Clinical Variables and Genetic Risk Factors Associated with the Acute Outcome of Ischemic Stroke: A Systematic Review
Por:
Torres-Aguila, NP, Carrera, C, Muino, E, Cullell, N, Carcel-Marquez, J, Gallego-Fabrega, C, Gonzalez-Sanchez, J, Bustamante, A, Delgado, P, Ibanez, L, Heitsch, L, Krupinski, J, Montaner, J, Marti-Fabregas, J, Cruchaga, C, Lee, JM, Fernandez-Cadenas, I
Publicada:
1 sep 2019
Resumen:
Stroke is a complex disease and one of the main causes of morbidity and mortality among the adult population. A huge variety of factors is known to influence patient outcome, including demographic variables, comorbidities or genetics. In this review, we expound what is known about the influence of clinical variables and related genetic risk factors on ischemic stroke outcome, focusing on acute and subacute outcome (within 24 to 48 hours after stroke and until day 10, respectively), as they are the first indicators of stroke damage. We searched the PubMed data base for articles that investigated the interaction between clinical variables or genetic factors and acute or subacute stroke outcome. A total of 61 studies were finally included in this review. Regarding the data collected, the variables consistently associated with acute stroke outcome are: glucose levels, blood pressure, presence of atrial fibrillation, prior statin treatment, stroke severity, type of acute treatment performed, severe neurological complications, leukocyte levels, and genetic risk factors. Further research and international efforts are required in this field, which should include genome-wide association studies.
Filiaciones:
Torres-Aguila, NP:
St Pau Res Inst, Stroke Pharmacogen & Genet Lab, C St Antoni Maria Claret 167, Barcelona 08025, Spain
Autonomous Univ Barcelona, Vall dHebron Res Inst VHIR, Neurovasc Res Lab, Barcelona, Spain
Carrera, C:
St Pau Res Inst, Stroke Pharmacogen & Genet Lab, C St Antoni Maria Claret 167, Barcelona 08025, Spain
Autonomous Univ Barcelona, Vall dHebron Res Inst VHIR, Neurovasc Res Lab, Barcelona, Spain
Muino, E:
St Pau Res Inst, Stroke Pharmacogen & Genet Lab, C St Antoni Maria Claret 167, Barcelona 08025, Spain
Cullell, N:
Mutua Terrassa Hosp, Mutua Terrasa Fdn Teaching & Res, Stroke Pharmacogen & Genet Lab, Terrassa, Spain
Carcel-Marquez, J:
St Pau Res Inst, Stroke Pharmacogen & Genet Lab, C St Antoni Maria Claret 167, Barcelona 08025, Spain
Gallego-Fabrega, C:
St Pau Res Inst, Stroke Pharmacogen & Genet Lab, C St Antoni Maria Claret 167, Barcelona 08025, Spain
Mutua Terrassa Hosp, Mutua Terrasa Fdn Teaching & Res, Stroke Pharmacogen & Genet Lab, Terrassa, Spain
Gonzalez-Sanchez, J:
St Pau Res Inst, Stroke Pharmacogen & Genet Lab, C St Antoni Maria Claret 167, Barcelona 08025, Spain
Mutua Terrassa Hosp, Mutua Terrasa Fdn Teaching & Res, Stroke Pharmacogen & Genet Lab, Terrassa, Spain
Manchester Metropolitan Univ All St, Hlth Care Sci Dept, Manchester, Lancs, England
Bustamante, A:
Autonomous Univ Barcelona, Vall dHebron Res Inst VHIR, Neurovasc Res Lab, Barcelona, Spain
Delgado, P:
Autonomous Univ Barcelona, Vall dHebron Res Inst VHIR, Neurovasc Res Lab, Barcelona, Spain
Ibanez, L:
Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA
Heitsch, L:
Washington Univ, Sch Med, Div Emergency Med, St Louis, MO USA
Washington Univ, Sch Med, Dept Neurol, 660 S Euclid Ave, St Louis, MO 63110 USA
Krupinski, J:
Mutua Terrassa Hosp, Mutua Terrasa Fdn Teaching & Res, Stroke Pharmacogen & Genet Lab, Terrassa, Spain
Manchester Metropolitan Univ All St, Hlth Care Sci Dept, Manchester, Lancs, England
Montaner, J:
Virgin Rocio & Macarena Hosp, Inst Biomed Seville IBiS, Dept Neurol, Seville, Spain
Marti-Fabregas, J:
St Cross & St Pau Hosp, Dept Neurol, Stroke Unit, Barcelona, Spain
Cruchaga, C:
Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA
Lee, JM:
Washington Univ, Sch Med, Dept Neurol, 660 S Euclid Ave, St Louis, MO 63110 USA
Fernandez-Cadenas, I:
St Pau Res Inst, Stroke Pharmacogen & Genet Lab, C St Antoni Maria Claret 167, Barcelona 08025, Spain
Gold, Green Published
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