Agreement of amyloid PET and CSF biomarkers for Alzheimer's disease on Lumipulse
Por:
Alcolea, D, Pegueroles, J, Munoz, L, Camacho, V, Lopez-Mora, D, Fernandez-Leon, A, Le Bastard, N, Huyck, E, Nadal, A, Olmedo, V, Sampedro, F, Montal, V, Vilaplana, E, Clarimon, J, Blesa, R, Fortea, J, Lleo, A
Publicada:
1 sep 2019
Ahead of Print:
1 ago 2019
Resumen:
Objective To determine the cutoffs that optimized the agreement between F-18-Florbetapir positron emission tomography (PET) and A beta 1-42, A beta 1-40, tTau, pTau and their ratios measured in cerebrospinal fluid (CSF) on the LUMIPULSE G600II instrument, we quantified the levels of these four biomarkers in 94 CSF samples from participants of the Sant Pau Initiative on Neurodegeneration (SPIN cohort) using the Lumipulse G System with available F-18-Florbetapir imaging. Methods Participants had mild cognitive impairment (n = 35), AD dementia (n = 12), other dementias or neurodegenerative diseases (n = 41), or were cognitively normal controls (n = 6). Levels of A beta 1-42 were standardized to certified reference material. Amyloid scans were assessed visually and through automated quantification. We determined the cutoffs of CSF biomarkers that optimized their agreement with F-18-Florbetapir PET and evaluated concordance between markers of the amyloid category. Results A beta 1-42, tTau and pTau (but not A beta 1-40) and the ratios with A beta 1-42 had good diagnostic agreement with F-18-Florbetapir PET. As a marker of amyloid pathology, the A beta 1-42/A beta 1-40 ratio had higher agreement and better correlation with amyloid PET than A beta 1-42 alone. Interpretation CSF biomarkers measured with the Lumipulse G System show good agreement with amyloid imaging in a clinical setting with heterogeneous presentations of neurological disorders. Combination of A beta 1-42 with A beta 1-40 increases the agreement between markers of amyloid pathology.
Filiaciones:
Alcolea, D:
Univ Autonoma Barcelona, Biomed Res Inst St Pau IIB St Pau, Hosp Santa Creu & St Pau, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Pegueroles, J:
Univ Autonoma Barcelona, Biomed Res Inst St Pau IIB St Pau, Hosp Santa Creu & St Pau, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Munoz, L:
Univ Autonoma Barcelona, Biomed Res Inst St Pau IIB St Pau, Hosp Santa Creu & St Pau, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Camacho, V:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Nucl Med Dept, Barcelona, Spain
Lopez-Mora, D:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Nucl Med Dept, Barcelona, Spain
Fernandez-Leon, A:
Univ Autonoma Barcelona, Biomed Res Inst St Pau, Hosp Santa Creu & St Pau, Nucl Med Dept, Barcelona, Spain
Le Bastard, N:
Fujirebio Europe NV, Ghent, Belgium
Huyck, E:
Fujirebio Europe NV, Ghent, Belgium
Nadal, A:
Fujirebio Iberia SL, Barcelona, Spain
Olmedo, V:
Fujirebio Iberia SL, Barcelona, Spain
Sampedro, F:
CIBERNED, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Montal, V:
Univ Autonoma Barcelona, Biomed Res Inst St Pau IIB St Pau, Hosp Santa Creu & St Pau, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Vilaplana, E:
Univ Autonoma Barcelona, Biomed Res Inst St Pau IIB St Pau, Hosp Santa Creu & St Pau, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Clarimon, J:
Univ Autonoma Barcelona, Biomed Res Inst St Pau IIB St Pau, Hosp Santa Creu & St Pau, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Blesa, R:
Univ Autonoma Barcelona, Biomed Res Inst St Pau IIB St Pau, Hosp Santa Creu & St Pau, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Fortea, J:
Univ Autonoma Barcelona, Biomed Res Inst St Pau IIB St Pau, Hosp Santa Creu & St Pau, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Lleo, A:
Univ Autonoma Barcelona, Biomed Res Inst St Pau IIB St Pau, Hosp Santa Creu & St Pau, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
CIBERNED, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Gold, Green Published
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