Safety and effectiveness of conventional systemic therapy and biological drugs in patients with moderate to severe psoriasis and HIV infection: a retrospective multicenter study
Por:
Montes-Torres, A, Aparicio, G, Rivera, R, Vilarrasa, E, Marcellan, M, Notario, J, Soria, C, Carrascosa, JM, Gomez, FJ, Salgado, L, Velasco, M, Descalzo, MA, Dauden, E, Carretero, G, Torrado, R, Ferrandiz, C, Llamas-Velasco, M, Gomez-Garcia, FJ, Jimenez, R, de la Cueva, P, Galiano, S, Herrera-Ceballos, E, Herrera-Acosta, E, Belinchon, I, Lopez-Estebaranz, JL, Ruiz-Genao, D, Alsina, M, Sanchez-Carazo, JL, Ferran, M, Baniandres, O, Garcia-Doval, I, Mollet, J
Publicada:
4 jul 2019
Resumen:
Background: The management of HIV-positive patients with psoriasis is controversial and limited to individual cases or short series of patients. Objectives: To evaluate the safety and effectiveness of conventional and biologic immunosuppressive drugs in the treatment of patients with psoriasis and concomitant HIV infection. Methods: A retrospective multicenter study was conducted. The study included data from 2008 to 2016. Inclusion criteria were: HIV adult patients with moderate-to-severe psoriasis, HIV viral load determinations at baseline and at least after 6 months of treatment, and systemic immunosuppressive treatment for at least 6 months. A descriptive analysis was performed. Results: Twenty-three patients with plaque-type psoriasis and HIV infection (five with AIDS) were included. Median follow-up time was 3.2 years. The main drugs used were etanercept, methotrexate, and ustekinumab. In most cases, viral load and CD4 cell count not only remained stable but also improved throughout the follow-up. Six patients presented severe adverse events during the follow-up, four of them in the AIDS stage. At the end of the follow-up period, 76.5% of the patients had achieved a PASI 75. Conclusion: Biologic drugs, both anti-TNF alpha agents and ustekinumab, seem to have an acceptable safety profile and high effectiveness in HIV-positive patients.
Filiaciones:
Montes-Torres, A:
Hosp Univ La Princesa, Dept Dermatol, Madrid, Spain
Hosp Cent Def Gomez Ulla, Dept Dermatol, Madrid, Spain
Aparicio, G:
Hosp Univ Vall Hebron, Dept Dermatol, Barcelona, Spain
Rivera, R:
Hosp Univ Doce Octubre, Dept Dermatol, Madrid, Spain
Hosp Univ 12 Octubre, Madrid, Spain
Vilarrasa, E:
Hosp Univ Santa Creu & St Pau, Dept Dermatol, Barcelona, Spain
Marcellan, M:
Hosp Univ Marques Valdecilla, Dept Dermatol, Santander, Spain
Notario, J:
Hosp Univ Bellvitge, Dept Dermatol, Lhospitalet De Llobregat, Spain
Soria, C:
Hosp Gen Univ Reina Sofia, Dept Dermatol, Murcia, Spain
Carrascosa, JM:
Hosp Badalona Germans Trias & Pujol, Dept Dermatol, Badalona, Spain
Hosp Badalona Germans Trias & Pujol, Badalona, Spain
Gomez, FJ:
Hosp Univ Reina Sofia, Dept Dermatol, Cordoba, Spain
Salgado, L:
Complejo Hosp Univ Pontevedra, Dept Dermatol, Pontevedra, Spain
Velasco, M:
Hosp Arnau Vilanova, Dept Dermatol, Valencia, Spain
Hosp Univ La Princesa, Madrid, Spain
Descalzo, MA:
Fdn Piel Sana AEDV, Res Unit, Madrid, Spain
Dauden, E:
Hosp Univ La Princesa, Dept Dermatol, Madrid, Spain
Hosp Univ La Princesa, Madrid, Spain
Carretero, G:
Hosp Univ Gran Canaria Dr Negrin, Las Palmas Gran Canaria, Spain
Torrado, R:
Hosp Univ Gran Canaria Dr Negrin, Las Palmas Gran Canaria, Spain
Ferrandiz, C:
Hosp Badalona Germans Trias & Pujol, Badalona, Spain
Llamas-Velasco, M:
Hosp Univ La Princesa, Madrid, Spain
Gomez-Garcia, FJ:
Hosp Univ Reina Sofia, Cordoba, Spain
Jimenez, R:
Hosp Univ Reina Sofia, Cordoba, Spain
de la Cueva, P:
Hosp Univ Infanta Leonor, Dept Dermatol, Madrid, Spain
Hosp Univ Infanta Leonor, Madrid, Spain
Galiano, S:
Hosp Univ Infanta Leonor, Madrid, Spain
Herrera-Ceballos, E:
Hosp Univ Virgen Victoria, Malaga, Spain
Herrera-Acosta, E:
Hosp Univ Virgen Victoria, Malaga, Spain
Belinchon, I:
Hosp Gen Univ Alicante, Dept Dermatol, Alicante, Spain
Hosp Gen Univ Alicante, Alicante, Spain
Lopez-Estebaranz, JL:
Fdn Hosp Alcorcon, Madrid, Spain
Ruiz-Genao, D:
Fdn Hosp Alcorcon, Madrid, Spain
Alsina, M:
Hosp Clin Barcelona, Barcelona, Spain
Sanchez-Carazo, JL:
Hosp Gen Univ Valencia, Valencia, Spain
Ferran, M:
Hosp Mar, Dept Dermatol, Parc Salut Mar, Barcelona, Spain
Hosp Mar, Parc Salut Mar Barcelona, Barcelona, Spain
Baniandres, O:
Hosp Gen Univ Gregorio Maranon, Madrid, Spain
Garcia-Doval, I:
Complejo Hosp Univ Vigo, Dept Dermatol, Vigo, Spain
Fdn Piel Sana AEDV, Madrid, Spain
Mollet, J:
Hosp Univ Vall Hebron, Barcelona, Spain
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