HTLV-1 infection in solid organ transplant donors and recipients in Spain
Por:
de Mendoza, C, Roc, L, Benito, R, Reina, G, Ramos, JM, Gomez, C, Aguilera, A, Rodriguez-Iglesias, M, Garcia-Costa, J, Fernandez-Alonso, M, Soriano, V, Rodriguez, C, Vera, M, del Romero, J, Marcaida, G, Ocete, MD, Caballero, E, Molina, I, Rodriguez-Calvino, JJ, Navarro, D, Rivero, C, Vilarino, MD, Algarate, S, Gil, J, de Lejarazu, RO, Rojo, S, Eiros, JM, Miguel, AS, Manzardo, C, Miro, JM, Garcia, J, Paz, I, Poveda, E, Calderon, E, Escudero, D, Trigo, M, Diz, J, Garcia-Campello, M, Hernandez-Betancor, A, Martin, AM, Gimeno, A, Gutierrez, F, Rodriguez, JC, Sanchez, V, Gomez-Hernando, C, Cilla, G, Perez-Trallero, E, Lopez-Aldeguer, J, Fernandez-Pereira, L, Niubo, J, Hernandez, M, Lopez-Lirola, AM, Gomez-Sirvent, JL, Force, L, Cifuentes, C, Perez, S, Morano, L, Raya, C, Gonzalez-Praetorius, A, Perez, JL, Penaranda, M, Hernaez-Crespo, S, Montejo, JM, Martinez-Sapina, A, Viciana, I, Cabezas, T, Lozano, A, Fernandez, JM, Garcia-Bermejo, I, Gaspar, G, Garcia, R, Gorgolas, M, Vegas, C, Blas, J, Miralles, P, Valeiro, M, Aldamiz, T, Margall, N, Guardia, C, do Pico, E, Polo, I, Aguinaga, A, Ezpeleta, C, Sauleda, S, Piron, M, Gonzalez, R, Barea, L, Jimenez, A, Blanco, L, Suarez, A, Rodriguez-Avial, I, Perez-Rivilla, A, Parra, P, Fernandez, M, Trevino, A, Requena, S, Benitez-Gu-tierrez, L, Cuervas-Mons, V, Barreiro, P, Soriano, V, Corral, O, Gomez-Gallego, F
Publicada:
9 ago 2019
Resumen:
Background HTLV-1 infection is a neglected disease, despite infecting 10-15 million people worldwide and severe illnesses develop in 10% of carriers lifelong. Acknowledging a greater risk for developing HTLV-1 associated illnesses due to immunosuppression, screening is being widely considered in the transplantation setting. Herein, we report the experience with universal HTLV testing of donors and recipients of solid organ transplants in a survey conducted in Spain. Methods All hospitals belonging to the Spanish HTLV network were invited to participate in the study. Briefly, HTLV antibody screening was performed retrospectively in all specimens collected from solid organ donors and recipients attended since the year 2008. Results A total of 5751 individuals were tested for HTLV antibodies at 8 sites. Donors represented 2312 (42.2%), of whom 17 (0.3%) were living kidney donors. The remaining 3439 (59.8%) were recipients. Spaniards represented nearly 80%. Overall, 9 individuals (0.16%) were initially reactive for HTLV antibodies. Six were donors and 3 were recipients. Using confirmatory tests, HTLV-1 could be confirmed in only two donors, one Spaniard and another from Colombia. Both kidneys of the Spaniard were inadvertently transplanted. Subacute myelopathy developed within 1 year in one recipient. The second recipient seroconverted for HTLV-1 but the kidney had to be removed soon due to rejection. Immunosuppression was stopped and 3 years later the patient remains in dialysis but otherwise asymptomatic. Conclusion The rate of HTLV-1 is low but not negligible in donors/recipients of solid organ transplants in Spain. Universal HTLV screening should be recommended in all donor and recipients of solid organ transplantation in Spain. Evidence is overwhelming for very high virus transmission and increased risk along with the rapid development of subacute myelopathy.
Filiaciones:
de Mendoza, C:
Hosp Univ Puerta Hierro Majadahonda, Madrid, Spain
Univ CEU San Pablo, Madrid, Spain
IIS Hosp Univ Puerta Hierro, Majadahonda, Spain
Roc, L:
Hosp Miguel Servet, Zaragoza, Spain
Benito, R:
Hosp Lozano Blesa, Zaragoza, Spain
Hosp Clin Univ Lozano Blesa, Zaragoza, Spain
Reina, G:
Clin Univ Navarra, Pamplona, Spain
Ramos, JM:
Hosp Gen Univ, Alicante, Spain
Hosp Univ, Alicante, Spain
Gomez, C:
Complejo Hosp, Toledo, Spain
Aguilera, A:
Hosp Conxo CHUS, Santiago, Spain
Rodriguez-Iglesias, M:
Hosp Puerta del Mar, Cadiz, Spain
Hosp Univ, Puerto Real, Spain
Garcia-Costa, J:
Complejo Hosp Univ, Orense, Spain
Fernandez-Alonso, M:
Clin Univ Navarra, Pamplona, Spain
Clin Univ, Pamplona, Spain
Soriano, V:
UNIR Hlth Sci Sch & Med Ctr, Calle Almansa 101, Madrid 28040, Spain
Rodriguez, C:
Ctr Sanitario Sandoval, Madrid, Spain
Vera, M:
Ctr Sanitario Sandoval, Madrid, Spain
del Romero, J:
Ctr Sanitario Sandoval, Madrid, Spain
Marcaida, G:
Hosp Gen Univ, Valencia, Spain
Ocete, MD:
Hosp Gen Univ, Valencia, Spain
Caballero, E:
Hosp Valle De Hebron, Barcelona, Spain
Molina, I:
Hosp Valle De Hebron, Barcelona, Spain
Rodriguez-Calvino, JJ:
Hosp Conxo CHUS, Santiago, Spain
Navarro, D:
Hosp Conxo CHUS, Santiago, Spain
Rivero, C:
Hosp Conxo CHUS, Santiago, Spain
Vilarino, MD:
Hosp Conxo CHUS, Santiago, Spain
Algarate, S:
Hosp Clin Univ Lozano Blesa, Zaragoza, Spain
Gil, J:
Hosp Clin Univ Lozano Blesa, Zaragoza, Spain
de Lejarazu, RO:
Hosp Clin Univ, Valladolid, Spain
Rojo, S:
Hosp Clin Univ, Valladolid, Spain
Eiros, JM:
Hosp Rio Hortega, Valladolid, Spain
Miguel, AS:
Hosp Rio Hortega, Valladolid, Spain
Manzardo, C:
IDIBAPS, Hosp Clin, Barcelona, Spain
Miro, JM:
IDIBAPS, Hosp Clin, Barcelona, Spain
Garcia, J:
Hosp Cristal Pinor, Orense, Spain
Paz, I:
Hosp Cristal Pinor, Orense, Spain
Poveda, E:
INIBIC Complejo Hosp Univ, La Coruna, Spain
Calderon, E:
Hosp Virgen Rocio, Seville, Spain
CIBERESP, Seville, Spain
Escudero, D:
Hosp Badalona Germans Trias & Pujol, Barcelona, Spain
Trigo, M:
Complejo Hosp, Pontevedra, Spain
Diz, J:
Complejo Hosp, Pontevedra, Spain
Garcia-Campello, M:
Complejo Hosp, Pontevedra, Spain
Hernandez-Betancor, A:
Hosp Insular Hosp Univ, Las Palmas Gran Canaria, Spain
Martin, AM:
Hosp Insular Hosp Univ, Las Palmas Gran Canaria, Spain
Gimeno, A:
Hosp Univ, Alicante, Spain
Gutierrez, F:
Hosp Gen, Elche, Spain
Rodriguez, JC:
Hosp Gen, Elche, Spain
Sanchez, V:
Hosp Gen, Elche, Spain
Gomez-Hernando, C:
Complejo Hosp Virgen Salud, Toledo, Spain
Cilla, G:
Hosp Donostia, San Sebastian, Spain
Perez-Trallero, E:
Hosp Donostia, San Sebastian, Spain
Lopez-Aldeguer, J:
Hosp La Fe, Valencia, Spain
Fernandez-Pereira, L:
Hosp San Pedro Alcantara, Caceres, Spain
Niubo, J:
Hospital Universitari de Bellvitge, Barcelona, Spain
Hernandez, M:
Hosp Univ Laguna, Tenerife, Spain
Lopez-Lirola, AM:
Hosp Univ Laguna, Tenerife, Spain
Gomez-Sirvent, JL:
Hosp Univ Laguna, Tenerife, Spain
Force, L:
Hosp Gen, Mataro, Spain
Cifuentes, C:
Hosp Son Llatzer, Palma De Mallorca, Spain
Perez, S:
Hosp Meixoeiro, Vigo, Spain
Morano, L:
Hosp Meixoeiro, Vigo, Spain
Raya, C:
Hosp Bierzo, Ponferrada, Spain
Gonzalez-Praetorius, A:
Hosp Univ, Guadalajara, Spain
Perez, JL:
Hosp Son Espases, Mallorca, Spain
Penaranda, M:
Hosp Son Espases, Mallorca, Spain
Hernaez-Crespo, S:
Hosp Basurto, Bilbao, Spain
Montejo, JM:
Hosp Cruces, Bilbao, Spain
Martinez-Sapina, A:
Hosp Miguel Servet, Zaragoza, Spain
Viciana, I:
Hosp Virgen Victoria, Malaga, Spain
Cabezas, T:
Hosp Poniente, Almeria, Spain
Lozano, A:
Hosp Poniente, Almeria, Spain
Fernandez, JM:
Hosp Poniente, Almeria, Spain
Garcia-Bermejo, I:
Hosp Univ, Getafe, Spain
Gaspar, G:
Hosp Univ, Getafe, Spain
Garcia, R:
Fdn Jimenez Diaz, Madrid, Spain
Gorgolas, M:
Fdn Jimenez Diaz, Madrid, Spain
Vegas, C:
Fdn Jimenez Diaz, Madrid, Spain
Blas, J:
Fdn Jimenez Diaz, Madrid, Spain
Miralles, P:
Hosp Gregorio Maranon, Madrid, Spain
Valeiro, M:
Hosp Gregorio Maranon, Madrid, Spain
Aldamiz, T:
Hosp Gregorio Maranon, Madrid, Spain
Margall, N:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Guardia, C:
ICS, Barcelona, Spain
do Pico, E:
ICS, Barcelona, Spain
Polo, I:
Complejo Hosp Navarra, Pamplona, Spain
Aguinaga, A:
Complejo Hosp Navarra, Pamplona, Spain
Ezpeleta, C:
Complejo Hosp Navarra, Pamplona, Spain
Sauleda, S:
Banco Sangre & Tejidos, Barcelona, Spain
Piron, M:
Banco Sangre & Tejidos, Barcelona, Spain
Gonzalez, R:
Ctr Transfus, Madrid, Spain
Barea, L:
Ctr Transfus, Madrid, Spain
Jimenez, A:
Ctr Hemoterapia & Hemodonac Castilla & Leon, Valladolid, Spain
Blanco, L:
Ctr Hemoterapia & Hemodonac Castilla & Leon, Valladolid, Spain
Suarez, A:
Hosp Clin San Carlos, Madrid, Spain
Rodriguez-Avial, I:
Hosp Clin San Carlos, Madrid, Spain
Perez-Rivilla, A:
Hosp Univ 12 Octubre, Madrid, Spain
Parra, P:
Hosp Univ 12 Octubre, Madrid, Spain
Fernandez, M:
Hosp Univ 12 Octubre, Madrid, Spain
Trevino, A:
IIS Hosp Univ Puerta Hierro, Majadahonda, Spain
Requena, S:
IIS Hosp Univ Puerta Hierro, Majadahonda, Spain
Benitez-Gu-tierrez, L:
IIS Hosp Univ Puerta Hierro, Majadahonda, Spain
Cuervas-Mons, V:
IIS Hosp Univ Puerta Hierro, Majadahonda, Spain
Barreiro, P:
La Paz Univ Hosp, Madrid, Spain
Soriano, V:
UNIR Hlth Sci Sch & Med Ctr, Calle Almansa 101, Madrid 28040, Spain
Corral, O:
UNIR Hlth Sci Sch & Med Ctr, Calle Almansa 101, Madrid 28040, Spain
Gomez-Gallego, F:
UNIR Hlth Sci Sch & Med Ctr, Calle Almansa 101, Madrid 28040, Spain
Gold, Green Published
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