High Adherence to the Nordic Diet Is Associated with Lower Levels of Total and Platelet-Derived Circulating Microvesicles in a Norwegian Population
Por:
Chiva-Blanch, G, Laake, K, Myhre, P, Bratseth, V, Arnesen, H, Solheim, S, Badimon, L, Seljeflot, I
Publicada:
1 may 2019
Resumen:
Circulating microvesicles (cMV) are small phospholipid-rich blebs shed from the membrane of activated vascular cells that contribute to vascular disease progression. We aimed to investigate whether the quality of the Nordic diet is associated with the degree of blood and vascular cell activation measured by MV shedding in elderly patients after an acute myocardial infarction (AMI). One-hundred and seventy-four patients aged 70-82 years were included in this cross-sectional study. Fasting blood samples were taken within 2 to 8 weeks after an AMI. Annexin V (AV)(+) cMV derived from blood and vascular cells were measured through flow cytometry. A patient's usual diet was recorded with the SmartDiet (R) questionnaire. Patients with higher adherence to the Nordic diet (highest diet score) had lower levels of total AV(+) and platelet-derived (CD61(+)/AV(+) and CD31(+)/AV(+)) cMV. Dietary habits influence cellular activation. A high adherence to the Nordic diet (assessed by the SmartDiet (R) score) in elderly post-AMI patients was associated with lower levels of platelet activation, which was reflected by a lesser release of MV carrying platelet-derived epitopes, potentially contributing to an explanation of the cardioprotective effects of the Nordic diet.
Filiaciones:
Chiva-Blanch, G:
Oslo Univ Hosp Ulleval, Dept Cardiol, Ctr Clin Heart Res, N-0450 Oslo, Norway
Hosp Santa Creu & Sant Pau, Res Inst, Cardiovasc Program, ICCC, Barcelona 08025, Spain
Univ Oslo, Fac Med, N-0372 Oslo, Norway
Laake, K:
Oslo Univ Hosp Ulleval, Dept Cardiol, Ctr Clin Heart Res, N-0450 Oslo, Norway
Univ Oslo, Fac Med, N-0372 Oslo, Norway
Myhre, P:
Oslo Univ Hosp Ulleval, Dept Cardiol, Ctr Clin Heart Res, N-0450 Oslo, Norway
Univ Oslo, Fac Med, N-0372 Oslo, Norway
Bratseth, V:
Oslo Univ Hosp Ulleval, Dept Cardiol, Ctr Clin Heart Res, N-0450 Oslo, Norway
Univ Oslo, Fac Med, N-0372 Oslo, Norway
Arnesen, H:
Oslo Univ Hosp Ulleval, Dept Cardiol, Ctr Clin Heart Res, N-0450 Oslo, Norway
Univ Oslo, Fac Med, N-0372 Oslo, Norway
Solheim, S:
Oslo Univ Hosp Ulleval, Dept Cardiol, Ctr Clin Heart Res, N-0450 Oslo, Norway
Badimon, L:
Hosp Santa Creu & Sant Pau, Res Inst, Cardiovasc Program, ICCC, Barcelona 08025, Spain
Seljeflot, I:
Oslo Univ Hosp Ulleval, Dept Cardiol, Ctr Clin Heart Res, N-0450 Oslo, Norway
Univ Oslo, Fac Med, N-0372 Oslo, Norway
Gold, Green Published
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