ACROSTART: A retrospective study of the time to achieve hormonal control with lanreotide Autogel treatment in Spanish patients with acromegaly
Por:
Alvarez-Escola, C, Venegas-Moreno, EM, Garcia-Arnes, JA, Blanco-Carrera, C, Marazuela-Azpiroz, M, Galvez-Moreno, MA, Menendez-Torre, E, Aller-Pardo, J, Salinas-Vert, I, Resmini, E, Torres-Vela, EM, Gonzalo-Redondo, MA, Vilchez-Joya, R, de Miguel-Novoa, MP, Halperin-Rabinovich, I, Paramo-Fernandez, C, de la Cruz-Sugranyes, G, Houchard, A, Pico-Alfonso, AM, ACROSTART Study Grp
Publicada:
1 may 2019
Resumen:
Objectives: The ACROSTART study was intended to determine the time to achieve normalization of GH and IGF-I levels in responding patients with acromegaly administered different dosage regimens of lanreotide Autogel (Somatuline (R) Autogel (R)).
Methods: From March 2013 to October 2013, clinical data from 57 patients from 17 Spanish hospitals with active acromegaly treated with lanreotide for >= 4 months who achieved hormonal control (GH levels <2.5 ng/ml and/or normalized IGF-I levels in >= 2 measurements) were analyzed. The primary objective was to determine the time from start of lanreotide treatment to hormonal normalization.
Results: Median patient age was 64 years, 21 patients were male, 39 patients had undergone surgery, and 14 patients had received radiotherapy. Median hormonal values at start of lanreotide treatment were: GH, 2.6 ng/ml; IGF-I, 1.6 x ULN. The most common starting dose of lanreotide was 120 mg (29 patients). The main initial regimens were 60 mg/4 weeks (n=13), 90 mg/4 weeks (n=6), 120 mg/4 weeks (n=13), 120 mg/6 weeks (n=6), and 120 mg/8 weeks (n=9). An initial treatment regimen with a long interval (>6 weeks) was administered in 25 patients. Mean duration of lanreotide treatment was 68 months (7-205). Median time to achieve hormonal control was 4.9 months. Injections were managed without healthcare assistance in 13 patients. Median number of visits to endocrinologists until hormonal control was achieved was 3. Fifty-one patients were "satisfied" / "very satisfied" with treatment and 49 patients did not miss any dose.
Conclusions: Real-life treatment with lanreotide Autogel resulted in early hormonal control in responding patients, with high treatment adherence and satisfaction despite disparity in starting doses and dosing intervals. (C) 2019 SEEN y SED. Published by Elsevier Espana, S.L.U. All rights reserved.
Filiaciones:
Alvarez-Escola, C:
Hosp Univ La Paz, Endocrinol & Nutr Dept, Madrid, Spain
Venegas-Moreno, EM:
Hosp Univ Virgen Rocio, Endocrinol Dept, Seville, Spain
Garcia-Arnes, JA:
Univ Malaga, Endocrinol & Nutr Serv, Hosp Reg, Malaga, Spain
Blanco-Carrera, C:
Hosp Univ Principe Asturias, Endocrinol Dept, Madrid, Spain
Marazuela-Azpiroz, M:
Univ Autonoma Madrid, Endocrinol Dept, Hosp Univ La Princesa, Inst Princesa, Madrid, Spain
Galvez-Moreno, MA:
Hosp Univ Reina Sofia Cordoba, Endocrinol Serv, Cordoba, Spain
Menendez-Torre, E:
Hosp Univ Cent Asturias, Endocrinol & Nutr Dept, Oviedo, Spain
Aller-Pardo, J:
Hosp Univ Puerta de Hierro, Endocrinol Dept, Neuroendocrinol & Endocrine Oncol Unit, Madrid, Spain
Salinas-Vert, I:
Hosp Badalona Germans Trias & Pujol, Endocrinol & Nutr Dept, Barcelona, Spain
Resmini, E:
Hosp Santa Creu & Sant Pau, CIBER ER, Unidad 747, Barcelona, Spain
Univ Autonoma Barcelona, Barcelona, Spain
Torres-Vela, EM:
Complejo Hosp Univ, Endocrinol & Nutr, Granada, Spain
Gonzalo-Redondo, MA:
Fdn Jimenez Diaz, Endocrinol & Nutr Dept, Madrid, Spain
Vilchez-Joya, R:
Hosp Univ Virgen Nieves, Endocrinol & Nutr Serv, Granada, Spain
de Miguel-Novoa, MP:
Univ Complutense Madrid, Endocrinol Dept, Hosp Clin San Carlos, Madrid, Spain
Halperin-Rabinovich, I:
Univ Barcelona, Endocrinol Dept, Hosp Clin, Barcelona, Spain
Paramo-Fernandez, C:
Complejo Hosp Xeral Cies Vigo, Endocrinol & Nutr Dept, Vigo, Pontevedra, Spain
de la Cruz-Sugranyes, G:
IPSEN PHARMA SA, Med Dept, Barcelona, Spain
Houchard, A:
IPSEN PHARMA, Stat Dept, Boulogne, France
Pico-Alfonso, AM:
Hosp Gen Univ Alicante ISABIAL FISABIO, Endocrinol Dept, Alicante, Spain
Green Published, Hybrid Gold
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