The poor prognosis of low hypodiploidy in adults with B-cell precursor acute lymphoblastic leukaemia is restricted to older adults and elderly patients
Por:
Ribera, J, Granada, I, Morgades, M, Vives, S, Genesca, E, Gonzalez, C, Nomdedeu, J, Escoda, L, Montesinos, P, Mercadal, S, Coll, R, Gonzalez-Campos, J, Abella, E, Barba, P, Bermudez, A, Gil, C, Tormo, M, Pedreno, M, Martinez-Carballeira, D, Hernandez-Rivas, JM, Orfao, A, Martinez-Lopez, J, Esteve, J, Bravo, P, Garcia-Guinon, A, Deben, G, Moraleda, JM, Queizan, JA, Ortin, X, Moreno, MJ, Feliu, E, Sole, F, Ribera, JM
Publicada:
1 jul 2019
Resumen:
The prognostic significance of low-hypodiploidy has not been extensively evaluated in minimal residual disease (MRD)-oriented protocols for adult acute lymphoblastic leukaemia (ALL). We analysed the outcome of hypodiploid adult ALL patients treated within Programa Espanol de Tratamientos en Hematologia (PETHEMA) protocols. The 5-year cumulative incidence of relapse (CIR) of low-hypodiploid B-cell precursor (BCP)-ALL was significantly higher than that of high-hypodiploids (52% vs. 12%, P = 0.013). Low-hypodiploid BCP-ALL patients aged <= 35 years showed superior survival (71% vs. 21%, P = 0.026) and lower 5-year CIR (17% vs. 66%, P = 0.090) than low-hypodiploids aged >35 years. Older adults and elderly low-hypodiploid BCP-ALL patients show dismal prognosis although achieving an end-induction good MRD response.
Filiaciones:
Ribera, J:
Univ Autonoma Barcelona, Hosp Germans Trias & Pujol, Inst Recerca Leucemia Josep Carreras, Barcelona, Spain
Hosp Badalona Germans Trias & Pujol, Inst Catala Oncol, Barcelona, Spain
Granada, I:
Univ Autonoma Barcelona, Hosp Germans Trias & Pujol, Inst Recerca Leucemia Josep Carreras, Barcelona, Spain
Hosp Badalona Germans Trias & Pujol, Inst Catala Oncol, Barcelona, Spain
Morgades, M:
Univ Autonoma Barcelona, Hosp Germans Trias & Pujol, Inst Recerca Leucemia Josep Carreras, Barcelona, Spain
Hosp Badalona Germans Trias & Pujol, Inst Catala Oncol, Barcelona, Spain
Vives, S:
Univ Autonoma Barcelona, Hosp Germans Trias & Pujol, Inst Recerca Leucemia Josep Carreras, Barcelona, Spain
Hosp Badalona Germans Trias & Pujol, Inst Catala Oncol, Barcelona, Spain
Genesca, E:
Univ Autonoma Barcelona, Hosp Germans Trias & Pujol, Inst Recerca Leucemia Josep Carreras, Barcelona, Spain
Gonzalez, C:
Univ Autonoma Barcelona, Hosp Germans Trias & Pujol, Inst Recerca Leucemia Josep Carreras, Barcelona, Spain
Nomdedeu, J:
Hosp Santa Creu & Sant Pau, Inst Recerca Leucemia Josep Carreras, Barcelona, Spain
Escoda, L:
Hosp Joan 23, Inst Catala Oncol, Tarragona, Spain
Montesinos, P:
Hosp La Fe, Valencia, Spain
Mercadal, S:
Hospitalet Llobregat, Hosp Duran & Reynals, Inst Catala Oncol, Lhospitalet De Llobregat, Spain
Coll, R:
Hosp Josep Trueta, Inst Catala Oncol, Girona, Spain
Gonzalez-Campos, J:
Hosp Univ Virgen Rocio, Seville, Spain
Abella, E:
Hosp Mar, Barcelona, Spain
Barba, P:
Hosp Valle De Hebron, Barcelona, Spain
Bermudez, A:
Hosp Marques Valdecilla, Santander, Spain
Gil, C:
Hosp Gen Alicante, Alicante, Spain
Tormo, M:
Hosp Clin, Valencia, Spain
Pedreno, M:
Hosp Doctor Peset, Valencia, Spain
Martinez-Carballeira, D:
Hosp Univ Cent Asturias, Oviedo, Spain
Hernandez-Rivas, JM:
Univ Salamanca, Hosp Univ Salamanca, IBMCC CSIC USAL, IBSAL, Salamanca, Spain
CIBERONC, Salamanca, Spain
Hosp Doce Octubre, Madrid, Spain
Orfao, A:
Univ Salamanca, Hosp Univ Salamanca, IBMCC CSIC USAL, IBSAL, Salamanca, Spain
CIBERONC, Salamanca, Spain
Martinez-Lopez, J:
Hosp Doce Octubre, Madrid, Spain
Esteve, J:
Hosp Clin Barcelona, Inst Recerca Leucemia Josep Carreras, Barcelona, Spain
Bravo, P:
Hosp Univ Fuenlabrada Fuenlabrada, Lleida, Spain
Garcia-Guinon, A:
Hosp Arnau Vilanova, Lleida, Spain
Deben, G:
Hosp Juan Canalejo, La Coruna, Spain
Moraleda, JM:
Univ Murcia, Hosp Clin Univ Virgen Arrixaca, IMIB, Murcia, Spain
Queizan, JA:
Hosp Gen Segovia, Segovia, Spain
Ortin, X:
Hosp Verge Cinta, Tortosa, Spain
Moreno, MJ:
Hosp Virgen Victoria, Malaga, Spain
Feliu, E:
Univ Autonoma Barcelona, Hosp Germans Trias & Pujol, Inst Recerca Leucemia Josep Carreras, Barcelona, Spain
Hosp Badalona Germans Trias & Pujol, Inst Catala Oncol, Barcelona, Spain
Sole, F:
Univ Autonoma Barcelona, Hosp Germans Trias & Pujol, Inst Recerca Leucemia Josep Carreras, Barcelona, Spain
Ribera, JM:
Univ Autonoma Barcelona, Hosp Germans Trias & Pujol, Inst Recerca Leucemia Josep Carreras, Barcelona, Spain
Hosp Badalona Germans Trias & Pujol, Inst Catala Oncol, Barcelona, Spain
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