Rationale and design of the HIP fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) Trial: a protocol for an international randomised controlled trial evaluating early surgery for hip fracture patients
Por:
Borges, FK, Bhandari, M, Patel, A, Avram, V, Guerra-Farfan, E, Sigamani, A, Umer, M, Tiboni, M, Adili, A, Neary, J, Tandon, V, Sancheti, PK, Lawendy, A, Jenkinson, R, Ramokgopa, M, Biccard, BM, Szczeklik, W, Wang, CY, Landoni, G, Forget, P, Popova, E, Wood, G, Nur, AN, John, B, Sleczka, P, Feibel, RJ, Balaguer-Castro, M, Deheshi, B, Winemaker, M, de Beer, J, Kolesar, R, Teixidor-Serra, J, Tomas-Hernandez, J, McGillion, M, Shanthanna, H, Moppett, I, Vincent, J, Pettit, S, Harvey, V, Gauthier, L, Alvarado, K, Devereaux, PJ
Publicada:
1 jun 2019
Resumen:
Introduction Annually, millions of adults suffer hip fractures. The mortality rate post a hip fracture is 7%-10% at 30 days and 10%-20% at 90 days. Observational data suggest that early surgery can improve these outcomes in hip fracture patients. We designed a clinical trial-HIP fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) to determine the effect of accelerated surgery compared with standard care on the 90-day risk of all-cause mortality and major perioperative complications.
Methods and analysis HIP ATTACK is a multicentre, international, parallel group randomised controlled trial (RCT) that will include patients >= 45 years of age and diagnosed with a hip fracture from a low-energy mechanism requiring surgery. Patients are randomised to accelerated medical assessment and surgical repair (goal within 6 h) or standard care. The co-primary outcomes are (1) all-cause mortality and (2) a composite of major perioperative complications (ie, mortality and non-fatal myocardial infarction, pulmonary embolism, pneumonia, sepsis, stroke, and life-threatening and major bleeding) at 90 days after randomisation. All patients will be followed up for a period of 1 year. We will enrol 3000 patients.
Ethics and dissemination All centres had ethics approval before randomising patients. Written informed consent is required for all patients before randomisation. HIP ATTACK is the first large international trial designed to examine whether accelerated surgery can improve outcomes in patients with a hip fracture. The dissemination plan includes publishing the results in a policy-influencing journal, conference presentations, engagement of influential medical organisations, and providing public awareness through multimedia resources.
Filiaciones:
Borges, FK:
Populat Hlth Res Inst, Dept Perioperat Med, Hamilton, ON, Canada
Bhandari, M:
McMaster Univ, Dept Surg, Hamilton, ON, Canada
Patel, A:
McMaster Univ, Dept Med, Hamilton, ON, Canada
Avram, V:
McMaster Univ, Dept Surg, Hamilton, ON, Canada
Guerra-Farfan, E:
Vall dHebron Univ Hosp, Dept Orthopaed Surg & Traumatol, Barcelona, Spain
Sigamani, A:
Narayana Hlth, Dept Clin Res, Bangalore, Karnataka, India
Umer, M:
Aga Khan Univ, Dept Orthopaed Surg, Karachi, Pakistan
Tiboni, M:
McMaster Univ, Dept Med, Hamilton, ON, Canada
Adili, A:
McMaster Univ, Dept Surg, Hamilton, ON, Canada
Neary, J:
McMaster Univ, Dept Med, Hamilton, ON, Canada
Tandon, V:
McMaster Univ, Dept Med, Hamilton, ON, Canada
Sancheti, PK:
Sancheti Inst Orthopaed & Rehabil, Dept Orthopaed Surg, Pune, Maharashtra, India
Lawendy, A:
London Hlth Sci Ctr, Dept Surg, London, England
Jenkinson, R:
Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada
Univ Toronto, Dept Surg, Toronto, ON, Canada
Univ Toronto, Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada
Ramokgopa, M:
Chris Hani Baragwanath Acad Hosp, Dept Orthopaed Surg, Johannesburg, South Africa
Univ Witwatersrand, Johannesburg, South Africa
Biccard, BM:
Univ Cape Town, Dept Anaesthesia & Perioperat Med, Cape Town, South Africa
Szczeklik, W:
Jagiellonian Univ, Dept Intens Care & Perioperat Med, Med Coll, Krakow, Poland
Wang, CY:
Univ Malaya, Dept Anaesthesiol, Kuala Lumpur, Malaysia
Landoni, G:
Univ Vita Salute San Raffaele, Milan, Italy
IRCCS San Raffaele Sci Inst, Dept Anaesthesia & Intens Care, Milan, Italy
Forget, P:
Univ Ziekenhuis Brussel, Dept Anesthesiol & Perioperat Med, Brussels, Belgium
Popova, E:
Biomed Res Inst IIB St Pau, Barcelona, Spain
Wood, G:
Queens Univ, Dept Surg, Kingston, ON, Canada
Nur, AN:
Shifa Int Hosp, Islamabad, Pakistan
John, B:
Christian Med Coll & Hosp, Dept Orthopaed Surg, Ludhiana, Punjab, India
Sleczka, P:
SPZOZ, Orthopaed, Myslenice, Poland
Feibel, RJ:
Univ Ottawa, Dept Surg, Ottawa, ON, Canada
Balaguer-Castro, M:
Parc Tauli Hosp Univ, Dept Orthopaed Surg & Traumatol, Barcelona, Spain
Deheshi, B:
Sharif Surg Oncol, Dept Orthopaed, Ft Worth, TX USA
Winemaker, M:
McMaster Univ, Dept Surg, Hamilton, ON, Canada
de Beer, J:
McMaster Univ, Dept Surg, Hamilton, ON, Canada
Kolesar, R:
McMaster Univ, Dept Anaesthesia, Hamilton, ON, Canada
Teixidor-Serra, J:
Vall dHebron Univ Hosp, Dept Orthopaed Surg & Traumatol, Barcelona, Spain
Tomas-Hernandez, J:
Vall dHebron Univ Hosp, Dept Orthopaed Surg & Traumatol, Barcelona, Spain
McGillion, M:
McMaster Univ, Sch Nursing, Hamilton, ON, Canada
Moppett, I:
Univ Nottingham, Dept Anaesthesia & Crit Care, Nottingham, England
Vincent, J:
Populat Hlth Res Inst, Dept Perioperat Med, Hamilton, ON, Canada
Pettit, S:
Populat Hlth Res Inst, Dept Perioperat Med, Hamilton, ON, Canada
Harvey, V:
Populat Hlth Res Inst, Dept Perioperat Med, Hamilton, ON, Canada
Gauthier, L:
Hamilton Hlth Sci, Hamilton, ON, Canada
Devereaux, PJ:
Populat Hlth Res Inst, Dept Perioperat Med, Hamilton, ON, Canada
McMaster Univ, Dept Hlth Res Methods, Hamilton, ON, Canada
McMaster Univ, Dept Evidence, Hamilton, ON, Canada
McMaster Univ, Dept Impact HEI, Hamilton, ON, Canada
Gold, Green Published
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