgado-Mederos, R:
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau IIB St Pau, Dept Neurol, Stroke Unit, Barcelona, Spain
Cotta, G:
Barcelona Inst Sci & Technol, ICFO Inst Ciencies Fotan, Castelldefels, Barcelona, Spain
Giacalone, G:
Barcelona Inst Sci & Technol, ICFO Inst Ciencies Fotan, Castelldefels, Barcelona, Spain
Ist Sci San Raffaele, Milan, Italy
Maruccia, F:
Barcelona Inst Sci & Technol, ICFO Inst Ciencies Fotan, Castelldefels, Barcelona, Spain
Univ Autonoma Barcelona, Res Inst, Vall dHebron Univ, Neurotraumatol & Neurosurg Res Unit, Barcelona, Spain
Avtzi, S:
Barcelona Inst Sci & Technol, ICFO Inst Ciencies Fotan, Castelldefels, Barcelona, Spain
Prats-Sanchez, L:
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau IIB St Pau, Dept Neurol, Stroke Unit, Barcelona, Spain
Martinez-Domeno, A:
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau IIB St Pau, Dept Neurol, Stroke Unit, Barcelona, Spain
Camps-Renom, P:
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau IIB St Pau, Dept Neurol, Stroke Unit, Barcelona, Spain
Marti-Fabregas, J:
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau IIB St Pau, Dept Neurol, Stroke Unit, Barcelona, Spain
Durduran, T:
Barcelona Inst Sci & Technol, ICFO Inst Ciencies Fotan, Castelldefels, Barcelona, Spain
Inst Catalana Recerca & Estudis Avancats, Barcelona, Spain
Mayos, M:
Hosp Santa Creu & Sant Pau, Sleep Unit, Dept Resp Med, Barcelona, Spain
CIBER Enfermedades Resp, CB06-06, Madrid, Spain
Gold, Green Published
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