Obstructive sleep apnea and longitudinal Alzheimer's disease biomarker changes
Por:
Bubu, OM, Pirraglia, E, Andrade, AG, Sharma, RA, Gimenez-Badia, S, Umasabor-Bubu, OQ, Hogan, MM, Shim, AM, Mukhtar, F, Sharma, N, Mbah, AK, Seixas, AA, Kam, K, Zizi, F, Borenstein, AR, Mortimer, JA, Kip, KE, Morgan, D, Rosenzweig, I, Ayappa, I, Rapoport, DM, Jean-Louis, G, Varga, AW, Osorio, RS, Alzheimers Dis Neuroimaging Ini
Publicada:
1 jun 2019
Resumen:
Study Objectives: To determine the effect of self-reported clinical diagnosis of obstructive sleep apnea (OSA) on longitudinal changes in brain amyloid PET and CSF biomarkers (A beta 42, T-tau, and P-tau) in cognitively normal (NL), mild cognitive impairment (MCI), and Alzheimer's disease (AD) elderly.
Methods: Longitudinal study with mean follow-up time of 2.52 +/- 0.51 years. Data were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. Participants included 516 NL, 798 MCI, and 325 AD elderly. Main outcomes were annual rate of change in brain amyloid burden (i.e. longitudinal increases in florbetapir PET uptake or decreases in CSF A beta 42 levels); and tau protein aggregation (i.e. longitudinal increases in CSF total tau [T-tau] and phosphorylated tau [P-tau]). Adjusted multilevel mixed effects linear regression models with randomly varying intercepts and slopes was used to test whether the rate of biomarker change differed between participants with and without OSA.
Results: In NL and MCI groups, OSA+ subjects experienced faster annual increase in florbetapir uptake (B =.06, 95% CI =.02,.11 and B =.08, 95% CI =.05, .12, respectively) and decrease in CSF A beta 42 levels (B = -2.71, 95% CI = -3.11, -2.35 and B = -2.62, 95% CI = -3.23, -2.03, respectively); as well as increases in CSF T-tau (B = 3.68, 95% CI = 3.31, 4.07 and B = 2.21, 95% CI = 1.58, 2.86, respectively) and P-tau (B = 1.221, 95% CI = 1.02, 1.42 and B = 1.74, 95% CI = 1.22, 2.27, respectively); compared with OSA- participants. No significant variations in the biomarker changes over time were seen in the AD group.
Conclusions: In both NL and MCI, elderly, clinical interventions aimed to treat OSA are needed to test if OSA treatment may affect the progression of cognitive impairment due to AD.
Filiaciones:
Bubu, OM:
Univ S Florida, Coll Publ Hlth, Dept Epidemiol & Biostat, Tampa, FL USA
NYU, Dept Psychiat, Langone Med Ctr, Ctr Brain Hlth, 550 1St Ave, New York, NY 10016 USA
Wheaton Coll, Dept Appl Hlth Sci, Wheaton, IL 60187 USA
NYU, Sch Med, Ctr Healthful Behav Change, Dept Populat Hlth, New York, NY USA
Pirraglia, E:
NYU, Dept Psychiat, Langone Med Ctr, Ctr Brain Hlth, 550 1St Ave, New York, NY 10016 USA
Andrade, AG:
NYU, Dept Psychiat, Langone Med Ctr, Ctr Brain Hlth, 550 1St Ave, New York, NY 10016 USA
Sharma, RA:
NYU, Dept Psychiat, Langone Med Ctr, Ctr Brain Hlth, 550 1St Ave, New York, NY 10016 USA
Gimenez-Badia, S:
Univ Barcelona, IIB St Pau Dept Clin Psychobiol, Hosp Santa Creu & St Pau, Multidisciplinary Sleep Unit,Resp Dept, Barcelona, Spain
Umasabor-Bubu, OQ:
Suny Downstate Med Ctr, Brooklyn, NY 11203 USA
Hogan, MM:
Wheaton Coll, Dept Appl Hlth Sci, Wheaton, IL 60187 USA
Shim, AM:
Wheaton Coll, Dept Appl Hlth Sci, Wheaton, IL 60187 USA
Mukhtar, F:
Univ S Florida, Coll Publ Hlth, Dept Epidemiol & Biostat, Tampa, FL USA
Sharma, N:
Univ Rome, Dipartmento Sci Biochim A Rossi Fanelli, Rome, Italy
Mbah, AK:
Univ S Florida, Coll Publ Hlth, Dept Epidemiol & Biostat, Tampa, FL USA
Seixas, AA:
NYU, Sch Med, Ctr Healthful Behav Change, Dept Populat Hlth, New York, NY USA
Kam, K:
Icahn Sch Med Mt Sinai, Div Pulm Crit Care & Sleep Med, New York, NY 10029 USA
Zizi, F:
NYU, Sch Med, Ctr Healthful Behav Change, Dept Populat Hlth, New York, NY USA
Borenstein, AR:
Univ Calif San Diego, Dept Family Med & Publ Hlth, San Diego, CA 92103 USA
Mortimer, JA:
Univ S Florida, Coll Publ Hlth, Dept Epidemiol & Biostat, Tampa, FL USA
Kip, KE:
Univ S Florida, Coll Publ Hlth, Dept Epidemiol & Biostat, Tampa, FL USA
Morgan, D:
Michigan State Univ, Dept Mol Sci & Translat Med, Grand Rapids, MI USA
Univ South Florida Hlth, Byrd Alzheimers Dis Inst, Coll Med Psychiat & Behav Neurosci, Tampa, FL USA
Rosenzweig, I:
Guys Hosp, Sleep Disorders Ctr, London, England
Kings Coll London, IoPPN, Sleep & Brain Plast Ctr, Dept Neuroimaging, London, England
Ayappa, I:
Icahn Sch Med Mt Sinai, Div Pulm Crit Care & Sleep Med, New York, NY 10029 USA
Rapoport, DM:
Icahn Sch Med Mt Sinai, Div Pulm Crit Care & Sleep Med, New York, NY 10029 USA
Jean-Louis, G:
NYU, Sch Med, Ctr Healthful Behav Change, Dept Populat Hlth, New York, NY USA
Varga, AW:
Icahn Sch Med Mt Sinai, Div Pulm Crit Care & Sleep Med, New York, NY 10029 USA
Osorio, RS:
NYU, Dept Psychiat, Langone Med Ctr, Ctr Brain Hlth, 550 1St Ave, New York, NY 10016 USA
Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA
Green Published
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