Life expectancy of follicular lymphoma patients in complete response at 30 months is similar to that of the Spanish general population
Por:
Magnano, L, Alonso-Alvarez, S, Alcoceba, M, Rivas-Delgado, A, Muntanola, A, Nadeu, F, Setoain, X, Rodriguez, S, Andrade-Campos, M, Espinosa-Lara, N, Rodriguez, G, Sancho, JM, Moreno, M, Mercadal, S, Carro, I, Salar, A, Garcia-Pallarols, F, Arranz, R, Cannata, J, Terol, MJ, Teruel, AI, Jimenez-Ubiet, A, Rodrigue, A, de Villambrosi, SG, Bell, JL, Lopez, L, Novelli, S, de Cabo, E, Infante, ME, Pardal, E, Monsalvo, S, Gonzalez, M, Martin, A, Caballero, MD, Lopez-Guillermo, A
Publicada:
1 may 2019
Resumen:
The use of immunochemotherapy has improved the outcome of follicular lymphoma (FL). Recently, complete response at 30 months (CR30) has been suggested as a surrogate for progression-free survival. This study aimed to analyse the life expectancy of FL patients according to their status at 30 months from the start of treatment in comparison with the sex and age-matched Spanish general population (relative survival; RS). The training series comprised 263 patients consecutively diagnosed with FL in a 10-year period who needed therapy and were treated with rituximab-containing regimens. An independent cohort of 693 FL patients from the Grupo Espanol de Linfomas y Trasplante Autologo de Medula & Oacute; sea (GELTAMO) group was used for validation. In the training cohort, 188 patients were in CR30, with a 10-year overall survival (OS) of 53% and 87% for non-CR30 and CR30 patients, respectively. Ten-year RS was 73% and 100%, showing no decrease in life expectancy for CR30 patients. Multivariate analysis indicated that the FL International Prognostic Index was the most important variable predicting OS in the CR30 group. The impact of CR30 status on RS was validated in the independent GELTAMO series. In conclusion, FL patients treated with immunochemotherapy who were in CR at 30 months showed similar survival to a sex- and age-matched Spanish general population.
Filiaciones:
Magnano, L:
Hosp Clin Barcelona, Haematol Dept, Villarroel 170, E-08036 Barcelona, Spain
CIBERONC, Madrid, Spain
Alonso-Alvarez, S:
Hosp Univ Salamanca, Haematol Dept, Salamanca, Spain
IBSAL, Salamanca, Spain
Alcoceba, M:
CIBERONC, Madrid, Spain
Hosp Univ Salamanca, Haematol Dept, Salamanca, Spain
IBSAL, Salamanca, Spain
Rivas-Delgado, A:
Hosp Clin Barcelona, Haematol Dept, Villarroel 170, E-08036 Barcelona, Spain
CIBERONC, Madrid, Spain
Muntanola, A:
Hosp Univ Mutua Terrassa, Haematol Dept, Terrassa, Spain
Nadeu, F:
Inst Invest Biomed August Pi & Sunyer IDIBAP, Lymphoid Neoplasms Program, Barcelona, Spain
Setoain, X:
CIBER BBN 2, Hosp Clin Barcelona, Nucl Med Dept, Barcelona, Spain
Rodriguez, S:
CIBER BBN 2, Hosp Clin Barcelona, Nucl Med Dept, Barcelona, Spain
Andrade-Campos, M:
Hosp Miguel Servet, Haematol Dept, Zaragoza, Spain
Espinosa-Lara, N:
Hosp Miguel Servet, Haematol Dept, Zaragoza, Spain
Rodriguez, G:
Hosp Virgen Rocio, Haematol Dept, Seville, Spain
Sancho, JM:
Hosp GermansTrias & Pujol ICO IJC, Haematol Dept, Badalona, Spain
Moreno, M:
Hosp GermansTrias & Pujol ICO IJC, Haematol Dept, Badalona, Spain
Mercadal, S:
Hosp Duran & Reynals ICO, Haematol Dept, Hospitalet, Barcelona, Spain
Carro, I:
Hosp Duran & Reynals ICO, Haematol Dept, Hospitalet, Barcelona, Spain
Salar, A:
Hosp Mar, Haematol Dept, Barcelona, Spain
Garcia-Pallarols, F:
Hosp Mar, Haematol Dept, Barcelona, Spain
Arranz, R:
Hosp Princesa, Haematol Dept, Madrid, Spain
Cannata, J:
Hosp Princesa, Haematol Dept, Madrid, Spain
Terol, MJ:
Hosp Clin Valencia, Haematol Dept, Valencia, Spain
Teruel, AI:
Hosp Clin Valencia, Haematol Dept, Valencia, Spain
Jimenez-Ubiet, A:
Hosp 12 Octubre, Haematol Dept, Madrid, Spain
Rodrigue, A:
Hosp 12 Octubre, Haematol Dept, Madrid, Spain
de Villambrosi, SG:
Hosp Valdecilla Santander, Haematol Dept, Santander, Spain
Bell, JL:
Hosp Nuestra Senora Esperanza, Haematol Dept, Santiago De Compostela, Spain
Lopez, L:
Hosp MD Anderson, Haematol Dept, Madrid, Spain
Novelli, S:
Hosp Santa Creu & Sant Pau, Haematol Dept, Barcelona, Spain
de Cabo, E:
Hosp Bierzo, Haematol Dept, Ponferrada, Spain
Infante, ME:
Hosp Infanta Leonor, Haematol Dept, Madrid, Spain
Pardal, E:
Hosp Virgen Puerto, Haematol Dept, Plasencia, Spain
Monsalvo, S:
Hosp Fdn Jimenez Diaz, Haematol Dept, Madrid, Spain
Gonzalez, M:
CIBERONC, Madrid, Spain
Hosp Univ Salamanca, Haematol Dept, Salamanca, Spain
IBSAL, Salamanca, Spain
Martin, A:
CIBERONC, Madrid, Spain
Hosp Univ Salamanca, Haematol Dept, Salamanca, Spain
IBSAL, Salamanca, Spain
Caballero, MD:
CIBERONC, Madrid, Spain
Hosp Univ Salamanca, Haematol Dept, Salamanca, Spain
IBSAL, Salamanca, Spain
Lopez-Guillermo, A:
Hosp Clin Barcelona, Haematol Dept, Villarroel 170, E-08036 Barcelona, Spain
CIBERONC, Madrid, Spain
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