Acute heart failure and adverse events associated with the presence of renal dysfunction and hyperkalaemia. EAHFE- renal dysfunction and hyperkalaemia
Por:
Jacob, J, Llauger, L, Herrero-Puente, P, Martin-Sanchez, FJ, Llorens, P, Gil, V, Fuentes, M, Miro, O, Gil, C, Alonso, H, Perez-Llantada, E, Llopis-Garcia, G, Santos-Matallana, MC, Barrenechea-Moxo, MLD, Salgado-Perez, L, Escoda, R, Xipell, C, Sanchez, C, Gaytan, JM, Perez-Dura, MJ, Salvo, E, Pavon, J, Noval, A, Torres, JM, Lopez-Grima, ML, Valero, A, Juan, MA, Aguirre, A, Pedragosa, MA, Minguez-Maso, S, Alonso, MI, Ruiz, F, Franco, JM, Mecina, AB, Tost, J, Berenguer, M, Donea, R, Sanchez-Ramon, S, Carbajosa-Rodriguez, V, Pinera, P, Sanchez-Nicolas, JA, Garate, RT, Alquezar-Arbe, A, Rizzi, MA, Herrera, S, Roset, A, Cabello, I, Haro, A, Richard, F, Alvarez-Perez, JM, Lopez-Diez, MP, Vazquez-Alvarez, J, Prieto-Garcia, B, Garcia, MG, Gonzalez, MS, Javaloyes, P, Marquina, V, Jimenez, I, Hernandez, N, Brouzet, B, Espinosa, B, Andueza, JA, Romero, R, Ruiz, M, Calvache, R, Serralta, MTL, Javez, LEC, Arriaga, BA, Bergua, BS, Mojarro, EM, Jimenez, BSA, Becquer, LT, Burillo, G, Garcia, LL, LaSalle, GC, Urbano, CA, Soto, ABG, Padial, ED, Ferrer, ES, Garrido, JM, Lucas-Imbernon, FJ, Gaya, R, Bibiano, C, Mir, M, Rodriguez, B, Carballo, JL, Rodriguez-Adrada, E, Miranda, BR
Publicada:
1 sep 2019
Resumen:
Objective: To study the outcomes of patients with acute heart failure (AHF) presenting renal dysfunction (RD) or hyperkalaemia (Hk) alone or in combination.
Method: We analysed the data of the EAHFE registry, a multicentre, non interventionist cohort with prospective follow-up of patients with AHF. Four groups were defined based on the presence or not of RD or Hk alone or in combination. The primary endpoint was 30-day all-cause mortality.
Results: A total of 11,935 of the 13,791 patients included in the EAHFE registry were analysed. Of these, 5088 (42.6%) did not have RD or Hk (NoRD-NoHk), 150 (1.3%) had no RD but had Hk (NoRD-Hk), 6012 (50.4%) had RD but not Hk (RD-NoHk) and 685 (5.7%) had both RD and Hk (RD-Hk). Thirty-day all-cause mortality was greatest in the RD-Hk group with an adjusted Hazard Ratio (HR) of 2.44 (confidence interval 95% [C195%] 1.67-3.55; p < 0.001) and in the RD-NoHk group with an adjusted HR of 1.34 (CI95% 1.04-1.71; p = 0.022). There were no significant differences in in-hospital mortality and reconsultation at 30 days for HF. For the combined endpoint of 30-day all-cause mortality the adjusted HR was 1.33 (CI95% 1.04-1.70); (p = 0.021) for the RD-Hk group.
Conclusions: The association of 30-day all-cause mortality with the presence of RD and Hk in patients presenting AHF at admission is greater than in those without this combination.
Filiaciones:
Jacob, J:
Hosp Univ Bellvitge, Emergency Dept, Barcelona, Catalonia, Spain
Llauger, L:
Hosp Univ Vic, Emergency Dept, Barcelona, Spain
Herrero-Puente, P:
Hosp Univ Cent Asturias, Emergency Dept, Oviedo, Spain
Martin-Sanchez, FJ:
Univ Complutense, Hosp Clin San Carlos IdISSC, Fac Med, CNIC,Inst Invest Sanitaria,Emergency Dept, Madrid, Spain
Llorens, P:
Hosp Gen Alicante, Short Stay Unit & Home Hospitalizat, Emergency Dept, Alicante, Spain
Gil, V:
Univ Barcelona, Hosp Clin, Emergency Dept, Barcelona, Catalonia, Spain
Fuentes, M:
Hosp Univ Salamanca, Emergency Dept, Salamanca, Spain
Miro, O:
Univ Barcelona, Hosp Clin, Emergency Dept, Barcelona, Catalonia, Spain
Gil, C:
Hosp Univ Salamanca, Salamanca, Spain
Alonso, H:
Hosp Marques Valdecilla Santander, Santander, Spain
Perez-Llantada, E:
Hosp Marques Valdecilla Santander, Santander, Spain
Llopis-Garcia, G:
Hosp Clin San Carlos Madrid, Madrid, Spain
Santos-Matallana, MC:
Hosp Clin San Carlos Madrid, Madrid, Spain
Barrenechea-Moxo, MLD:
Hosp Clin San Carlos Madrid, Madrid, Spain
Salgado-Perez, L:
Hosp Clin Barcelona, Barcelona, Spain
Escoda, R:
Hosp Clin Barcelona, Barcelona, Spain
Xipell, C:
Hosp Clin Barcelona, Barcelona, Spain
Sanchez, C:
Hosp Clin Barcelona, Barcelona, Spain
Gaytan, JM:
Hosp Politen La Fe Valencia, Valencia, Spain
Perez-Dura, MJ:
Hosp Politen La Fe Valencia, Valencia, Spain
Salvo, E:
Hosp Politen La Fe Valencia, Valencia, Spain
Pavon, J:
Hosp Dr Negrin Las Palmas Gran Canaria, Las Palmas Gran Canaria, Spain
Noval, A:
Hosp Insular Las Palmas Gran Canaria, Las Palmas Gran Canaria, Spain
Torres, JM:
Hosp Reina Sofia Cordoba, Cordoba, Spain
Lopez-Grima, ML:
Hosp Dr Peset Valencia, Valencia, Spain
Valero, A:
Hosp Dr Peset Valencia, Valencia, Spain
Juan, MA:
Hosp Dr Peset Valencia, Valencia, Spain
Aguirre, A:
Hosp del Mar Barcelona, Barcelona, Spain
Pedragosa, MA:
Hosp del Mar Barcelona, Barcelona, Spain
Minguez-Maso, S:
Hosp del Mar Barcelona, Barcelona, Spain
Alonso, MI:
Hosp Valme Sevilla, Seville, Spain
Ruiz, F:
Hosp Valme Sevilla, Seville, Spain
Franco, JM:
Hosp Miguel Server Zaragoza, Zaragoza, Spain
Mecina, AB:
Hosp Alcorcon Madrid, Madrid, Spain
Tost, J:
Consorci Sanitari Terrassa, Terrassa, Spain
Berenguer, M:
Consorci Sanitari Terrassa, Terrassa, Spain
Donea, R:
Consorci Sanitari Terrassa, Terrassa, Spain
Sanchez-Ramon, S:
Hosp Univ Rio Hortega Valladolid, Valladolid, Spain
Carbajosa-Rodriguez, V:
Hosp Univ Rio Hortega Valladolid, Valladolid, Spain
Pinera, P:
Hosp Reina Sofia Murcia, Murcia, Spain
Sanchez-Nicolas, JA:
Hosp Reina Sofia Murcia, Murcia, Spain
Garate, RT:
Hosp Severo Ochoa Madrid, Madrid, Spain
Alquezar-Arbe, A:
Hosp Santa Creu & St Pau Barcelona, Barcelona, Spain
Rizzi, MA:
Hosp Santa Creu & St Pau Barcelona, Barcelona, Spain
Herrera, S:
Hosp Santa Creu & St Pau Barcelona, Barcelona, Spain
Roset, A:
Hosp Univ Bellvitge, Emergency Dept, Barcelona, Catalonia, Spain
Hosp Univ Bellvitge Barcelona, Barcelona, Spain
Cabello, I:
Hosp Univ Bellvitge Barcelona, Barcelona, Spain
Haro, A:
Hosp Univ Bellvitge Barcelona, Barcelona, Spain
Richard, F:
Hosp Univ Burgos, Burgos, Spain
Alvarez-Perez, JM:
Hosp Univ Burgos, Burgos, Spain
Lopez-Diez, MP:
Hosp Univ Burgos, Burgos, Spain
Vazquez-Alvarez, J:
Hosp Univ Cent Asturias Oviedo, Oviedo, Spain
Prieto-Garcia, B:
Hosp Univ Cent Asturias Oviedo, Oviedo, Spain
Garcia, MG:
Hosp Univ Cent Asturias Oviedo, Oviedo, Spain
Gonzalez, MS:
Hosp Univ Cent Asturias Oviedo, Oviedo, Spain
Javaloyes, P:
Hosp Gen Alicante, Alicante, Spain
Marquina, V:
Hosp Gen Alicante, Alicante, Spain
Jimenez, I:
Hosp Gen Alicante, Alicante, Spain
Hernandez, N:
Hosp Gen Alicante, Alicante, Spain
Brouzet, B:
Hosp Gen Alicante, Alicante, Spain
Espinosa, B:
Hosp Gen Alicante, Alicante, Spain
Andueza, JA:
Hosp Gen Univ Gregorio Maranon Madrid, Madrid, Spain
Romero, R:
Hosp Univ Getafe Madrid, Madrid, Spain
Ruiz, M:
Hosp Henares Madrid, Madrid, Spain
Calvache, R:
Hosp Henares Madrid, Madrid, Spain
Serralta, MTL:
Hosp Tajo Madrid, Madrid, Spain
Javez, LEC:
Hosp Tajo Madrid, Madrid, Spain
Arriaga, BA:
Hosp Clin Lozano Blesa Zaragoza, Zaragoza, Spain
Bergua, BS:
Hosp Clin Lozano Blesa Zaragoza, Zaragoza, Spain
Mojarro, EM:
Hosp St Pau & Santa Tecla Tarragona, Tarragona, Spain
Jimenez, BSA:
Hosp St Pau & Santa Tecla Tarragona, Tarragona, Spain
Becquer, LT:
Hosp Univ Canarias Tenerife, Tenerife, Spain
Burillo, G:
Hosp Univ Canarias Tenerife, Tenerife, Spain
Garcia, LL:
Hosp Univ Vic Barcelona, Barcelona, Spain
LaSalle, GC:
Hosp Univ Vic Barcelona, Barcelona, Spain
Urbano, CA:
Hosp Costa Sol Marbella Malaga, Malaga, Spain
Soto, ABG:
Hosp Costa Sol Marbella Malaga, Malaga, Spain
Padial, ED:
Hosp Costa Sol Marbella Malaga, Malaga, Spain
Ferrer, ES:
Hosp Josep Trueta Girona, Girona, Spain
Garrido, JM:
Hosp Virgen Macarena Sevilla, Seville, Spain
Lucas-Imbernon, FJ:
Hosp Gen Univ Albacete, Emergency Dept, Albacete, Spain
Hosp Gen Univ Albacete, Albacete, Spain
Gaya, R:
Hosp Juan XXIII Tarragona, Tarragona, Spain
Bibiano, C:
Hosp Infanta Leonor Madrid, Madrid, Spain
Mir, M:
Hosp Infanta Leonor Madrid, Madrid, Spain
Rodriguez, B:
Hosp Infanta Leonor Madrid, Madrid, Spain
Carballo, JL:
Complejo Hosp Univ Ourense, Orense, Spain
Rodriguez-Adrada, E:
Hosp Rey Juan Carlos Mostoles Madrid, Madrid, Spain
Miranda, BR:
Hosp Rey Juan Carlos Mostoles Madrid, Madrid, Spain
Green Accepted
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