Cerebrospinal fluid cytokines in multiple system atrophy: A cross-sectional Catalan MSA registry study
Por:
Compta, Y, Dias, SP, Giraldo, DM, Perez-Soriano, A, Munoz, E, Saura, J, Fernandez, M, Bravo, P, Camara, A, Pulido-Salgado, M, Painous, C, Rios, J, Marti, MJ, Pagonabarraga, J, Valldeoriola, F, Hernandez-Vara, J, Classen, SJ, Puente, V, Pont, C, Caballol, N, Tolosa, E, Bayes, A, Campdelacreu, J, de Fabregues, O, Avila, A, Calopa, M, Gaig, C, Fabregat, N, Pastor, P, Aguilar, M, Pujol, M, Sanchez, A, Planellas, L, Ezquerra, M, Fernandez-Santiago, R, Botta, T, Tartaglia, G
Publicada:
1 ago 2019
Resumen:
Introduction: Neuroinflammation is a potential player in neurodegenerative conditions, particularly the aggressive ones, such as multiple system atrophy (MSA). Previous reports on cytokine levels in MSA using serum or cerebrospinal fluid (CSF) have been inconsistent, including small samples and a limited number of cytokines, often without comparison to Parkinson's disease (PD), a main MSA differential diagnosis.
Methods: Cross-sectional study of CSF levels of 38 cytokines using a multiplex assay in 73 participants: 39 MSA patients (19 with parkinsonian type [MSAp], 20 with cerebellar type [MSAc]; 31 probable, 8 possible), 19 PD patients and 15 neurologically unimpaired controls. None of the participants was under non-steroidal anti-inflammatory drugs at the time of the lumbar puncture.
Results: There were not significant differences in sex and age among participants. In global non-parametric comparisons FDR-corrected for multiple comparisons, CSF levels of 5 cytokines (FGF-2, IL-10, MCP-3, IL-12p40, MDC) differed among the three groups. In pair-wise FDR-corrected non-parametric comparisons 12 cytokines (FGF-2, eotaxin, fractalkine, IFN-alpha 2, IL-10, MCP-3, IL-12p40, MDC, IL-17, IL-7, MIP-1 beta, TNF-alpha) were significantly higher in MSA vs. non-MSA cases (PD + controls pooled together). Of these, MCP-3 and MDC were the most significant ones, also differed in MSA vs. PD, and were significant MSA-predictors in binary logistic regression models and ROC curves adjusted for age. CSF levels of fractalkine and MIP-1 alpha showed a strong and significant positive correlation with UMSARS-2 scores.
Conclusion: Increased CSF levels of cytokines such as MCP-3, MDC, fractalkine and MIP-1 alpha deserve consideration as potential diagnostic or severity biomarkers of MSA.
Filiaciones:
Compta, Y:
Univ Barcelona, Parkinsons Dis & Movement Disorders Unit, Inst Neurociencies, Hosp Clin IDIBAPS CIBERNED European Reference Net, Catalonia, Spain
Dias, SP:
Univ Barcelona, Parkinsons Dis & Movement Disorders Unit, Inst Neurociencies, Hosp Clin IDIBAPS CIBERNED European Reference Net, Catalonia, Spain
Ctr Hosp Lisboa Cent, Dept Neurol, Lisbon, Portugal
Giraldo, DM:
Univ Barcelona, Parkinsons Dis & Movement Disorders Unit, Inst Neurociencies, Hosp Clin IDIBAPS CIBERNED European Reference Net, Catalonia, Spain
Perez-Soriano, A:
Univ Barcelona, Parkinsons Dis & Movement Disorders Unit, Inst Neurociencies, Hosp Clin IDIBAPS CIBERNED European Reference Net, Catalonia, Spain
Munoz, E:
Univ Barcelona, Parkinsons Dis & Movement Disorders Unit, Inst Neurociencies, Hosp Clin IDIBAPS CIBERNED European Reference Net, Catalonia, Spain
Saura, J:
Univ Barcelona, Biochem & Mol Biol Unit, Dept Biomed, Sch Med,Inst Neurociencies, Catalonia, Spain
Fernandez, M:
Univ Barcelona, Parkinsons Dis & Movement Disorders Unit, Inst Neurociencies, Hosp Clin IDIBAPS CIBERNED European Reference Net, Catalonia, Spain
Bravo, P:
Univ Barcelona, Parkinsons Dis & Movement Disorders Unit, Inst Neurociencies, Hosp Clin IDIBAPS CIBERNED European Reference Net, Catalonia, Spain
Camara, A:
Univ Barcelona, Parkinsons Dis & Movement Disorders Unit, Inst Neurociencies, Hosp Clin IDIBAPS CIBERNED European Reference Net, Catalonia, Spain
Pulido-Salgado, M:
Univ Barcelona, Parkinsons Dis & Movement Disorders Unit, Inst Neurociencies, Hosp Clin IDIBAPS CIBERNED European Reference Net, Catalonia, Spain
Painous, C:
Univ Barcelona, Parkinsons Dis & Movement Disorders Unit, Inst Neurociencies, Hosp Clin IDIBAPS CIBERNED European Reference Net, Catalonia, Spain
Rios, J:
Univ Autonoma Barcelona, IDIBAPS, Med Stat Core Facil, Catalonia, Spain
Univ Autonoma Barcelona, Fac Med, Biostat Unit, Catalonia, Spain
Marti, MJ:
Univ Barcelona, Parkinsons Dis & Movement Disorders Unit, Inst Neurociencies, Hosp Clin IDIBAPS CIBERNED European Reference Net, Catalonia, Spain
Pagonabarraga, J:
Univ Barcelona, Parkinsons Dis & Movement Disorders Unit, Inst Neurociencies, Hosp Clin IDIBAPS CIBERNED European Reference Net, Catalonia, Spain
Hosp Santa Creu & Sant Pau, Movement Disorders Unit, Barcelona, Catalonia, Spain
Valldeoriola, F:
Univ Barcelona, Parkinsons Dis & Movement Disorders Unit, Inst Neurociencies, Hosp Clin IDIBAPS CIBERNED European Reference Net, Catalonia, Spain
Hernandez-Vara, J:
Hosp Valle De Hebron, Movement Disorders Unit, Barcelona, Catalonia, Spain
Classen, SJ:
Hosp Bellvitge Princeps Espanya, Movement Disorders Unit, Barcelona, Catalonia, Spain
Puente, V:
Hosp Mar, Movement Disorders Unit, Barcelona, Catalonia, Spain
Pont, C:
Hosp Gen Granollers, Granollers, Catalonia, Spain
Caballol, N:
Hosp St Joan Despi Moises Broggi Consorci Sanitar, Movement Disorders Unit, Lhospitalet De Llobregat, Catalonia, Spain
Tolosa, E:
Univ Barcelona, Parkinsons Dis & Movement Disorders Unit, Inst Neurociencies, Hosp Clin IDIBAPS CIBERNED European Reference Net, Catalonia, Spain
Bayes, A:
Univ Barcelona, Parkinsons Dis & Movement Disorders Unit, Inst Neurociencies, Hosp Clin IDIBAPS CIBERNED European Reference Net, Catalonia, Spain
Ctr Med Teknon, Movement Disorders Unit, Barcelona, Catalonia, Spain
Campdelacreu, J:
Hosp Bellvitge Princeps Espanya, Movement Disorders Unit, Barcelona, Catalonia, Spain
de Fabregues, O:
Hosp Valle De Hebron, Movement Disorders Unit, Barcelona, Catalonia, Spain
Avila, A:
Hosp St Joan Despi Moises Broggi Consorci Sanitar, Movement Disorders Unit, Lhospitalet De Llobregat, Catalonia, Spain
Calopa, M:
Hosp Bellvitge Princeps Espanya, Movement Disorders Unit, Barcelona, Catalonia, Spain
Gaig, C:
Univ Barcelona, Parkinsons Dis & Movement Disorders Unit, Inst Neurociencies, Hosp Clin IDIBAPS CIBERNED European Reference Net, Catalonia, Spain
Fabregat, N:
Hosp Plato, Barcelona, Catalonia, Spain
Pastor, P:
Univ Hosp Mutua Terrassa, Neurol, Movement Disorders Unit, Terrassa, Catalonia, Spain
Aguilar, M:
Univ Hosp Mutua Terrassa, Neurol, Movement Disorders Unit, Terrassa, Catalonia, Spain
Pujol, M:
Hosp Santa Maria Lleida, Lleida, Catalonia, Spain
Sanchez, A:
Univ Barcelona, Parkinsons Dis & Movement Disorders Unit, Inst Neurociencies, Hosp Clin IDIBAPS CIBERNED European Reference Net, Catalonia, Spain
Planellas, L:
Univ Barcelona, Parkinsons Dis & Movement Disorders Unit, Inst Neurociencies, Hosp Clin IDIBAPS CIBERNED European Reference Net, Catalonia, Spain
Ezquerra, M:
IDIBAPS, Lab Parkinson Dis & Other Neurodegenerat Movement, Barcelona, Catalonia, Spain
Fernandez-Santiago, R:
IDIBAPS, Lab Parkinson Dis & Other Neurodegenerat Movement, Barcelona, Catalonia, Spain
Botta, T:
Univ Pompeu Fabra, ICREA, Ctr Genom Regulat CRG, Gene Funct & Evolut Grp, Barcelona, Catalonia, Spain
Tartaglia, G:
Univ Pompeu Fabra, ICREA, Ctr Genom Regulat CRG, Gene Funct & Evolut Grp, Barcelona, Catalonia, Spain
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