Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy

Por: Labrador, J, Luno, E, Vellenga, E, Brunet, S, Gonzalez-Campose, J, Chillon, MC, Holowiecka, A, Esteve, J, Bergua, J, Gonzalez-Sanmiguel, JD, Gil, C, Tormo, M, Salamero, O, Manso, F, Fernandez, I, de laSerna, J, Moreno, MJ, Perez-Encinas, M, Krsnik, I, Ribera, JM, Cervera, J, Calasanz, MJ, Boluda, B, Sobas, M, Lowenberg, B, Sanz, MA, Montesinos, P, Palmer, L, Ciarlo, S, Bezares, F, Rojas, F, Longoni, H, Gelemur, M, Fazio, P, Canepa, C, Saba, S, Balladares, G, Negri, P, Giunta, M, Milone, J, Prates, MV, Lafalse, D, Sossa, C, Jaramillo, F, Mayer, J, Protivankova, M, Scwarz, J, Jakubas, B, Skret-Norwicz, A, Bizgalska-Skrzypek, P, Pluta, A, Becht, R, Kielbinski, M, Watek, M, Paluszewska, M, Gadomska, A, Rzenno, E, Piszcz, J, Ejduk, A, Dobrzanska, J, Calbecka, M, Kostyra, A, Malek, M, Grosicki, S, Knopinska, W, de Heredia, JMB, Hernandez, JM, Arias, J, Ramos, F, Roman, A, Negri, S, Rayon, C, Fernandez-Calvo, FJ, Diaz-Mediavilla, J, Olave, M, Amutio, E, Pedro, C, Gorosquieta, A, Viguria, M, Zudaire, M, Molero, T, Sayas, MJ, Guardia, R, Rivas, C, Esquembre, C, Garcia, R, Alcala, A, Lopez, JA, Rubio, V, Amigo, ML, Linares, M, San Miguel, JDG, Deben, G, Escoda, L, de la Camara, R, Molines, A, Loureiro, C, Allegue, MJ, Amador, L, Marti, JM, Madero, L, Lassaletta, A, Cabezudo, M, Garcia-Larana, J, Rojas, R, Ortega, F, Penarrubia, MJ, Puente, F, Lopez-Ibor, B, Ibanez, J, Sanchez, P, Novo, A, Font, LL, Guinea, JM, Montero, A, Gonzalez, M, Martin, G, Martinez, J, Verdeguer, A, Garcia, P, Conde, E, Garcia, J, Capote, FJ, Krsnik, I, Bueno, J, Bastida, P, Rubio, A, Fuster, JL, Perez, I, Molina, J, Mateos, MC, Ardaiz, MA, Rodriguez-calvillo, M, Poderos, C, Arnan, M, Duarte, R, Hernandez, JA, Diaz-Morfa, M, Martin-Chacon, E, Calvo-Villas, JM, Garcia-Belmonte, D, Hernandez-Maraver, D, Ossenkoppele, GJ, van der Lelie, J, Sonneveld, P, Zijlmans, M, Maertens, J, de Valk, B, Wijermans, PW, de Groot, MR, Schouten, HC, Biesma, DH, Kooy, MV, de Lisa, E

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Publicada: 16 abr 2019

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Filiaciones:
Labrador, J:
 Hosp Univ Burgos, Burgos, Spain

Luno, E:
 Hosp Univ Cent Asturias, Dept Hematol, Oviedo, Spain

Vellenga, E:
 Hosp Univ Burgos, Burgos, Spain

 Univ Groningen, Univ Med Ctr Groningen, Groningen, Netherlands

 Erasmus Univ, Med Ctr, Rotterdam, Netherlands

 Univ Med Ctr Groningen, Groningen, Netherlands

Brunet, S:
 Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, IIB St Pau, Barcelona, Spain

 Univ Autonoma Barcelona, Jose Carreras Leukemia Res Inst, Barcelona, Spain

 Hosp Santa Creu & Sant Pau, Barcelona, Spain

Gonzalez-Campose, J:
 Hosp Univ Virgen del Rocio, Seville, Spain

Chillon, MC:
 Univ Hosp Salamanca, Inst Invest Biomed Salamanca, Salamanca, Spain

 Inst Carlos III, CIBERONC, Madrid, Spain

Holowiecka, A:
 Silesian Med Univ, Dept Haematol & BMT, Katowice, Poland

Esteve, J:
 Hosp Clin Barcelona, Barcelona, Spain

Bergua, J:
 Hosp San Pedro Alcantara, Caceres, Spain

 Hosp San Pedro de Alcantara, Caceres, Spain

Gonzalez-Sanmiguel, JD:
 Hosp Insular, Las Palmas Gran Canaria, Spain

Gil, C:
 Hosp Gen Alicante, Alicante, Spain

 Hosp Clin San Carlos, Madrid, Spain

Tormo, M:
 Hosp Clin Univ Valencia, Valencia, Spain

 Hosp Clin Univ, Valencia, Spain

Salamero, O:
 Hosp Univ Vall dHebron, Barcelona, Spain

Manso, F:
 Hosp Gen, Albacete, Spain

 Hosp Gen Albacete, Albacete, Spain

Fernandez, I:
 Fundaleu, Buenos Aires, DF, Argentina

de laSerna, J:
 Hosp 12 Octubre, Madrid, Spain

Moreno, MJ:
 Hosp Virgen Victoria, Malaga, Spain

Perez-Encinas, M:
 Hosp Clin Univ, Santiago De Compostela, Spain

 Hosp Clin Univ Santiago de Compostela, Santiago De Compostela, Spain

Krsnik, I:
 Hosp Puerta de Hierro, Madrid, Spain

 Hosp Univ Puerta de Hierro, Madrid, Spain

Ribera, JM:
 Univ Autonoma Barcelona, ICO Hosp Univ Germans Trias & Pujol, Josep Carreras Leukemia Res Inst, Barcelona, Spain

Cervera, J:
 Hosp Univ & Politecn La Fe, Hematol Dept, Avinguda Fernando Abril Martorell 106, Valencia 46026, Spain

Calasanz, MJ:
 Inst Carlos III, CIBERONC, Madrid, Spain

 CIMA Lab Diagnost, Pamplona, Spain

 Univ Navarra, Pamplona, Spain

Boluda, B:
 Inst Carlos III, CIBERONC, Madrid, Spain

 Hosp Univ & Politecn La Fe, Hematol Dept, Avinguda Fernando Abril Martorell 106, Valencia 46026, Spain

Sobas, M:
 Wroclaw Med Univ, Dept Haematol Blood Neoplasms & Bone Marrow Trans, Wroclaw, Poland

Lowenberg, B:
 Erasmus Univ, Med Ctr, Rotterdam, Netherlands

Sanz, MA:
 Inst Carlos III, CIBERONC, Madrid, Spain

 Hosp Univ & Politecn La Fe, Hematol Dept, Avinguda Fernando Abril Martorell 106, Valencia 46026, Spain

 Univ Valencia, Dept Med, Valencia, Spain

Montesinos, P:
 Inst Carlos III, CIBERONC, Madrid, Spain

 Hosp Univ & Politecn La Fe, Hematol Dept, Avinguda Fernando Abril Martorell 106, Valencia 46026, Spain

 Univ La Fe, Valencia, Spain

Palmer, L:
 Complejo Med Policia Fed, GATLA, La Plata, Buenos Aires, Argentina

Ciarlo, S:
 Hosp Clemente Alvarez, Rosario, Santa Fe, Argentina

Bezares, F:
 Hosp Clemente Alvarez, Rosario, Santa Fe, Argentina

Rojas, F:
 Hosp Clin Buenos Aires, Buenos Aires, DF, Argentina

Longoni, H:
 Hosp Clin Buenos Aires, Buenos Aires, DF, Argentina

Gelemur, M:
 Hosp Gen San Martin, La Plata, Buenos Aires, Argentina

Fazio, P:
 Hosp Gen San Martin, La Plata, Buenos Aires, Argentina

Canepa, C:
 Hosp Rossi, La Plata, Buenos Aires, Argentina

Saba, S:
 Hosp Rossi, La Plata, Buenos Aires, Argentina

Balladares, G:
 Hosp Rossi, La Plata, Buenos Aires, Argentina

Negri, P:
 Hosp San Martin Parana, Parana, Entre Rios, Argentina

Giunta, M:
 Inst Privado Hematol, Parana, Argentina

Milone, J:
 Inst Trasplante Medula Osea, La Plata, Buenos Aires, Argentina

Prates, MV:
 Inst Trasplante Medula Osea, La Plata, Buenos Aires, Argentina

Lafalse, D:
 Hosp Tornu, Buenos Aires, DF, Argentina

Sossa, C:
 Inst FOSCAL, Bucaramanga, Colombia

Jaramillo, F:
 Fdn Valle del Lili, Cali, Colombia

Mayer, J:
 Fac Hosp, Brno, Czech Republic

Protivankova, M:
 Fac Hosp, Brno, Czech Republic

Scwarz, J:
 IHBT, Prague, Czech Republic

Jakubas, B:
 Jagiellonian Univ, Coll Med, Krakow, Poland

Skret-Norwicz, A:
 City Hosp, Rzeszow, Poland

Bizgalska-Skrzypek, P:
 City Hosp, Poznan, Poland

Pluta, A:
 Med Univ, Lodz, Poland

Becht, R:
 Univ Hosp, Szczecin, Poland

Kielbinski, M:
 Univ Hosp, Wroclaw, Poland

Watek, M:
 Ctr Oncol, Kielce, Poland

Paluszewska, M:
 Med Univ, Warsaw, Poland

Gadomska, A:
 City Hosp, Bydgoszcz, Poland

Rzenno, E:
 City Hosp, Krakow, Poland

Piszcz, J:
 Med Univ, Bialystok, Poland

Ejduk, A:
 Inst Hematol, Warsaw, Poland

Dobrzanska, J:
 Inst Hematol, Warsaw, Poland

Calbecka, M:
 City Hosp, Tornu, Poland

Kostyra, A:
 City Hosp, Tornu, Poland

Malek, M:
 Med Univ, Lublin, Poland

Grosicki, S:
 City Hosp, Chorzow, Poland

Knopinska, W:
 Med Univ Sch, Gdansk, Poland

de Heredia, JMB:
 Basurtuko Ospitalea, PETHEMA, Programa Espanol Tratamiento Hemopatias Malignas, Bilbao, Spain

Hernandez, JM:
 Complejo Hosp Segovia, Segovia, Spain

Arias, J:
 Complexo Hosp Xeral Calde, Lugo, Spain

Ramos, F:
 Hosp Univ, Leon, Spain

Roman, A:
 Fdn Jimenez Diaz, Madrid, Spain

Negri, S:
 Hosp Carlos Haya, Malaga, Spain

Rayon, C:
 Hosp Univ Cent Asturias, Oviedo, Spain

Fernandez-Calvo, FJ:
 Hosp Clin Valladolid, Valladolid, Spain

Diaz-Mediavilla, J:
 Hosp Clin San Carlos, Madrid, Spain

Olave, M:
 Hosp Clin Univ Lozano Blesa, Zaragoza, Spain

Amutio, E:
 Hosp Cruces, Baracaldo, Spain

Pedro, C:
 Hosp del Mar, Barcelona, Spain

Gorosquieta, A:
 Hosp Navarra, Pamplona, Spain

Viguria, M:
 Hosp Navarra, Pamplona, Spain

Zudaire, M:
 Hosp Navarra, Pamplona, Spain

Molero, T:
 Hosp Dr Negrin, Las Palmas Gran Canaria, Spain

Sayas, MJ:
 Hosp Dr Peset, Valencia, Spain

Guardia, R:
 Hosp Dr Trueta, Girona, Spain

Rivas, C:
 Hosp Gen Alicante, Alicante, Spain

Esquembre, C:
 Hosp Gen Alicante, Oncol Pediat, Alicante, Spain

Garcia, R:
 Hosp Gen Castellon, Castellon De La Plana, Spain

Alcala, A:
 Hosp Gen Especialidades Ciudad Jaen, Jaen, Spain

Lopez, JA:
 Hosp Gen Especialidades Ciudad Jaen, Jaen, Spain

Rubio, V:
 Hosp Gen Jerez de la Frontera, Jerez de la Frontera, Spain

Amigo, ML:
 Hosp Gen Murcia, Murcia, Spain

Linares, M:
 Hosp Gen Valencia, Valencia, Spain

San Miguel, JDG:
 Hosp Insular Las Palmas, Las Palmas Gran Canaria, Spain

Deben, G:
 Hosp Juan Canalejo, La Coruna, Spain

Escoda, L:
 Hosp Joan 23, Tarragona, Spain

de la Camara, R:
 Hosp La Princesa, Madrid, Spain

Molines, A:
 Hosp Maternoinfantil Las Palmas, Las Palmas Gran Canaria, Spain

Loureiro, C:
 Hosp Meixoeiro, Vigo, Spain

Allegue, MJ:
 Hosp Montecelo, Pontevedra, Spain

Amador, L:
 Hosp Montecelo, Pontevedra, Spain

Marti, JM:
 Hosp Mutua de Terrasa, Terrassa, Spain

Madero, L:
 Hosp Nino Jesus, Madrid, Spain

Lassaletta, A:
 Hosp Nino Jesus, Madrid, Spain

Cabezudo, M:
 Hosp Ntra Sra de Sonsoles, Avila, Spain

Garcia-Larana, J:
 Hosp Ramon & Cajal, Madrid, Spain

Rojas, R:
 Hosp Reina Sofia, Cordoba, Spain

Ortega, F:
 Hosp Rio Carrion, Palencia, Spain

Penarrubia, MJ:
 Hosp Rio Hortega, Valladolid, Spain

Puente, F:
 Hosp San Jorge, Huesca, Spain

Lopez-Ibor, B:
 Hosp San Rafael, Madrid, Spain

Ibanez, J:
 Hosp Santa Maria del Rosell, Cartagena, Spain

Sanchez, P:
 Hosp Severo Ochoa, Leganes, Spain

Novo, A:
 Hosp Son Dureta, Palma de Mallorca, Spain

Font, LL:
 Hosp Tortosa, Tortosa, Spain

Guinea, JM:
 Hosp Txagorritxu, Vitoria, Spain

Montero, A:
 Hosp Univ Aire, Madrid, Spain

Gonzalez, M:
 Hosp Univ Salamanca, Salamanca, Spain

Martin, G:
 Univ La Fe, Valencia, Spain

Martinez, J:
 Univ La Fe, Valencia, Spain

Verdeguer, A:
 Hosp Univ La Fe, Hosp Infantil, Valencia, Spain

Garcia, P:
 Hosp Univ La Paz, Hosp Infantil, Madrid, Spain

Conde, E:
 Hosp Univ Marques de Valdecilla, Santander, Spain

Garcia, J:
 Hosp Univ Principe Asturias, Alcala De Henares, Spain

Capote, FJ:
 Hosp Univ Puerta del Mar, Cadiz, Spain

Krsnik, I:
 Hosp Puerta de Hierro, Madrid, Spain

 Hosp Univ Puerta de Hierro, Madrid, Spain

Bueno, J:
 Hosp Univ Vall dHebron, Barcelona, Spain

Bastida, P:
 Hosp Univ Maternoinfantil Vall DHebron, Barcelona, Spain

Rubio, A:
 Hosp Univ Virgen de la Arrixaca, Murcia, Spain

Fuster, JL:
 Hosp Univ Virgen de la Arrixaca, Pediat, Murcia, Spain

Perez, I:
 Hosp Univ Virgen de la Victoria, Malaga, Spain

Molina, J:
 Hosp Virgen del Camino Infantil, Pamplona, Spain

Mateos, MC:
 Hosp Virgen del Camino Adultos, Pamplona, Spain

Ardaiz, MA:
 Hosp Virgen del Camino Adultos, Pamplona, Spain

Rodriguez-calvillo, M:
 Clin San Miguel, Pamplona, Spain

Poderos, C:
 Hosp Xeral Cies, Vigo, Spain

Arnan, M:
 Inst Catala Oncol, Lhospitalet De Llobregat, Spain

Duarte, R:
 Inst Catala Oncol, Lhospitalet De Llobregat, Spain

Hernandez, JA:
 Hosp Fuenlabrada, Fuenlabrada, Spain

Diaz-Morfa, M:
 Hosp Gen Guadalajara, Guadalajara, Spain

Martin-Chacon, E:
 Hosp Juan Ramon Jimenez, Huelva, Spain

Calvo-Villas, JM:
 Hosp Doctor Jose Molina Orosa, Lanzarote, Spain

Garcia-Belmonte, D:
 Hosp Madrid Norte Sanchinarro, Madrid, Spain

Hernandez-Maraver, D:
 Hosp Univ La Paz, Madrid, Spain

Ossenkoppele, GJ:
 VU Med Ctr Amsterdam, Amsterdam, Netherlands

van der Lelie, J:
 Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands

Sonneveld, P:
 Erasmus Univ, Med Ctr, Rotterdam, Netherlands

Zijlmans, M:
 Erasmus Univ, Med Ctr, Rotterdam, Netherlands

Maertens, J:
 Gasthuisberg Hosp, Leuven, Belgium

de Valk, B:
 OLVG Hosp, Amsterdam, Netherlands

Wijermans, PW:
 Den Haag Hosp, Leyenburg, Netherlands

de Groot, MR:
 Med Spectrum Twente Hosp, Enschede, Netherlands

Schouten, HC:
 Acad Hosp Maastricht, Maastricht, Netherlands

Biesma, DH:
 St Antonius Hosp, Nieuwegein, Netherlands

Kooy, MV:
 Sophia Hosp, Zwolle, Netherlands

de Lisa, E:
 Hosp Maciel, Montevideo, Uruguay

Silesian Med Univ, PALG, Katowice, Poland
ICO Hosp Germans Trias & Pujol, Badalona, Spain