High BDNF serum levels are associated to good cognitive functioning in bipolar disorder
Por:
Mora, E, Portella, MJ, Pinol-Ripoll, G, Lopez, R, Cuadras, D, Forcada, I, Teres, M, Vieta, E, Mur, M
Publicada:
1 ago 2019
Resumen:
Background: Neurotrophins such as brain-derived neurotrophic factor (BDNF), inflammation and oxidative damage may contribute to the pathophysiology of bipolar disorder (BD) in terms of illness activity. To date, there is a lack of studies linking the cognitive impairment observed in BD with these neurobiological mechanisms. This study aimed to investigate the role of these neurobiological factors in clinical and cognitive outcomes in a sample of bipolar individuals.
Methods: We measured serum BDNF, cytokines and oxidative stress markers in a sample of 133 individuals: 52 euthymic bipolar patients, 32 manic patients and 49 healthy controls. They were all assessed with a comprehensive cognitive battery. Sociodemographic and clinical data were collected. Multiple linear regression models were built to study associations of neurotrophins and inflammatory and oxidative measures with cognitive functioning.
Results: BDNF levels were decreased in euthymic (p = 0.039) and manic (p < 0.001) individuals. Conversely, inflammatory (interleukin 6 (IL-6)) (p = 0.019) and oxidative stress (p = 0.003) measures were increased in bipolar individuals compared to controls. BDNF levels were associated with executive functioning (beta = 0.01, p = 0.02) and verbal memory (beta = 0.013, p = 0.005), together with other demographic variables. In particular, verbal memory was also associated with obesity (beta=-0.04, p = 0.005). Neither inflammatory markers, oxidative stress markers nor other relevant clinical variables showed any association with cognitive outcome.
Conclusions: Of all the peripheral neurobiological factors analysed, BDNF was the only one significantly associated with cognitive dysfunction in bipolar disorder individuals. This study emphasizes the role of BDNF not only across mood phases but also in cognitive functioning. (C) 2019 Elsevier Masson SAS. All rights reserved.
Filiaciones:
Mora, E:
Univ Lleida, Biol Fdn Mental Disorders, Lleida Inst Biomed Res Dr Pifarre Fdn, Hosp Univ Santa Maria,Psychiat Serv,IRBLleida, Lleida, Catalonia, Spain
Hosp St Joan de Deu Terres Lleida, Child & Adolescent Mental Hlth Ctr, Catalonia, Spain
Portella, MJ:
Autonomous Univ Barcelona, CIBERSAM, Hosp Santa Creu & St Pau, Psychiat Serv,Res Inst, Barcelona, Catalonia, Spain
Pinol-Ripoll, G:
Univ Lleida, Cognit Disorders Unit, Lleida Inst Biomed Res Dr Pifarre Fdn, Hosp Univ Santa Maria,Neurosci Clin Grp,IRBLleida, Lleida, Catalonia, Spain
Lopez, R:
Univ Lleida, Hosp Univ Arnau de Vilanova, Lleida Inst Biomed Res Dr Pifarre Fdn, Lab Dept,IRBLleida, Lleida, Catalonia, Spain
Cuadras, D:
St Joan de Deu Res Fdn, Stat Unit, Parc Sanitari St Joan de Deu, Barcelona, Catalonia, Spain
Forcada, I:
Univ Lleida, Biol Fdn Mental Disorders, Lleida Inst Biomed Res Dr Pifarre Fdn, Hosp Univ Santa Maria,Psychiat Serv,IRBLleida, Lleida, Catalonia, Spain
Teres, M:
Univ Lleida, Biol Fdn Mental Disorders, Lleida Inst Biomed Res Dr Pifarre Fdn, Hosp Univ Santa Maria,Psychiat Serv,IRBLleida, Lleida, Catalonia, Spain
Vieta, E:
Univ Barcelona, IDIBAPS, CIBERSAM, Bipolar Disorder Program,Hosp Clin,Inst Neurosci, Barcelona, Catalonia, Spain
Mur, M:
Univ Lleida, Biol Fdn Mental Disorders, Lleida Inst Biomed Res Dr Pifarre Fdn, Hosp Univ Santa Maria,Psychiat Serv,IRBLleida, Lleida, Catalonia, Spain
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