A collection of integration-free iPSCs derived from Parkinson's disease patients carrying mutations in the GBA1 gene
Por:
Rodriguez-Traver, E, Diaz-Guerra, E, Rodriguez, C, Fernandez, P, Arenas, F, Arauzo-Bravo, M, Orera, M, Kulisevsky, J, Moratalla, R, Vicario, C
Publicada:
1 jul 2019
Resumen:
Mutations in the GBA1 gene, which encodes the lysosomal enzyme Glucocerebrosidase1 are major risk factors for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). We have generated induced pluripotent stem cells (iPSCs) from fibroblasts of four PD patients carrying the N370S/wt or the L444P/wt heterozygous mutations in GBA1. The iPSCs presented a normal morphology, expressed endogenous pluripotency markers and could be differentiated into endodermal, mesodermal and ectodermal cells. These iPSCs were free from Sendai viral vectors and reprogramming factors, had a normal karyotype and maintained the original GBA1 genotype.
Filiaciones:
Rodriguez-Traver, E:
CSIC, Inst Cajal, Madrid, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Diaz-Guerra, E:
CSIC, Inst Cajal, Madrid, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Rodriguez, C:
Hosp Gen Univ Gregorio Maranon, Serv Bioquim Clin, Madrid, Spain
Fernandez, P:
CSIC, Inst Cajal, Madrid, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Arenas, F:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Hosp Santa Creu & Sant Pau, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
Arauzo-Bravo, M:
Biodonostia Hlth Res Inst, San Sebastian, Spain
Orera, M:
Hosp Gen Univ Gregorio Maranon, Serv Bioquim Clin, Madrid, Spain
Kulisevsky, J:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Hosp Santa Creu & Sant Pau, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
Moratalla, R:
CSIC, Inst Cajal, Madrid, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Vicario, C:
CSIC, Inst Cajal, Madrid, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Gold, Green Published
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